Cost-effectiveness of atezolizumab plus bevacizumab versus sorafenib as first-line therapy in unresectable hepatocellular carcinoma in the US and Chinese setting: a modelling compa... by Lei Wang, Lulu Liu, Yiling Ding, Qilin Zhang, Yamin Shu

“…The combined usage of these two medications could result in substantial consumption of resources, primarily due to their exceptionally high costs. The current study aims to evaluate the cost-effectiveness of atezolizumab plus bevacizumab as a first-line treatment for advanced HCC from the perspective of payers in developed and developing countries.Design A partitioned survival model was constructed to evaluate the cost-effectiveness of atezolizumab plus bevacizumab versus sorafenib as a first-line treatment for advanced HCC. …”
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Reducing Plasmodium falciparum malaria transmission in Africa: a model-based evaluation of intervention strategies. by Jamie T Griffin, T Deirdre Hollingsworth, Lucy C Okell, Thomas S Churcher, Michael White, Wes Hinsley, Teun Bousema, Chris J Drakeley, Neil M Ferguson, María-Gloria Basáñez, Azra C Ghani

“…However, it remains unclear what overall reduction in transmission is achievable using currently available tools.<h4>Methods and findings</h4>We developed an individual-based simulation model for Plasmodium falciparum transmission in an African context incorporating the three major vector species (Anopheles gambiae s.s., An. arabiensis, and An. funestus) with parameters obtained by fitting to parasite prevalence data from 34 transmission settings across Africa. …”
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CO2 methanation over low-loaded Ni-M, Ru-M (M = Co, Mn) catalysts supported on CeO2 and SiC by Chopendra G. Wasnik, Maki Nakamura, Taiki Shimada, Hiroshi Machida, Koyo Norinaga

“…An efficient circulation and utilization of CO2 is critical in the current environmental context. Methanation, an exothermic process, emerges as a critical strategy for effective CO2 utilization. …”
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Analysis of production and financial potential as a basis for developing a strategy for modernizing the Russian economy by Ljudmila I. Rozanova, Sergei V. Tishkov

“…This goal predetermines the solution of such problems as analysis of the current state of the production base, assessment of financial resources for the production upgrade, identification of opportunities and risks in the implementation of modernization processes. …”
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MECHANISMS FOR ENSURING THE ECONOMIC DEVELOPMENT OF RURAL AREAS THROUGH THE FORMATION OF THEIR ENERGY DEPENDENCE BASED ON THE INTENSIFICATION OF BIOFUEL PRODUCTION by Yuliia Okhota, Denys Titov, Svitlana Dotsiuk

“…To achieve this goal, the article discusses the theoretical aspects of energy independence, analyzes current practices of biofuel production, and provides recommendations for their further implementation. …”
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Ecological Momentary Assessment to Measure Social Connectedness in Older Adults: Integrative Review by Seongmi Choi, Hun Kang, Jiyoung Shin, Sang Hui Chu, JiYeon Choi

“…ConclusionsThe findings of this study highlight the current state of science in measuring social connectedness in older adults through EMA and demonstrate its feasibility in real-world settings. …”
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Understanding Device Integrations Within Diabetes Apps: Mixed Methods Analysis of App Features and User Reviews by Jessica Turner, Katarzyna Stawarz

“…First, we aimed to understand the current landscape of device integrations within diabetes apps and how well they meet users’ needs. …”
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Propagation Characteristics of Multi-Cluster Hydraulic Fracturing in Shale Reservoirs with Natural Fractures by Lianzhi Yang, Xinyue Wang, Tong Niu

“…Understanding the effects of reservoir and fracturing conditions on fracture propagation is of great significance for optimizing the hydraulic fracturing process and has not been adequately explored in the current literature. In the context of shale reservoirs in Yibin, Sichuan Province, China, the study selects outcrops to prepare samples for uniaxial compression and Brazilian splitting tests. …”
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Significant fundamental translational research on breast cancer in China: progress and prospects by LU Yufeng, WANG Han, XIE Yifan, JIANG Yizhou, SHAO Zhimin

“…Breast cancer is the most prevalent malignant tumor that poses a threat to women's health in China, with incidence and mortality rates persistently increasing. Given this critical situation, there is an urgent need to optimize therapeutic options through basic translational research to address current treatment challenges. …”
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Adaptation Potential of Teachers of the Third Age in the Conditions of Higher Education Transformation by E. A. Shuklina, M. V. Pevnaya, E. A. Shirokova

