SFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2 by Hyun-Ju Cho, Joy Smith, Christopher H Switzer, Eleni Louka, Rebecca L Charles, Oleksandra Prysyazhna, Ewald Schroder, Mariana Fernandez-Caggiano, Daniel Simoes de Jesus, Seda Eminaga, Xiaoke Yin, Xiaoping Yang, Steven Lynham, Manuel Mayr, Valle Morales, Katiuscia Bianchi, Vinothini Rajeeve, Pedro R Cutillas, Adam J Mead, Philip Eaton

“…SFX-01, an α-cyclodextrin-stabilized sulforaphane complex currently in clinical development, covalently adducts cysteine residues. …”
Get full text

Recent advances in the biosynthesis and production optimization of gentamicin: A critical review by Feng Xu, Kaihao Hu, Ali Mohsin, Jie Wu, Lihuan Su, Yuan Wang, Rong Ben, Hao Gao, Xiwei Tian, Ju Chu

“…Overall, this article serves as a pivotal resource for researchers and professionals engaged in gentamicin research, furnishing a meticulous introduction to efficient synthesis technologies and diverse applications, alongside presenting innovative concepts and methodologies aimed at increasing gentamicin production.…”
Get full text

Digital platforms and news publishers: uneasy relationship by Petros Iosifidis

“…Whereas many of these activities were conducted through legacy news media, entities such as Google, Facebook, YouTube and Instagram currently dominate in most national contexts. The business models of digital platforms, their global nature and the pace that digital technologies and services evolve challenge existing regulatory frameworks concerning consumer protection, transparency, and power imbalances, especially in ensuring that substantial market power does not reduce competition in media and advertising services markets. …”
Get full text

White Rabbit FMC mezzanine as an interface for the new 10G WR-NIC to remote WR DAQ nodes by Bawaj Mateusz, Chiarusi Tommaso, Travaglini Riccardo

“…The White Rabbit protocol (WR), developed at CERN for the distribution of sub-nanosecond timing to thousands of nodes displaced over large geographic areas, is becoming increasingly reliable and is being utilized in various contexts, notably in modern multi-messenger astronomy experiments in progress such as KM3NeT, CTAO and ET. …”
Get full text

Innovation and Resignification: Social Entrepreneurship for Reincorporating Women into Peace Communities by Luz Elena Malagón-Castro, José Carlos Vázquez-Parra, Gloria Clemencia Valencia-González, Luis Guillermo Restrepo-Jaramillo

“…Educational strategies that foster Social Innovation, Entrepreneurship, and Complex Thinking are increasingly recognized as essential tools in this process, helping to rebuild social cohesion and empower local leadership. …”
Get full text

HIGH VOLUME BRICK POWDER CONCRETE SYNERGISTIC WITH METAKAOLIN: PHYSICOMECHANICAL PROPERTIES AND DRYING SHRINKAGE by Mahmood Fawzi Ahmed

“…The workability of the mixes containing 10%MK:40%BP and 20%MK:30%BP has slightly decreased, while the mechanical properties were increased and the drying shrinkage were declined. …”
Get full text

Molecular identification of Moniliophthora roreri isolates from cocoa orchards in Norte de Santander, Colombia by Liliana Yanet Suárez Contreras

“…The disease destroys the cocoa pod and crop production decreases, the losses reach up to 60% in the department of Norte de Santander. …”
Get full text

Exercise Promotes Hippocampal Neurogenesis in T2DM Mice via Irisin/TLR4/MyD88/NF-κB-Mediated Neuroinflammation Pathway by Haocheng Xu, Xin Tian, Yuanxin Wang, Junjie Lin, Baishu Zhu, Chen Zhao, Bin Wang, Xin Zhang, Yu Sun, Nan Li, Xun Sun, Fanxi Zeng, Mingzhi Li, Xiquan Ya, Renqing Zhao

“…Moreover, exercise markedly increased the levels of fibronectin type III domain-containing protein 5 (FNDC5)/irisin protein while decreasing the expression of Toll-like receptor 4 (TLR4), myeloid differential protein-88 (MyD88), and nuclear factor kappa-B (NF-κB) in the hippocampus of T2DM mice. …”
Get full text

Who does technology serve? A critical analysis of sociocultural factors shaping opportunities, practices and barriers faced by a smallholders in south-western Colombia by Marcela Ramos, Natalia Triana, Stefan Burkart, Jhon Freddy Gutiérrez, Diana María Gutiérrez-Zapata, Alejandro Ruden, Lady Sepúlveda, Brian Barrett

“…Therefore, the study contends that, when understanding technology adoption, it is not only a question of what farmers do or do not do but of what they can be and do in increasingly demanding contexts.…”
Get full text

The Profile of Multidrug Tuberculosis Regimen and Treatment Outcomes in Pulmonary MDR-TB Patients at the Tertiary Referral Hospital Dr. Soetomo, East Java, Indonesia: A Seven-Year... by Muhamad Frendy Setyawan, Ni Made Mertaniasih, Soedarsono Soedarsono

