Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH). by Jessica Min-DeBartolo, Franklin Schlerman, Sandeep Akare, Ju Wang, James McMahon, Yutian Zhan, Jameel Syed, Wen He, Baohong Zhang, Robert V Martinez

“…Untreated, NAFLD may progress to non-alcoholic steatohepatitis (NASH), cirrhosis and death. However, currently there are no FDA approved therapies that treat NAFLD/NASH. …”
Get full text

Hybrid compatible grid forming inverters with coordinated regulation for low inertia and mixed generation grids by Biddut Bhowmik, Moses Amoasi Acquah, Sung-Yul Kim

“…Abstract The rapid displacement of synchronous generators (SGs) by renewable energy sources has resulted in low-inertia power systems that are increasingly vulnerable to frequency instability, poor power-sharing coordination, and limited fault recovery. …”
Get full text

Unravelling the myriad physiologic roles of transthyretin: critical considerations for treating transthyretin amyloidosis by Morie A. Gertz, Mandar A. Aras, Nicole Bart, Thomas H. Brannagan, Jan M. Griffin, Amy R. Kontorovich, Andrew M. Rosen

“…While a link between low TTR and severe disease and mortality is well established, it remains unclear whether long-term TTR suppression via ATTR therapies increases risk of disease. Clinical decisions in ATTR, however, should reflect the current understanding of the roles of TTR and the patient’s clinical history.Conclusion TTR serves vital physiologic roles across organ systems. …”
Get full text

Pharmacological and pupillary evidence for the noradrenergic contribution to reinforcement learning in Parkinson’s disease by Claire O’Callaghan, Frank H. Hezemans, Naresh Subramaniam, Rong Ye, Kamen A. Tsvetanov, Alexander G. Murley, Negin Holland, Isabella F. Orlando, Ralf Regenthal, Roger A. Barker, Caroline H. Williams-Gray, Luca Passamonti, Trevor W. Robbins, James B. Rowe

“…Testing the noradrenergic framework of learning in the context of human diseases offers a test bed for current normative neuroscience theories and may also indicate therapeutic potential. …”
Get full text

Assessment of the feed additive consisting of canthaxanthin (Carophyll® Red 10%) for breeder hens for the renewal of its authorisation (DSM Nutritional Products Ltd.) by EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Ilen Röhe, Katerina Theodoridou, Jaume Galobart, Orsolya Holczknecht, Alberto Navarro‐Villa, Fabiola Pizzo, Maria Vittoria Vettori

“…In the absence of data, the Panel could not conclude whether the additive CAROPHYLL® Red 10% remains safe for the environment under the current conditions of the authorisation. There is no need for assessing the efficacy of the additive in the context of the renewal of the authorisation.…”
Get full text

Antibiotics resistance in El Tor Vibrio cholerae 01 isolated during cholera outbreaks in Mozambique from 2012 to 2015. by Liliana Candida Dengo-Baloi, Cynthia Amino Semá-Baltazar, Lena Vania Manhique, Jucunu Elias Chitio, Dorteia Luísa Inguane, José Paulo Langa

“…Antibiotic therapy is recommended in specific situations for management and control of cholera outbreaks. However, an increase in resistance rates to antibiotics by Vibrio cholerae has been reported in several epidemic outbreaks worldwide. …”
Get full text

STRATEGIC COMPETENCE AS A GUARANTEE OF PROFESSIONAL ACTIVITY OF A MODERN IT SPECIALIST by Volkova Nataliia, Oliinyk Iryna, Karpova Maryna

“…This makes it possible to manage the IT sector, in particular, in the context of IT infrastructure management, IT projects, IT costs, to increase the security and stability of the industry. …”
Get full text

SOME ASPECTS OF ADMINISTRATIVE-LEGAL REGULATION OF ACTIVITY OF EXECUTIVE POWER BODIES IN THE DIGITAL REALITY by B. Koybaev, Z. Zoloeva

