Cost-effectiveness of atezolizumab plus bevacizumab versus sorafenib as first-line therapy in unresectable hepatocellular carcinoma in the US and Chinese setting: a modelling compa... by Lei Wang, Lulu Liu, Yiling Ding, Qilin Zhang, Yamin Shu

“…In scenario analyses, the atezolizumab plus bevacizumab treatment becomes favourable when the cost of atezolizumab decreases to 67.85% and 18.45% of its original price in the USA and China, respectively.Conclusions The atezolizumab plus bevacizumab is unlikely to be cost-effective compared with sorafenib for patients with unresectable HCC in the context of the USA and China. …”
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Application of urinary peptide-biomarkers in trauma patients as a predictive tool for prognostic assessment, treatment and intervention timing by Gökmen Aktas, Felix Keller, Justyna Siwy, Agnieszka Latosinska, Harald Mischak, Jorge Mayor, Jan Clausen, Michaela Wilhelmi, Vesta Brauckmann, Stephan Sehmisch, Tarek Omar Pacha

“…CE-MS peptidome analysis identified 191 significantly altered peptides in severely injured patients. A consistent increase in the abundance of peptides from A1AT, AHSG, and HBA1 was observed, while peptides derived from PIGR and UROM were consistently decreased. …”
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A framework for integrating neural development and social networks in adolescence by Jimmy Capella, Eva H. Telzer

“…Adolescence is a developmental period characterized by increasingly complex and influential peer contexts. Concurrently, developmental changes in neural circuits, particularly those related to social cognition, affective salience, and cognitive control, contribute to individuals’ social interactions and behaviors. …”
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Microsaccades in applied environments: Real-world applications of fixational eye movement measurements by Robert G Alexander, Stephen L Macknik, Susana Martinez-Conde

“…Here we present the state of the art in the practical applications of fixational eye movement research, examine its potential future uses, and discuss the benefits of including microsaccade measures in existing eye movement detection technologies. Current evidence supports the inclusion of fixational eye movement measures in real-world contexts, as part of the development of new or improved oculomotor assessment tools. …”
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Shifting of Distribution and Changing of Antibiotic Resistance in Gram-Positive Bacteria from Bile of Patients with Acute Cholangitis by Hao Y, Li L, Du W, Lu J

“…Yuqi Hao,1 Lianxin Li,2 Wenting Du,1 Jinshuai Lu1 1Department of General Internal Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China; 2Endoscopy Center, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of ChinaCorrespondence: Jinshuai Lu, Department of General Internal Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China, Email lujinshuai@xjrmyy.comBackground: Gram-negative bacteria are the predominant pathogens responsible for biliary infections; however, the prevalence of Gram-positive bacteria is currently increasing. Investigating the bacterial spectrum and evolving antibiotic resistance patterns of Gram-positive bacteria is crucial for optimizing the management of acute cholangitis, particularly in the context of the global rise in antibiotic resistance.Methods: This retrospective analysis focused on Gram-positive bacteria isolated from the bile of patients undergoing biliary drainage with acute cholangitis at our hospital from January 1, 2018, to March 31, 2024. …”
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Effects of coriander components linalool and geranyl acetate on stress-related neuroendocrine and behavioral measures in adult zebrafish (Danio rerio) by Maureen L. Petrunich-Rutherford

“…However, it is currently unclear how the individual phytochemical components of coriander regulate anxiety-like behavior and stress axis activity. …”
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Angiotensin-(1-7) protective effects in neurocognitive disorders: molecular mechanisms to therapeutic implications by Lillia C. Lucas, Katherine D. Kimbark, Victoria L. Vernail, Yuval Silberman, Amy C. Arnold

“…Current treatments for neurocognitive disorders have limited efficacy and typically focus on symptom attenuation rather than targeting intrinsic pathophysiology. …”
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Invisible lives, visible challenges: The socio-environmental impacts of undocumented Afghan immigrants on the host society by K. Iqbal, H. Liang

“…ABSTRACTBACKGROUND AND OBJECTIVE:Today's illegal immigrant crisis in general and the illegal Afghan immigrant crisis, in particular, are considered a continuous challenge of the current century since the mass migration of people from their country of origin has exponentially increased. …”
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Internet of Things in healthcare: An adaptive ethical framework for IoT in digital health by Abubakar Wakili, Sara Bakkali

“…The research reveals pressing issues related to data privacy, security, and user autonomy and highlights the imperative need for an increased focus on algorithmic transparency and the integration of ethical considerations in the design and development of IoT applications. …”
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Battle for “Donat”: а discussion about the old and new classical philology in Russia (1847–1848) by Kira Ilina