“…The treatment outcome profile of MDR-TB patients shows the average percentage of cured (15%), died (12%), lost-to-follow-up cases (27%), moved to an individualized regimen or a different health facility (42%), and currently in the evaluation stage (4%). Overall from January 2017 to July  2022, the number of LTFU cases decreased (42, 46, 29, 19, 8, 4)%. …”
Get full text

Chemistry Teachers’ Perspectives on the Implementation of Interdisciplinary Science Projects in Vocational Schools: Challenges and Strategic Solutions by Devy Lestari, Rosi Oktiani, Ulfa Lutfianasari, Muhamad Imaduddin

“…The integration of interdisciplinary approaches in science education has gained increasing prominence, particularly within vocational school contexts. …”
Get full text

Enhancing the use of artificial intelligence in architectural education – case study Saudi Arabia by Adnan Alshahrani, Ayman Mohamed Mostafa

“…In the present study, we explored the ways in which Artificial Intelligence (AI) is currently integrated into architectural education in Saudi Arabia, a country undergoing rapid digital and educational transformation. …”
Get full text

From attention to action: Advancing inclusivity in the landscape of anatomy education by Lily Evans, Katie Snow, Aiden Jayanth, Siobhan M. Moyes

“…Application of these methods yielded richer and more nuanced data, thus increasing the validity of the study. Although anatomy education may not currently represent diverse populations, positive action towards change is underway, with many in the discipline eager to actively confront exclusion. …”
Get full text

“We’re all in it together”: uniting a diverse range of professionals and people with lived experience within the development of a complex, theory-based paediatric speech and langua... by Lucy Rodgers, Nicola Botting, Natalie Abdo, Meriem Amer-El-Khedoud, Emma Baker, Sophie Franks, Dave Harford, Patrycja Salimi-Tabar, Laura Temple, Ros Herman

“…Our structured reflection has implications for future intervention development research, by highlighting that the provision of a safe, supportive space and nurturing of shared values is key when involving a diverse range of parties. Such contexts promote sustained involvement and therefore have longer term implications for increasing the relevance of the research for those it is aiming to help.…”
Get full text

Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration by Andjela Sekulic, Sarah M. Herr, Kelly Mulfaul, Inga-Marie Pompös, Silvia Winkler, Carola Dietrich, Benedikt Obermayer, Robert F. Mullins, Thomas Conrad, Peter F. Zipfel, Florian Sennlaub, Christine Skerka, Olaf Strauß

“…Polymorphisms in complement factor-H increase, while absence of factor-H-related protein-1 (FHR1) decreases the AMD risk, currently explained by their opposing relationship. …”
Get full text

Soil Decomposer Can Regulate the Legacy Effect of Photodegradation on Forest Marcescent Litter Decomposition, but Emerging Microplastics Disrupt This by Kai Tian, Xin Wang, Rumeng Ye, Yingqi Wang, Zhicheng Chen, Xiaojing Liu, Wenxia Wang, Lunguang Yao

“…ABSTRACT Photodegradation—photochemical mineralization of standing litters—often exerts a legacy effect aiding biodegradation in soil (PLE), which is overlooked in deciduous forests containing marcescent leaves. Meanwhile, increasing anthropogenic microplastics have deposited in forests, how they would affect the PLE on subsequent litter bio‐decomposition is currently unknown. …”
Get full text

Bcl-2 Overexpression Improves Survival and Efficacy of Neural Stem Cell-Mediated Enzyme Prodrug Therapy by Rachael Mooney, Asma Abdul Majid, Daniel Mota, Adam He, Soraya Aramburo, Linda Flores, Jennifer Covello-Batalla, Diana Machado, Joanna Gonzaga, Karen S. Aboody

“…However, like other stem cell-based therapies, survival of therapeutic NSCs after transplantation is currently suboptimal. One approach to prolonging cell survival is to transiently overexpress an antiapoptotic protein within the cells prior to transplantation. …”
Get full text

Effects of Metamorphic Degree of Coal on Coal Dust Wettability and Dust-Suppression Efficiency via Spraying by Pengfei Wang, Han Han, Ronghua Liu, Yongjun Li, Xuanhao Tan

“…According to the experimental results of coal’s microproperties, with the improvement of metamorphic degree, the content of hydrophilic oxygen-containing functional groups on the surface, the surface roughness, the specific surface area, and the interpore diameter all decreased. …”
Get full text

The Influence of Exometabolites of Fungus Botrytis Cinerеa on the Growth of Chinese Cabbage’s Callus Tissue (Brassica Pekinensis) by NGUYEN THI VUONG, E. A. KALASHNIKOVA

“…Currently vegetable crop loss from fungal, bacterial and viral diseases during storage and cultivation is a large proportion, sometimes even 100%. …”
Get full text

Optimal Operation Strategy of Ship Power System Under Battle Damage for Enhancing Survivability in Long-Term Missions by Chunhan Bai, Yun Tan, Fanrong Wei, Xiangning Lin

“…After a ship suffers an external strike, the system is often in a poor state of battle damage. Currently, the support capacity of the system in all aspects decreases dramatically, the operation interval narrows, and it is not easy to ensure the completion of the long-term mission chain, especially when it involves impact loads, which is more significant. …”
Get full text