Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Results Our findings showed that CL-NPs loaded with anti-NOTCH1/-SF3B1 siRNAs-PTX significantly suppressed NOTCH1 and SF3B1 expression in PBMCs and BMMCs isolated from CLL cases in comparison with the untreated samples, leading to increased leukemic cell sensitivity to PTX and decreased the proliferative capacity of leukemic cells. …”
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Cooperative control method for multi-agent ground fracturing truck group based on offline reinforcement learning by RuYi Wang, HuiShen Jiao, YingCheng Tian, Yi Zhao, SiQi Wang, Ke Zhang, Bo Huang, QinRui Sun, DanDan Zhu

“…Abstract The increasing scale of unconventional oil and gas resource development has driven the demand for complex fracturing technologies. …”
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A review on the synergism between corrosion and fatigue of magnesium alloys: Mechanisms and processes on the micro-scale by Mara Cristina Lopes de Oliveira, Rejane Maria Pereira da Silva, Ricardo M. Souto, Renato Altobelli Antunes

“…Understanding the interaction between cyclic stresses and corrosion of magnesium (Mg) and its alloys is increasingly in demand due to the continuous expansion of structural applications of these materials. …”
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Development of recipes and technologies for producing functional desserts using sea buckthorn fruits by S. O. Nekrasova, A. V. Komarov

“…Currently, most confectionery products are high in calories and low in dietary fiber, pectins, vitamins and minerals. …”
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Tracking development assistance for health from China, 2007–2017 by Angela E Micah, Catherine S Chen, Abigail Chapin, Joseph L Dieleman, Paul H Lee, Michael R Phillips, Kun Tang, Shenglan Tang, Jost Jonas, Shiwei Liu, Yingxi Zhao, Bianca S. Zlavog, Golsum Tsakalos, Stephen Gloyd, Man Tat Alexander Ng, Enrico Rubagotti, Mustafa Younis, Yunquan Zhang

“…However, relative to population size and government spending, China’s contributions are modest.Conclusion In the current context of plateauing in the growth rate of DAH contributions, China has the potential to contribute to future global health financing, especially financing for health system strengthening.…”
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The Circular Kitchen by Bas Jansen

“…While start-ups favor radical innovation, established manufacturers, like the CIK’s producer, opt for incremental improvements (outside of a research context). This suggests that when aiming for large-scale implementation that can only be reached with large-scale production, the feasibility of the design should be prioritized, while still improving environmental performance compared to current, non-circular kitchens. …”
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SISTEMAS FISIOGRÁFICOS DEL ÁREA NATURAL PROTEGIDA “VALLE CRETÁCICO”, PROVINCIA DE RÍO NEGRO by Romina Solorza, Marcos D. Mare

“…The physiographic systems study shows that there is a marked susceptibility to the erosion processes increase, especially gully erosion. The natural vegetation, as a consequence of its physiognomic characteristics adapted to semiarid and mesothermal climate and of the historical social land use overloading , currently presents a low coverage, associated with low levels of soil aggregation. …”
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Evaluation of the Antistaphylococcal Activity of the Pyrimidine Derivative by A. A. Tsibizova, A. L. Yasenyavskaya, I. N. Tyurenkov, A. A. Ozerov, O. A. Baskina, M. A. Samotrueva

“…The development of safe and effective drugs with antimicrobial activity is currently a priority task of modern pharmacology. The need to obtain new antimicrobial agents is associated with the presence of problems, the main of which is the development of polyresistance of the pathogenic pathogen to existing antibacterial drugs. …”
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Potential therapeutic effects of IL28RA inhibition on acute myocardial infarction through phosphorylated JAK1/STAT1 signaling pathways by Ge Gong, Xiangxuan Chen, Xinghu Zhang, Jian Yin, Wenhui Wan

“…Abstract While current coronary intervention therapies and surgical bypass procedures are widely utilized, the treatment of acute myocardial infarction (AMI) in the elderly continues to pose significant challenges. …”
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Characteristics, outcomes, and maternity care experiences of women with children’s social care involvement who subsequently died: national cohort study and confidential enquiry by Marian Knight, Abigail Easter, Jane Sandall, Elsa Montgomery, Nicola Vousden, Emma Rose, Claire Mason, Kirsty Kitchen, Kaat De Backer, Allison Marjorie Felker, Caroline Bull, Oluwaseun Labisi

