Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype. by Ruthiran Kugathasan, Ksenia Sukhova, Maya Moshe, Paul Kellam, Wendy Barclay

“…New variants of SARS-CoV-2 are continually emerging with mutations in spike associated with increased transmissibility and immune escape. Phenotypic maps can inform the prediction of concerning mutations from genomic surveillance, however most of these maps currently derive from studies using monomeric RBD, while spike is trimeric, and contains additional domains. …”
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Ghrelin stimulation of growth hormone-releasing hormone neurons is direct in the arcuate nucleus. by Guillaume Osterstock, Pauline Escobar, Violeta Mitutsova, Laurie-Anne Gouty-Colomer, Pierre Fontanaud, François Molino, Jean-Alain Fehrentz, Danielle Carmignac, Jean Martinez, Nathalie C Guerineau, Iain C A F Robinson, Patrice Mollard, Pierre-François Méry

“…Indeed, ghrelin does not modify synaptic currents of GHRH neurons. However, ghrelin exerts a strong and direct depolarizing effect on GHRH neurons, which supports their increased firing rate.…”
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Development of recipes and technologies for producing functional desserts using sea buckthorn fruits by S. O. Nekrasova, A. V. Komarov

“…In modern society there is a problem of malnutrition of the population associated with the consumption of high-energy food containing an insufficient amount of macro and micro elements, vitamins and other essential substances. …”
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Disease progression & treatment need in sub-genotype C4 hepatitis B infection: a retrospective cohort study in the Northern Territory, Australia by Genevieve E. Martin, Kelly Hosking, Kelly Banz, Catherine Gargan, Geoff Stewart, Belinda Greenwood-Smith, Penelope Ramsay, Jaclyn Tate-Baker, Christine Connors, Paula Binks, Melita McKinnon, Prashanti Manchikanti, George Garambaka Gurruwiwi, Nicole Allard, Ashleigh Qama, Jessica Michaels, Emily Vintour-Cesar, Robert Batey, Catherine Marshall, Peter Nihill, Tammy-Allyn Fernandes, Karen Fuller, Steven Y. C. Tong, David Boettiger, Benjamin Cowie, Joshua S. Davis, Sarah Mariyalawuy Bukulatjpi, Jane Davies, on behalf of the Hep B PAST Partnership

“…Only 6·7% of untreated individuals were treatment eligible under current guidelines. Using the 2024 World Health Organisation guidelines, this increased to 50% due mostly to fibrosis and population prevalence of diabetes. …”
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Berberis lycium: A Miracle Medicinal Plant with Multifaceted Health Benefits by Bashir Ahmad, Abduh Murshed, Mohamed Y. Zaky, Imran Khan, Faiz ur Rahman, Magda H. Abdellattif, Guojun Liu, Jun Lu

“…The annual sale of medicinal plants increases over time. In plants, Berberis vulgaris f. lycium (Royle) Parsa (Berberis lycium), also called boxthoran barberry, Indian barberry, or Indian lyceum contains key alkaloids such as berberine, camptothecin, koumidine, salutaridine, luteanine, palmatine, and protopine. …”
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A Review of Reject Brine Disposal, Management, and Construction Applications by Pranita Banerjee, Essam K. Zaneldin, Ali H. Al-Marzouqi, Waleed K. Ahmed

“…Desalination is becoming crucial to meet the increasing global demand for potable water. Despite its benefits, desalination produces reject brine, a highly concentrated saline byproduct, which poses substantial environmental risks if not managed properly. …”
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The Middle East Shiite Arc: A Real Threat or Geopolitical Chimera? by A. V. Sarabiev

“…The term Shiite Crescent, or Shiite Arc, is becoming increasingly popular in political and academic discourse as well as in the media. …”
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Specific features of antagonism of <i>Bacillus</i> bacteria against toxinogenic <i>Fusarium</i> fungi in protecting plants against disease and contamination with mycotoxins (review... by T. M. Sidorova, A. M. Asaturova, V. V. Allakhverdyan

“…The role of lipopeptides produced by bacteria in inhibiting the growth of fungi, which manifests itself both through the destruction of the cell wall of the fungus and by increasing the immune status of the plant, has been shown. …”
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Editor’s Note by Alberto Raposo

“…This indicates that JIS is being increasingly recognized as an interesting publication vehicle. …”
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Interactive Mode of Teaching Students in the Context of the Competence Paradigm by G. P. Sikorskaya, T. V. Savelyeva