“…In the 1830–40s (time of the transformation of classical philology into a scientific discipline) during discussions in the Ministry of Public Education and in the public sphere, norms for teaching classical disciplines were developed and the number of ancient languages textbooks were rapidly increased. The article focuses on the reconstruction of the discussion about the Latin language textbook “Donat”, prepared by Moscow University professor Karl Hofman. …”
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Human Perspectives and Social Infrastructures: Prioritising People in GLAM Digitisation by Megan Gooch, Rebecca Kahn, Edurne Kugeler

“…Much discussion in current digital humanities research and funding is concerned with creating, using and maintaining technical and research infrastructures. …”
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“It’s easy to be burned out in this line of work”: Experiences of burnout among Black women pelvic floor therapists in the United States by Shemeka Thorpe, Praise Iyiewuare, Brenice Duroseau, Natalie Malone, Kaylee A Palomino

“…The physical and emotional demands of pelvic floor therapists, coupled with identity-based stressors, may place Black women pelvic floor therapists at an increased risk for experiencing burnout. Objective: The purpose of this study was to explore the experiences of burnout among Black women pelvic floor therapists in the United States. …”
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Effects of step width and gait speed on the variability of mediolateral control in the head and trunk during gait. by Yu Takada, Tomoaki Atomi, Takayuki Yagi, Shoma Yamamoto, Masao Tomita, Miho Shimizu, Yoriko Atomi

“…Further, it is related to the control of center of mass (COM) and trunk movements and gait speed. The current study aimed to validate the effect of conditioning using combined step width (narrow and wide) and gait speed (normal [4.5 km/h] and slow [2.2 km/h]) on the segmental control of the head, thorax, and pelvis with respect to the BOS. …”
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Urban Regeneration for the Resilient City: Implementation of Sustainable Urban Drainage Solutions in Pisa's High Flash Flood Risk Areas by Luisa Santini, Greta Frosini, Cinelli Fabrizio

“…This research, funded by UNIPI PRA_2022_22, titled “Mitigating Risks in Urban Areas”, aims to develop a methodology to analyse and evaluate the benefits of increased resilience in urban contexts following the implementation of NBS. …”
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Epigenetic regulation and memories: possible applications to grapevine in Uruguay by Mercedes Fourment, Philippe Gallusci

“…This article summarizes the current understanding of epigenetic regulation in grapevines, emphasising their significance in a clonally propagated plant with limited genetic diversity. …”
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Recommendations for Interventions to Improve Function in Patients With Lung Cancer: A Clinical Practice Guideline by Mary Vargo, Lynn H. Gerber, Laura S. Gilchrist, Mary Insana Fisher

“…Further study is needed into sustainability of performing the interventions and durability of outcomes; increased breadth of interventions and functional outcome domains examined; and exploration of specific contexts including advanced disease, survivorship, high medical complexity and frailty, and caregiver‐related factors. …”
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What type of leadership is more effective for managing change during force majeure? Achieving organizational effectiveness during the pandemic by Nazia Habib, Shaheryar Naveed, Muhammad Mumtaz, Rabia Sultana, Shoaib Akhtar

“…Moreover, the effectiveness of TL significantly increased and the same decreased for EL during COVID-19. …”
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THE IMPACT OF THE USE OF BIOFUELS ON CO2 EMISSIONS AT THE LEVEL OF EUROPEAN COUNTRIES FROM THE PERSPECTIVE OF ABSOLUTE DECOUPLING by Valentina SIMION, Liviu MARCUTA, Maricel CAZACU, Nicolae MINEA, Camelia HODOAȘAN

“…During pandemic limitations, emissions temporarily decreased in tourism-oriented nations like Malta, Italy, and Spain; however, as economic activity resumed, emissions increased. …”
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Bleomycin: A worthy alternative by Gursev Sandlas, Paras Kothari, Parag Karkera, Abhaya Gupta

“…Complications of the therapy were few and far between. 2 patients developed fever after injection, one patients reported a transient increase in size of swelling, 2 patients have developed discoloration of the overlying skin and are currently being followed up for final outcome. …”
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The neurobiological basis of emotions and their connection to facial expressions in non-human mammals: insights in nonverbal communication by Daniel Mota-Rojas, Alexandra L. Whittaker, Cécile Bienboire-Frosini, Jhon Buenhombre, Patricia Mora-Medina, Adriana Domínguez-Oliva, Julio Martínez-Burnes, Ismael Hernández-Avalos, Adriana Olmos-Hernández, Antonio Verduzco-Mendoza, Alejandro Casas-Alvarado, Karina Lezama-García, Temple Grandin

“…Considering these coded facial movements, current research aims to associate certain facial expressions with the animals’ emotional states and affective contexts. …”
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