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361
Complementary Strategy of Maternal Immunization with RSVpreF Vaccine and Monoclonal Antibodies for the Prevention of Respiratory Syncytial Virus Among Italian Infants: A Cost-Effec...
Published 2025-07-01“…Methods Using a model (with a cohort framework and a Markov-type process) specifically adapted to the Italian context, the study provided cost-effectiveness and cost-utility assessment of prevention strategies adding the maternal vaccination to the existing immunization opportunities with palivizumab or nirsevimab administered to high risk and unprotected infants. …”
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362
Increasing day three parasitaemia is observed after treatment of patients with artemether-lumefantrine and single dose of primaquine for uncomplicated Plasmodium falciparum malaria...
Published 2025-03-01“…These findings support the ongoing use of AL with a single dose of PQ as the primary treatment option for uncomplicated P. falciparum infections in the study area. In the context of the emergence and spread of partial artemisinin-based combination therapy(ACT) resistance in Africa, regular monitoring of the efficacy of current artemisinin-based combinations is recommended for the early detection of emerging drug resistance in the study setting and beyond.…”
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363
Impact of metabolic-associated fatty liver disease on the cholesterol efflux capacity of high-density lipoproteins in adolescents with type 2 diabetes
Published 2024-12-01“…ContextType 2 diabetes (DM2) is an emerging disease in the pediatric population. …”
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364
Effects of ibrutinib and venetoclax on the expression of immune checkpoint molecules in leukemic blasts of patients with acute lymphoblastic leukemia
Published 2025-06-01“…By elucidating the precise underlying mechanisms, these drugs could emerge as promising therapeutic options, particularly in the context of combination therapy for ALL.…”
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365
Progress of arylacetamide deacetylase research in metabolic diseases
Published 2025-05-01“…It plays a significant role in drug metabolism, lipid metabolism, and the pathogenesis of various diseases. In the context of drug metabolism, AADAC is vital for ensuring the safety of ester-based drugs. …”
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366
Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1
Published 2025-03-01“…Overexpression of the splicing factor 3b subunit 1 (SF3B1) and neurogenic locus notch homolog protein 1 (NOTCH1) factors is typically found in chronic lymphocytic leukemia (CLL), leading to the development of chemotherapy resistance. Objective The current investigation aims to evaluate the chemosensitivity of CLL cells by blocking NOTCH1 and SF3B1 using chitosan lactate (CL) nanoparticles (NPs). …”
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367
The Immune Environment in Colorectal Adenoma: A Systematic Review
Published 2025-03-01“…<b>Methods:</b> In this systematic review, we aim to provide a thorough analysis of the current research examining the immune infiltration patterns in sporadic colorectal adenoma tissues in the context of immune cell-based, cytokine-based, and other immunological factor-related changes along the conventional adenoma–carcinoma sequence. …”
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368
The role of anifrolumab in reshaping the treatment landscape of extra-renal systemic lupus erythematosus
Published 2025-07-01“…Hypothetical scenarios derived from clinical practice were examined to identify real-life contexts suitable for the early initiation of anifrolumab treatment. …”
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369
Job Satisfaction Analysis of Nurses, who Work in Neurology and Neurosurgery Units
Published 2022-12-01“…Satisfaction, facing problems and motivation are currently strategic points to be analysed in terms of nurses’ work. …”
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370
Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the IL‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants...
Published 2025-03-01“…Modification of the CCL2 secretion seemed to be context dependent in the human explants: where EVs treatment stimulated CCL2 secretion but in the presence of IL‐1β this effect was counteracted. …”
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371
Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection
Published 2017-01-01“…This review highlights what is currently known about the clinical context of pre and posttransplant antibodies, antibody characteristics that influence AMR, and the paths after donor specific antibody production (no rejection, subclinical rejection, and clinical dysfunction with AMR).…”
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372
Conceptual approaches to the complex of restoration of the affected territories as a result of military actions in Ukraine
Published 2024-07-01“…Results and conclusions: The land relations during the reconstruction of Ukraine should be based on the following principles and approaches: openness of the public cadastral map of Ukraine; simplification of permit procedures; assessment of land and soil quality, inventory; continuation of the trend of decreasing arable land; conservation of lands, the use of which could harm human life and health as well as the state of the environment; expropriation of land from tenants who are connected to Russia or Belarus; soil conservation in the context of war; introduction of the state system for the control of land resources and the responsibility of land users.…”
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373
Attributing climate and weather extremes to Northern Hemisphere sea ice and terrestrial snow: progress, challenges and ways forward
Published 2025-05-01“…Both sea ice and spring snow in the Northern Hemisphere (NH) have been decreasing at an alarming rate in a changing climate. …”
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374
Multidisciplinary approach to the diagnosis of disorders of coagulation system in childrenwith various pathologies
Published 2023-01-01“…Thrombosis in children with genetically determined thrombophilia often occur in the context of risk factors. In the early neonatal period, the deficiency of anticoagulant factors manifests as the form of fulminant purpura, followed by the development of skin necrosis. …”
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375
Legal Challenges of Marine Insurance Laws in the Use of Unmanned Ships
Published 2025-03-01“…For this reason, The study aims to address t to what extent unmanned ships can be insured within current regulations, and whether there's a necessity to modify traditional insurance principles to ensure coverage for these ships. …”
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376
Quality failures in Energy- saving renovation projects in Northern China
Published 2021-04-01“…The energy-saving renovation of an existing building is a critical strategy in achieving a long-term energy goal in the Chinese context. In response to the high energy consumption, the Chinese government encourages that the energysaving renovation projects of the existing residential buildings should be widely carry out in Northern China (Chen et al. 2015). …”
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377
Characterizing dengue transmission in rural areas: A systematic review.
Published 2023-06-01“…We conducted a systematic review to synthesize research on dengue in rural areas and apply this knowledge to summarize aspects of rurality used in current epidemiological studies of DENV transmission given changing and mixed environments. …”
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378
CIS Countries Foreign Economic Activity — from Challenges to New Opportunities
Published 2024-12-01“…Aim and tasks. To identify current trends and issues in foreign trade, the international financial system, and the investment activity of CIS member states, and to provide recommendations that contribute to sustainable economic development and strengthened mutual cooperation.Methods. …”
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379
Unlocking the hidden forces: deformation and associated stress distribution in the present-day Geneva Basin and Jura fold-and-thrust belt
Published 2025-06-01“…Abstract In foreland fold-and-thrust belts, the distribution of deformation and of the associated stress field can notably be perturbed due to local-scale features such as tectonic structures or surface topography. In the context of geothermal exploration and the planning of the future circular collider (CERN) in the Geneva Basin, it is of particular interest to constrain possible future deformation in the area and the associated stress state. …”
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380
Effectiveness of Nursing Intervention Protocol on Nurses’ Performance and Patients’ Self-Care after Cataract Surgery
Published 2024-04-01“… Context: Cataract is the leading cause of poor vision worldwide. …”
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