Transcriptomic analysis on pancreatic adenocarcinoma patients uncovers KRAS-mediated PPAR pathway alteration by Giuseppe Defazio, Federico Scolari, Sara Fancelli, Simone Polvani, Daniele Lavacchi, Lucia Picariello, Alessandro Tubita, Michaela Luconi, Lorenzo Antonuzzo, Lorenzo Antonuzzo, Andrea Galli, Serena Pillozzi

“…The incidence and mortality of pancreatic adenocarcinoma (PC) are expected to increase in the coming years, with survival rates remaining poor due to limited treatment options. …”
Get full text

Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances by Qiu Jiang, Jie Liu, Shan Huang, Xuan-Yue Wang, Xiaowei Chen, Guang-Hui Liu, Keqiang Ye, Weihong Song, Colin L. Masters, Jun Wang, Yan-Jiang Wang

“…Abstract In the context of global ageing, the prevalence of neurodegenerative diseases and dementia, such as Alzheimer’s disease (AD), is increasing. …”
Get full text

TRANSFORMING MUSIC EDUCATION IN UKRAINE: OPPORTUNITIES AND CHALLENGES IN CULTURAL AND ARTISTIC EDUCATION REFORM by Ihor ZAKUS, Nataliia LEBEDIEVA, Irma GVINIASHVILI, Viktoriya KORZHENOK, Dennis ADU

“… The article discusses the current challenges and prospects for developing music education in Ukraine while reforming the cultural and artistic sphere. …”
Get full text

From bench to bedside: nanomedicine development for intracerebral hemorrhage – exploring microenvironment, innovation, and translation by Gui Wan, Lingui Gu, Yangyang Chen, Yiqing Wang, Ye Sun, Zhenwei Li, Wenbin Ma, Xinjie Bao, Renzhi Wang

“…Finally, the progress of nanomedicines in clinical translation is analyzed, highlighting the challenges, opportunities, and future prospects for their application in the context of ICH. Graphical abstract…”
Get full text

Rebooting Master’s Programs in an Updated Higher Education System: Management Track by E. A. Kuklina

“…It is recommended that master’s programs be updated in accordance with the developed principles of reengineering: taking into account transformational mega-trends when developing program content; strengthening the management component in the curriculum structure; increasing the level of originality of content through the development of “professorial” courses and reflecting this in the KPI system; the possibility of reformatting the curriculum into a block-modular format; participation of employers in the implementation of the master’s training curriculum in order to solve pressing problems of the real sector of the economy; formation of scientific groups of students to carry out research on current research topics with the possibility of using the results obtained in preparing reports on design and analytical work and writing a final qualifying thesis. …”
Get full text

Tax regulation of enterprise R&D expenditures: special aspects and problems of regulation by T. A. Loginova

“…As a second step authors are performing the analysis of current rules related to tax accounting of R&D costs and intangibles in accordance with Tax Code of Russian Federation. …”
Get full text

Dynamic Analysis of the Interconnection of a Set of FPSO Units to an Onshore System via HVDC by Johnny Orozco Nivelo, Carlos A. Villegas Guerrero, Lúcio José da Motta, Marcos R. de Paula Júnior, José M.d. Carvalho Filho, Alex Reis, José Carlos Oliveira, José Mauro T. Marinho, Vinicius Z. Silva, Carlos A. C. Cavaliere

“…In an effort to restrict further increases in climate change, governments and companies are exploring ways to reduce greenhouse gas (GHG) emissions. …”
Get full text

Supporting antiretroviral therapy uptake and adherence: the SUPA research programme and RCT by Rob Horne, Caroline Sabin, Trudie Chalder, Vanessa Cooper, Lucy Campbell, Elizabeth Glendinning, Iris Mosweu, Paul McCrone

“…In the United Kingdom, the uptake of antiretroviral therapy is generally high, but a delay in starting antiretroviral therapy and non-adherence compromise the health and well-being of people living with human immunodeficiency virus, increase the risk of transmission of human immunodeficiency virus and increase National Health Service costs. …”
Get full text

Interactions Between Nanoparticles and Tomato Plants: Influencing Host Physiology and the Tomato Leafminer’s Molecular Response by Inzamam Ul Haq, Xiangyun Cai, Habib Ali, Muhammad Rehan Akhtar, Muhammad Adeel Ghafar, Moazam Hyder, Youming Hou

“…The current study illustrates the broader implications of nanoparticle use in agriculture, which is a sustainable pathway to increase crop resilience and productivity while reducing the impact of pests. …”
Get full text

Dying of starvation if not from bombs: assessing measurement properties of the Food Insecurity Experiences Scale (FIES) in Gaza’s civilian population experiencing the world’s worst... by Feten Fekih-Romdhane, Kamel Jebreen, Tasnim Swaitti, Mohammed Jebreen, Eqbal Radwan, Wafa Kammoun-Rebai, Inad Nawajah, Omar Shamsti, Sahar Obeid, Souheil Hallit

