Scientific and Regulatory Lessons Learnt on Building a Chemistry, Manufacturing, and Controls (CMC) Package for COVID-19 Variant Vaccine Updates in the EU—A Regulator’s Perspective... by Ragini Shivji, Elena Grabski, Veronika Jekerle

“…The experience gained from the vaccine adaptations, combined with a continuous early regulator-developer scientific discussion, permits increasingly greater predictability for timing and positive regulatory outcomes. …”
Get full text

Phylogenetic Groups and Antimicrobial Resistance among Uropathogenic Escherichia coli Isolates from Hospitalized Patients in Tehran by Mana Talebi Farahani, Mohammad Karim Rahimi, Mehdi Goudarzi

“…Background: The presence of Escherichia coli among uropathogens is increasing significantly worldwide. It accounts for a considerable amount of morbidity and high medical costs and also can lead to mortality. …”
Get full text

IoT Device Identification Techniques: A Comparative Analysis for Security Practitioners by Ashley Andrews, George Oikonomou, Simon Armour, Paul Thomas, Thomas Cattermole

“…As the Internet of Things (IoT) continues to grow, networks are increasingly at risk from vulnerable devices that allow access to attackers. …”
Get full text

Policies and guidelines supporting the sustainability of human milk donation to milk banks in Switzerland: a document analysis by Christelle Kaech, Tracy Humphrey, Catherine Kilgour, Céline Julie Fischer Fumeaux, Claire de Labrusse

“…Globally, despite an increasing number of human milk banks, the demand for donor milk exceeds the supply, and access remains inequitable and insufficient. …”
Get full text

Copper homeostasis and neurodegenerative diseases by Yuanyuan Wang, Daidi Li, Kaifei Xu, Guoqing Wang, Feng Zhang

“…Copper is a potent oxidant that increases reactive oxygen species production and promotes oxidative stress. …”
Get full text

US Deterrence against Russia and China (based on strategic documents of J. Biden administration) by V. I. Batyuk

“…A closer examination of key strategic documents published in recent years shows that if from a political and military point of view, the US strategists come up with a generally rational list of measures aimed at countering the challenge, posed by Russia and China, from an ideological point of view they doggedly follow liberal-hegemonic premises that are increasingly inconsistent with current international political realities. …”
Get full text

Spatio-temporal changes of water quality variables in a highly disturbed river by Z. Abdollahi, A. Kavian, S.H.R. Sadeghi

“…Many rivers in developing countries are unhealthy because they contain harmful physical, chemical and biological agents. …”
Get full text

Brownian motion effects and thermophoresis on heat transmission mechanism of hybrid nano liquid flow over a stretched wedge surface by Sharanayya Swami, Suresh Biradar, Jagadish V Tawade, Vediyappan Govindan, Haewon Byeon, Busayamas Pimpunchat

“…The current study observes the impact of thermophoresis, Brownian motion, and magnetic fields on the flow and heat transfer properties of a hybrid nanofluid containing Al2O3, CuO, and ethylene glycol over a wedge-shaped surface undergoing horizontal stretching. …”
Get full text

Identification of widely conserved biosynthetic gene cluster involved in pigment production of Bacillus subtilis by Rune Overlund Stannius, Christopher A. Dunlap, Estelle Morvan, Mélanie Berbon, Sophie Lecomte, Antoine Loquet, Ákos T. Kovács

“…This study describes the chemical and biological features of a new class of SM BGC, which we hope will serve to improve the current BGC discovery pipelines in Bacilli.IMPORTANCEIdentification of novel microbial secondary metabolites (SMs) and their biosynthetic gene cluster (BGC) has become increasingly difficult, especially in Bacilli, as the tools for screening and genome mining are dependent on clear function or similarity to already known BGCs. …”
Get full text

Effects of long-term pioglitazone treatment on peripheral and central markers of aging. by Eric M Blalock, Jeremiah T Phelps, Tristano Pancani, James L Searcy, Katie L Anderson, John C Gant, Jelena Popovic, Margarita G Avdiushko, Don A Cohen, Kuey-Chu Chen, Nada M Porter, Olivier Thibault

“…Finally, a combination of microarray analyses on hippocampal tissue and serum-based multiplex cytokine assays revealed that age-dependent inflammatory increases were not reversed by PIO.<h4>Conclusions</h4>While current research efforts continue to identify the underlying processes responsible for the progressive decline in cognitive function seen during normal aging, available medical treatments are still very limited. …”
Get full text

