Towards a sustainable rare disease and orphan drug ecosystem in Saudi Arabia: policy insights from a multi-stakeholder workshop by Ghada Mohammed Abozaid, Ghada Mohammed Abozaid, Hussain Abdulrahman Al-Omar, Abdulaziz Alrabiah, Asma AlMuaither, Amy Jayne McKnight

“…Through a series of presentations, educational sessions, and plenary discussions, participants examined the current landscape of RDs in SA, identified barriers to accessing ODs, and recommended strategies and initiatives to improve the accessibility, innovation, and sustainability of ODs.ResultsThe workshop highlighted key challenges recognized by a diverse group of 59 participants, including the absence of a national strategy, absent of local RDs and ODs definitions in the Saudi context, limited awareness and understanding of RDs among healthcare professionals, delayed diagnoses, scarcity of treatment and diagnosis centers for RDs, insufficient screening and prevention programs, regulatory hurdles in approving and importing ODs, and financial constraints. …”
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Propagation Characteristics of Multi-Cluster Hydraulic Fracturing in Shale Reservoirs with Natural Fractures by Lianzhi Yang, Xinyue Wang, Tong Niu

“…Understanding the effects of reservoir and fracturing conditions on fracture propagation is of great significance for optimizing the hydraulic fracturing process and has not been adequately explored in the current literature. In the context of shale reservoirs in Yibin, Sichuan Province, China, the study selects outcrops to prepare samples for uniaxial compression and Brazilian splitting tests. …”
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Significant fundamental translational research on breast cancer in China: progress and prospects by LU Yufeng, WANG Han, XIE Yifan, JIANG Yizhou, SHAO Zhimin

“…Breast cancer is the most prevalent malignant tumor that poses a threat to women's health in China, with incidence and mortality rates persistently increasing. Given this critical situation, there is an urgent need to optimize therapeutic options through basic translational research to address current treatment challenges. …”
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Investigating The Performance Of Local And Indigenous Businesses In Times Of Economic Recession With Emphasis On Developing The Capabilities Of Cooperatives In Sistan And Baluchest... by Ali Asghar Tabavar, Abdoulnaser Derakhshan, Sahar Arefi

“…Empowerment of local people and presence in domestic and local businesses leads to the growth of these businesses and increases self-confidence in creating a local business for local people. …”
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Analysis of Factors Influencing the Development of Community-Based Tourism in Rural Areas, Case Study: Villages Targeted by Tourism in the Markazi Province by Hamid Afshari, Behrouz Mohammadi Yeganeh, Hossein Farahani, Mehdi Cheraghi

“…In the socio-cultural dimension, it should be said that there is a strong relationship between cultural sustainability and participation, and the local community is very vulnerable to the indiscriminate and unprincipled increase in tourism. The results of the current research showed that due to the lack of correct and principled planning in all dimensions, including the cultural dimension, the participation of the local community in tourism was very small. …”
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Dietary Passion Fruit Seed Oil Supplementation for Health and Performance of Laying Hens by Laís Garcia Cordeiro, Paola Aparecida Damázio Rodrigues, Gabrieli Andressa de Lima, Elis Omar Figueroa Castillo, Joyce Andrade da Silva, Júlia de Lima Lopes, Anna Luísa Lang, Samir Moura Kadri, Antônio Celso Pezzato, José Roberto Sartori

“…The groups were fed a corn–soybean basal diet containing 0.00%, 0.45%, and 0.90% PFSO for 16 weeks. …”
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The prognostic value of serum apolipoprotein A1 levels in elderly patients with de novo SARS-CoV-2 omicron infection by Cong Shi, Ruishuang Ma, Miao Zhou, Shujun Yang, Shengping Gong

“…The omicron variant is currently the predominant strain circulating worldwide. …”
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“If that would have lessened my symptoms, that would have been great...”: a qualitative study about the acceptability of tecovirimat as treatment for mpox by Sara Paparini, Rosalie Hayes, Benjamin Weil, Will Nutland, Ismael Maatouk, Teodora Wi, Chloe M. Orkin, Rosamund Lewis

“…Conclusions This exploratory study suggest that offering tecovirimat (or comparable emergency-licensed treatments) to people with mpox is acceptable, although uptake will depend on knowledge of mpox treatment options, trust in medicine and medical professionals and provision of relevant information and choice. To increase acceptability of such treatments, clinicians should ensure patients are aware of mpox symptom management options, including pain relief; acknowledge and address patient concerns upfront and within the context of non-stigmatising care; and communicate offers in a consistent and supportive manner in line with locally approved eligibility criteria and protocols at the time.…”
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Evaluation of biokinetics and dosimetry in [131I]-NaI therapies: whole-body images quantification versus lower limb region by Bianca Lemos Lima, Jamille da Silveira Almeida, Maria da Penha Albuquerque Potiens, Rogério Alexandre Pelissoni, Marcelo Tatit Sapienza, Carlos Alberto Buchpiguel, José Willegaignon

“…Even presenting correlation between the data obtained through the two ROIs, we suggest further studies with a larger group of patients, which could increase the level of reliability of the dosimetric method using ROI in the thigh region.…”
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Advances and prospect in natural beauty evaluation: insights for the World Heritage karst by Xi Zhao, Kangning Xiong, Meng Zhang

