Immunological and physiological changes of exercise-released lactate on tumors: an important and new research window by Amir Hossein Ahmadi Hekmatikar, Arsham Entesari, Hossein Shirvani

“…In the cancer immune cycle, the immune checkpoint PD-1 and its ligand PD-L1 collaborate to facilitate immune escape and promote tumor progression (Keir et al., 2008). In this context, a study revealed that lactate can enhance the expression of PD-L1 on tumor cells, suggesting that lactate may have a protective effect against tumors by increasing PD-L1 expression (Feng et al., 2017). …”
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The role of Pakistan Medical & Dental Council in steering undergraduate medical curriculum reforms in Pakistan by Gohar Wajid, Lubna Baig, Syeda Kauser Ali, Usman Mahboob, Ahsan Sethi, Rehan Ahmed Khan

“…There has been an exponential increase in the number of medical colleges in Pakistan over the past few decades, especially in the private sector. …”
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Enhancing Speaker Recognition with CRET Model: a fusion of CONV2D, RESNET and ECAPA-TDNN by Pinyan Li, Lap Man Hoi, Yapeng Wang, Xu Yang, Sio Kei Im

“…Abstract In today’s society, speaker recognition plays an increasingly important role. Currently, neural networks are widely employed for extracting speaker features. …”
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Traditional Islamic spiritual meditative practices: powerful psychotherapies for mental wellbeing by Farah R. Zahir, Farah R. Zahir, M. Walid Qoronfleh

“…The new millennium is witnessing a remarkable shift within the scientific community, to be increasingly understanding and accepting the impact of meditative, spiritual, and even religious practices, on health and wellbeing. …”
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Repetitive transcranial magnetic stimulation for the treatment of suicidality in opioid use disorder: a pilot feasibility randomized controlled trial by Victor M. Tang, Bernard Le Foll, Zafiris J. Daskalakis, An-Li Wang, Leslie Buckley, Daniel M. Blumberger, Daphne Voineskos

“…Conclusion We present the first data piloting a structural neuroimaging-guided, multi-session rTMS treatment course in outpatients with suicidality and OUD in the current North American context. Recruitment and retention were the main challenges given the highly unstable medical and psychosocial context of this patient population. …”
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Interpersonal counselling for adolescent depression delivered by youth mental health workers without core professional training: the ICALM feasibility RCT by Jon Wilson, Viktoria Cestaro, Eirini Charami-Roupa, Timothy Clarke, Aoife Dunne, Brioney Gee, Sharon Jarrett, Thando Katangwe-Chigamba, Andrew Laphan, Susie McIvor, Richard Meiser-Stedman, Jamie Murdoch, Thomas Rhodes, Carys Seeley, Lee Shepstone, David Turner, Paul Wilkinson

“…However, alterations to the referral pathways did not increase the number of referrals made to the study. …”
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Job insecurity, work passion, and work–life balance in diverse work arrangements by Chantell Ribas, Gerhard H. Rabie, Karina Mostert, Leon De Beer

“…Orientation: The coronavirus disease 2019 (COVID-19) pandemic shifted work settings, revealing gaps in current literature on how work arrangements affect employee experiences and well-being. …”
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Case Report: Locally invasive thyroid metastases from renal cell carcinoma: surgery after neoadjuvant therapy by Dana M. Hartl, Mohamed-Amine Bani, Abir Al Ghuzlan, Andreea-Elena Simonescu, Ingrid Breuskin, Alix Marhic, Laurence Albiges, Laurence Albiges, Livia Lamartina, Livia Lamartina, Julien Hadoux, Julien Hadoux

“…Patient 1 received lenvatinib and a bispecific anti–Programmed cell Death protein 1/ cytotoxic T-lymphocyte-associated protein 4 (PD-1/CTLA-4) antibody in the context of a clinical trial. The second patient received nivolumab and cabozantinib.ResultsThe observed tumor response in patient 1 showed a decrease in mean surgical complexity score from unresectable (prevertebral fascia invasion) to severe (risk of recurrent nerve paralysis) and in patient 2 from unresectable (prevertebral fascia) to moderate (superficial esophageal invasion). …”
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The Chem-Sex Inventory Scale (CSI): A Tool to Assess the Mental Health Risk of Chemsex Behaviors in Men Who Have Sex with Men by Pablo Del Pozo-Herce, Enrique Baca-García, Antonio Martínez-Sabater, Rubén Pérez-Elvira, Vicente Gea-Caballero, Elena Chover-Sierra, Pedro José Satústegui-Dordá, Alberto Tovar-Reinoso, Francisco José Rodríguez-Velasco, Mercedes Sánchez-Barba, Jesús Pérez, Raúl Juárez-Vela

“…Drugs associated with chemsex can trigger mental health problems such as anxiety, depression, risk of psychosis and suicidal ideation, social isolation, stigmatization, and even loss of impulse control and lack of coping strategies. Currently, the increase in illicit drugs in a sexual context is considered an outbreak of a public health emergency. …”
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A group psychological intervention for postnatal depression in British mothers of South Asian origin – the ROSHNI-2 RCT by Nusrat Husain, Karina Lovell, Carolyn A Chew-Graham, Farah Lunat, Penny Bee, Matthias Pierce, Najia Atif, Saadia Aseem, Kamaldeep Bhui, Peter Bower, Traolach Brugha, Nasim Chaudhry, Akbar Ullah, Linda Davies, Nadeem Gire, Deepali Sharma, Jahanara Miah, Waqas Ahmed, Joe Kai, Ilyas Mirza, Jillian Morrison, Naeem Mohmed, Atif Rahman, Shanaya Rathod, Najma Siddiqi, Waquas Waheed, Christopher Williams, Nosheen Zaidi, Richard Emsley, Richard Morriss

