Non-linear oral bioavailability and clinical pharmacokinetics of high-dose Andrographis paniculata ethanolic extract: relevant dosage implications for COVID-19 treatment by Phanit Songvut, Jaratluck Akanimanee, Tawit Suriyo, Nanthanit Pholphana, Nuchanart Rangkadilok, Duangchit Panomvana, Porranee Puranajoti, Jutamaad Satayavivad

“…These findings suggest that current extraction process of ethanolic extract may hinder its effectiveness. …”
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Stability and change in latent movement behaviour profiles during adolescence and links with future depressive symptoms by Christopher Knowles, Gavin Breslin, Angela Carlin, Kyle Paradis, Stephen Shannon

“…Transition patterns containing a period of minimal movement predicted worse depressive symptoms at ages 18 and 22. …”
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TIM-3 teams up with PD-1 in cancer immunotherapy: mechanisms and perspectives by Zhuohong Yan, Chunmao Wang, Jinghong Wu, Jinghui Wang, Teng Ma

“…Among these candidates, T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is considered a promising target. …”
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Descriptive, analytical and molecular epidemiology of pancreatic cancer by O. V. Shangina, D. M. Maximovich, D. G. Zaridze

“…The purpose of the study was to present current data on the role of lifestyle and heredity factors in the etiology of pancreatic cancer (PC). …”
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An Experimental Study on the Geotechnical, Mineralogical, and Swelling Behavior of KPK Expansive Soils by Bakht Zamin, Hassan Nasir, Khalid Mehmood, Qaiser Iqbal, Asim Farooq, Mohammad Tufail

“…The swell characteristic of expansive soils increases with the increase in the percentage of the fine specifically the clay fraction. …”
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Automatic Guided Vehicles Introduction Impacts to Roll-On/Roll-Off Terminals: Simulation and Cost Model Analysis by Sang Hyung Park, Jeho Hwang, Sohyun Yun, Sihyun Kim

“…Results revealed that a system using 29 AGVs matched the productivity of the current loading system, and using more AGVs increased the productivity. …”
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Effects of ibrutinib and venetoclax on the expression of immune checkpoint molecules in leukemic blasts of patients with acute lymphoblastic leukemia by Armin Dozandeh-Jouybari, Fatemeh Mousavi-Mirkalaei, Saeid Taghiloo, Hossein Karami, Mohammad Naderisorki, Ehsan Zaboli, Mohammad Eslami-Jouybari, Tohid Kazemi, Hossein Asgarian-Omran

“…By elucidating the precise underlying mechanisms, these drugs could emerge as promising therapeutic options, particularly in the context of combination therapy for ALL.…”
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High prevalence of the hotspot complement factor I p.Ile357Met pathogenic variant in Tunisian atypical hemolytic uremic syndrome patients: report of three new cases and review of t... by Asma Tajouri, Asma Tajouri, Asma Tajouri, Imen Ayadi, Imen Ayadi, Rimeh BenBrahim, Rimeh BenBrahim, Ikram Mami, Abir Boussetta, Hend Jlajla, Hend Jlajla, Yousr Zerzeri, Haifa Arbi Sassi, Jamila Ben Sassi, Hela Sahli, Lilia Laadhar, Lilia Laadhar, Tahar Gargah, Mohamed Karim Zouaghi, Maryam Kallel Sellami, Maryam Kallel Sellami

“…The recurrence of this variant in the Tunisian cohort led us to suggest that it could be characteristic of the Tunisian population.MethodsIn this context, we conducted the current study which included 8 adults and three children with suspected aHUS and decreased factor I levels, as well as one relative. …”
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The comparative study of the corrosion stability of Zn-Ni-Co alloy coatings deposited from chloride and sulphate baths by Marija G. Riđošić, Jelena B. Bajat

