Clinical and cost-effectiveness of first contact physiotherapy for musculoskeletal disorders in primary care: the FRONTIER, mixed method realist evaluation by Nicola E Walsh, Alice Berry, Serena Halls, Rachel Thomas, Hannah Stott, Cathy Liddiard, Zoe Anchors, Fiona Cramp, Margaret E Cupples, Peter Williams, Heather Gage, Dan Jackson, Paula Kersten, Dave Foster, Justin Jagosh

“…Year on year, there continue to be unprecedented numbers of consultations in primary care; between 20% and 30% are related to MSKDs. Given the increasing demand for general practitioner (GP) services and current difficulties surrounding GP recruitment and retention, alternative implementable and affordable models of care are essential. …”
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STAT2/SLC27A3/PINK1-Mediated Mitophagy Remodeling Lipid Metabolism Contributes to Pazopanib Resistance in Clear Cell Renal Cell Carcinoma by Dingheng Lu, Yuxiao Li, Xinyang Niu, Jiazhu Sun, Weitao Zhan, Yuchen Shi, Kai Yu, Suyuelin Huang, Xiaoyan Liu, Liping Xie, Xueyou Ma, Ben Liu

“…While tyrosine kinase inhibitors (TKIs) are currently the first-line treatments for advanced/metastatic ccRCC, patients often develop resistance after TKI therapy. …”
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Trends and Prospects in Educational Modernisation: A Hermeneutic Approach by A. F. Zakirova, Ye. N. Volodina

“…To overcome this situation and to break this deadlock, a profound reconsideration of the values underlying mechanisms of reform is required, taking into account multifaceted personal, social, national and universal relations, as well as unity of content, forms and means of education.The aims of the research were identified as follows: to analyse the current trends of modernisation in comprehensive schools and higher educational establishments; to justify humanistic mechanisms for improving the modernisation in the context of language education, which performs personally developing and socialising functions under ideological pluralism and opposition of value systems.Methodology and research methods. …”
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Sala de aula invertida com Tecnologias Digitais e Ferramenta Metacognitiva para potencializar as aulas do Ensino Superior / Flipped classroom with digital technologies and metacogn... by Caroline Medeiros Martins de Almeida, Camila Maria Bandeira Scheunemann, Paulo Tadeu Campos Lopes

“…A utilização do material autossuficiente baseado nas tecnologias digitais auxiliou os alunos na apreensão dos conceitos de fibromialgia, pois oferecia o conteúdo de modo organizado, atendendo as necessidades dos estudantes. /// In the current digital context, students are increasingly involved by digital technologies in their daily lives, which drives their insertion in the educational field, at different levels of education, in order to make classes more attractive, interesting and dynamic. …”

Optimizing a Novel Smartphone App to Prevent Postpartum Depression Adapted From an Evidence-Based Cognitive Behavioral Therapy Program: Qualitative Study by Adam K Lewkowitz, Melissa Guillen, Katrina Ursino, Rackeem Baker, Liana Lum, Cynthia L Battle, Crystal Ware, Nina K Ayala, Melissa Clark, Megan L Ranney, Emily S Miller, Kate M Guthrie

“…ConclusionsAdapting MBapp to incorporate end users’ perspectives optimized our digital PPD prevention intervention, ideally increasing its appeal to future users. Our team’s next steps will confirm that MBapp is a feasible, acceptable intervention among English- and Spanish-speaking perinatal people at risk of PPD.…”
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Presentation of Financial Assets in the Statistics of Foreign Economic Relations by V. N. Salin, L. Yu. Arhangelskaya, O. G. Tretyakova

“…The paper identifies the main directions for the statisticalstudy of financial assets, based on current international standards, taking into account national practice. …”
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Where heat does not come in waves: a framework for understanding and managing chronic heat by Mayra Cruz, Katharine J Mach, Lynée L Turek-Hankins, Kilan C Ashad-Bishop, Zinzi D Bailey, Scotney D Evans, Ashley Fanning, Margo Fernandez-Burgos, Jane Gilbert, Bereatha Howard, Monique Mahabir, Julia Marturano, Lisa N Murphy, Nkosi Muse, Joanne Pérodin, Amy C Clement

“…Research on heat and its risks has focused on heat waves as an increasing emergency under climate change, but this emphasis has obscured the chronic—not just acute and episodic—exposure of billions of people globally to increasingly dangerous levels of heat. …”
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Issues of Interpretation and Application of the Notion of “International Legal Legitimation” by A. M. Korzhenyak

“…Therefore, this phenomenon encapsulates a tremendous applied value in the context of the increasing number of hybrid threats to the national security of our country and the emergence of new sources of such threats.MATERIALS AND METHODS. …”
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Reassessing immediate coal phase-out: Dual imperatives of capacity control and renewables expansion in China’s net-zero strategy by Jiaxing Wang, Xi Lu, Hao Wang, Yang Ou, Jianxiao Wang, Dan Tong, Yan Li, Ziwen Ruan, Zihua Yin, Wenlong Zhou, Benjamin McLellan, Emily Xing, Anna M. MacLennan, Jingli Fan, Xian Zhang, Michael B. McElroy, Kebin He

