Novel chlorine-containing curcumin analogue CAK06 promotes neuroprotection and rapid antidepressant through Nrf2-induced anti-inflammatory and antioxidant effects by Tao Chen, Suyu Yin, Ruxu Yue, Chao Pi, Ying Zuo, Yongqiang Jiang, Wenwu Zheng, Jun Jiang, Yan Yang, Shifeng Chu, Kezhi Liu, Yumeng Wei, Ling Zhao

“…Currently, conventional antidepressants are often limited by poor efficacy and delayed onset, and there is an urgent need for the development of rapid acting antidepressant alternatives. …”
Get full text

Quantifying Flavin mononucleotide: an internationally validated methodological approach for enhanced decision making in organ transplantationResearch in context by Keyue Sun, Chunbao Jiao, Rebecca Panconesi, Sangeeta Satish, Omer F. Karakaya, Femke H.C. De Goeij, Tobias Diwan, Khaled Ali, Lorenzo A. Cadinu, Beatrice Cazzaniga, Qiang Liu, Yuki Miyazaki, Alejandro Pita, Mazhar Khalil, JaeKeun Kim, Ahmed Hussein, Philipp C. Müller, Federico Aucejo, David H.C. Kwon, Eduardo Fernandes, Jamak Modaresi Esfeh, Jacek Cywinski, Masato Fujiki, Lidong Sun, Antonio Pinna, Philipp Dutkowski, Chase J. Wehrle, Robert L. Fairchild, David Meierhofer, Jeroen De Jonge, Charles Miller, Koji Hashimoto, Andrea Schlegel

Get full text

Tailoring consent to context: designing an appropriate consent process for a biomedical study in a low income setting. by Fasil Tekola, Susan J Bull, Bobbie Farsides, Melanie J Newport, Adebowale Adeyemo, Charles N Rotimi, Gail Davey

Get full text

Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage by Anell Fernandez, Maider Artola, Sergio Leon, Nerea Otegui, Aroa Jimeno, Diego Serrano, Alfonso Calvo

“…Several small-molecule inhibitors targeting ATM/Chk2 or ATR/Chk1 are currently being tested in preclinical and/or clinical settings, showing promise in cancer models and patients. …”
Get full text

A Critical Analysis of Cooperative Caching in Ad Hoc Wireless Communication Technologies: Current Challenges and Future Directions by Muhammad Ali Naeem, Rehmat Ullah, Sushank Chudhary, Yahui Meng

“…In this paper, we discuss the problems and issues in the current wireless ad hoc paradigms as well as spotlight versatile cooperative caching as the potential solution to the increasing complications in ad hoc networks. …”
Get full text

A Bibliometric Analysis of Mountain Research Literature on Journal of Mountain Research and Development: Current Situation and Future Directions by İsmet Güney, Merve Altundal Öncü, Burcu Göközkut, Mehmet Somuncu

“…Academic studies on mountains have increased since the 1990s. The aim of this study is to examine the current situation and development of the international literature on mountainous areas. …”
Get full text

Citizens’ perspectives on sustainable mobility transitions in a semi-urban context: tensions between everyday practices and sustainability advancements by Jonas Ihlström, Karolina Isaksson, Jonna Nyberg

“…As illuminated in the studied semi-urban context, many established everyday practices are car-dependent. …”
Get full text

Cost–consequence analysis of COPD treatment according to NICE and GOLD recommendations compared with current clinical practice in the UK by Jennifer K Quint, Helene Vioix, Toby Capstick, Sue Langham, Jennifer Cook, Antony Wright, Shamika de Silva

“…Savings were achieved overall despite a small increase in the rate of exacerbations due to the redistribution of certain patients currently undergoing triple inhaled therapy to therapies not containing inhaled corticosteroids.Conclusion Redistribution of patients with COPD from current clinical practice to treatment according to published recommendations would provide substantial cost savings over the first year.…”
Get full text

Applications of Machine Learning (ML) in the context of marketing: a bibliometric approach [version 2; peer review: 2 approved] by Erica Agudelo-Ceballos, Ezequiel Martínez Rojas, Sebastián Cardona-Acevedo, Carlos Flores Goycochea, Juana De La Cruz Ramírez Dávila, Diana Arango-Botero, Jesus Alberto Jimenez Garcia, Alejandro Valencia-Arias

