The Impact of Globalization on the Dynamics of the Domestic Market of National Economies by Yu. S. Bogachev, S. R. Bekulova

“…In the context of the turbulence of the global economy, the relevance of research aimed at determining the ability to ensure the sustainable development of national economies within the current model of global economic development is increasing.   …”
Get full text

Young TPI: empowering animal-free science among the next- generation of scientists by Marta G. Valverde, Marta G. Valverde, Fatima Zohra Abarkan, Fatima Zohra Abarkan, Rebecca Van Eijden, Rebecca Van Eijden, Julia M. L. Menon, Julia M. L. Menon, Nikolas Gaio, Nikolas Gaio, Aarti Ramchandran, Aarti Ramchandran, Victoria C. De Leeuw, Victoria C. De Leeuw

“…Promotion and encouragement for use of animal-free innovations among the next-generation of scientists, alongside knowledge acquisition and training in the increased capabilities of novel technologies, are fundamental for advancing science and the welfare of animals used for scientific purposes. …”
Get full text

Improving mesophilic anaerobic digestion of compostable packaging through efficient and versatile thermo-alkaline pre-treatment by Gaël Huet, Julie Lamarque, Florian Monlau, Valentin Puchelle, Cecilia Sambusiti, Juliana Catalina Suarez Murcia, Sandra Domenek, Florian Pion, Emmanuelle Gastaldi

“…In the current European regulatory context, which requires its Member States to collect biowaste separately with a view to its organic recovery, the co-processing of compostable food packaging with biowaste by mesophilic anaerobic digestion (AD) offers the dual opportunity of promoting its conversion into biogas while reducing plastic contamination of the environment. …”
Get full text

Clinical and cost-effectiveness of paramedics working in general practice: a mixed-methods realist evaluation by Matthew Booker, Sarah Voss, Nicky Harris, William Hollingworth, Nouf Jeynes, Hazel Taylor, Kirsty Garfield, Helen Baxter, Jonathan Benger, Andy Gibson, Trudy Goodenough, Justin Jagosh, Kim Kirby, Cathy Liddiard, Alyesha Proctor, Sarah Purdy, Behnaz Schofield, Hannah Stott, Grace Scrimgeour, Nicola Walsh

“…Background General practice services are under pressure due increased demand. Alongside substantial national recruitment challenges, there exists a shortage of general practitioners to meet current need. …”
Get full text

Evaluating the Constructive Alignment of Learning Objectives Within Haptics Simulation in the Dental Undergraduate Curriculum by Susha Rajadurai, Tapan Hebballi, Zahra Sharif, Guneet Kaur Kukreja, Ithar Derdour

“…This study seeks to explore whether the current learning objectives constructively align with our current haptics simulation curriculum – in the specific context of how well they are being met by year 1 undergraduate dental students. …”
Get full text

Pregnancy-related acute kidney injury leads to hypertension, reduced kidney function and cognitive impairment in postpartum rats by Ashley Griffin, Jamie Szczepanski, Shauna-Kay Spencer, Shauna-Kay Spencer, Lucia Solis, Teylor Bowles, Reanna Robinson, Jan M. Williams, Patrick B. Kyle, Kedra Wallace, Kedra Wallace

“…Both hypertensive disorders of pregnancy and Acute Kidney Injury (AKI) outside the context of pregnancy have been associated with an increased risk of developing Chronic Kidney Disease (CKD) and cognitive impairment. …”
Get full text

Genome-Wide DNA Methylation Analysis during Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Yangyang Cao, Haoqing Yang, Luyuan Jin, Juan Du, Zhipeng Fan

“…We found that the majority of cytosines in a CpG context were methylated in induced BMSCs. Our results also revealed that, along with the induced osteogenic differentiation in BMSCs, the average genomic methylation levels and CpG methylation in transcriptional factor regions (TFs) were increased, the CpG methylation level of various genomic elements was mainly in the medium-high methylation section, and CpG methylation levels in the repeat element had highly methylated levels. …”
Get full text

