ALDH^High Breast Cancer Stem Cells Exhibit a Mesenchymal–Senescent Hybrid Phenotype, with Elevated Metabolic and Migratory Activities by Luis Larrea Murillo, Conor J. Sugden, Bela Ozsvari, Zahra Moftakhar, Ghada S. Hassan, Federica Sotgia, Michael P. Lisanti

“…Cancer stem cells (CSCs) account for 0.01 to 2% of the total tumor mass; however, they play a key role in tumor progression, metastasis and resistance to current cancer therapies. The generation and maintenance of CSCs are usually linked to the epithelial–mesenchymal transition (EMT), a dynamic process involved in reprogramming cancer cells towards a more aggressive and motile phenotype with increased stemness potential. …”
Get full text

Special features for functionalization of carbon nanotubes nanopowders by N. O. Oliinyk, G. D. Ilnytska, G. A. Bazaliy, I. M. Zaitseva, M. A. Marinich, O. M. Sizonenko, A. S. Torpakov

“…In order to create new composite materials that contain CNT powders as a filler, it is necessary to achieve functionalization of powder surface. …”
Get full text

Warming Yang,Promoting Blood Circulation and Inducing Diuresis in the treatment of diabetic nephropathy:a meta-analysis by WANG Lan, WANG Xiao-qin

“…Objective To evaluate the efficacy and safety of ’Warming Yang,Promoting Blood Circulation and Inducing Diuresis’ in the treatment of diabetic nephropathy(DN).Methods The used electronic databases contained foreign databases such as PubMed,EMBASE,Cochrane Library,and Chinese databases such as CNKI,SinoMed,Wanfang Data,CQVIP.The clinical data of "Warming Yang,Promoting Blood Circulation and Inducing Diuresis" in treatment of DN were collected comprehensively.The literature retrieval ended on April 1,2016,and the meta analysis of appropriate literature was processed by RevMan 5.3 software.Results The cases of randomized controlled trials totaled16 and the cases of DN patients totaled 1 107.The results of Meta analysis showed that compared to western medicine control group,the experimental group of integrated traditional Chinese medicine and western medicine,based on "Warming Yang and Benefiting Qi,Promoting Blood Circulation and Inducing Diuresis",perfonned better in the significant efficiency and total efficiency of the treatment of DN(RR=1.97,95%CI 1.50~2.59,Z = 4.86,P<0.01;RR=1.48,95%CI 1.35~1.62,Z=8.58,P<0.01),in the decrease of the serum creatinine(MD=-32.33,95%CI-58.20~-6.47,Z =2.45,P= 0.01),in the increase of high density lipoprotein(MD= 0.16,95%CI 0.09~0.23,Z =4.33,P<0.01),in the decrease of cholesterol,triglyceride,low density lipoprotein(MD=-0.82,95%CI 1.28~-0.36,Z = 3.49,P = 0.0005;MD=-0.40,95%CI-0.53~-0.26,Z=5.95,P<0.01;MD=-0.49,95%CI-0.76~-0.21,Z=3.46,P = 0.000 5),in the decrease of urinary protein(MD=-0.46,95%I-0.61~-0.31,Z=6.01,P<0.01),in the control of fasting blood glucose(MD=-0.34,95%CI-0.57~-0.12,Z = 3.00,P = 0.003),and performed the same in the decrease of the levels of tumor necrosis factor alpha(P= 0.33).Conclusions The current limited evidence suggests that the efficacy and safety of integrated traditional Chinese medicine and western medicine in the treatment of DN is better than the traditional protocols alone.…”
Get full text

Valorization of 3D/4D models of disappeared or ruined heritage sites in 3D modeling environments by M. Koehl, J.-E. Heitz, E. Sommer, M. Fuchs

“…These models allow for the restoration of shapes and dimensions, and their placement within a historical context. To help users better project themselves, it is also interesting to place them in current urban contexts. …”
Get full text

An open-label phase I comparator-controlled clinical trial to assess tolerability and pharmacokinetics of IHL-675 A a fixed dose combination of cannabidiol plus hydroxychloroquine... by George Williams Mbogo, Pia Kroner, Rosemarie Walsh, Jonathan Newchurch, Mark Robert Bleackley

“…IHL-675 A is Incannex Healthcare Pty Ltd.’s proprietary product formulated using UniGel™ technology consisting of a solid, film coated HCQ tablet contained within a CBD-oil solution gel cap. Each IHL-675 A gel cap contains 75 mg of CBD and 100 mg HCQ. …”
Get full text

Adolescent and parental proxy online record access: analysis of the empirical evidence based on four bioethical principles by Josefin Hagström, Maria Hägglund, Charlotte Blease

“…Methods In this paper, we apply biomedical ethical principles to explore key questions about adolescents’ and parents’ access to adolescents’ EHRs, with the aim of informing future discussions about the development of ethical and policy practice guidelines. Results Drawing on current empirical research, we find preliminary evidence that in some contexts, patient online record access (ORA) could help to facilitate autonomy for adolescents and parents as well as offering support in managing appointments and medications. …”
Get full text

Java deserialization vulnerability defense technologybased on run-time detection by LI Yulin, CHEN Libo, LIU Yujiang, DU Wenlong, XUE Zhi

“…By correlating the deserialization entry function with the context information, the system can determine if the current behavior constitutes an exploitation of a deserialization vulnerability. …”
Get full text