“…An additional substudy was incorporated following the pandemic to explore the impact of other associated risk factors related to maternal mental health and specifically in the pandemic’s context. We aimed to increase the understanding of the pandemic-related impact on BSA women, including interpersonal violence (IPV) in their communities. …”
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Ethnozootechnical Perspectives on the Decline of Traditional Knowledge About Local Goat and Sheep Breeds in the Semi-Arid Region of Paraíba, Brazil by Raissa C. Silva, Marilene N. Melo, Carlos F. T. de Oliveira, José V. Cardoso, Luis A. C. Cevallos, Laura L. da Rocha, Janaina K. G. Arandas, Maria N. Ribeiro

“…Two workshops were held to assess the diversity of breeds in the past landscape (PP) and current landscape (PA), using the Recall technique. …”
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Assessing Immunization Coverage and the Negative Impact of Local Vaccine Production Cessation in Ecuador by Esteban Ortiz-Prado, Lissette Carolina Villacreses-Brito, Jorge Vasconez-Gonzalez, Cristina Anabel Jacome, Marlon Arias-Intriago, Juan S. Izquierdo-Condoy

“…For BCG, median coverage decreased from 100% during the production period to 87.8% post-cessation (<i>p</i> < 0.0001). …”
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Effect of social perspectives in the relationship between suicidal ideation and depression among young women in slums of Kampala, Uganda by Charles Natuhamya, Enid Nabukalu, Matthew Lyons, Kevin B. Gittner, Jane Palmier, Rachel Culbreth, Monica H. Swahn

“…TOPOWA is a multi-component, prospective cohort study examining the mechanistic pathways of mental illness in the context of social determinants of mental health and lived experience among young women aged 18 to 24 years living in the urban slums of Kampala. …”
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Jian-Pi-Gu-Shen-Hua-Yu Decoction Alleviated Diabetic Nephropathy in Mice through Reducing Ferroptosis by Shuquan Lv, Lirong Fan, Xiaoting Chen, Xiuhai Su, Li Dong, Qinghai Wang, Yuansong Wang, Hui Zhang, Huantian Cui, Shufang Zhang, Lixin Wang

“…Diabetic nephropathy (DN), one of the most frequent complications of diabetes mellitus, is a leading cause of end-stage renal disease. However, the current treatment methods still cannot effectively halt the progression of DN. …”
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Study of Different Recycling Approaches for Gypsum-Based Composites with Recycled Rubber Aggregates by Daniel Ferrández, Alicia Zaragoza-Benzal, Evangelina Atanes-Sánchez, Beatriz Merillas, Ricardo Mateus, Paulo Santos

“…Therefore, this research outlines the potential of gypsum recycling with recycled rubber aggregates, thus promoting the circularity of construction products and decreasing the building’s environmental footprint. This represents a novelty compared to current studies, which are more oriented towards recycling and recovery of waste from conventional plasterboards.…”
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Comparing the technical and individual possession statistics of academy players across different age groups in match-play. by Emily Escreet, Steve Barrett, John Toner, John Iga, Christopher Towlson

“…<h4>Conclusion</h4>Attacking players (AM & ST) are required to move the ball quicker as they progress from U16 to U23's within the current English football academy. Further exploration is required to assess if these changes are context specific given requirements of those age groups.…”
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A Review of Renewable Energy Technologies in Municipal Wastewater Treatment Plants (WWTPs) by Derick Lima, Li Li, Gregory Appleby

“…Through a comprehensive review of current practices and emerging technologies, this study underscores the transformative potential of these innovations in advancing low-emission wastewater management.…”
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Explaining the Comprehensive Human-To-Human Marketig System in the Health Tourism Industry by Ali Pourang, Meysam Shirkhodaie, Mahmood Yahyazadeh far, Mohsen Alizadeh San, Masoomeh Tavangar

“…Governments worldwide are increasingly investing in this sector due to its economic potential and ability to enhance destination competitiveness (Kim & Hyun, 2022). …”
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The Chinese version of the autonomy preference index for advanced cancer patients: a study on cultural adaptation based on cognitive interview by Chao Yan, Yonghong Li, Ji Ai, Shenghuan Yang

“…Background The global cancer burden is becoming increasingly severe. In the context of patient-centred medicine, respecting patients’ autonomy and preferences is of paramount importance. …”
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Health Technology Assessment in China’s Health Care Sector: Development and Applications by Wudong Guo, Peimeng Wang, Yuzheng Zhang, Xue Li, Yaoling Wang, Kun Zhao, Francis Ruiz, Rui Li, Feiyi Xiao, Xuefei Gu, Mao You, Qiang Fu

“…In promoting its medical insurance system reform, China is actively developing health technology assessment (HTA) with principles and applications adapted to the Chinese context. This study aims to analyze the evolution of HTA in China with a focus on context, actors, process, content, and challenges encountered through applying a modified verson of Walt and Gilson’s policy triangle framework. …”
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