Topical Application of RNAi Therapy Using Surface-Modified Liposomes for Treating Retinal-Vein Occlusion by Taishi Shiratori, Takaaki Ito, Anri Nishinaka, Ryosuke Matsumiya, Eriko Yamazoe, Hirofumi Takeuchi, Hideaki Hara, Kohei Tahara

“…Recently, antibody- and nucleic acid-based pharmaceuticals have increasingly been used to treat retinal diseases, with improvement or cure as the goal; however, these drugs are currently only administered by intravitreal injection. …”
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Evaluation of the efficacy and safety of cytoflavin as a neuroprotector based on a systematic review by E. K. Krasova, I. A. Titovich, K. O. Sidorov, S. V. Okovityi

“…There is a tendency towards rejuvenation and an increase in morbidity. Drug therapy aimed at neuroprotection and improving the restoration of neurological functions according to clinical recommendations includes a succinate-containing drug – Cytoflavin. …”
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Evolution of taxis responses in virtual bacteria: non-adaptive dynamics. by Richard A Goldstein, Orkun S Soyer

“…We currently lack a full understanding of the different pathway structures and dynamics and how this integration is achieved. …”
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Spaciotemporal distribution characteristics of glacial lakes and the factors influencing the Southeast Tibetan Plateau from 1993 to 2023 by Yu Mingwei, Guo Yonggang, Zhang Jian, Li Feng, Su Libin, Qin Deshun

“…However, given the backdrop of a slight increase in precipitation and a gradual increase in temperature, the proliferation of glacial lakes is projected to accelerate predominantly in Nyingchi City’s eastern and western regions.…”
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Safety of a change of specifications of phytosterols/phytostanols as a novel food pursuant to Regulation (EU) 2015/2283 by EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Monika Neuhäuser‐Berthold, Helle Katrine Knutsen, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk vanLoveren, Wolfgang Gelbmann, Harry J. McArdle

“…Regarding the maximum limit of the specification parameter ‘other sterols/stanols’, the applicant asks for an increase from currently less than 3% to less than 7% to better reflect and cover the natural composition and proportions of sunflower‐based phytosterols/phytostanols, noting that the existing specifications have been established largely based on the NF when sourced from soy. …”
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Optimizing enzyme thermostability by combining multiple mutations using protein language model by Jiahao Bian, Pan Tan, Ting Nie, Liang Hong, Guang‐Yu Yang

“…It showed a 10.19°C increase in the melting temperature and an ~655‐fold increase in the half‐life at 58°C. …”
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Military and political security in the Arctic before and amidst the Ukrainian crisis by I. A. Arzhanov

“…This course has been reflected in a whole series of alliance’s military exercises, which, as shown in the article, are becoming increasingly extensive and regular year by year. The author concludes that the Ukrainian crisis has only laid bare the true aspirations of the NATO countries seeking to contain Russia in the Far North and refusing to consider its interests and build a constructive dialogue in the field of military and political security. …”
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UML/OCL based design and the transition towards temporal object relational database with bitemporal data by Soumiya Ain El Hayat, Fouad Toufik, Mohamed Bahaj

“…In software modeling, UML (Unified modeling language) receives increasing attention from designers of real-time systems in software development. …”
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Improvement of RT-DETR model for ground glass pulmonary nodule detection. by Siyuan Tang, Qiangqiang Bao, Qingyu Ji, Tong Wang, Naiyu Wang, Min Yang, Yu Gu, Jinliang Zhao, Yuhan Qu, Siriguleng Wang

“…Currently, pulmonary nodules detection work mostly focus on recognition and diagnosis of solid nodules. …”
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Melt‐Processable and Electrospinnable Shape‐Memory Hydrogels by Turdimuhammad Abdullah, Cagatay Altınkok, Oguz Okay

“…Abstract Due to their ability to adapt to subtle changes in response to various external and internal stimuli, smart hydrogels have become increasingly popular in research and industry. However, many currently available hydrogels suffer from poor processability and inferior mechanical properties. …”
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Investigation of hydrogen embrittlement in steel alloys: mechanism, factors, advanced methods and materials, applications, challenges, and future directions: A review by Umme Javeria, Sung Jin Kim

“…Hydrogen embrittlement (HE) remains a critical challenge in structural metals, particularly steels, compromising their mechanical integrity in hydrogen-containing environments. The process typically initiates with crack nucleation and progresses to fracture due to a reduction in ductility and an increase in brittleness. …”
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Does Beta Explain Global Equity Market Volatility – Some Empirical Evidence by Radosław Kurach

“…In the subsidiary outcomes of our verification procedure, we argue that country betas are time-varying and that currently, global factors are the dominant source of equity market volatility. …”
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Incomplete epidemiological transition in Kazakhstan: changes in the structure of life expectancy and causes of death by А. Алдангаркызы, М. Денисенко

“… This article examines Kazakhstan's epidemiological transition, focusing on shifts in mortality patterns and life expectancy within the context of socioeconomic and demographic influences. …”
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The role of non-antibacterial agents in the prevention of recurrent urinary tract infections by E. V. Shikh, O. V. Zhukova

“…Currently, European recommendations for the prevention of recurrent urinary tract infections include non-antibacterial agents such as D-mannose; preparations containing cranberries and/or products of its processing. …”
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Mapping the global distribution and conservation status of oases—ecosystems of pivotal biocultural relevance by Juan Antonio Hernández-Agüero, Mechthilde Falkenhahn, Jessica Hetzer, Karsten Wesche, Christiane Zarfl, Klement Tockner

“…However, less than 0.5% of their total area is currently under protection, making oases one of the least conserved ecosystems worldwide. …”
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Investigation of neuromodulation of the endbulb of Held synapse in the cochlear nucleus by serotonin and norepinephrine by Maria Groshkova, Maria Groshkova, Maria Groshkova, Maria Groshkova, Maria Groshkova, Theocharis Alvanos, Theocharis Alvanos, Theocharis Alvanos, Yumeng Qi, Fangfang Wang, Carolin Wichmann, Carolin Wichmann, Carolin Wichmann, Carolin Wichmann, Yunfeng Hua, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser

“…Patch-clamp recordings from BCs revealed an increase in frequency of miniature excitatory postsynaptic currents (mEPSCs) upon application of NE but not 5-HT. …”
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Forensic Investigation of Stainless Steel 316 Hydrogen-Membrane and Ammonia-Cracking Reactors Through Mechanical Testing by Alexander Ilyushechkin, Veronica Gray, Riley Ingle, Lachlan Carter, Liezl Schoeman

“…We examined samples of reactor walls exposed to hydrogen-containing atmospheres for >100 and ~1000 h at elevated temperatures during hydrogen separation and ammonia cracking. …”
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Tax planning: organization features at enterprise by Grabchuk I.L., Laichuk S.M.

“…The research determines the need for studying the «cloud» technologies as the method of saving company’s resources and increasing the efficiency of processing accounting data. …”
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Optimization procedure for conformance control by Konstantin M. Fedorov, Rodion M. Ganopolsky, Alexander Ya. Gilmanov, Alexander P. Shevelev

“…The article is devoted to the development of an optimization procedure for conformance control treatment. Currently, due to the significant share of reservoirs with high water cut, it is relevant to use methods that allow reducing the rate of production water cut increase. …”
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Trial in absentia and the modern international criminal procedure by A. B. Mezyaev

“…The practice of these courts demonstrates a very inconsistent application and not always convincing interpretation of the rights of the accused in general and the right to be tried in his presence. Currently, this practice is trying to change the previously formed trend towards increasingly severe restrictions on exceptions to the right of the accused to be tried in his presence.…”
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