THE PERSPECTIVES OF PHYSICAL EDUCATION AND SPORT IN MOUNTAINOUS BANAT by Zuiac Silvia Sorina, Ghitescu Roxana Emanuela

“…At the level of Caras – Severin County there is a strategy that is the basis for ensuring the necessary support for carrying out the physical education and sports activities at the level of the current international requirements. Even in the current socio-economic context, including through the European funds allocated for this purpose, there are favorable premises for the development of physical education and sport.…”
Get full text

Conflitos envolvendo indígenas e agricultores no Rio Grande do Sul: dilemas de políticas públicas contraditórias by Henrique Aniceto Kujawa

“…This article discusses these conflicts and analyzes them from the point of view of their historical roots and the current context. It characterizes the social subjects involved (indigenous and farmers) from the perspective of the emerging diversity and shows that the current public policy contributes to increase the conflict and does not meet the needs neither of indigenous people nor of farmers. …”
Get full text

A comparative analysis of the development modes of the IoT for telecom operators by Kaikai LIU, Xun ZHANG

“…In recent years,the development of IoT is in full swing.It is of great significance for the current transformation and development of domestic telecom operators.In this context,the business model is very important for operators to achieve “overtaking” in the IoT industry.Based on the analysis of the operation status of the IoT of operators,the development strategies of the IoT industry at home and abroad were compared,and three different development strategies was summarized.Telecom operators had advantages in customers,channels and other aspects,but limited by many factors.It was suggested that in constructing the development model,they should follow the principle of gradual progress,fully according to their own enterprise positioning,combined with national policies,pay attention to their own positioning in the industry chain of the IoT,pay attention to risks,and ultimately realize it.Better development model improve the current situation of increasing revenue in the telecommunications industry.…”
Get full text

Burnout Syndrome in Maternal Role by Anida Vrcić Amar

“…Since correlates of maternal burnout are still underresearched, understanding the context of motherhood through a cultural-psychological dimension is deemed important. …”
Get full text

Evaluation of the Wind-Resistant Performance of Long-Span Cable-Stayed Bridge Using the Monitoring Correlation between the Static Cross Wind and Its Displacement Response by Gaoxin Wang, Youliang Ding, Dongming Feng, Jihong Ye

“…However, few studies currently focus on assessing the wind-resistant performance of existing long-span cable-stayed bridge structures, and at present, no studies have revealed how to identify the deterioration of the wind-resistant performance using a bridge health-monitoring technique. …”
Get full text

Effect Of Citrullus Lanatus Juice On Hemoglobin, Red Blood Cells And Liver Enzyme; An Experimental Study by Shahid Ali, Nuzhat Sultana, Muslim Abbas, Zareen Naz, Muhammad Akbar Hassan, Muhammad Abid

“…As far as liver enzyme serum glutamate pyruvate transaminase (SGPT) was concerned its concentration decreases slightly. Conclusion: Citrullus lanatus juice contain ingredients which are important for RBC hemoglobin and synthesis .It also contains important antioxidants that have organoprotective role due to which SGPT level decreases even in healthy animals as compared to control groups. …”
Get full text

Quo Vadis the Common Agricultural Policy amid Tomorrow’s Challenges? by ANDREEA - EMANUELA DRĂGOI

“…Our main objective is to illustrate the future of CAP funding using as case study Romania’s approved CSP, while presenting the specific measures proposed in this country to support its agricultural sector among the challenges brought for its farmers by the current economic international context. …”
Get full text

Prospects of Cooperation in the Commonwealth of Independent States by Anita S. Rypnevskaya

“…The current crisis has a major impact on the Commonwealth of Independent States, and the effect is both negative and positive. …”
Get full text

The Other Side of the Coin: can Turkey ''Get'' West by Oil? by Bestenigar KARA, Alexandru GRIBINCEA, Lilia SHARGU

“…The topic of article is and has always been a current issue. Oil has always come to the forefront taking into account for example oil crises throughout history, the global developments together with new technologies or growing population together with increasing energy demand alongside of its wide range of use in different sectors from textile to transportation. …”
Get full text

High responsivity UV detector based on TiO2-rGO nanocomposite material by A. Жумабеков, A. Касанова, Н. Испулов, K. Досумбеков, Ж. Оспанова, T. Досанов, A. Курманов

“…It has been illustrated that during hydrothermal synthesis further reduction of rGO occurs, i.e. the variety of oxygen-containing groups decreases. Studies of current-voltage characteristics have displayed the availability of rGO in the nanocomposite leads to an increase in the photo induced current to more than 40 µA. …”
Get full text

Evaluating the Constructive Alignment of Learning Objectives Within Haptics Simulation in the Dental Undergraduate Curriculum by Susha Rajadurai, Tapan Hebballi, Zahra Sharif, Guneet Kaur Kukreja, Ithar Derdour

“…This study seeks to explore whether the current learning objectives constructively align with our current haptics simulation curriculum – in the specific context of how well they are being met by year 1 undergraduate dental students. …”
Get full text

Universal or Specific? A Modeling-Based Comparison of Broad-Spectrum Influenza Vaccines against Conventional, Strain-Matched Vaccines. by Rahul Subramanian, Andrea L Graham, Bryan T Grenfell, Nimalan Arinaminpathy

“…In future, conventional and novel vaccines are likely to play complementary roles in vaccination strategies against influenza: in this context, our results suggest important characteristics to monitor during the clinical development of emerging vaccine technologies.…”
Get full text