“…Broader context: Reducing CO2 emissions in power systems is crucial for China in achieving its net-zero emission target. …”
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The methyl-CpG binding domain 2 regulates peptidylarginine deiminase 4 expression and promotes neutrophil extracellular trap formation via the Janus kinase 2 signaling pathway in e... by Biao Peng, Mu-Yun Yan, Yun-Rong Chen, Fei Sun, Xu-Dong Xiang, Da Liu

“…Objective The prognosis for severe asthma is poor, and the current treatment options are limited. The methyl-CpG binding domain protein 2 (MBD2) participates in neutrophil-mediated severe asthma through epigenetic regulation. …”
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Food Application of Orange Seed Powder through Incorporation in Wheat Flour to Boost Vitamin and Mineral Profiles of Formulated Biscuits by Ashiq Hussain, Salah Laaraj, Tusneem Kausar, Aziz Tikent, Hanane Azzouzi, Samina Kauser, Qurat Ul An, Aqsa Iqbal, Saima Akram, Rizwan Nisar, Ayesha Najam, Haya Fatima, Shazia Yaqub, Kaoutar Elfazazi

“…In the current work, orange seed powder replaced wheat flour at 0, 2.5, 5, 7.5, and 10% levels, to observe changes in physicochemical features of developed biscuits. …”
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Family Medicine for internally displaced persons in Mali: A training of trainers approach by Drissa M. Sidibé, Ann Isabelle Grégoire, Véronique Lisée, Pierre Rodrigue Traoré, Inhissa B. Bengaly, Aboubakary Konaté, Ibrahim H. Sidibé, Sabina Abou Malham, David-Martin Milot, Gabriel Blouin-Genest

“…The outcomes include increased awareness of the challenges faced by internally displaced persons and strengthening local capabilities. …”
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A quantitative assessment of the behavior of metallic elements in urban soils exposed to industrial dusts near Dunkerque (northern France) by M. Casetta, S. Philippe, L. Courcot, D. Dumoulin, G. Billon, F. Baudin, F. Henry, M. Hermoso, J. Caillaud

“…In this context, the monitoring of industrial PTEs in these urban soils is highly recommended, considering (1) the presence of allotment gardens in the vicinity of emitters and (2) the potential evolution of soil conditions due to increasing flood events.…”
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The Validity of Cryptocurrency Transactions and the Analysis of Associated Disputes by Hossein Qahari, Javad Hosseinzadeh

“…Introduction The complex economic relations in the current era increasingly demand the provision of efficient, rational, and comprehensive legal norms. …”
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Advancing life cycle assessment of bioenergy crops with global land use models by Anders Arvesen, Florian Humpenöder, Tomás Navarrete Gutierrez, Thomas Gibon, Paul Baustert, Jan Philipp Dietrich, Konstantin Stadler, Cristina-Maria Iordan, Gunnar Luderer, Alexander Popp, Francesco Cherubini

“…We find that land use-related CO _2 emission for bioenergy range from 2 to 35 tonne TJ ^−1 , depending on bioenergy demand, policy context, year and accounting method. GHG emissions per unit of bioenergy do not increase with bioenergy demand in presence of an emission tax. …”
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The Symbiotic Bacterial Profile of Laboratory-Reared and Field-Caught <i>Aedes albopictus</i> Mosquitoes from Greece by Elias Asimakis, Ioannis Galiatsatos, Georgia Apostolopoulou, Eleni C. Savvidou, Georgios Balatsos, Vasileios Karras, Vasiliki Evangelou, Eva Dionyssopoulou, Antonios Augustinos, Nikos T. Papadopoulos, Antonios Michaelakis, Panagiota Stathopoulou, George Tsiamis

“…The use of symbiotic bacteria to improve the application of SIT or design combined SIT/incompatible insect technique (IIT) approaches is currently considered. In this context, exploring the microbiota of local mosquito populations is crucial for identifying interesting components. …”
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Medical Assistance in Dying for Persons Suffering Solely from Mental Illness in Canada by Chloe Eunice Panganiban, Srushhti Trivedi

“…Utilitarianism: Minimizing Intolerable Suffering and Dying with Dignity Overall, utilitarianism is largely concerned with the greatest happiness principle—to increase the amount of happiness for the greatest number of people. …”
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A Strong Link Between Oceanographic Conditions and Zooplankton δ¹³C and δ¹⁵N Values in the San Jorge Gulf, Argentina by David Edgardo Galván, Manuela Funes, Flavio Emiliano Paparazzo, Virginia Alonso Roldán, Carla Derisio, Juan Pablo Pisoni, Brenda Temperoni, Daniela Alejandra del Valle, Valeria Segura, Seth D. Newsome

“…These spatial patterns in nutrient dynamics and copepod carbon and nitrogen isotope values are interpreted in the context of the dominant northward current and temporal development of the frontal systems in the SJG.…”
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A Model of Human Resource Management System Suitable for the New Generation Z in Executive Organizations with Thematic Analysis Approach by Moein Pourahmadi, Saeed Jafarinia, Yusuf Vakili, Akbar Hasanpour

“…Effective managers believe that retaining and maintaining Generation Z employees is crucial for customer satisfaction, increased retention, and business satisfaction in government organizations. …”
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The course and outcomes of COVID-19 in patients with ANCA-associated systemic vasculitis, receiving biological therapy (Rituximab, Mepolizumab): The results of the first 8 months o... by T. V. Beketova, V. V. Babak, M. D. Suprun

“…Since September 2020, the incidence has increased 3-fold, with a more severe course of COVID-19. …”
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