“…On the other hand, [Co2+]/Ni2+] ion ratio showed a significant influence on corrosion behaviour of ternary alloy coatings, and this influence was more pronounced with alloys deposited from chloride baths. It was shown that increased corrosion protection of steel can be achieved by electrochemical deposition of ternary alloys that contained lower amount off the alloying elements, while the composition of the ternary alloy can be optimized by proper choice of the type and composition of the deposition bath.…”
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Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…The enrichment analysis highlighted the fundamental pathways where the NOTCH1- and SF3B1-associated ceRNA network exerts its influence in the context of CLL. Conclusions This study implies the efficacy of combined therapy by CL-NPs loaded with anti-NOTCH1/-SF3B1 siRNAs and PTX as a novel therapeutic strategy for CLL, even though further studies are required to warrant the findings. …”
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Cohort profile: the PHARMO Perinatal Research Network (PPRN) in the Netherlands: a population-based mother–child linked cohort by E. Houben, L. Broeders, E.A.P. Steegers, R.M.C. Herings

“…Additionally, mother–child linkage is currently available for a quarter of these pregnancies (‘Child Cohort’). …”
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Potential impacts of plant pests and diseases on trees and forests in the United Kingdom by Daniel P. Bebber, Ilya M. D. Maclean, Jonathan R. Mosedale, Benjamin D. Youngman

“…The UK Plant Health Risk Register (PHRR) provides semiquantitative estimates of invasion probability and impact on host plants for PPDs thought to pose a risk to the United Kingdom to help prioritize biosecurity activities. The PHRR currently contains 636 PPDs potentially affecting 74 tree species found in the United Kingdom. …”
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Effectiveness of AdaBoost and XGBoost Algorithms in Sentiment Analysis of Movie Reviews by I Gusti Ayu Nandia Lestari, Ni Made Rai Masita Dewi, Komang Gita Meiliana, I Komang Agus Ady Aryanto

“…Currently there are many entertainment platforms that provide various movies, TV shows, games, and other content. …”
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Advancing Alzheimer’s disease detection: a novel convolutional neural network based framework leveraging EEG data and segment length analysis by Md Nurul Ahad Tawhid, Siuly Siuly, Enamul Kabir, Yan Li

“…Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that primarily affects memory, thinking, and behavior, leading to dementia, a severe cognitive decline. While no cure currently exists, recent advancements in preventive drug trials and therapeutic management have increased interest in developing clinical algorithms for early detection and biomarker identification. …”
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Contact Lenses in Pediatric Ophthalmological Practice by E. Yu. Markova, E. A. Perfilyeva

“…Currently, the indication for contact lenses use in children are the same as for the adults (with certain specific and limitations). …”
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Numerical Analysis of Leakage and Diffusion Characteristics of In-Situ Coal Gas with Complex Components by Enbin Liu, Lianle Zhou, Ping Tang, Bo Kou, Xi Li, Xudong Lu

“…Currently, the area of consequence of the harm caused by a leak in a gathering pipeline transporting in-situ coal gas has not been clarified. …”
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Effect of Tin Oxide/Black Paint Coating on Absorber Plate Temperature for Improved Solar Still Production: A Controlled Indoor and Outdoor Investigation by Sayfar Rasachak, Rana Sami Ullah Khan, Laveet Kumar, Taiba Zahid, Usman Ghafoor, Jeyraj Selvaraj, Rehena Nasrin, Muhammad Shakeel Ahmad

“…The current high-end and large-scale technologies are becoming way more expensive and not friendly to the environment. …”
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Sustainable concrete manufactured with mixed recycled aggregate and biomass bottom ash, replacing aggregate and cement to a high percentage by M. Rosales, J. Rosales, S. Moreno, F. Agrela, J.L. Díaz-López

“…Given the current problem of CO2 emissions and the overexploitation of natural resources, it is essential to make a change in the materials typically used for concrete manufacturing. …”
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Effects of coix seed polyphenol extract on rumen fermentation, milk production, fatty acid profile, antioxidant activity, and polyphenol content in dairy goats by X.Z. Tian, Y.Q. Xu, J.X. Qin, X. Wang, S.L. Xie, R. Chen, Q. Lu, X. Chen

“…An increase in dietary CSE linearly and quadratically increased milk production parameters, and quadratically increased milk protein, lactose, and SNF. …”
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Pharmaceutical Providing for Prevention and Treatment of Influenza in Children by Olіynyk O., Kіrda І., Voitsekhivska I.

“…The mortality rate of uncomplicated influenza is 0.01-0.2 %, but it increases sharply in the case of illness in frail persons and young children. …”
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