Metabolic engineering of crocins and picrocrocin apocarotenoids in potato group phureja by Lourdes Gómez‐Gómez, Alberto José López‐Jimenez, Cristian Martinez Fajardo, Lucía Morote, Sarah Frusciante, José Luis Rambla, Gianfranco Diretto, Ángela Rubio‐Moraga, María Mondejar‐López, Enrique Niza, Javier Argandoña, Silvia Presa, Antonio Granell, Oussama Ahrazem

“…Previously, we developed Desirée potato tubers enriched with these apocarotenoids which also showed increased potential benefits for human health. In the current study, Solanum tuberosum (S. tuberosum) Group Phureja 01H15 which accumulates high levels of zeaxanthin, was engineered to produce saffron apocarotenoids to increase the levels of these metabolites in potato tubers using a construct namely O6, which contains the CsCCD2L, UGT74AD1, and UGT709G1 genes necessary for the biosynthesis of crocin and picrocrocin under the control of the patatin promoter. …”
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Persistent anti-NY-ESO-1-specific T cells and expression of differential biomarkers in a patient with metastatic gastric cancer benefiting from combined radioimmunotherapy treatmen... by Deepak Kumar, Said Dermime, Maysaloun Merhi, Afsheen Raza, Varghese Philipose Inchakalody, Kodappully S Siveen, Fairooz Sahir, Sarra Mestiri, Shereena Hydrose, Niloofar Allahverdi, Munir Jalis, Allan Relecom, Lobna Al Zaidan, Mohamed Sir Elkhatim Hamid, Mai Mostafa, Abdul Rehman Zar Gul, Shahab Uddin, Mohammed Al Homsi

“…Combined radioimmunotherapy is currently being investigated to treat patients with cancer. …”
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Leasing impact on transformation processes in the Russian agricultural sector under sanctions pressure by A. A. Kiritsa, Yu. V. Chutcheva

“…With consideration to  the current situation in   the domestic market, decreased prices for agricultural products and rapid growth of   prices for agricultural machinery, the most promising areas for the use of  leasing mechanisms have been proposed to   help accelerate technical re-equipment in   the agricultural sector: application of   leasing solutions in   the agricultural industry that have already been tested and proven successful in   other market segments (for example, subscription, agrocarsharing, etc.); combination of   leasing mechanisms with trade-in programmes which make it  possible to  comprehensively solve issues not only of   updating machinery and tractor fleet, but also of  recycling worn-out agricultural equipment; use of   leasing mechanisms for the development of  machine and technological complexes as a   modern form of  joint use of   machinery in  agriculture which allows accelerating technical equipment of   the industry. …”
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Disease progression & treatment need in sub-genotype C4 hepatitis B infection: a retrospective cohort study in the Northern Territory, Australia by Genevieve E. Martin, Kelly Hosking, Kelly Banz, Catherine Gargan, Geoff Stewart, Belinda Greenwood-Smith, Penelope Ramsay, Jaclyn Tate-Baker, Christine Connors, Paula Binks, Melita McKinnon, Prashanti Manchikanti, George Garambaka Gurruwiwi, Nicole Allard, Ashleigh Qama, Jessica Michaels, Emily Vintour-Cesar, Robert Batey, Catherine Marshall, Peter Nihill, Tammy-Allyn Fernandes, Karen Fuller, Steven Y. C. Tong, David Boettiger, Benjamin Cowie, Joshua S. Davis, Sarah Mariyalawuy Bukulatjpi, Jane Davies, on behalf of the Hep B PAST Partnership

“…Only 6·7% of untreated individuals were treatment eligible under current guidelines. Using the 2024 World Health Organisation guidelines, this increased to 50% due mostly to fibrosis and population prevalence of diabetes. …”
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Self-generated temperature gradient under uniform heating in p–i–n junction carbon nanotube thermoelectric generators by Oga Norimasa, Ryota Tamai, Hiroto Nakayama, Yoshiyuki Shinozaki, Masayuki Takashiri

“…The output voltage and current of the SWCNT-TEG increased with increasing temperature. …”
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The Palliative Care in Patients with Oncological Diseases - a New Medical and Therapeutic Approach by Catalina FLORESCU, Octavian VASILIU, Dan PRELIPCEANU

“…A new notion, created by the first author, is supported by this research, i.e., “long-term oncological survivorship care,” which will replace the former concept of palliative care, which refers to “end-of-life care,” or “comfort care,” in relation to the oncological context.…”
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Polyphenols of Mulberry White (Morus alba L.) Leaves as a Source of Functional Food: A Review by Hagar F. Forsan, Menatalla R. Fayed, Noureldin M. Farahat, Walaa M. Gabr, Ezzeldeen M. Alswerky, Asmaa E. Abd El-Hak, Mohamed A. Fouda, Mennat-Allah Safwat

