Ghrelin stimulation of growth hormone-releasing hormone neurons is direct in the arcuate nucleus. by Guillaume Osterstock, Pauline Escobar, Violeta Mitutsova, Laurie-Anne Gouty-Colomer, Pierre Fontanaud, François Molino, Jean-Alain Fehrentz, Danielle Carmignac, Jean Martinez, Nathalie C Guerineau, Iain C A F Robinson, Patrice Mollard, Pierre-François Méry

“…Indeed, ghrelin does not modify synaptic currents of GHRH neurons. However, ghrelin exerts a strong and direct depolarizing effect on GHRH neurons, which supports their increased firing rate.…”
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Sustainable agricultural mechanization in Timor-Leste: status, challenges and further action by Jelle Van Loon, Mayling Flores Rojas

“…Beyond this, a reform of the current government mechanization hire schemes is needed: integrated approaches, as found from business model analyses and training exercises during field missions, are needed, that entail context-specific solutions for targeted rural communities, with special attention given to participatory extension, inclusive co-validation of technologies, and private sector-led business model development around mechanization service delivery. …”
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The role of anifrolumab in reshaping the treatment landscape of extra-renal systemic lupus erythematosus by Fulvia Ceccarelli, Matteo Piga, Alessandra Bortoluzzi, Laura Coladonato, Micaela Fredi, Daniele Mauro, Chiara Tani, Luca Iaccarino

“…Hypothetical scenarios derived from clinical practice were examined to identify real-life contexts suitable for the early initiation of anifrolumab treatment. …”
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Acute effects of single-bout isometric handgrip exercise on selected cardiovascular parameters in young normotensive adults at a tertiary care center of West Bengal by Anisha Dutta, Anish Bhowmik

“…Context: Hypertension is currently prevalent along with other lifestyle disorders, which further adds up to cardiovascular morbidity. …”
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"Glowing head" mice: a genetic tool enabling reliable preclinical image-based evaluation of cancers in immunocompetent allografts. by Chi-Ping Day, John Carter, Zoe Weaver Ohler, Carrie Bonomi, Rajaa El Meskini, Philip Martin, Cari Graff-Cherry, Lionel Feigenbaum, Thomas Tüting, Terry Van Dyke, Melinda Hollingshead, Glenn Merlino

“…Preclinical therapeutic assessment currently relies on the growth response of established human cell lines xenografted into immunocompromised mice, a strategy that is generally not predictive of clinical outcomes. …”
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Insomnia, Cognitive Impairment, or a Combination of Both, Alter Lipid Metabolism Due to Changes in Acylcarnitine Concentration in Older Persons by Selma Karime Castillo-Vazquez, Berenice Palacios-González, Marcela Vela-Amieva, Isabel Ibarra-González, Ricardo Morales, Paola García-delaTorre, Sergio Sánchez-García, Carmen García-Peña, Ricardo Reyes-Chilpa, Raúl Hernán Medina-Campos, Jessica Hernández-Pineda, Juan Carlos Gomez-Verjan, Nadia Alejandra Rivero-Segura

“…However, the relationship between the two entities (insomnia and CI) is poorly understood. In this context, adults with insomnia show metabolic changes, including alterations in the catabolism of branched-chain amino acids, glycerophospholipids, and glutathione and glutamate biosynthesis. …”
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A predictive analysis of STEM vocation through students’ attitudes to school science classes by María-Antonia Manassero-Mas, Ángel Vázquez-Alonso

“…Six school science class items significantly predicted the students’ degree of STEM vocation by sharing 46.1% of their common variance. In decreasing order of prediction power, the six significant predictors are “liking school science better than most other subjects,” “helping to understand sustainability solutions,” “becoming more critical and skeptical,” “importance of science for our way of life,” “difficulty of school science,” and “opening my eyes to new and exciting jobs.”DiscusionThe implications of this study for promoting STEM vocations suggest that teachers carefully cultivate those relevant characteristics of school science classes through appropriate pedagogies and inclusive and equitable contexts for all, especially for girls.…”
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The comparative study of the corrosion stability of Zn-Ni-Co alloy coatings deposited from chloride and sulphate baths by Marija G. Riđošić, Jelena B. Bajat

“…On the other hand, [Co2+]/Ni2+] ion ratio showed a significant influence on corrosion behaviour of ternary alloy coatings, and this influence was more pronounced with alloys deposited from chloride baths. It was shown that increased corrosion protection of steel can be achieved by electrochemical deposition of ternary alloys that contained lower amount off the alloying elements, while the composition of the ternary alloy can be optimized by proper choice of the type and composition of the deposition bath.…”
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Protocol for a randomized controlled trial of patient–portal–based screening for substance use among people with HIV by Eric Roessler, Daniela Zimmer, Jon Grant, Harold Pollack, Basmattee Boodram, Jessica Schmitt, Jessica Schmitt, Eleanor Friedman, Jade Pagkas-Bather, Jade Pagkas-Bather, Russell A. Brewer, Jessica Ridgway, Neda Laiteerapong, Neda Laiteerapong