“…To achieve this, field practitioners, researchers and decision-makers should be equipped with user-friendly and psychometrically sound measures tailored to real-life war situations and the Palestinian context. Therefore, the present study aimed to test the psychometric properties of the Food Insecurity Experiences Scale (FIES) in a sample of Arabic-speaking community adults currently living in the Gaza Strip during the war. …”
Get full text

Reducing long‐term use of benzodiazepine receptor agonists: In‐depth interview study with primary care stakeholders by Kristien Coteur, Sanne Peters, Pieter Jansen, Birgitte Schoenmakers, Marc Van Nuland

“…Although primary care professionals in this study found discontinuation of long‐term BZRA use relevant to the patient's health, many organisational and personal barriers were reported. Moreover, the current social and healthcare context is not empowering patients and professionals to reduce long‐term BZRA use for insomnia. …”
Get full text

Extraterritorial Human Rights Obligations in the Area of Climate Change: Why the European Union Should Take Them Seriously by Chiara Tea Antoniazzi

“…After exploring the wide array of EU climate measures and their extensive impacts on third countries and persons living therein, the Article offers an overview of the historical evolution and current state of ex-traterritorial human rights obligations in general and in the context of climate change specifically, pay-ing special attention to recent judicial and quasi-judicial developments. …”
Get full text

Subject composition of the state financial control system in ensuring budget security by O.S. Dyka, M.V. Bilyachenko, Y.Yu. Levytskyi

“…Subject composition of the state financial control system in ensuring budget security Ensuring budget security is of particular importance in the context of military challenges and in the process of post-war economic transformation of Ukraine. …”
Get full text

Overview on the development and application of the key concepts for decision-making in health care by Nicolás Flores Uribe, Diego Grandi Pincheira, Roberto Garnham Parra, Eva Madrid Aris, Nicolas Meza Concha

“…In this context, promoting knowledge dissemination through reliable sources and fostering health literacy among the general population is crucial. …”
Get full text

A MODEL OF THE ENGLISH-UKRAINIAN SUB-CORPUS OF TEXTS OF NATO, UN AND WTO OFFICIAL AND BUSINESS DOCUMENTS by Yuliya I. Demyanchuk

“…The model of the English-Ukrainian sub-corpus of official and business documents texts of NATO, UN, and WTO provides for a clear division into categories of homogeneous texts and a quick search for special terminology of international organizations, such as NATO, UN, and WTO, in the EUS. In the context of the texts analyzed in the current paper numerous separated words and expressions-identifiers can help to carry out search and refer to a relevant text in the sub-corpus. …”
Get full text

Key Drivers Affecting the Future of Power Relations in Tehran Metropolis with a Scenario-Writing Approach by Afshin Mottaghi, Arash Ghorbani Sepehr, Joseph Saloukadz

“…Given this context, the central question guiding the present research was this: What are the drivers and future scenarios of power relations in Tehran Metropolis? …”
Get full text

A Legal Analysis of Liability for the Loss of the Subject Matter of Sale after Contract Termination: A New Inquiry into Sunni Jurisprudence by Mohammad Hossein Taghipour Darzi Naghibi, Umm al-Banin Ramzan Zadeh, Mostafa Firoozi Rad

“…Determining who bears the liability for this loss becomes a contentious issue: should it be the party currently in possession or the rightful owner awaiting the return? …”
Get full text

Marketing Logistics and its Digitalization by Iryna Polishchuk, Yuriy Dovhan, Iryna Kramar, Larysa Dovhan, Oksana Yakushevska

“…The purpose of the article is to highlight the historical process of forming marketing logistics as a modern management concept and the current trends in its digitalization. The theoretical foundations of marketing logistics summarized in this work will facilitate the integration of digital technologies into marketing logistics, improve business processes, and support the sustainable development of companies in the context of dynamic changes in the global market. …”
Get full text

The Direction of Indonesia’s Legal Policy on the ASEAN Mutual Legal Assistance Treaty in Criminal Matters: A Path to Law Reform in Cross-Border Crime Enforcement in Southeast Asia... by Ridwan Arifin, Rodiyah Rodiyah, Waspiah Waspiah, Asyaffa Ridzqi Amandha, Elizabeth Yunita Krisnawati, Tirta Sandi, Michael Timothy Napitupulu

“…First, it provides a comprehensive analysis of the current state of Indonesia’s legal policy on AMLAT, highlighting key areas for legal reform. …”
Get full text

Energy recovery analysis through numerical simulations of steam injection in continental shale oil reservoirs by Maryelin Josefina Briceño Montilla, Shouding Li, Zhaobin Zhang, Yanzhi Hu, Jianming He, Zheng Bo, Xiao Li

“…However, optimizing energy utilization to maximize hydrocarbon production remains a significant challenge, particularly in the context of current energy limitations. This study compares two steam injection strategies using a thermal-flow-chemical (TFC) simulator to assess energy recovery efficiency. …”
Get full text