“…Multiple individual and systemic barriers hindered access and engagement with healthcare.Conclusions Women with CSC involvement who died during or in the year after pregnancy encountered multiple inequalities and were at an increased risk of maternal mortality from psychiatric causes and homicide. …”
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The Problem of Ensuring Maritime Security in the Asian Region by V. N. Koval, S. V. Ochkurenko, S. A. Vasiliev

“…As a territorial scope, interstate relations of Asian countries, including Russia, were considered as the most promising and interesting region from a scientific point of view, including in the context of increased measures of negative economic pressure on Russia from a number of states in North America and Europe. …”
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Komodifikasi Musik Bertema Cinta: Pertunjukan Yovie Widianto “Billion Songs Concert and Festival” by Assalova Schissandra Zahra, Royke Bobby Koapaha

“…These findings imply that the commodification strategies used have successfully increased Yovie Widianto's popularity and exposure, and have cemented the position of love-themed music as a valuable commodity in today's music industry. …”
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Caught Up Between War, Localism and EU Land Policy Regulations. Unravelling Local Land Use Decision-Making in Ukraine by Oleksandr Anisimov, Yegor Vlasenko, Dominic Stead, Maria Smirnova

“… In global discussions on land use amid increasing land scarcity, municipal-level decision-making remains underexplored despite municipalities playing a crucial role in regulating land competition. …”
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Assessing municipal solid waste in Indian smart cities: A path towards Waste-to-Energy by Ateeb Hamdan, Sugato Panda, Mayur Shirish Jain, Veena Raj, Sathyajith Mathew

“…It also maps its current waste management practices in the demographic space of 10 Indian smart cities. …”
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Oligomerization of the Clostridioides difficile transferase B component proceeds through a stepwise mechanism. by Robin M Mullard, Michael J Sheedlo

“…While Toxin A and Toxin B are thought to drive the pathology associated with the disease, strains that produce CDT have been linked to increased disease severity, higher rates of infection recurrence, and increased incidence of mortality. …”
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Contemporary problems of reflection theory by E. N. Gnatik, V. M. Naidysh

“…In connection with the rapid development of cognitive sciences in epistemology, philosophy of consciousness, realistic concepts of cognition are actualized, and with them, interest in the theory of reflection, its current state, is growing again. The article analyzes the main paradigms of the theory of reflection, the paths of their historical development and its current problems. …”
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Developing and validating the scale of language teachers’ design thinking competency in artificial intelligence language teaching (LTDTAILT) by Amir Reza Rahimi

“…Nowadays, cultivating DT within any educational program is becoming increasingly important for teachers since Artificial Intelligence (AI) and chatbots are available to all students. …”
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Artificial Intelligence (AI) Integration in Urban Decision-Making Processes: Convergence and Divergence with the Multi-Criteria Analysis (MCA) by Maria Rosaria Guarini, Francesco Sica, Alejandro Segura

“…The study’s goal is to investigate the cross-functional relationships between Artificial Intelligence (AI) and current decision-making support systems, which are increasingly being used to interpret urban growth and development from a multi-dimensional perspective, such as a multi-criteria one. …”
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Opportunities of the discipline of «Training professional communication» in the formation of students’ universal competences by Alexandra Vladimirovna Leontyeva, Irina Vladimirovna Detkova

“…The indication of the need for the formation of universal competencies in students in the current FSES HE 3++ has activated the scientific and pedagogical community to search for ways to solve this problem. …”
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AMEND 2.0: module identification and multi-omic data integration with multiplex-heterogeneous graphs by Samuel S. Boyd, Chad Slawson, Jeffrey A. Thompson

“…Conclusions While the analysis of multi-omic datasets in a network context is poised to provide deeper understanding of health and disease, new methods are required to fully take advantage of this increasingly complex data. …”
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