Assessment of the effect of the COVID-19 pandemic on levels of satisfaction in marital relationships during and post-lockdown by Rasha Aziz Attia Salama, Rabab Gad Abd El-Kader, Talaat Matter Tadross, Shaimaa Hashem Elsalous

“…The current study aimed to assess marital satisfaction during and post the lockdown of the COVID-19 pandemic and explore the factors influencing marital satisfaction among the public. …”
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Universal multilayer network embedding reveals a causal link between GABA neurotransmitter and cancer by Léo Pio-Lopez, Michael Levin

“…Abstract Background The volume and complexity of biological data have significantly increased in recent years, often represented as network models continue to increase at a rapid pace. …”
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Perspectives of guardians/parents in Portugal: interpreting the inclusive education policy through lived school practices by Ana Eloisa Carvalho, Amélia Veiga

“…These changes align with the personalization of the educational process, particularly through the multi-level approach (MLA) to the curriculum and the increased involvement of the educational community, where the role of the guardian becomes increasingly central. …”
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Global road extraction using a pseudo-label guided framework: from benchmark dataset to cross-region semi-supervised learning by Xiaoyan Lu, Yanfei Zhong, Zhuo Zheng, JunJue Wang, Dingyuan Chen, Yu Su

“…Recent advancements in satellite remote sensing technology and computer vision have enabled rapid extraction of road networks from massive, Very High-Resolution (VHR) satellite imagery. However, current road extraction methods face the following limitations: 1) Insufficient availability of accurate and diverse training datasets for global-scale road extraction; 2) Costly and time-consuming manual labeling of millions of road samples; and 3) Limited generalization ability of deep learning models across diverse global contexts, resulting in better performance for regions well-represented in the training dataset, but worse performance when faced with domain gaps. …”
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Apolipoprotein L1 (APOL1): Consideration of Molecular Evolution, Interaction with APOL3, and Impact of Splice Isoforms Advances Understanding of Cellular and Molecular Mechanisms o... by Razi Khalaila, Karl Skorecki

“…In the absence of a consistent mechanistic explanation for differential kidney injury, we propose pursuing three interrelated avenues of investigation informed by prior epidemiological and mechanistic evidence linking them to APOL1’s cytotoxicity: (1) Molecular evolution of APOL1 haplotypes in human populations, (2) APOL1 splicing and consequent splice isoforms, (3) Interaction of APOL1 with other APOL gene family members, prioritizing APOL3. In the current study, we use reanalysis of population genetics datasets to resolve the haplotype contexts of all protein-altering APOL1 variants, uncovering previously unrecognized variant–haplotype couplings. …”
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Ethical considerations for a more equitable approach to One Health in forced migration by Dr Dorien Hanneke Braam

“…Objective: This review aims to provide an overview of current ethical considerations in, and proposals for, One Health, and how these may be applied to the approach in forced migration contexts. …”
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INTERACTION BETWEEN DENTO-MAXILLOFACIAL ANOMALIES AND GENERAL-SOMATIC HUMAN CONDITION (LITERATURE REVIEW) by L.V. Smaglyuk, H.V. Voronkova, A.Ye. Karasiunok, A.V. Liakhovska, V.I. Smaglyuk

“…Over the last decade, there has been a clear trend towards an increase in the prevalence of malocclusion, which reaches 80% according to current scientific literature and sometimes it exceeds this percentage. …”
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Introducing the non-invasive prenatal test for trisomy 21 in Belgium: a cost-consequences analysis by Mattias Neyt, Frank Hulstaert, Wilfried Gyselaers

“…The objective is to estimate the consequences of introducing NIPT for the detection of T21.Methods A cost-consequences analysis was performed presenting the impact on benefits, harms and costs. Context-specific real-world information was available to set up a model reflecting the current screening situation in Belgium. …”
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Strategizing Soft Skills Resilience: A Holistic Approach to Mitigating COVID-19 Pandemic Impact on Workforce Development by Mariia Vesolovska, Lyubomyr Shved

“…They also have a crucial impact on the economy, as the acquisition of soft skills contributes to the more efficient functioning of enterprises and the economy as a whole. However, in the current context, due to the consequences of the COVID-19 pandemic, certain difficulties have arisen in their development in countries around the world. …”
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Ashwagandha and Its Role in Stress Reduction, Hormonal Balance, and Athletic Recovery: An Evidence-Based Review by Weronika Ossowska, Maksymilian Czarnota, Wiktoria Ösztreicher

