Design and Synthesis of Bis-Chalcones as Curcumin Simplified Analogs and Assessment of Their Antiproliferative Activities Against Human Lung Cancer Cells and <i>Trypanosoma cruzi</... by Gabriela Alves de Souza, Lorrane de Souza Chaves, Afonso Santine M. M. Velez, Jorge Lucas F. Lacerda, Paulo Pitasse-Santos, Jayane Clys Conceição dos Santos, Otávio Augusto Chaves, Carlos Serpa, Raphael do Carmo Valente, Leonardo Marques da Fonseca, Marcos André Rodrigues da Costa Santos, Jhenifer Santos dos Reis, Carlos Antônio do Nascimento Santos, Lucia Mendonça-Previato, Jose Osvaldo Previato, Celio Geraldo Freire-de-Lima, Debora Decoté-Ricardo, Leonardo Freire-de-Lima, Marco Edilson Freire de Lima

“…<b>Background: </b>Anticancer therapies represent the primary treatment option for a significant number of cancer patients globally; however, many of these treatments are associated with severe side effects as they target molecular structures present in both cancerous and healthy cells. In a similar context, the treatment of Chagas disease, a neglected tropical illness, is hindered by the high toxicity of the currently available drugs. …”
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Solid waste management service chain and sanitation safety: a case study of existing practice in Addis Ababa, Ethiopia by Shegaw Fentaye Sisay, Sirak Robele Gari, Sirak Robele Gari, Argaw Ambelu

“…Additionally, 85% of households used storage and transport containers that had leaks, potentially leading to contamination and infection. …”
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“Locality – Adaptation” Research of Hydropower Resettlement Communities in the Jinsha River Basin: A Case Study of Ludila Hydropower Station by Fang WANG, Zhuoqi LI, Haoyi XU, Jiaqi YAN

“…ObjectiveWithin human – environment systems, river basins constitute the earliest geographical units of human activity and currently represent the most critical zones of strained human – environment interactions. …”
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On the added value of sequential deep learning for the upscaling of evapotranspiration by B. Kraft, B. Kraft, B. Kraft, J. A. Nelson, S. Walther, F. Gans, U. Weber, G. Duveiller, M. Reichstein, W. Zhang, M. Rußwurm, D. Tuia, M. Körner, Z. Hamdi, M. Jung

“…However, together with the non-temporal FCN model, they exhibited a larger ensemble spread than XGBoost, and they yielded lower global ET estimates than what is currently understood. XGBoost showed a smaller ensemble spread compared to neural networks, in particular when conditions were poorly represented in the training data, but it was more sensitive to the covariate setup. …”
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Early Warning and Assessment of Chinese Marathon Events' Exposure to High Temperature under Climate Warming by Yu Dandan, Shi Yong, Chen Shuman, Mei Yuru

“…In recent years, the number of marathons in China has expanded rapidly, but the impact of high-temperature weather has become more apparent. Current high-temperature early warning systems lack tailored thresholds and unified standards for sports scenarios. …”
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Regulatory culture and architectural project by Mario Losasso

“…They are attentive to a quality that does not depend on construction solutions or on techno-typological, morphological or physical-chemical characteristics, but which is linked to a system of needs to be satisfied, the outcome of the interaction between construction and cultural, socio-economic and environmental context. Today’s regulatory landscape has expanded, increasing sensitivities to environmental challenges, health and the qualities of living space. …”
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HIV-1 suppression and rare dolutegravir resistance in antiretroviral-experienced people with HIV in Liberia by James Soka Moses, Alice K. Pau, Safia Kuriakose, Greg Grandits, Cavan Reilly, Brad T. Sherman, Weizhong Chang, Lisheng Dai, Muhammad A. Khan, Helene Highbarger, Moses Mannah, Johnathan McCullough, Carla Chorley, Isaac Morlu, Joseph Dorbor, Ophelia Talweh Bongolee, Rebecca Slewion, Esther Akpa, Barthalomew Wilson, April L. Poole, Stacy L. Kopka, Tracey Miller, Cecelia J. Nuta, Christina Lindan, David Glidden, Jeffrey N. Martin, Kumblytee L. Johnson, Robin L. Dewar, Ian Wachekwa, Stephen A. Migueles

“…Abstract Background Increasingly, persons with HIV in Liberia are receiving antiretroviral therapy containing the integrase strand-transfer inhibitor (InSTI) dolutegravir (DTG), but the prevalence of and factors associated with virologic failure and HIV drug resistance (HIVDR) remain unknown. …”
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Isolation and characterization of novel bioactive peptides from legume seed wastes and their application as eco-friendly coating improve the physicochemical, microbiological, aroma... by Samir A. Mahgoub, Hayfa Habes Almutairi, Nourhan H.I. Abd-El Fattah, Ashraf S. El-Sayed, Merfat O. Aljhdli, Salah A. Khalifa, Ahmed M. Saad, Layla A. Almutairi, Mohammed A. Alqahtani, Eman A. Beyari, Wafaa Ahmed Alhazmi, Nahed A. El-Wafai, Khaled A. El-Tarabily, Mohamed T. El-Saadony

