Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Results Our findings showed that CL-NPs loaded with anti-NOTCH1/-SF3B1 siRNAs-PTX significantly suppressed NOTCH1 and SF3B1 expression in PBMCs and BMMCs isolated from CLL cases in comparison with the untreated samples, leading to increased leukemic cell sensitivity to PTX and decreased the proliferative capacity of leukemic cells. …”
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The Emphases and Main Trends of China Studies in Thailand by Pornpawis Lhapeerakul, Yunke Zhai

“…This paper will outline the historical context and background of Chinese studies in Thailand, discuss the facilitating role of the Belt and Road Initiative in this field, and analyze the current state of Chinese studies in Thailand, highlighting its positive developmental trends.…”
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Enhancing Linear Programming Education Through Comprehensive and Maritime Relevant Teaching Materials by Putri Nurul Hilda Syani, Fera Mirta, Siregar Nur Asma Riani

“…Furthermore, the teaching materials currently in use have not been integrated with maritime contexts, despite their significance for students living in the maritime-based region of the Riau Islands. …”
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Innovative enterprise accounting reporting features by S.E. Pyrizhok, E.H. Melnyk

“…The article defines innovative enterprises' accounting reporting features, which reflect the specifics of their activity in the context of increased risk and has a risk-oriented direction of the generated information resource for management purposes. …”
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Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity by Bhavani Sowndharya Balamurugan, Mathan Muthu Chinnakannu Marimuthu, Vickram Agaram Sundaram, Bharath Saravanan, Prasanth Chandrababu, Hitesh Chopra, Tabarak Malik

“…For example, it points out the modulatory effects of vitamin D on both innate and adaptive immunity, with a specific focus on its ability to suppress pro-inflammatory cytokines synthesis while enhancing regulatory T-cell function. In the same context, also zinc is described as important nutrient for thymic function and T-cell differentiation but exhibits immunomodulatory functions by decreasing inflammation. …”
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The 'care' of children in need in contemporary Scotland the role of positivism and performance indicators in official imaginings of childhood and wellbeing by Chris Holligan, Lucy Hanson, Gillian Henderson, Maria Adams

“…We examine this within the current policy context for vulnerable children in Scotland.…”

A phenomenological study of knowledge concealment in country water and sewage engineering company by Gholamreza Moghadasi, Hamidreza Rezaei Kelidbari, Mohammad Doostar

“…Abstract The purpose of the current research is to investigate the effective factors in hiding knowledge in the country's water and sewage engineering company. …”
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National Museums and Their Societal Roles: A Case Study of Finland and Japan by Shikoh Shiraiwa

“…In this article I focuses on museum professionals in Finnish and Japanese national museums within the context of current social and cultural sustainability discourses, who face an increased responsibility to democratize museum narratives and acknowledge inconvenient histories and the ongoing coloniality of the institutions and repatriation of cultural insignia. …”
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Political Communication in the Age of Platforms by Stylianos Papathanassopoulos, Iliana Giannouli

“…It further explores the challenges that accompany these transformations, such as the spread of disinformation, rising political polarization, increasing incivility, and privacy concerns stemming from advanced digital marketing techniques in political contexts.…”
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The need for greater transparency in the moderation of borderline terrorist and violent extremist content by Ellie Rogers

“…Through a review of the literature, this article discusses the importance of increased transparency surrounding the moderation of borderline TVEC, and demonstrates the ways in which current legislation, tech company policies and content moderation processes are not conforming to transparent practices in the context of borderline TVEC moderation.…”
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The influence of entrepreneurial role model on entrepreneurial intention: a cross-level investigation by Mu Xuan, Liu Yankai