Improving follow-up imaging practices for patients with community-acquired pneumonia by Meirian Evans, Aazaz Rehman, Joseph Marchant, Matthew Pavitt, Rachel Buxton-Thomas

“…Introduction: The incidence of lung cancer in patients presenting to hospital with community-acquired pneumonia (CAP) is variably reported as 1–9.2%.1–3 The radiographic features of pneumonia and lung cancer can be similar. Therefore, in the context of lower respiratory tract symptoms, a malignancy visible on a chest X-ray may be missed.The British Thoracic Society (BTS) guidelines for the management of CAP in adults (2009) recommend that high-risk patients (aged >50 and current or ex-smokers) with consolidation on a chest X-ray should be followed up with a repeat chest X-ray 6 weeks after their initial presentation to ensure resolution of changes and to exclude an underlying malignancy.3Initial audit data in our local respiratory department showed that 41% of patients were incorrectly not followed up with repeat imaging. …”
Get full text

Absence of progression risk of chronic kidney disease in patients with urine protein-creatinine ratio below 500 mg/g: a cohort study with competing risk analysis by Jiang Bai, Lijuan Zhang, Jingkai Di, Wenyu Wang, Yawen Wu, Yun Zhou, Yun Zhou, Yun Zhou

“…The results of the Fine and Gray competing risk survival regression model showed the same trend.ConclusionIn patients with CKD and UPCR levels below 500 mg/g, there was no increased risk of CKD progression associated with the higher proteinuria levels.…”
Get full text

Validation of the Mild Behavioral Impairment Scale (MBI-S) for brief self-assessment of Mild Behavioral Impairment in people without dementia by Paula Hinkl, Elmar Graessel, Nicolas Rohleder, Peter Landendoerfer, Thomas Kuehlein, Natascha Lauer, Anna Pendergrass

“…It has high test economy and measures current neuropsychiatric symptoms and their intensity as a state criterion. …”
Get full text

Knowledge of Preconception Healthcare and Associated Factors: A Study among Mothers in Jinka Town, Southern Region, Ethiopia by Kassahun Fikadu Tesema, Tamirat Cheneka, Alemayehu Alemu, Mekonen Feyissa, Birhanu Birkaye, Hafiza Mohammed, Eleni Kidu, Getahun Wegaso, Biresaw Wasihun

“…Preconception healthcare is promising to improve the reproductive health status of women and couples if they receive care three months to two years before conception. In the current context of Ethiopia, however, preconception healthcare is overlooked in the continuum of care. …”
Get full text

Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components by Marion Henderson, Anja Wittkowski, Katie Buston, Karen Crawford, Alice MacLachlan, Alex McConnachie, Emma McIntosh, Claudia-Martina Messow, Catherine Nixon, Rosaleen O’Brien, Shona Shinwell, Daniel Wight, Yiqiao Xin, Rachel Calam, Ruth Dundas, James Law, Helen Minnis, Lucy Thompson, Philip Wilson

“…Mellow Bumps in comparison, comprises of seven weekly antenatal sessions and one postnatal session. It aims to decrease maternal stress, increase understanding of neonates’ capacity for social interaction, and emphasise the importance of early interaction for brain development and attachment. …”
Get full text

PROTOCOL: The Application of Information and Communication Technologies in Physical Activity Interventions for Breast Cancer: A Scoping Review Protocol by Xin Chen, Maaz Imam, Yutong Yi, JJ Pionke, Lixcy Vega, Anna Arthur, Jessie Chin, Chungyi Chiu

“…While technology‐based interventions have received increased attention in recent years, there is still limited consensus within the scientific literature surrounding ICT‐based PA interventions for BCS. …”
Get full text

Feasibility of cognitive testing and ecological momentary assessments using smartphones in middle aged and older adults with insomnia by Sara Ghadimi, Jason Ereso, Alexander J. Kaula, Nick Taptiklis, Francesca Cormack, Cathy Alessi, Jennifer L. Martin, Joseph M. Dzierzewski, Arash Naeim, Sarah Kremen, Tue Te, Constance H. Fung

