Transcriptomic analysis on pancreatic adenocarcinoma patients uncovers KRAS-mediated PPAR pathway alteration by Giuseppe Defazio, Federico Scolari, Sara Fancelli, Simone Polvani, Daniele Lavacchi, Lucia Picariello, Alessandro Tubita, Michaela Luconi, Lorenzo Antonuzzo, Lorenzo Antonuzzo, Andrea Galli, Serena Pillozzi

“…The incidence and mortality of pancreatic adenocarcinoma (PC) are expected to increase in the coming years, with survival rates remaining poor due to limited treatment options. …”
Get full text

Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances by Qiu Jiang, Jie Liu, Shan Huang, Xuan-Yue Wang, Xiaowei Chen, Guang-Hui Liu, Keqiang Ye, Weihong Song, Colin L. Masters, Jun Wang, Yan-Jiang Wang

“…Abstract In the context of global ageing, the prevalence of neurodegenerative diseases and dementia, such as Alzheimer’s disease (AD), is increasing. …”
Get full text

TRANSFORMING MUSIC EDUCATION IN UKRAINE: OPPORTUNITIES AND CHALLENGES IN CULTURAL AND ARTISTIC EDUCATION REFORM by Ihor ZAKUS, Nataliia LEBEDIEVA, Irma GVINIASHVILI, Viktoriya KORZHENOK, Dennis ADU

“… The article discusses the current challenges and prospects for developing music education in Ukraine while reforming the cultural and artistic sphere. …”
Get full text

CAR-T cells and TRUCKs that recognize an EBNA-3C-derived epitope presented on HLA-B*35 control Epstein-Barr virus-associated lymphoproliferation by Michael Hudecek, Anna Christina Dragon, Katharina Zimmermann, Thomas Nerreter, Deborah Sandfort, Julia Lahrberg, Stephan Klöß, Christina Kloth, Caroline Mangare, Agnes Bonifacius, Sabine Tischer-Zimmermann, Rainer Blasczyk, Britta Maecker-Kolhoff, Barbara Uchanska-Ziegler, Hinrich Abken, Axel Schambach, Britta Eiz-Vesper

“…Background Immunosuppressive therapy or T-cell depletion in transplant patients can cause uncontrolled growth of Epstein-Barr virus (EBV)-infected B cells resulting in post-transplant lymphoproliferative disease (PTLD). Current treatment options do not distinguish between healthy and malignant B cells and are thereby often limited by severe side effects in the already immunocompromised patients. …”
Get full text

Formation of Innovative Infrastructure of the Industrial Sphere by M. Ya. Veselovsky

“…Purpose: in article problems of formation of innovative infrastructure of the industrial sphere in the Russian Federation are investigated, her merits and demerits are considered. In the context of foreign experience the analysis of statistics of development of innovative infrastructure on the basis of which is carried out the main shortcomings constraining efficiency of her work are allocated. …”
Get full text

Assessment of Reader Technologies for Over-the-Counter Diagnostic Testing by Mia Cirrincione, Maren Downing, Kevin Leite, Samuel Dolphin, Adam Samuta, Mack Schermer, Kimberly Noble, Brian Walsh

“…Reader technology type, which is predictive of core reader attributes, should be considered when selecting a reader technology for a specific LFA test within the context of regulatory guidance. As diagnostics increase in complexity, readers provide solutions to accessibility challenges, facilitate public health reporting, and ease the transition to multiplex testing, therefore increasing market availability.…”
Get full text

Defining, assessing, and implementing organizational health literacy: barriers, facilitators, and tools – a systematic review by Nicola Pelizzari, Loredana Covolo, Elisabetta Ceretti, Carlotta Fiammenghi, Umberto Gelatti

“…This systematic review synthesizes current research on OHL, focusing on its definitions, assessment tools, implemented practices, outcomes, and the factors influencing successful OHL integration within healthcare settings. …”
Get full text

Relevance of reporting leprosy related disability at the completion of multi drug therapy: A 5-year retrospective analysis of disability in persons affected by leprosy at ALERT Hos... by Bereket Abebayehu Tegene, Thomas Asfaw Atnafu

“…This study aims to show the significance of reporting leprosy-related disability at the end of MDT and critique how disability is counted in the context of WHO data.<h4>Methods</h4>This is a mixed method study with a 5-year retrospective analysis of outcomes of newly diagnosed leprosy patients at ALERT Hospital in Ethiopia from 2016 to 2020. …”
Get full text

Co-benefits of resilience planning: a review of analysis tools and methods by Jennifer F. Helgeson, Azin Al Kajbaf, Juan F. Fung

“…Fung and Helgeson reviewed the literature on co-benefits with a specific focus on the definition of co-benefits, areas where co-benefits are used the most (considering the literature related to climate change), and co-benefit measurement and assessment methodologies in the context of resilience planning. The current study further explores these areas by focusing on the development of the literature on co-benefits published since 2017. …”
Get full text