“…Social implications – At the same time, role models should be presented differently in diverse cultural contexts. For example, in countries with a strong collectivist orientation, the media should include collectivist messages when promoting entrepreneurial role models, such as his cooperation with the government, family and friends, which is in line with collectivist values, so that potential entrepreneurs in a collectivist context may perceive more similarity to role models and thus increase their entrepreneurial intentions (Morris et al., 1994); On the contrary, in countries with low collectivist tendencies, the media can appropriately carry an element of individualism when promoting entrepreneurial role models, for example, by telling how entrepreneurs succeed on their own strength and superior abilities, which is in accordance with the values of individualism. …”
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Recognizing the Conceptual Model of Re-creating the Central Core of Cities based on Local Community Culture with Meta-Synthesis Method by Maryam Hematian Dehkordi, Afsoon Mahdavi, Mohammad Reza Iravani

“…Following developments in the technological, economic, and social fields, as well as the movement of population and activities, the central core of cities has faced a decrease in physical, economic, and social quality, and this process has reduced the dynamics of neighborhoods and created problematic urban contexts. …”
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Combined CNN-BiLSTM-Att tourism flow prediction based on VMD-MWPE decomposition reconstruction by Maomao Luo, Danhong Chen, Xinxing Hou, Kang Luo, Tao Wang

“…The demonstrated performance, combined with its methodological robustness, suggests strong practical applicability and promising potential for implementation across similar tourism management contexts.…”
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Comparative Morphological Study on the Contemporary liveable Cities: Liveable Urban Form from East to West (Iran, Turkey, and Europe) by Ayda Rastiemadabadi, Sadaf Tabatabaee

“…Four different approaches to urban morphology used in current analysis: historical and natural context, evolution process, space syntax and spatial structure. …”
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Mapping the Landscape of Impostor Phenomenon Research in Organizational Behavior: A Bibliometric Study between 2003 and 2022 by Füsun Çınar Altıntaş, Hümeyra Demirbas

“…This study aims to provide a comprehensive overview of the research status of this topic during this period and to determine the main and sub-themes in which this concept has been examined in academic contexts. The current study focuses on determining which main and sub-themes this concept is examined in academic context. …”
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Clinical and epidemiological characteristic of chronic hepatitis C in the republic of Tyva by A. A. Saryglar, S. O. Dongak, A. D. Ibrohimova, K. E. Novak, E. V. Esaulenko

“…Over the past two years, the decrease in incidence in the Republic of Tyva is likely due to a decrease in the number of examinations, a decrease in patients seeking outpatient care, and insufficient screening in the context of the COVID-19 pandemic. …”
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Comprehensive Review and Analysis of Image Encryption Techniques by K. Mahalakshmi, Sivakumar Nagarajan

“…Through comparative analysis, this study highlights the strengths, weaknesses, and applicability of these methods in various contexts. The review concludes by discussing the current challenges and suggesting future research directions to improve the security, scalability, and real-time processing capabilities of image encryption systems.…”
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Adolescents’ exposure to explicit sexual content on digital media: a quantitative, cross-sectional study by Semen Sebsbie, Anteneh Tsegaye

“…Although adolescents’ screen media use has been broadly studied, little attention has been paid to the consumption of sexually explicit screen media content, especially in low- and middle-income contexts where access to digital media technologies is increasing. …”
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A systematic review of serious games as tools for STEM education by Talia Tene, Diego Fabián Vique López, Paulina Elizabeth Valverde Aguirre, Nilo Israel Cabezas Oviedo, Cristian Vacacela Gomez, Stefano Bellucci

“…A total of 37 peer-reviewed journal articles met the inclusion criteria, guided by the PICOS framework, which focused on studies reporting the use of serious games in STEM education contexts. Data extraction included study characteristics, game types, participant demographics, educational contexts, and reported outcomes.AnalysisThe selected studies were analyzed to assess the effectiveness of serious games in enhancing learning outcomes, engagement, and performance in STEM education. …”
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Ambivalence in Place Attachment by Xin Li, Reinout Kleinhans, Maarten van Ham

“…The impending neighbourhood demolition uncovers accumulated social issues in danwei communities in the context of market reforms and institutional changes in current China, such as the emergence of deprived social groups and their struggles for better housing. …”
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