Apolipoprotein L1 (APOL1): Consideration of Molecular Evolution, Interaction with APOL3, and Impact of Splice Isoforms Advances Understanding of Cellular and Molecular Mechanisms o... by Razi Khalaila, Karl Skorecki

“…In the absence of a consistent mechanistic explanation for differential kidney injury, we propose pursuing three interrelated avenues of investigation informed by prior epidemiological and mechanistic evidence linking them to APOL1’s cytotoxicity: (1) Molecular evolution of APOL1 haplotypes in human populations, (2) APOL1 splicing and consequent splice isoforms, (3) Interaction of APOL1 with other APOL gene family members, prioritizing APOL3. In the current study, we use reanalysis of population genetics datasets to resolve the haplotype contexts of all protein-altering APOL1 variants, uncovering previously unrecognized variant–haplotype couplings. …”
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Association of plasma levels of Sestrin2 with adiposity and metabolic function indices in healthy and diabetic subjects from Qatar Biobank by Muhammad Ammar Zahid, Shahenda Salah Abdelsalam, Hicham Raïq, Hanan H. Abunada, Aijaz Parray, Abdelali Agouni

“…Conversely, in the diabetic cohort, higher Sestrin2 levels were paradoxically linked to increased triglycerides (OR: 1.57), the product of triglyceride glucose and waist circumference (OR: 1.8), body fat (OR: 1.72), waist circumference (OR: 1.82), waist-to-hip ratio (OR: 1.96) and metabolic syndrome (OR: 1.48).ConclusionsThese findings suggest that Sestrin2 may play a complex and context-dependent role in metabolic regulation, potentially serving as a protective factor in healthy individuals but contributing to metabolic dysfunction in the context of established diabetes. …”
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Enhancing malaria elimination in high-transmission settings: the synergy of concurrent vector control and chemotherapy by Ronald Mulebeke, Adoke Yeka, Jean-Pierre van Geertruyden

“…Thus, tailoring strategies to the specific local context and transmission dynamics is essential for maximizing impact. …”
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Artificial intelligence as a policy response to teaching and learning issues in education in Ghana by Joshua Osondu, Emmanuel Jean Francois, Jesse Strycker

“…This paper offers a literature synthesis on the role of artificial intelligence (AI) as a strategic policy instrument in tackling the challenges of Teaching and Learning (TL) within the Ghanaian educational context. By examining the current state and prospects of AI in education (AIEd), specifically in Ghana, this study highlights how AI can address unique educational challenges faced by Ghanaian students and educators. …”
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Big oil and climate change: An ecolinguistic perspective by Richard John Alexander, Douglas Mark Ponton

“…Five years later, that challenge has become even greater due to a continued increase in greenhouse gas emissions. The pace and scale of what has been done so far, and current plans, are insufficient to tackle climate change.” …”
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Improved method for a pedestrian detection model based on YOLO by Yanfei LI, Chengyi DONG

“…The proposed method had superior performance in dense agricultural contexts while improving detection capabilities for pedestrian distribution patterns under complex farmland conditions, including variable lighting and mechanical occlusions. …”
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Prospects for distributed self-consumption generation in urban circuits with the use of photovoltaic systems by Diego Cordova, Secundino Marrero, Carlos Quinatoa, Manuel Leon

“…Electric distribution systems currently present a marked interest in solving problems related to technical losses, overloading of lines and being able to assimilate the increase in energy demand. …”
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Effects of complex whole-body movements on EEG activity: a scoping review by Gabriel Müller, Atef Salem, Wolfgang I. Schöllhorn

“…This issue is currently being increasingly investigated using movements in which metabolism is not increased accordingly. …”
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When IEEE 802.11 and 5G Meet Time-Sensitive Networking by Mahin K. Atiq, Raheeb Muzaffar, Oscar Seijo, INaki Val, Hans-Peter Bernhard

