Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Results Our findings showed that CL-NPs loaded with anti-NOTCH1/-SF3B1 siRNAs-PTX significantly suppressed NOTCH1 and SF3B1 expression in PBMCs and BMMCs isolated from CLL cases in comparison with the untreated samples, leading to increased leukemic cell sensitivity to PTX and decreased the proliferative capacity of leukemic cells. …”
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Smart Campus Tools by Bart Valks

“…The main research question is: How can smart campus tools optimally contribute to the match between demand for and supply of space, both on the current campus and on the future campus? To answer the research question, this PhD dissertation explores the use of Smart campus tools in Dutch and international contexts, at universities and other organisations. …”
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Human immunodeficiency virus prevention and testing strategies among men who have sex with men in the UK: the PANTHEON research programme including the SELPHI RCT by Janey Sewell, T Charles Witzel, David Dunn, Fiona Lampe, Fiona Burns, Peter Weatherburn, Sheena McCormack, Leanne McCabe, Alec Miners, Valentina Cambiano, Roger Pebody, Roy Trevelion, Nadia Hanum, Andrew Phillips, Alison Rodger

“…Modelling suggested that provision of oral tenofovir/emtricitabine pre-exposure prophylaxis increased human immunodeficiency virus testing, with anti-retroviral therapy initiation at diagnosis, and reductions in the level of condom-less sex, that each played an important role in decreasing human immunodeficiency virus incidence among men who have sex with men, and that the current human immunodeficiency virus incidence would have been double what it is if any one of them had not occurred. …”
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Reflecting on Challenges and Opportunities: Examining the Colour Economy of Innovation and Entrepreneurship by Estrada Salvador, Cabrera-Flores Mayer, León-Pozo Alicia, Cota-Cota Creta

“…Nearly a quarter of a century has passed, and current socio-economic and cultural conditions necessitate new approaches to conceptualizing Economics. …”
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How STEM content is presented in mathematics textbooks from the U.S. and China: a comparative study by Shuhui Li, Lianghuo Fan, Jietong Luo

“…The PEP series contained more from engineering and agriculture, and presented more in the main text; the BIM series presented more in statistics and probability, placed more in chapter previews, had more moderate-level content (i.e., partial integration of content knowledge) and a balanced distribution of authentic and non-authentic contexts in enriched-level content. Conclusion and implications The current STEM content, especially those at enriched-level, is limited. …”
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Applications of Indocyanine Green in Breast Cancer for Sentinel Lymph Node Mapping: Protocol for a Scoping Review by Feryal Kurdi, Yahya Kurdi, Igor Vladimirovich Reshetov

“…This review aims to assess the accuracy, efficacy, and safety of ICG in this context and to identify gaps in the existing research. …”
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Problems in preparation of legally binding documents for oncological and palliative patients and their solutions by P. G. Gabay, B. Sh. Kamolov

“…To consider problems arising when an oncological or palliative patient decides to dispose of their property and to suggest solutions to these problems.Materials and methods. An analysis of the current normative legal acts and legal precedents in the Russian Federation in the context of property disposal by severely ill patients was performed. …”
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Internalized Stigma of Mental Illness and Its Relation with Self- Esteem and Social Support among Psychiatric Patients by Amany A. Mohamed

“… Context: Mentally ill patients challenging dual difficulties that are illness and stigma. …”
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Exploring efficacy of spiritual-based interventions (SBIs) in addressing depressive symptoms among cardiac patients in MENA region: a scoping review by Rizwana Amin

“…Studies were analyzed using the Population-Concept-Context (PCC) framework, as outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews (PRISMA-ScR).ResultsThe analysis pinpoints numerous Spiritual Interventions, such as prayer, mindfulness, and Faith-based counseling, as usual practices. …”
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Towards a Common Agricultural Data Space in the European Union: A Sustainable Development Perspective by Katarzyna Kosior

“…It was concluded that the achievement of sustainability goals with the help of the planned common data space remains challenging, particularly in the context of rapid, but uneven pace of digital transformation in the agri-food sector in the EU. …”
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PRESERVATION OF THE OLD‐GROWTH RELIC BUSULUK PINE FOREST UNDER THE CONDITIONS OF OIL FIELD DEVELOPMENT by P. V. Velmovsky, A. A. Chibilyov