“…We assessed the feasibility of self-administered cognitive testing via smartphone apps for collecting in-moment, in-context data about a person’s current state (ecological momentary assessment, EMA). …”
Get full text

Intravesical instillation-based mTOR-STAT3 dual targeting for bladder cancer treatment by Dae Hoon Lee, Jung Ki Yoo, Ki Hwan Um, Wootae Ha, Soo Min Lee, Junseong Park, Min Jeong Kye, Jungyo Suh, Jin Woo Choi

“…Graphical Abstract The current investigation introduces an innovative conceptualization of bispecific short hairpin RNA (bs_shRNA) tailored for the equilibrated modulation of dual genes within a singular cellular context. …”
Get full text

The role of nanotechnologies in diagnostics and treatment of female reproductive system cancer by Z. R. Faizullina, A. A. Zhilenko, A. Kh. Islamgulov, E. A. Chernaya, A. I. Tochieva, A. A. Sanova, D. A. Dryaeva, S. Sh. Khaknazarov, T. R. Gazizov, M. M. Otadzhonov, Kh. A. Merzhoeva, E. V. Malikova, V. A. Glazepa, A. K. Matviets

“…Such systems, including liposomes, nanoparticles, micelles, and dendrimers, are characterized by advanced efficiency, reduced toxicity, as well as the opportunity for controlled release of active components. Nanotechnologies increase the effectiveness of vaccines by prolonging their half-life, affect the СС microenvironment and potentiate the antitumor immune response with minimal toxicity. …”
Get full text

COZMIC. III. Cosmological Zoom-in Simulations of Self-interacting Dark Matter with Suppressed Initial Conditions by Ethan O. Nadler, Rui An, Daneng Yang, Hai-Bo Yu, Andrew Benson, Vera Gluscevic

“…In particular, P ( k ) suppression that saturates current warm DM constraints almost entirely erases core collapse in isolated halos. …”
Get full text

Human Blood Serum Banks in the System of Seroepidemiological Monitoring of Population Immunity by T. A. Semenenko, V. A. Gushchin, Ya. V. Simakova, A. E. Potapkina, T. I. Subbotina, D. A. Kleymenov, A. A. Pochtovy, A. L. Ginzburg

“…Using the infrastructure of the blood serum bank makes it possible to obtain information on the seroprevalence, effectiveness of specific prevention programs and the level of susceptibility of various age and social groups of the population to vaccine-controlled infections.Conclusion. In the context of expanding the range of real and potential biological threats, the effective functioning of human blood serum banks creates additional opportunities for studying population immunity, contributing to an increase in the effectiveness of the seroepidemiological monitoring system for current infections among the population.…”
Get full text

Effects of a novel non-pharmacological intervention based on respiratory biofeedback, neurofeedback and median nerve stimulation to treat children with ADHD by Eduardo Santamaría-Vázquez, Eduardo Santamaría-Vázquez, Eduardo Santamaría-Vázquez, Anayali Estudillo-Guerra, Lna Ali, Diana Martinez, Roberto Hornero, Roberto Hornero, Leon Morales-Quezada

“…Despite its high prevalence, current pharmacological treatments are not effective in 30% of cases and show poor long-term adherence. …”
Get full text

Healthcare-Associated Infections: The Role of Microbial and Environmental Factors in Infection Control—A Narrative Review by Andreea M. Sandu, Mariana C. Chifiriuc, Corneliu O. Vrancianu, Roxana-E. Cristian, Cristina F. Alistar, Marian Constantin, Mihaela Paun, Alexandru Alistar, Loredana G. Popa, Mircea I. Popa, Ana C. Tantu, Manuela E. Sidoroff, Mara M. Mihai, Andreea Marcu, George Popescu, Monica M. Tantu

“…One of the most serious consequences of HAIs is the increase in the rate of antibiotic resistance (AR) generated by the prolonged, frequent, and sometimes incorrect use of antibiotics, which leads to the selection of resistant bacteria, making treatment difficult and expensive, with direct consequences for the safety of patients and healthcare personnel. …”
Get full text