“…State of Knowledge: Current clinical studies suggest that ashwagandha may effectively lower cortisol levels, thereby supporting stress resilience in both mentally and physically demanding contexts. …”
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Prospects for distributed self-consumption generation in urban circuits with the use of photovoltaic systems by Diego Cordova, Secundino Marrero, Carlos Quinatoa, Manuel Leon

“…Electric distribution systems currently present a marked interest in solving problems related to technical losses, overloading of lines and being able to assimilate the increase in energy demand. …”
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Ambivalence in Place Attachment by Xin Li, Reinout Kleinhans, Maarten van Ham

“…The impending neighbourhood demolition uncovers accumulated social issues in danwei communities in the context of market reforms and institutional changes in current China, such as the emergence of deprived social groups and their struggles for better housing. …”
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The Biographical Narratives of an Adolescent in Kinship Care: A Complex Post-Traumatic Stress Disorder Case Study by Grant T. Ryan

“…The presence and impacts of violence, abuse, and neglect in the context of Australian children in kinship care is an ongoing concern for health services. …”
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A Five-Year Evaluation of Safety and Traffic Course by Students and Lecturers Using the CIPP Evaluation Model by Homayoun Sadeghi-bazargani, Mina Golestani, Saeideh Ghaffarifar, Abdolhassan Kazemi, Ali Jafari-Khounigh, Sepideh Harzand-Jadidi, Mahdi Rezaei

“…This study evaluated a traffic safety course to inform further implementation of the course in all Iranian universities. The current study used the CIPP evaluation model and included questionnaires and interviews to evaluate the one-credit course by students and lecturers at 15 universities from 2016 to 2020. …”
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The legal nature of crypto assets and its reflection in the civil and tax legislation of the Russian Federation by A. O. Simonov

“…Without clear and unambiguous legal regulation, it is difficult to ensure proper control and taxation of transactions with crypto assets, which can lead to significant tax losses and a decrease in budget revenues.Moreover, the concept of “digital currency” used in Russian legislation does not correspond to the generally accepted meaning in international practice and is mainly considered in an economic context, rather than in a legal one. …”
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Effects of ibrutinib and venetoclax on the expression of immune checkpoint molecules in leukemic blasts of patients with acute lymphoblastic leukemia by Armin Dozandeh-Jouybari, Fatemeh Mousavi-Mirkalaei, Saeid Taghiloo, Hossein Karami, Mohammad Naderisorki, Ehsan Zaboli, Mohammad Eslami-Jouybari, Tohid Kazemi, Hossein Asgarian-Omran

“…Following treatment, the proliferation of leukemic cells was significantly decreased and the apoptosis rate was significantly increased, which was more remarkable for venetoclax. …”
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Human immunodeficiency virus prevention and testing strategies among men who have sex with men in the UK: the PANTHEON research programme including the SELPHI RCT by Janey Sewell, T Charles Witzel, David Dunn, Fiona Lampe, Fiona Burns, Peter Weatherburn, Sheena McCormack, Leanne McCabe, Alec Miners, Valentina Cambiano, Roger Pebody, Roy Trevelion, Nadia Hanum, Andrew Phillips, Alison Rodger

“…Modelling suggested that provision of oral tenofovir/emtricitabine pre-exposure prophylaxis increased human immunodeficiency virus testing, with anti-retroviral therapy initiation at diagnosis, and reductions in the level of condom-less sex, that each played an important role in decreasing human immunodeficiency virus incidence among men who have sex with men, and that the current human immunodeficiency virus incidence would have been double what it is if any one of them had not occurred. …”
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Investigating the impact of armed conflict, cultural factors, and demographic characteristics on access to family planning services in Northwest Syria: a cross-sectional study by Okba Doghim, Abdulselam Daif, Abdulkarim Ekzayez, Kristen Meagher, Preeti Patel

“…Among them, 58% reported current contraceptive use. Analysis by age groups revealed that individuals aged 26–35 exhibited the highest proportion of contraceptive usage at 41.5%, while the under-18 age group showed the lowest at 7.7%. …”
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Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Results Our findings showed that CL-NPs loaded with anti-NOTCH1/-SF3B1 siRNAs-PTX significantly suppressed NOTCH1 and SF3B1 expression in PBMCs and BMMCs isolated from CLL cases in comparison with the untreated samples, leading to increased leukemic cell sensitivity to PTX and decreased the proliferative capacity of leukemic cells. …”
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Effect of 5-fluorouracil on Pseudomonas aeruginosa: impact on virulence, biofilm formation, and bacterial growth by Amani A. Niazy, May M. Alrashed, Abdurahman A. Niazy

“…By placing the current evidence in context, we hope to guide further studies toward determining the clinical viability of 5-FU as a treatment option against this formidable pathogen.…”
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