Cost-effectiveness of atezolizumab plus bevacizumab versus sorafenib as first-line therapy in unresectable hepatocellular carcinoma in the US and Chinese setting: a modelling compa... by Lei Wang, Lulu Liu, Yiling Ding, Qilin Zhang, Yamin Shu

“…In scenario analyses, the atezolizumab plus bevacizumab treatment becomes favourable when the cost of atezolizumab decreases to 67.85% and 18.45% of its original price in the USA and China, respectively.Conclusions The atezolizumab plus bevacizumab is unlikely to be cost-effective compared with sorafenib for patients with unresectable HCC in the context of the USA and China. …”
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THE IMPACT OF THE USE OF BIOFUELS ON CO2 EMISSIONS AT THE LEVEL OF EUROPEAN COUNTRIES FROM THE PERSPECTIVE OF ABSOLUTE DECOUPLING by Valentina SIMION, Liviu MARCUTA, Maricel CAZACU, Nicolae MINEA, Camelia HODOAȘAN

“…Decoupling economic growth from CO2 emissions completely is still a key goal of sustainability programs. According to the current research, nations with faster energy transitions and advanced technologies typically see a sharper decoupling, meaning that real GDP growth is attained without a rise in greenhouse gas emissions. …”
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Adverse birth outcome research case definitions associated with maternal HIV and antiretroviral drug use in pregnancy: a scoping review by Kopano R. Dube, Shani T. de Beer, Kathleen M. Powis, Michael McCaul, Amy L. Slogrove

“…Abstract Background Adverse birth outcomes (preterm birth, low birth weight, small for gestational age, and stillbirth) seem to persist in infants born to people with HIV, even in the context of maternal antiretroviral therapy. However, findings have been disparate, inconclusive, and difficult to compare directly across settings, partly owing to variable outcome definitions. …”
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Application of urinary peptide-biomarkers in trauma patients as a predictive tool for prognostic assessment, treatment and intervention timing by Gökmen Aktas, Felix Keller, Justyna Siwy, Agnieszka Latosinska, Harald Mischak, Jorge Mayor, Jan Clausen, Michaela Wilhelmi, Vesta Brauckmann, Stephan Sehmisch, Tarek Omar Pacha

“…The results obtained allow the planning of a well-powered prospective trial investigating the value of urinary peptides in this context in more detail.…”
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Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype. by Ruthiran Kugathasan, Ksenia Sukhova, Maya Moshe, Paul Kellam, Wendy Barclay

“…New variants of SARS-CoV-2 are continually emerging with mutations in spike associated with increased transmissibility and immune escape. Phenotypic maps can inform the prediction of concerning mutations from genomic surveillance, however most of these maps currently derive from studies using monomeric RBD, while spike is trimeric, and contains additional domains. …”
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Ghrelin stimulation of growth hormone-releasing hormone neurons is direct in the arcuate nucleus. by Guillaume Osterstock, Pauline Escobar, Violeta Mitutsova, Laurie-Anne Gouty-Colomer, Pierre Fontanaud, François Molino, Jean-Alain Fehrentz, Danielle Carmignac, Jean Martinez, Nathalie C Guerineau, Iain C A F Robinson, Patrice Mollard, Pierre-François Méry

“…Indeed, ghrelin does not modify synaptic currents of GHRH neurons. However, ghrelin exerts a strong and direct depolarizing effect on GHRH neurons, which supports their increased firing rate.…”
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Incomplete epidemiological transition in Kazakhstan: changes in the structure of life expectancy and causes of death by А. Алдангаркызы, М. Денисенко

“… This article examines Kazakhstan's epidemiological transition, focusing on shifts in mortality patterns and life expectancy within the context of socioeconomic and demographic influences. …”
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Flow and mixing of elongated particles in rotating drums of different sizes by Jinhua Song, Numan Naeem, Hu Fan, Guanhua Li, Maosong Li, Yu Guo, Jianzhong Lin, Jianzhong Lin, Jinxin Tie

“…For both monodisperse and binary particle systems, dynamic angle of repose is determined mainly by a Froude number Fr, measuring the ratio of centrifugal force to gravitational force on a particle, while it is insensitive to scale-up ratio α, defined as the ratio of cross-sectional areas of the current drum to the reference one. Average particle velocity and contact force generally increase with both Froude number and scale-up ratio. …”
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IAE-CDNet: A Remote Sensing Change Detection Network for Buildings With Interactive Attention-Enhanced by Zhaoyang Han, Linlin Zhang, Qingyan Meng, Chongchang Wang, Wenxu Shi, Maofan Zhao

“…Currently, the development of deep learning has had a positive impact on remote sensing image change detection tasks, but many current methods still face challenges in effectively processing global and local features, especially in the task of building change detection in high-resolution images containing complex scenes. …”
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What happens between first symptoms and first acute exacerbation of COPD – observational study of routine data and patient survey by Alex Bottle, Alex Adamson, Xiubin Zhang, Benedict Hayhoe, Jennifer K Quint

“…Most patients were offered the flu jab. Older patients, current smokers and those with other conditions such as heart failure had higher risk of an acute exacerbation. …”
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Effects of ultrasonic vibration on residual stress distribution and local mechanical properties of AA6061/Ti6Al4V dissimilar joints by resistance spot welding by Mohan He, Qian Wang, Yingjun He, Jinxiang Wang, Ninshu Ma, Yuanxun Wang

