Chlorpromazine directly inhibits Kv1.3 channels by facilitating the inactivation of channels by Seo-In Park, Soobeen Hwang, Young Lee, Hee-Yoon Lee, Soohyun Kim, Junseo Hong, Su-Hyun Jo, Se-Young Choi

“…The antipsychotic chlorpromazine (CPZ) demonstrates anti-inflammatory effects by decreasing Kv1.3 activity in mPFC microglia. However, the precise mechanism of CPZ’s effect in the mPFC remains unclear, given that CPZ is known to inhibit dopamine receptors and the mPFC contains various cell types with dopamine receptors. …”
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Cranberry Leaves as Feed Additive in Poultry Nutrition: Effects on Performance and Oxidative Stability by Arabela Elena Untea, Iulia Varzaru, Mihaela Saracila, Petru Alexandru Vlaicu, Alexandra-Gabriela Oancea, Tatiana Dumitra Panaite

“…The leaves belonging to that species can be considered a cost-effective alternative in the context of reducing antibiotics strategy in animal nutrition. …”
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Comparison of various feed additives on nutrient digestibility, digestive enzyme activity, blood metabolite levels, and gut microbiota composition in japanese quail chicks by Hassan Saleh, Omid Jangjou, Mohammad Taher Mirakzehi, Seyedeh Hamideh Hosseni

“…In contrast, quail chicks that received diets containing tetracycline antibiotics exhibited a decreased presence of Clostridium species and E. coli in the ileum, as compared to the control group (p < 0.05). …”
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Beyond the brain: early autonomic dysfunction in Alzheimer’s disease by Carmen Nanclares, Inés Colmena, Alicia Muñoz-Montero, Andrés M. Baraibar, Ricardo de Pascual, Aneta Wojnicz, Ana Ruiz-Nuño, Antonio G. García, Adrián Gironda-Martínez, Luis Gandía

“…These changes were accompanied by diminished sodium (INa), calcium (ICa), and nicotinic (IACh) currents, compromising CC excitability. With age, a shift toward increased potassium (IK) currents and enhanced catecholamine secretion may reflect compensatory adaptations aimed at preserving output. …”
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What type of leadership is more effective for managing change during force majeure? Achieving organizational effectiveness during the pandemic by Nazia Habib, Shaheryar Naveed, Muhammad Mumtaz, Rabia Sultana, Shoaib Akhtar

“…Originality/value – The study has carried out the comparative analyses in three different ways, including leadership styles (transformational and ethical), type of organization (private and public) and time frames (pre and during COVID-19), which is a true contribution of the research in the Pakistani context.…”
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Cost-effectiveness of atezolizumab plus bevacizumab versus sorafenib as first-line therapy in unresectable hepatocellular carcinoma in the US and Chinese setting: a modelling compa... by Lei Wang, Lulu Liu, Yiling Ding, Qilin Zhang, Yamin Shu

“…In scenario analyses, the atezolizumab plus bevacizumab treatment becomes favourable when the cost of atezolizumab decreases to 67.85% and 18.45% of its original price in the USA and China, respectively.Conclusions The atezolizumab plus bevacizumab is unlikely to be cost-effective compared with sorafenib for patients with unresectable HCC in the context of the USA and China. …”
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THE IMPACT OF THE USE OF BIOFUELS ON CO2 EMISSIONS AT THE LEVEL OF EUROPEAN COUNTRIES FROM THE PERSPECTIVE OF ABSOLUTE DECOUPLING by Valentina SIMION, Liviu MARCUTA, Maricel CAZACU, Nicolae MINEA, Camelia HODOAȘAN

“…Decoupling economic growth from CO2 emissions completely is still a key goal of sustainability programs. According to the current research, nations with faster energy transitions and advanced technologies typically see a sharper decoupling, meaning that real GDP growth is attained without a rise in greenhouse gas emissions. …”
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Adverse birth outcome research case definitions associated with maternal HIV and antiretroviral drug use in pregnancy: a scoping review by Kopano R. Dube, Shani T. de Beer, Kathleen M. Powis, Michael McCaul, Amy L. Slogrove

“…Abstract Background Adverse birth outcomes (preterm birth, low birth weight, small for gestational age, and stillbirth) seem to persist in infants born to people with HIV, even in the context of maternal antiretroviral therapy. However, findings have been disparate, inconclusive, and difficult to compare directly across settings, partly owing to variable outcome definitions. …”
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Application of urinary peptide-biomarkers in trauma patients as a predictive tool for prognostic assessment, treatment and intervention timing by Gökmen Aktas, Felix Keller, Justyna Siwy, Agnieszka Latosinska, Harald Mischak, Jorge Mayor, Jan Clausen, Michaela Wilhelmi, Vesta Brauckmann, Stephan Sehmisch, Tarek Omar Pacha