“…To provide additional context, we briefly describe the overall ePORTAL HIV-S project.MethodsThis project will utilize a culturally tailored approach to increase patient portal use among PLWH in our health system via a community health worker (CHW)-led initiative. …”
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Impact of Climate Change on the Narrow Endemic Herb Psilopeganum sinense (Rutaceae) in China by Ruixiong Deng, Kaitong Xiao, Xin Chen, Beibei Huang, Haoran Li, Lin Wu, Hang Ning, Hui Chen

“…Our results not only provide a scientific basis for managing P. sinense resources in the context of climate change but also serve as an important reference for restoring wild P. sinense populations.…”
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Dynamics of educational activity of students under the influence of digitalisation by D. Yu. Narkhov, E. N. Narkhova, D. V. Shkurin

“…The fixation of qualitative changes in educational activity in non-standard conditions, along with the development of a theoretical basis for the digital educational community of students, is necessary for making qualified managerial decisions.The aim of the present research was to identify the factors and dynamics of students as a digital educational community in the context of self-isolation and online learning.Methodology and research methods. …”
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Complementary Strategy of Maternal Immunization with RSVpreF Vaccine and Monoclonal Antibodies for the Prevention of Respiratory Syncytial Virus Among Italian Infants: A Cost-Effec... by Barbara Polistena, Fabio Midulla, Giovanni Sotgiu, Daniela d’Angela, Roberto Di Virgilio, Federico Spandonaro

“…Methods Using a model (with a cohort framework and a Markov-type process) specifically adapted to the Italian context, the study provided cost-effectiveness and cost-utility assessment of prevention strategies adding the maternal vaccination to the existing immunization opportunities with palivizumab or nirsevimab administered to high risk and unprotected infants. …”
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Increasing day three parasitaemia is observed after treatment of patients with artemether-lumefantrine and single dose of primaquine for uncomplicated Plasmodium falciparum malaria... by Bontu Abate, Bokretsion Gidey Brhane, Tsegahun Manyazewal, Hussien Mohammed, Yonas Wuletaw, Moges Kassa, Mesay Hailu, Getachew Tollera, Geremew Tasew, Ashenafi Assefa, Eyasu Makonnen

“…These findings support the ongoing use of AL with a single dose of PQ as the primary treatment option for uncomplicated P. falciparum infections in the study area. In the context of the emergence and spread of partial artemisinin-based combination therapy(ACT) resistance in Africa, regular monitoring of the efficacy of current artemisinin-based combinations is recommended for the early detection of emerging drug resistance in the study setting and beyond.…”
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Re-use of Building Products in the Netherlands by Loriane Icibaci

“…As the anthropogenic environment evolves, it is relevant to comprehend how fit the industrial system is in this dynamic context, leading to the second part of the study: The evolution of the housing stock as dynamic reserves (supply of reusable products). …”
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Comprehensive review on the potential of ultrasound for blue food protein extraction, modification and impact on bioactive properties by Ghumika Pandita, Savvy Sharma, Irin Elsa Oommen, Nishchhal Madaan, Yuvraj Bhosale, Vivien Nagy, Ayaz Mukarram Shaikh, Béla Kovács

“…Food security for the increasing global population is a significant challenge of the current times particularly highlighting the protein deficiencies. …”
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Genetic diversity analysis of the SARS-CoV-2 virus: a literature review by Svetlana COLAC, Mariana ULINICI, Olga BURDUNIUC

“…The genome of the Omicron variant contains more than 30 mutations in the conserved domain of the Spike protein. …”
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Acellular Pertussis Vaccine from Antigens of Freshly Isolated and Vaccine Strains of Bordetella pertussis with Different Genotypic Characteristics by E. M. Zaitsev, I. G. Bazhanova, M. V. Britsina, N. U. Mertsalova, M. N. Ozeretskovskaya

“…The most promising for further preclinical and clinical studies is AcPV3, which contains 2/3 of the antigens of the dominant «non-vaccine» genotype and 1/3 of the «vaccine» genotype, corresponding to the genes of PT, pertactin and fimbria to the currently circulating B. pertussis strains.…”
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Rice plants response to modulation of the ERECTA signaling by Yasmin Vasques Berchembrock, Flávia Barbosa Silva Botelho, Bhuvan Pathak, Shan Zhao, Vibha Srivastava

“…However, there is limited information currently available on their expression pattern during the plant developmental stages. …”
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Adolescent and parental proxy online record access: analysis of the empirical evidence based on four bioethical principles by Josefin Hagström, Maria Hägglund, Charlotte Blease

“…Methods In this paper, we apply biomedical ethical principles to explore key questions about adolescents’ and parents’ access to adolescents’ EHRs, with the aim of informing future discussions about the development of ethical and policy practice guidelines. Results Drawing on current empirical research, we find preliminary evidence that in some contexts, patient online record access (ORA) could help to facilitate autonomy for adolescents and parents as well as offering support in managing appointments and medications. …”
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Designing multi-epitope vaccines against Echinococcus granulosus: an in-silico study using immuno-informatics by Jadoon Khan, Asma Sadiq, May M. Alrashed, Nosheen Basharat, Syed Nadeem Ul Hassan Mohani, Tawaf Ali Shah, Kotb A. Attia, Aamer Ali Shah, Hayat Khan, Ijaz Ali, Arif Ahmed Mohammed

“…The aim of the current study is to develop a multiepitope vaccine against CE by in-silico identification and using different Antigen B subunits. …”
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