“…The paper explores the theoretical and practical aspects of interactive mode of teaching students by using active educational methods improving the quality of educational process and increasing students’ motivation for comprehensive and in-depth learning. …”
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Sustainable Growth from a Factor Dependence and Technological Progress Perspective: A Case Study of East China by Ying Liu, Wan-Ming Chen, Sheng-Yuan Wang, Xiao-Lan Wu

“…The paper constructs an economic growth model that contains human, physical capital, innovation, and energy factors and estimates the output elasticity of seven provinces and cities in East China in the period of 2004–2018. …”
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Strengthening the Motivation of Staff as a Factor of Enterprise Competitiveness by Mahsma Mariya B.

“…The aim of the article is to study the theoretical and applied aspects of the functioning of the system of motivation of staff on the example of a production enterprise and to outline the directions of its improvement in the context of increasing the competitiveness of enterprise. The article analyzes the current state of staff motivation on the example of a leading Ukrainian company specializing in the trade of furniture components and accessories. …”
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Stochastic Dynamics of Emotional Characteristics of Cognitive Systems by A. A. Solodov, T. G. Trembach

“…This, in turn, made it possible to develop analytical relations for the relative amount of stress processed by the system for the current time. Thus, a model of the emotional state of the cognitive system (the development of the process of experiencing stress over time) is proposed in the form of a decreasing function of time with a certain time constant that characterizes the inertial properties of experiencing stress. …”
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IDEA: Image database for earthquake damage annotationZenodo by Ilaria Senaldi, Chiara Casarotti, Martina Mandirola, Alessio Cantoni

“…Such onthology, can be used either to expand the presented dataset or to produce new ones, in order to increase the availability of data annotated according to a common standard, from the structural engineering point of view. …”
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Hygienic requirements to the design of the positron-emission tomography centers and departments by O. V. Minonenko, T. B. Baltrukova, N. S. Bashketova, G. A. Gorskiy, T. V. Kryukova, E. A. Fedorova

“…The aim of the current study is to provide a critical analysis of the current hygienic requirements to the design of the PET, PET/CT and PET/MRI centers and departments. …”
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Distraction Osteogenesis in Oral and Maxillofacial Reconstruction Applications: Feasibility Study of Design and Development of an Automatic Continuous Distractor by Katayoun Hatefi, Shahrokh Hatefi, Milad Etemadi

“…The device contains mini stepper motor and gear-box, controller, mechatronic system, LCD, and keypad. …”
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Comparison of various feed additives on nutrient digestibility, digestive enzyme activity, blood metabolite levels, and gut microbiota composition in japanese quail chicks by Hassan Saleh, Omid Jangjou, Mohammad Taher Mirakzehi, Seyedeh Hamideh Hosseni

“…Results: Japanese quail chicks that were fed a diet containing iron oxide nanoparticles and antibiotics exhibited a statistically significant increase (p < 0.05) in body weight gain (BWG) between 1 and 5 weeks of age (5.65 and 5.67 g/d, respectively). …”
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The comparative study of the corrosion stability of Zn-Ni-Co alloy coatings deposited from chloride and sulphate baths by Marija G. Riđošić, Jelena B. Bajat

“…On the other hand, [Co2+]/Ni2+] ion ratio showed a significant influence on corrosion behaviour of ternary alloy coatings, and this influence was more pronounced with alloys deposited from chloride baths. It was shown that increased corrosion protection of steel can be achieved by electrochemical deposition of ternary alloys that contained lower amount off the alloying elements, while the composition of the ternary alloy can be optimized by proper choice of the type and composition of the deposition bath.…”
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Physical and chemical characterization of experimental newly formulated polymer infiltrated lithium disilicate ceramic network versus polymer infiltrated feldspathic ceramic networ... by Alaa Hussein, Moustafa Aboushlieb, Nour A. Habib

“…PILN-25 showed higher porosity% than PILN-20 and the porosity decreased after polymer infiltration. PILN-20 showed higher density than PILN-25 and density increased after polymer infiltration. …”
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Results of Using Different Modes of Presentation of Stereostimuli in the Study of Stereo Vision in Normal Children and in Children with Non-Paralytic Strabismus without Functional... by S. I. Rychkova, V. G. Likhvantseva

“…In children of the control group when switching from the simple alternation regime to the “empty” interval regime the maximal durations of monocular phases, which preserved the stereoeffect, decreased and when switching to the binocular phase regime they significantly increased. …”
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