“…In this paper, we set out to analyse the problem of preservation of old‐growth relic pine forests under in the context of oil field development.Discussion. The Buzuluk pine forest is the largest natural island forest in the steppe zone of European Russia. …”
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Assessment of soil microbial properties in some regions affected by climate change by Mohammed Khalid Al-Atrash, Fatima Amer Abd Algabar, Lamiaa Saoud Abbod

“…The soil enzymes activity was estimated by fluorescence enzyme assays. The current study showed a significant decrease in the activity of soil microbial communities in this region in response to climate changes that affected physicochemical soil properties. …”
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Optimizing Decision Making on Business Processes Using a Combination of Process Mining, Job Shop, and Multivariate Resource Clustering by Hanung Nindito Prasetyo, Riyanarto Sarno, Dedy Rahman Wijaya, Raden Budiraharjo, Indra Waspada, Kelly Rossa Sungkono, Abdullah Faqih Septiyanto

“…The large scale and complexity of business processes pose a challenge in improving the quality of process model because the effectiveness of time and the efficiency of existing resources are the biggest challenges. In the context of optimizing business processes with a process mining approach, most current process models are optimized with a trace clustering approach to explore the model and to perform analysis on the resulting process model. …”
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Climate Change Risk, Performance, and Value Added in Agricultural Sector by Ramin Amani, Zanko Ghorbani, Zana Mozaffari

“…This, in turn, results in decreased production costs, increased investment returns, surplus domestic supply, and expanded agricultural product exports. …”
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Depoliticization and Criminalization of Social Protest through Economic Decisionism: the Colombian Case by María Carolina Olarte

“… This article argues that current manifestations of criminalization of protest in contexts rich in natural resources can be inscribed in a wider economic context that contributes to the neutralization of political claims to land, natural resources and self-determination. …”
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Giant pandas hold great potential umbrella effectiveness for golden snub‐nosed monkeys under climate change by Jia‐Wen Liu, Yang Yu, Rui‐Feng Wu, Wen‐Bo Li, Cyril C. Grueter, Xue‐Lin Jin, Yang Teng, Ying Shen, Ming Li

“…However, empirical data on their potential effectiveness, particularly in the context of climate change, is limited and inconclusive. …”
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Le réseau hydraulique à Pompéi (Italie) de l’époque des Samnites à Auguste (fin ive-fin ier s. av. J.-C.) by Federico Giletti

“…While the latter type appears equally in both private and public contexts, the burrow cistern by contrast differs in that it is excavated entirely into the lava stratum and has been demonstrated, as far as we currently know, only on the main outcrops of the lava plateau, such as on the rocky crest of the southern drop in height below insula 2 of Regio VIII.While the type of cistern with a burrow or bainhole seems to have been inspired by models already widespread in Punic-Carthaginian sites in Africa and on the islands and in the Magna-Greek area, cases of cisterns with a burrow collected to several arms primarily bear strong similarities to Etruscan-Latian examples, as does the technique of drainage tunnels entirely excavated in the geological bank and the custom of digging deep artesian wells. …”
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Separation of Maternal and Newborn Care in US Hospitals: A Systemic Threat to Survival, Health and Well-Being by Kavya I. Anjur, Gary L. Darmstadt

“…This information is evaluated in the context of modern scientific advancements to show that the conditions which shaped health systems to separate mothers and newborns in the past no longer hold. …”
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Improving the national qualifications system as a factor in the formation of a new quality of human capital by A. A. Satybaldin, I. N. Dauranov, Z. K. Chulanova, A. A. Nazerke

“…The aim of the work is to study approaches to the formation of a qualification system in order to improve the quality of human capital in the labor market in the context of the economy. digitalization. The article discusses the issues of quality modernization of the vocational and educational sphere based on the creation of a national system of qualifications (NSQ). …”
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MENTORING AND TRAINING OF UNIVERSITY TEACHING STAFF by Alexandrina Mihaela POPESCU, Andreea Aurora Maria BUGA

“…The transition to an academic career represents a critical stage in the professional development of young teaching staff, characterized by complex challenges that require specialized support and professional guidance. In the current context of higher education, marked by structural transformations and increasing pressures, mentoring must be viewed as a fundamental necessity for ensuring the success and retention of new members of the university teaching staff. …”
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