“…However, this residue in mulberry leaves naturally contains high levels of bioactive compounds, especially polyphenols. …”
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Antioxidative and Antimelanoma Effects of Various Tea Extracts via a Green Extraction Method by Yihui Chen, Jyun-Yin Huang, Yichi Lin, I-Fan Lin, Yi-Ru Lu, Li-Heng Liu, Hui-Min David Wang

“…Tea (Camellia sinensis) contains high level of antioxidant elements and is a well-known beverage consumed worldwide. …”
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Comprehensive analysis of the mechanisms conferring resistance to phenamacril in the Fusarium species by Alexander Dumbai Joe, Runze Liu, Xiao Luo, Ruqiya Syed, Farhan Aslam, Zhenying Luo, Zhitian Zheng

“…We emphasize the importance of continued research and integrating different approaches to monitoring and managing drug-resistant Fusarium spp. populations. Integrating current inventions to inform strategies for sustainable disease control practices, and increase plant health, and yield will contribute to ongoing global efforts to achieve food and nutritional sustainability for the world's rapidly growing population while ensuring the effectiveness of the fungicidal product.…”
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Berberis lycium: A Miracle Medicinal Plant with Multifaceted Health Benefits by Bashir Ahmad, Abduh Murshed, Mohamed Y. Zaky, Imran Khan, Faiz ur Rahman, Magda H. Abdellattif, Guojun Liu, Jun Lu

“…The annual sale of medicinal plants increases over time. In plants, Berberis vulgaris f. lycium (Royle) Parsa (Berberis lycium), also called boxthoran barberry, Indian barberry, or Indian lyceum contains key alkaloids such as berberine, camptothecin, koumidine, salutaridine, luteanine, palmatine, and protopine. …”
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Botulinum toxin treatment of lower extremity spasticity by S. E. Khat’kova, M. A. Akulov, O. R. Orlova, D. Yu. Usachev, A. S. Orlova, L. V. Krylova

“…The article reviews the current concept of lower extremity spasticity, which is a frequent disabling consequence of stroke. …”
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A Review of Reject Brine Disposal, Management, and Construction Applications by Pranita Banerjee, Essam K. Zaneldin, Ali H. Al-Marzouqi, Waleed K. Ahmed

“…The study also highlights current research gaps that are still unaddressed, hindering the complete realization of the full potential of reject brine as a sustainable resource.…”
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The Middle East Shiite Arc: A Real Threat or Geopolitical Chimera? by A. V. Sarabiev

“…The term Shiite Crescent, or Shiite Arc, is becoming increasingly popular in political and academic discourse as well as in the media. …”
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Specific features of antagonism of <i>Bacillus</i> bacteria against toxinogenic <i>Fusarium</i> fungi in protecting plants against disease and contamination with mycotoxins (review... by T. M. Sidorova, A. M. Asaturova, V. V. Allakhverdyan

“…The study contains information on the structure and mechanism of action of the main anti‐fungal cyclic lipopetides. …”
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Editor’s Note by Alberto Raposo

“…This indicates that JIS is being increasingly recognized as an interesting publication vehicle. …”
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Interactive Mode of Teaching Students in the Context of the Competence Paradigm by G. P. Sikorskaya, T. V. Savelyeva

“…The paper explores the theoretical and practical aspects of interactive mode of teaching students by using active educational methods improving the quality of educational process and increasing students’ motivation for comprehensive and in-depth learning. …”
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Sustainable Growth from a Factor Dependence and Technological Progress Perspective: A Case Study of East China by Ying Liu, Wan-Ming Chen, Sheng-Yuan Wang, Xiao-Lan Wu

“…The paper constructs an economic growth model that contains human, physical capital, innovation, and energy factors and estimates the output elasticity of seven provinces and cities in East China in the period of 2004–2018. …”
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Strengthening the Motivation of Staff as a Factor of Enterprise Competitiveness by Mahsma Mariya B.

“…The aim of the article is to study the theoretical and applied aspects of the functioning of the system of motivation of staff on the example of a production enterprise and to outline the directions of its improvement in the context of increasing the competitiveness of enterprise. The article analyzes the current state of staff motivation on the example of a leading Ukrainian company specializing in the trade of furniture components and accessories. …”
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Psycholinguistic Aspects of the Semantic Field of the Concept “War” in Modern Media Space by Yuliya Krylova-Grek

“…We underlined the link between the changes in the forms of international conflicts and the increase of the units contributing to the semantic field of the concept “war”. …”
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Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype. by Ruthiran Kugathasan, Ksenia Sukhova, Maya Moshe, Paul Kellam, Wendy Barclay

“…New variants of SARS-CoV-2 are continually emerging with mutations in spike associated with increased transmissibility and immune escape. Phenotypic maps can inform the prediction of concerning mutations from genomic surveillance, however most of these maps currently derive from studies using monomeric RBD, while spike is trimeric, and contains additional domains. …”
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