A Systematic Review Examining the Association of Falls With Diabetes‐Related Foot Ulcers by Mike Wu, Mallika Sinha, Chanika Alahakoon, Kristen S. Barratt, Shivshankar Thanigaimani, Jonathan Golledge

“…A meta‐analysis showed high heterogeneity between studies (I2 = 95%) and an increased risk of falls in people with DFU (risk ratio 2.25 and 95% CI 1.05–4.84). …”
Get full text

T cell epitope content comparison using EpiCC correlates with vaccine efficacy against heterologous porcine reproductive and respiratory syndrome virus type 2 strains by J. Mark Hammer, Andres H. Gutierrez, Lucas Huntimer, Benjamin Gabriel, William D. Martin, Sabine E. Hammer, Tobias Käser, Anne S. De Groot

“…While vaccines are available, they are not entirely effective, and the introduction of modified live virus vaccines (MLV) has contributed to an increase in the rate of viral evolution. While vaccines induce humoral responses that may contribute to immunity against PRRSV, vaccines containing T cell epitopes that are well-matched to circulating strains are believed to be more likely to induce protective effects upon challenge or field exposure. …”
Get full text

Analysis of Plasmids of the Klebsiella pneumoniae Complex Carrying a Cluster of Aerobactin Synthesis Genes as Presented in International Databases by V. V. Shapovalova, Р. S. Chulkova, V. A. Ageevets

“…It has been shown that an increase in virulence is associated with the acquisition of additional genetic material — a plasmid carrying a cluster of aerobactin genes. …”
Get full text

Herpetic infections in humans: modern approaches to etiopathogenetic therapy by D. S. Sukhanov, E. V. Timofeev, Yu. S. Alexeeva, S. N. Tretyakov, A. L. Korshunova

“…Viruses of the Herpesviridae family are DNA-containing viruses prone to latent lifelong persistence in various tissues of the body after primary infection. …”
Get full text

Versatile Gyroinclinometer Based on a Single Axis Angular Rate Sensor by Ya. I. Binder, I. A. Khazov

“…Introduction. Currently, the versatility and reliability of gyroscopic inclinometers (GI), more than accuracy, determine their configuration and design. …”
Get full text

Determination of Ethanol Content in Fuels with Phononic Crystal Sensor by N. V. Mukhin, A. Oseev, M. M. Kutia, E. S. Borodacheva, P. G. Korolev

“…In-line analysis of ethanol content in gasoline blends is currently one of the urgent needs of fuel industry. …”
Get full text

Research results of the screw dispenser of dry bulk feed components by S. Yu. Bulatov, A. N. Pronin

“…In the production of compound feeds, it is necessary to follow the recipe at the time of introducing all the necessary components, for which various types of dispensers are used. Currently, automatic dosing systems are widely used, providing increased dosing accuracy. …”
Get full text

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection. by Louis S Ates, Fadel Sayes, Wafa Frigui, Roy Ummels, Merel P M Damen, Daria Bottai, Marcel A Behr, Jeroen W J van Heijst, Wilbert Bitter, Laleh Majlessi, Roland Brosch

“…This unexpected finding stimulates a reassessment of the immunomodulatory properties of PE_PGRS/PPE-MPTR proteins, some of which are contained in vaccine formulations currently in clinical evaluation.…”
Get full text

Evaluation of physico-chemical parameters of the risk of pollution of the Jiu River in Gorj and Dolj Counties by Mihai Baroga, Eugenia Dumitrescu, Florin Muselin, Sergiu Aurel Orasan - Alic, Alexandru Octavian Doma, Razvan Florin Moruzi, Romeo Teodor Cristina

“…Water and soil were considered for a long time to be renewable resources, but currently, the opposite is demonstrated and water and soil pollution represent an important factor in causing ecological imbalances that can have serious consequences for the biosphere. …”
Get full text

Dual Reporter Gene Imaging by Jiantu Che, Mikhail Doubrovin, Inna Serganova, Ludmila Ageyeva, Pat Zanzonico, Ronald Blasberg

“…RG2-pQCNIG and RG2 tumors were readily differentiated by in vivo gamma camera imaging; radiotracer uptake increased in RG2-pQCNIG but declined in RG2 tumors over the 50-min imaging period. …”
Get full text