Target image detection algorithm of complex road scene based on improved multi-scale adaptive feature fusion technology by Xu Zhaosheng, Liao Zhongming, Xiao Xiaoyong, Ahmad Suzana, Mat Diah Norizan, Ismail Azlan

“…This study introduces computer vision-based approaches, including colour and texture recognition, object detection, and scene context understanding using Deep Neural Networks (DNN). …”
Get full text

The science behind the lifesum app: an intervention design analysis by Signe Svanfeldt, Chris Seth, Marcus Gners, Andreas Blomqvist

“…This was an intervention design analysis, designed to describe the theoretical model and intervention theory used to create the Lifesum app in its current embodiment. A pragmatic theoretical model describing behaviour change in the context of healthy eating was devised based on findings in literature. …”
Get full text

CMIP6 multi-model ensemble projection of reference evapotranspiration using machine learning algorithms by Milad Nouri, Shadman Veysi

“…This highlights the critical necessity for adaptive strategies in agricultural water management to mitigate the adverse CC effects. In this context, the current findings can assist decision-makers in identifying hotspots and quantifying CC impacts, thereby enabling the design of crucial adaptations.…”
Get full text

Insurtech innovations and telematics as «drivers» of change in the insurance industry by A.Yu. Polchanov, K.O. Halatiuk

“…The purpose of the article is to analyze the impact of the introduction of innovative technologies (Insurtech) and telematics on the development of the insurance market in the context of increasing globalization trends. Results. …”
Get full text

Modelling the supply and need for health professionals for primary health care in Ghana: Implications for health professions education and employment planning. by James Avoka Asamani, Christmal Dela Christmals, Gerda Marie Reitsma

“…By 2035, US$ 2.374 billion must be planned for the employment of those that would have to be trained to fill the need-based shortages and for sustaining the employment of those currently available.…”
Get full text

From bench to bedside: nanomedicine development for intracerebral hemorrhage – exploring microenvironment, innovation, and translation by Gui Wan, Lingui Gu, Yangyang Chen, Yiqing Wang, Ye Sun, Zhenwei Li, Wenbin Ma, Xinjie Bao, Renzhi Wang

“…Finally, the progress of nanomedicines in clinical translation is analyzed, highlighting the challenges, opportunities, and future prospects for their application in the context of ICH. Graphical abstract…”
Get full text

Arthroscopic-Assisted vs. Fluoroscopic-Only ORIF of Distal Radius Fractures: Clinical and Economic Perspectives by Wolfram Demmer, Antonina Jakob, Fabian Gilbert, Benedikt Fuchs, Sinan Mert, Nikolaus Wachtel, Riccardo Giunta, Verena Alt

“…Our findings demonstrate that DRF treatment, regardless of the method used, is either not or only marginally cost-covering under the current German reimbursement structure. In the context of the ongoing shift towards outpatient hand surgery, including the management of DRF, adequate reimbursement rates are necessary to ensure the economic viability of DRF management, particularly for complex intra-articular fractures requiring arthroscopic assistance.…”
Get full text

Dynamic Analysis of the Interconnection of a Set of FPSO Units to an Onshore System via HVDC by Johnny Orozco Nivelo, Carlos A. Villegas Guerrero, Lúcio José da Motta, Marcos R. de Paula Júnior, José M.d. Carvalho Filho, Alex Reis, José Carlos Oliveira, José Mauro T. Marinho, Vinicius Z. Silva, Carlos A. C. Cavaliere

“…In this context, the oil industry, which contributes to indirect GHG emissions, is seeking ways to develop solutions to this issue. …”
Get full text

Overview on the development and application of the key concepts for decision-making in health care by Nicolás Flores Uribe, Diego Grandi Pincheira, Roberto Garnham Parra, Eva Madrid Aris, Nicolas Meza Concha

“…In this context, promoting knowledge dissemination through reliable sources and fostering health literacy among the general population is crucial. …”
Get full text

Aspiring to Higher Education? Choice, complexity and confidence in secondary students’ decision-making by Zeta Williams-Brown, Matt Smith, David Thompson, Gavin Rhoades

“…This article reports on a programme designed to encourage young people who are currently in secondary school (age range 11-18) to apply to university. …”
Get full text

Marketing Logistics and its Digitalization by Iryna Polishchuk, Yuriy Dovhan, Iryna Kramar, Larysa Dovhan, Oksana Yakushevska

“…The purpose of the article is to highlight the historical process of forming marketing logistics as a modern management concept and the current trends in its digitalization. The theoretical foundations of marketing logistics summarized in this work will facilitate the integration of digital technologies into marketing logistics, improve business processes, and support the sustainable development of companies in the context of dynamic changes in the global market. …”
Get full text