“…In many countries around the world, the increase in life expectancy leads to significant social transformations. …”
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Multi-century mean summer temperature variations in the Southern Rhaetian Alps reconstructed from <i>Larix decidua</i> blue intensity data by R. Cerrato, M. C. Salvatore, M. C. Salvatore, M. Brunetti, A. Somma, C. Baroni, C. Baroni

“…<p>Ongoing climate change is likely to cause a worldwide temperature increase of 1.5 °C by the mid-century. To contextualize these changes in a long-term context, historical climatological data extending beyond data obtained from instrumental records are needed. …”
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Patient-Generated Collections for Organizing Electronic Health Record Data to Elevate Personal Meaning, Improve Actionability, and Support Patient–Health Care Provider Communicatio... by Drashko Nakikj, David Kreda, Karan Luthria, Nils Gehlenborg

“…This prevents patients from efficiently reviewing, exploring, and making sense of their EHR data based on current or ongoing health issues. The lack of personalized organization and important connections can limit patients’ ability to use their data and make informed health decisions. …”
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Model of complex rehabilitation for patients with a simple form of schizophrenia by V. V. Chuhunov, V. O. Kurylo, V. L. Pidlubnyi, S. M. Kanyhina

“…The effectiveness of the complex model of psychosocial rehabilitation for patients with a simple form of schizophrenia in the areas of socially useful activities (study and work) and social relations was developed and proved, which made it possible to increase the effectiveness of therapy for this contingent of patients.…”
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Application of urinary peptide-biomarkers in trauma patients as a predictive tool for prognostic assessment, treatment and intervention timing by Gökmen Aktas, Felix Keller, Justyna Siwy, Agnieszka Latosinska, Harald Mischak, Jorge Mayor, Jan Clausen, Michaela Wilhelmi, Vesta Brauckmann, Stephan Sehmisch, Tarek Omar Pacha

“…Preemptive personalized treatment aimed at preventing these events is a crucial objective of patient management; however, the currently available scoring systems provide only moderate guidance. …”
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Variation of all-cause and cause-specific mortality with body mass index in one million Swedish parent-son pairs: An instrumental variable analysis. by Kaitlin H Wade, David Carslake, Per Tynelius, George Davey Smith, Richard M Martin

“…Furthermore, we expect different patterns of bias in the current observational and IV analyses; therefore, the similarities between our findings from both methods increases confidence in the results. …”
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Interference in melanoma CD248 function reduces vascular mimicry and metastasis by Cheng-Hsiang Kuo, Ya-Fang Wu, Bi-Ing Chang, Chao-Kai Hsu, Chao-Han Lai, Hua-Lin Wu

“…Abstract Background Tumor vascular mimicry is an emerging issue that affects patient survival while having no treatment at the current moment. Despite several factors implicated in vascular mimicry, little is known about stromal factors that modulate tumor microenvironment and shape malignant transformation. …”
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3D-printed resin for permanent/definitive restorations: meta-analysis for bond strength by Minjoo Ki, Marc Hayashi, Mijoo Kim

“…This meta-analysis aimed to synthesize the current knowledge on the adhesion of 3D-printed restorations to resin cements and identify areas for future research. …”
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Emotional processing as mechanism of change in brief good psychiatric management for borderline personality disorder: results of a randomized controlled trial by Ueli Kramer, Loris Grandjean, José Blanco Machinea, Hélène Beuchat, Setareh Ranjbar, Yves de Roten, Jean-Nicolas Despland, Philippe Conus, Stéphane Kolly

“…The assessment of mechanisms of change contributes to focus the treatment on the essential ingredients of change. The current study aims to demonstrate the emotional processing as a mechanism of change, assessed in an ecologically valid experimental context, of brief GPM. …”
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A narrative review of applications and enhancements of ChatGPT in respiratory medicine by Jun Qi Lin, Zi Xuan Hua, Liu Zhang, Ying Ni Lin, Yong Jie Ding, Xi Xi Chen, Shi Qi Li, Yi Wang, Qing Yun Li

“…Although the utilization of ChatGPT in medicine has been actively explored, its application in respiratory medicine remains in the early stages. In this context, we outline ChatGPT’s current respiratory medicine applications, address potential limitations, and envision future avenues for its advancement and development.…”
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Financial security of Ukraine in debt burden: Assessment and forecasting by Fedir Zhuravka, Yuriy Petrushenko, Svitlana Chorna, Bohdana Huriy, Inessa Yarova, Olga Pankiv, Wojciech Duranowski

“…This study aims to comprehensively assess the state’s financial security of Ukraine in the context of mounting debt and economic instability. …”
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