“…The results obtained allow the planning of a well-powered prospective trial investigating the value of urinary peptides in this context in more detail.…”
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Development and characterization of amaranth protein-based edible films incorporating Satureja khuzestanica essential oil by Elahe Khalili, Gholamreza Jahed Khaniki, Saeedeh Shojaee-Aliabadi, Nabi Shariatifar, Ramin Aslani, Leila Mirmoghtadaie

“…The current research aimed to investigate the physicochemical and antimicrobial characteristics of the edible film based on amaranth protein containing Satureja khuzestanica essential oil. …”
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Incomplete epidemiological transition in Kazakhstan: changes in the structure of life expectancy and causes of death by А. Алдангаркызы, М. Денисенко

“… This article examines Kazakhstan's epidemiological transition, focusing on shifts in mortality patterns and life expectancy within the context of socioeconomic and demographic influences. …”
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Reducing the dietary starch:protein ratios in low-protein diets enhanced the growth performance of goslings from 1 to 28 days of age by Xucheng Zheng, Qian Lu, Chunhui Huang, Usman Nazir, Zhi Yang, Haiming Yang, Zhiyue Wang

“…The current study aimed to explore the suitable starch: protein ratios under different dietary protein levels for goslings. …”
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Possibilities of metabolic surgery for the treatment of type 2 diabetes mellitus in patients with grade 1 alimentary obesity by Vladimir V. Salukhov, Nikita S. Ilinskii, Evgenii V. Vasil'ev, Ruslan T. Sardinov, Dmitrii V. Gladyshev

“…Many studies have demonstrated the high effectiveness of bariatric surgery in patients with grade 2&ndash;3 obesity and type 2 diabetes mellitus. Currently, surgery is one of the most effective ways to decrease body mass, to maintain long-term weight loss and to manage type 2 diabetes mellitus. …”
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Interference in melanoma CD248 function reduces vascular mimicry and metastasis by Cheng-Hsiang Kuo, Ya-Fang Wu, Bi-Ing Chang, Chao-Kai Hsu, Chao-Han Lai, Hua-Lin Wu

“…Abstract Background Tumor vascular mimicry is an emerging issue that affects patient survival while having no treatment at the current moment. Despite several factors implicated in vascular mimicry, little is known about stromal factors that modulate tumor microenvironment and shape malignant transformation. …”
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3D-printed resin for permanent/definitive restorations: meta-analysis for bond strength by Minjoo Ki, Marc Hayashi, Mijoo Kim

“…This meta-analysis aimed to synthesize the current knowledge on the adhesion of 3D-printed restorations to resin cements and identify areas for future research. …”
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Temporal and Spatial Evolution and Driving Force Analysis of Water Conservation Function in Yunnan Province Based on Climate and Land Use Change by LIU Fengru, ZHAO Junsan, LIN Yilin, CHEN Guoping, ZHANG Longjiang, PENG Sufen

“…The framework can predict land use change and assess water conservation in the context of future climate change and different economic developments. …”
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The impacts of climate variability on conflict risk in conflict-prone regions worldwide by Xiaolan Xie, Fangyu Ding, Mengmeng Hao, Jun Zhuo, Shuai Chen, Jiajie Wu, Jiping Dong, Kai Sun, Qian Wang, Dong Jiang

“…The climate-conflict linkage is a topic of intense debate within the context of security implications. Previous quantitative studies exploring the causal link between climate variability and conflict risk present divergent findings due to the differences in modeling scale or strategies, such as the non-unified definition of conflict risk and the different settings of independent variables. …”
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Long-term dynamics of forests with Pinus sibirica in the upper reaches of the River Kolva (Northern Pre-Urals, Russia) from 1938 to 2023 by Alexei A. Aleinikov, Vadim E. Aleksutin, Foma K. Vozmitel, Alexey N. Gunya

“…Due to the exceptionally slow regeneration following fires and logging activities, Pinus sibirica is absent in the forests formed over the studied period. The current federal legal restrictions prove ineffective as they target the preservation of forest stands containing over 30% of Pinus sibirica, while the majority of forests in the study area contain less proportion of this species. …”
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Compost from the food waste for organic production of cabbage, cauliflower, and radish under sub-tropical conditions by Neha Kumari, Anit Sharma, Mamta Devi, Atif Zargar, Sunny Kumar, Umesh Thakur, Ajay Bhatia, Khushboo Badhan, Sunaina Chandel, Arpana Devi, Kriti Sharma, Shweta Kumari, Mussarat Choudhary, Arup Giri

“…Purpose In the current scenario, food wastage is a significant concern throughout the world. …”
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Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling by Asra Asgharzadeh, Mubarak Patel, Martin Connock, Sara Damery, Iman Ghosh, Mary Jordan, Karoline Freeman, Anna Brown, Rachel Court, Sharin Baldwin, Fatai Ogunlayi, Chris Stinton, Ewen Cummins, Lena Al-Khudairy

“…It is not known whether these issues persist in the current iQVIA CDM. The EAG assesses the cost-effectiveness of HCL and CSII + CGM. …”
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