“…Time-sensitive networking (TSN) standards aim at providing vendor agnostic, reliable, and deterministic communications over the Ethernet, but lack in flexibility and modularity provisions. In this context wireless communication systems are preferred given the obvious benefits in terms of increased flexibility, reduced deployment & maintenance costs, and inherent mobility support. …”
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Modeling Approaches for Accounting Radiation-Induced Effect in HVDC-GIS Design for Nuclear Fusion Applications by Francesco Lucchini, Alessandro Frescura, Kenji Urazaki Junior, Nicolò Marconato, Paolo Bettini

“…A key challenge in this context is the degradation of dielectric performance due to radiation-induced conductivity (RIC), a phenomenon specific to the harsh radioactive environments near fusion reactors. …”
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The role of nicotinamide-β-adenine dinucleotide phosphate-H-cytochrome P450 oxidoreductase in the activation of cytochromes by Popova Olga, Bylinskaya Daria, Nikitina Anastasia, Ukrainskaya Olga

“…The aim of this theoretical study is to investigate the mechanisms of action of these enzymes in the context of metabolism in highly productive animals. …”
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A Review of Fish Anomalies in Türkiye’s Waters by Özgen Yılmaz, Hasan Cerim, Sercan Yapıcı, İsmail Reis

“…In the context of this review, 34 articles and symposium proceedings were found to belong to fish anomalies in Türkiye’s waters. …”
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The balance between care and conflict may be key to understanding maternal aggression in canaries by C. Garcia-Co, F. Verbruggen, J. Morales, W. Müller

“…While maternal aggression—defined as aggressive interactions from mothers to the offspring within the family context—may be a seemingly maladaptive behaviour, it could also be an adaptive strategy allowing optimal resource allocation for current and future reproduction in the face of evolutionary conflicts of interest. …”
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Quinoa in Peru: Andean Pseudocereal, a food for present and future generations by Jesús De La Cruz-Arango

“…This is especially important in the current context, and it is necessary to take measures to adapt to climate change7. …”
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Normal Weight Obesity Associated with Enhanced Echo Intensity, Insulin Resistance, and Decreased Muscle Strength in Young Adults by R Aruna, Armel Arputha Sivarajan, Gunaseelan Revathy, CJ Vasanth

“…Context: Obesity refers to the accumulation of excess body fat. …”
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Voice quality types and uses in North American English by Richard Wright, Courtney Mansfield, Laura Panfili

“…While not contrastive, it plays an important role in phonology and a wide variety of other discourse, pragmatic, and social functions. In this context we present some of our current research into segmental and social factors relating to creaky voicing. …”
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Financial Interrelations of scenario Indicators of budget Forecasting with Indicators of the Federal budget of Russia by M. E. Kosov, E. K. Voronkova, A. Yu. Chalova

“…The purpose of this study is to assess the validity of the forecast values of scenario macroeconomic indicators that determine the key characteristics of the Russian federal budget in the current budget cycle, and to develop proposals for clarifying the composition and concretizing approaches to their forecasting for the medium term in conditions of increased uncertainty. …”
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Intraventricular Empyema Features of Surgery and Conservative’s Outcome: A Scoping Review by Farhad Balafif, Donny Wardhana, Tommy Nazwar, Mustofa Mustofa

“…This scoping review seeks to bridge the existing literature gap by systematically summarizing current knowledge, identifying consensus, and highlighting research opportunities. …”
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THE CONCEPT OF «NATIONAL SECURITY» WITHIN THE CATEGORICAL FRAMEWORK OF PUBLIC ADMINISTRATION by Liliia Muntian

“…It is emphasized that studying the concept of «national security» in the context of public administration is crucial for understanding and interpreting the «state policy of national security» strategy. …”
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Incorporación de contenidos de actividades en el medio natural y de ocio en la educación formal (TSEAS): Una experiencia de espeleología (Incorporation of contents of activities i... by Julio Fuentesal García, David Zamorano Sande

“…On this article we present a innovative speleology intervention conducted with a group of superior grade formative course of animation and sports students, under the new curricular context. …”
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