“…Valorizing food waste into bioactive compounds is a growing global trend. The current study aimed to evaluate the physicochemical, functional, and bioactive properties of chickpea seed waste peptides (CWP) and pea seed waste peptides (PWP) and assess their potential in enhancing probiotic-enriched Ras cheese. …”
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Mortality impact, risks, and benefits of general population screening for ovarian cancer: the UKCTOCS randomised controlled trial by Usha Menon, Aleksandra Gentry-Maharaj, Matthew Burnell, Andy Ryan, Jatinderpal K Kalsi, Naveena Singh, Anne Dawnay, Lesley Fallowfield, Alistair J McGuire, Stuart Campbell, Steven J Skates, Mahesh Parmar, Ian J Jacobs

“…While screening did not increase anxiety, there was slightly increased worry in women who were asked to return for more intense repeat testing. …”
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Spatio-temporal forecasting of COVID-19 cases in the Netherlands for source and contact tracing by Max Keuken, Jizzo R. Bosdriesz, Anders Boyd, Elisabeth M. den Boogert, Ivo K. Joore, Nicole H.T.M. Dukers – Muijrers, Gini van Rijckevorsel, Hannelore M. Götz, Irene E. Goverse, Mariska W.F. Petrignani, Stijn F.H. Raven, Susan van den Hof, Kirsten V.C. Wevers-de Boer, Maarten F. Schim van der Loeff, Amy Matser

“…Due to the rapid increases in incidence of COVID-19 in the Netherlands, the capacity to conduct a full SCT quickly became insufficient. …”
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The Structural Model of Happiness Based on Mindfulness with Mediator Role of Emotional Intelligence, Self-Compassion and Resilience by Mohammad Reza Tamannai far, Faezeh Taraffo

“…Moreover, the indirect effect of mindfulness on happiness was significant in that mindfulness leads to an increase in resilience by enhancing emotional intelligence and self-compassion, while it improves happiness by increasing resilience. …”
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Conceptualization of Policies, Strategies and Programs for Poverty Alleviation in Iran: A Qualitative Study by Hassan Danaeefard, Morteza Nabavi, Faramarz Nasri, Seyed Mohammad Javad Sajjadi Nezhad

“…., were created to help alleviate poverty in the country.The Research Center of the Islamic Council has stated in a report that the poverty line rate has been increasing since 2011 and has reached from 19.4% to 30/4% in 2021. …”
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An Integrated Profiling of Liver Metabolome and Transcriptome of Pigs Fed Diets with Different Starch Sources by Miao Yu, Zhenming Li, Yiyan Cui, Ting Rong, Zhimei Tian, Dun Deng, Zhichang Liu, Ruiyang Zhang, Xianyong Ma

“…However, current research on the effects of diets with different starch sources on animals at the extraintestinal level is still very limited. …”
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Social Networks Link Prediction Based on Incremental Learning by Jian SHU, Zhichen CHEN

“…However, the prediction performance of IL−SNLP on Ask Ubuntu and Super User decreases by only 4.54% and 5.25%, respectively, compared to its performance on Math Overflow. …”
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Effects of Conditioning Temperature on Pellet Quality, Nutrients Digestibility, and Metabolizable Energy of Broilers Diet by Seyedeh Vajiheh Shakhese Emampour, Abolghasem Golian, Heydar Zarghi, Ali Reza Hesabi Nameghi

“…So that the amount of electricity usage decreased (quadratic, p< 0.001), and increased pellet PDI (quadratic, p<0.001) and pellet hardness (linear, p<0.002) by increasing in conditioning temperature. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…This article examines the alignment of current predominant payment models of fee-for-service, capitation, and value-based payments with patient care ethics. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…This article examines the alignment of current predominant payment models of fee-for-service, capitation, and value-based payments with patient care ethics. …”
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A study of the safety and immunogenicity of a new vaccine for the prevention of COVID-19 based on virus-like particles in phase I clinical trials by Tatiana V. Grebennikova, Olga N. Zaykova, Alexey A. Plotnikov, Lyudmila V. Kostina, Yana Yu. Chernoryzh, Olesia V. Eliseeva, Oleg E. Latyshev, Viktor F. Larichev, Irina T. Fedyakina, Milana A. Losich, Ilya M. Kirillov, Ilya E. Filatov, Marina V. Balandina, Valery V. Tsibezov, Kirill I. Yurlov, Ekaterina I. Lesnova, Valeria M. Kondratieva, Alina A. Kozlova, Marina S. Baranets, Aleksandr L. Gintsburg

“…One of the more promising developments in preventing the spread of infections, including COVID-19, is the production of vaccines based on virus-like particles (VLP). Currently, in the National Research Center for Epidemiology and Microbiology named after N.F. …”
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Strengthening climate and health adaptation strategies to combat cholera in Angola and beyond by Abdulrakib Abdulrahim, Valdemiro Amilton Rafael, Bashar Haruna Gulumbe, Victor Abiola Adepoju, Safayet Jamil

“…Cholera, often referred to as a ‘disease of poverty,’ is currently classified as a disease of very high risk globally [5] ,[6] . …”
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Management and Operation Transformation of Urban Park Green Spaces from the Perspectives of Public Goods Provision and Fiscal Sustainability by Peiyi JIA

“…On the supply side, fiscal austerity and debt containment policies severely constrain traditional funding channels. …”
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