“…The combination of traditional and emerging technologies such as SD method, SBE method, AHP method, neuroscience, and UGC data has increased, breaking through time and space constraints and expanding data sources. (4) In future studies, the assessment of natural beauty should concentrate on aesthetic preferences across diverse cultural contexts, develop a concept of global localization, and enhance evaluators' aesthetic perception through multisensory integration. …”
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Research Progress on the Impact of Nighttime Outdoor Environments on Residents’ Health by Chongxian CHEN, Xinrui XIONG, Guangsi LIN, Jingyi LIU

“…ObjectiveWith the emergence of the “24-hour city” concept and the increasing diversification of the nighttime lifestyles and activities of urban residents, the impact of nighttime outdoor environments on public health has received growing attention. …”
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Prenatal and progressive coenzyme Q10 administration to mitigate muscle dysfunction in mitochondrial disease by Juan Diego Hernández‐Camacho, Cristina Vicente‐García, Lorena Ardila‐García, Ana Padilla‐Campos, Guillermo López‐Lluch, Carlos Santos‐Ocaña, Peter S. Zammit, Jaime J. Carvajal, Plácido Navas, Daniel J.M. Fernández‐Ayala

“…Abstract Background ADCK genes encode aarF domain‐containing mitochondrial kinases involved in coenzyme Q (CoQ) biosynthesis and regulation. …”
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Challenges in modelling the impact of frost and heat stress on the yield of cool-season annual grain crops by Jonathan Richetti, Victor Oscar Sadras, Victor Oscar Sadras, Victor Oscar Sadras, Di He, Brenton Leske, Pengcheng Hu, Yacob Beletse, C. Mariano Cossani, C. Mariano Cossani, C. Mariano Cossani, Ha Nguyen, Bangyou Zheng, David Matthews Deery, M. Fernanda Dreccer, Jeremy Whish, Julianne Lilley

“…These temperature extremes are increasing in frequency and intensity due to climate change in many parts of the broadacre cropping regions globally, presenting challenges to food production. …”
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CanASM: a comprehensive database for genome-wide allele-specific DNA methylation identification and annotation in cancer by Jianmei Zhao, Zeyu Zhao, Hongfei Li, Haojie Yu, Hao Lin, Hanqi Chen, Xuecang Li, Di Liu, Yiming Wang, Guohua Wang

“…Despite the increasing recognition of ASM as a potential biomarker in tumorigenesis, systematic resources dedicated to identifying and annotating ASMs in cancer contexts remain limited. …”
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Radiation accidents associated with violation of rules of gathering and recycling of ferrous and non-ferrous metal scrap in the Russian Federation in 2010-2023 by A. V. Gromov, A. M. Biblin, K. A. Sednev, R. R. Akhmatdinov

“…A negative trend in the accident frequency was observed, with an average annual decline rate of 12%, indicating a steady decrease in occurrences over the last 14 years. The primary sources of radioactive contamination in scrap metal included fragments of various radiation-related equipment, pipes, and technological equipment from the oil and gas industry contaminated with natural radionuclides during use (primarily 226Ra and its salts), as well as devices containing permanent luminescent substances based on 226Ra salts. …”
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Water- and frost-resistance of crushed stone mastic asphalt concrete prepared on sevilen-modified bitumen by V. V. Yadykina, S. N. Navolokina, A. M. Gridchin

“…Introduction. Currently, increasing the durability of road asphalt concrete pavements is one of the urgent issues, the solution of which provides a significant economic effect achieved by increasing the turnaround time, as well as the overall service life of highways. …”
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Investigating the impact of armed conflict, cultural factors, and demographic characteristics on access to family planning services in Northwest Syria: a cross-sectional study by Okba Doghim, Abdulselam Daif, Abdulkarim Ekzayez, Kristen Meagher, Preeti Patel

“…Attending awareness sessions on family planning was associated with increased contraceptive usage, with 67% of attendees reporting usage compared to 44% of non-attendees. …”
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A Framework for Successful Crowdfunding Campaigns: Insights from Social Media (A Systematic Review) by Saeideh Sadat Alavi, Mohammad Ghadamyari, Tahmoores Sohrabi

“…Campaign success can be measured by various dimensions, including the total amount of funds raised, increased brand awareness, and the achievement of specific project goals. …”
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Leveraging Administrative Health Databases to Address Health Challenges in Farming Populations: Scoping Review and Bibliometric Analysis (1975-2024) by Pascal Petit, Nicolas Vuillerme

“…Administrative health databases (AHDs) are increasingly reused in population-based research and digital public health, especially for populations such as farmers, who face distinct environmental risks. …”
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Climate science for 2050 by Guy Brasseur, Guy Brasseur, Detlef Stammer, Pierre Friedlingstein, Pierre Friedlingstein, Gabriele Hegerl, Tiffany Shaw, Kevin Trenberth, Kevin Trenberth, Jadwiga Richter, Carolina Vera, André Berger, Helen Cleugh, Steve Easterbrook, Paul Edwards, Daniela Jacob, Michael Mann, Valérie Masson-Delmotte, Gavin Schmidt, Mary Scholes, Thomas Stocker, Martin Visbeck, Guoxiong Wu

“…Finally, we speculate about the values and ethics of climate science and the nature of climate research in a world that will be increasingly affected by global warming in a geopolitical context very different from that of recent decades.…”
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