“…The maximum load of welding nugget region increased from 19.6 N to 22.3 N, and the elongation obtained 10% increase. …”
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Variation and prognostic potential of the gut antibiotic resistome in the FINRISK 2002 cohort by Katariina Pärnänen, Matti O. Ruuskanen, Guilhem Sommeria-Klein, Ville Laitinen, Pyry Kantanen, Guillaume Méric, Camila Gazolla Volpiano, Michael Inouye, Rob Knight, Veikko Salomaa, Aki S. Havulinna, Teemu Niiranen, Leo Lahti

“…Resistance was linked not only to prior use of antibiotics, as anticipated, but also to frequent consumption of fresh vegetables and poultry, two food groups previously reported to contain antibiotic-resistant bacteria. Interestingly, resistance was not linked to the consumption of high-fat and high-sugar foods, but was consistently higher in females and urban high-income individuals, who currently have generally lower mortality rates. …”
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Synthesis, structure, and visible-light-driven activity of o-YbFeO3/h-YbFeO3/CeO2 photocatalysts by Sofia M. Tikhanova, Lev A. Lebedev, Svetlana A. Kirillova, Maria V. Tomkovich, Vadim I. Popkov

“…It was found that nanocrystalline components were chemically and phase-pure, uniformly spatially distributed over the nanocomposite, and had multiple contacts with each other. Based on this fact and the established electronic structure of the nanocomposite components, the formation of I-type heterojunction with the participation of o-YbFeO3 (Eg = 2.15 eV), h-YbFeO3 (Eg = 2.08 eV), and CeO2 (Eg = 2.38 eV) was shown, the presence of which increased photocatalytic activity of the resulting nanocomposite. …”
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Establishing priorities for future land conservation to maximise biodiversity conservation and other ecosystem services in the Tilarán Mountains of Costa Rica by Lindsay Stallcup, Matthew D. Moran, Doris Rojas, Erich Mata

“…The opportunity to connect currently protected areas to one another through effective biological corridors still remains, possibly through conservation partnerships with landowners or direct land purchase, but time could be short as increasing development and changing land-use patterns threaten to further isolate habitats in the MAB.…”
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Exposure to secondhand smoke from cigarettes and secondhand aerosol from tobacco and nicotine products in indoor and outdoor public spaces in the European Union: a cross-sectional... by Anthony A Laverty, Ariadna Feliu, Filippos T Filippidis, Constantine I Vardavas, Cristina Martínez, Charis Girvalaki, Armando Peruga, Charlotte Xin Li, Pin-Chun Wang, Cornel Radu Loghin

“…Introduction In December 2024, the Council of the European Union (EU) adopted a recommendation to expand regulations on the use of nicotine-containing products both in indoor settings and specific outdoor areas. …”
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Effect of temperature on corrosion behaviors of copper in high-level nuclear waste disposal environment by Tianyu Wang, Chengtao Li, Lijun Song, Xiang Cai, Jian Chen, Zhilin Chen, Qichao Zhang, Yishan Jiang, Yanxin Qiao

“…The results showed that the increase in temperature can accelerate both cathodic and anodic reactions, thereby increasing the corrosion current density. …”
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Standalone ultrasound-based highly visualized volumetric spine imaging for surgical navigation by Xinben Hu, Tianjian Liu, Zhengyuan Zhang, Xuan Xiao, Lin Chen, Gao Wei, Yunjiang Wang, Keji Yang, Haoran Jin, Yongjian Zhu

“…Abstract Current navigation systems employing intraoperative CT have been applied in spinal interventions for accurate and visualized guidance. …”
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Temporal and Spatial Evolution and Driving Force Analysis of Water Conservation Function in Yunnan Province Based on Climate and Land Use Change by LIU Fengru, ZHAO Junsan, LIN Yilin, CHEN Guoping, ZHANG Longjiang, PENG Sufen

“…The framework can predict land use change and assess water conservation in the context of future climate change and different economic developments. …”
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Screen-printed Carbon Electrode from Coconut Shell Activated Carbon Modified with Ferrocene for Cobalt Detection by Muhammad Farhan, Eddy Heraldy, Abu Masykur, Muhammad A. Munir, Fitria Rahmawati

“…The cyclic voltammetry analysis found that 10% Fc on SPCE provides the highest current density compared to 20% and 30%. Meanwhile, the 2 mV s-1 scanning rate reveals a more defined anodic and cathodic peak than 3 mV s-1 and 5 mV s‑1. …”
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Genetic Diversity and Mutation Frequency Databases in Ethnic Populations: Systematic Review by Shumaila Khan, Mahmood Alam, Iqbal Qasim, Shahnaz Khan, Wahab Khan, Orken Mamyrbayev, Ainur Akhmediyarova, Nurzhan Mukazhanov, Zhibek Alibiyeva

“…The review also addressed standardization and data quality challenges prevalent in current NEMDBs. ResultsThe analysis of 42 NEMDBs revealed significant issues, with 70% (29/42) lacking standardized data formats and 60% (25/42) having notable gaps in the cross-comparison of genetic variations, and 50% (21/42) of the databases contained incomplete or outdated data, limiting their clinical utility. …”
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