Get full text

Gathering insights of the global scenario of floating-bed agriculture through systematic literature review for its promotion in Indian context by Tanmoy Kumar Ghosh, Ashish Kumar Singh, Sudip Mitra, Sougata Karmakar

“…This literature review aims to comprehensively document the current global scenario of floating-bed agriculture to promote it in India. …”
Get full text

A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosisResearch in context by Jeremy S. Lum, Mikayla L. Brown, Natalie E. Farrawell, Rachael Bartlett, Christen G. Chisholm, Jody Gorman, Anthony Dosseto, Florian Dux, Lachlan E. McInnes, Heath Ecroyd, Luke McAlary, Peter J. Crouch, Paul S. Donnelly, Justin J. Yerbury

Get full text

Unraveling the Complexity of the Ne/Nc Ratio for Conservation of Large and Widespread Pelagic Fish Species: Current Status and Challenges by Chrystelle Delord, Sophie Arnaud‐Haond, Agostino Leone, Jonathan Rolland, Natacha Nikolic

“…Secondly, we outline current knowledge about the influence of life history traits on the Ne/Nc ratio in the light of examples drawn from large and abundant pelagic fish species. …”
Get full text

Knowledge and Perception of Practicing Anesthetists on Current Techniques, Clinical Applications, and Limitations of Artificial Intelligence in Anesthesiology: An Indian Study by Manasij Mitra, Maitraye Basu, Amrita Ghosh, Ranabir Pal

“…Background: Artificial intelligence (AI) is increasingly gaining importance in modern medicine. Yet, there is a dearth of knowledge on what the anesthesiologists know and think about AI in context. …”
Get full text

Integrating sequencing methods with machine learning for antimicrobial susceptibility testing in pediatric infections: current advances and future insights by Zhuan Zou, Zhuan Zou, Fajuan Tang, Fajuan Tang, Lina Qiao, Lina Qiao, Sisi Wang, Sisi Wang, Haiyang Zhang, Haiyang Zhang

Get full text

The effectiveness of home-based transcranial direct current stimulation on chronic pain: A systematic review and meta-analysis by Annibale Antonioni, Andrea Baroni, Giulia Fregna, Ishtiaq Ahmed, Sofia Straudi

“…As pain is highly prevalent and imposes significant burdens, interest in its remote management is steadily increasing. Transcranial Direct Current Stimulation (tDCS) seems promising in this context. …”
Get full text

The Comprehensive-Adaptive Approach to the Innovative Development of the Enterprise in the Current Trends of Digitalization through the Interaction of External and Internal Factors by Arefieva Olena V., Dolzhenko Dmytro Yu.

Get full text

Use of Artificial Intelligence in Adolescents’ Mental Health Care: Systematic Scoping Review of Current Applications and Future Directions by Gauri Sharma, Mark J Yaffe, Pooria Ghadiri, Rushali Gandhi, Laura Pinkham, Genevieve Gore, Samira Abbasgholizadeh-Rahimi

Get full text

Spatiotemporal Dynamics of Urban Green Spaces and Climatic Vulnerability of Togolese Cities in the Context of Rapid Urbanisation: The Case of Lome and Kara by Yetondé Deton, Hodabalo Kamou, Abalo Atato, Bimare Kombate, Abalo Mabafei, Josef Yoka, Marra Dourma, Atsu Kudzo Guelly, Komlan Batawila, Koffi Akpagana

Get full text

A replicating RNA vaccine confers protection against Crimean-Congo hemorrhagic fever in cynomolgus macaquesResearch in context by David W. Hawman, Shanna Leventhal, Kimberly Meade-White, William Graham, Karen Gaffney, Amit Khandhar, Justin Murray, Jessy Prado-Smith, Carl Shaia, Greg Saturday, Henry Buda, Lenny Moise, Jesse Erasmus, Heinz Feldmann

Get full text

Strategic Aspects of Human Capital Development in Ukraine in the Context of Integration of Veterans into the Spheres of Industry 4.0 and 5.0 by Babichev Anatolii V., Peliukh Oleksandr I.

“…The article is devoted to the topical problem of integration of veterans into high-tech sectors of the Ukrainian economy, in particular into the spheres of Industry 4.0 and 5.0. In the context of a prolonged cyber war and the expected increase in the number of veterans to 5-6 million people, the issue of their effective reintegration into civilian life is of strategic importance for the country. …”
Get full text