“…Thus, the use of digital technologies in the activities of public authorities can increase the transparency of their activities, make them more open and at the same time accessible to citizens. …”
Get full text

Research on Green Construction Technology and Management Systems in Engineering Projects by Lyu Zhongye

“…In the context of increasingly strained global environmental resources, green building construction can achieve a win-win scenario by reducing resource consumption and environmental pollution during the construction process while simultaneously realizing economic and ecological benefits. …”
Get full text

DEVELOPMENT PROSPECTS OF THE RUSSIAN MARKET OF TECHNICAL SERVICING AND REPAIR IN THE СONTEXT OF A PANDEMIC by O. A. Tettsoeva

“…Currently, at a time of decreasing automotive production caused by the suspension of the plants in the period of lockdown, the reduction in purchasing power of communities connected with the risk of unemployment occurrence in consequence of business failures, the decline in wages and lower vacancy rates, is foreseen reduced demand for new cars against the background of significant increase in sales volumes in the used cars market segment and, therefore, sharp increase in demand for car services performing technical servicing and repair. …”
Get full text

Deep learning and satellite remote sensing for biodiversity monitoring and conservation by Nathalie Pettorelli, Jake Williams, Henrike Schulte to Bühne, Merry Crowson

“…Abstract In the context of the current nature crisis, being able to reliably and cost‐effectively track subtle changes in the biosphere across adequate spatial and temporal extents and resolutions is crucial. …”
Get full text

Making temporary homes by Marjolein Overtoom

“…Since 2015 more attention has been paid to how the influx of refugees increases the housing shortage and how difficult it is for urgent home seekers, including refugees, to find a place to live. …”
Get full text

The impact of non-ionizing electromagnetic radiation emitting devices on the male reproductive system by Michał Sienkiewicz, Bartosz Pawłowski, Magdalena Kłusek, Dorota Zatłoka-Mazur, Filip Klimas, Kacper Rusiński, Bartłomiej Sienkiewicz

“…The aim of the study was to analyse the current state of knowledge on the impact of NIR emitted by modern devices on the functioning of the male reproductive system and to identify possible mechanisms behind it. …”
Get full text

Low-cost nano biochar: a sustainable approach for drought stress mitigation in faba bean (Vicia faba L.) by Heba Ibrahim Abd El-Moaty, Heba Ibrahim Abd El-Moaty, Ali El-Dissouky, Amel F. Elhusseiny, Kareem M. Farag, Rasha Abu-Khudir, Rasha Abu-Khudir, Mayyadah Abdullah Alkuwayti, Najla K. Al Abdulsalam, Salwa M. Abdel Rahman

“…Surprisingly, the application of biochar increased soil water holding capacity and organic matter by 66% and 220%, respectively. …”
Get full text

Enhancing Gas Fermentation Efficiency via Bioaugmentation with <i>Megasphaera sueciensis</i> and <i>Clostridium carboxidivorans</i> by Clemens Hiebl, Dominik Pinner, Hannes Konegger, Franziska Steger, Dina Mohamed, Werner Fuchs

“…Gas fermentation aims to fix CO₂ into higher-value compounds, such as short or medium-chain fatty acids or alcohols. In this context, the use of mixed microbial consortia presents numerous advantages, including increased resilience and adaptability. …”
Get full text

Prevalence of smoking and its changes over time in Russia: data from the ESSE-RF study by O. M. Drapkina, S. A. Maksimov, S. A. Shalnova, Yu. A. Balanova, A. E. Imaeva, V. A. Kutsenko, G. A. Muromtseva, M. B. Kotova, N. S. Karamnova, S. E. Evstifeeva, A. V. Kapustina, A. A. Zelenina, O. A. Litinskaya, M. S. Pokrovskaya, E. B. Yarovaya, T. V. Repkina, T. O. Gonoshilova, A. V. Kudryavtsev, N. I. Belova, L. L. Shagrov, M. A. Samotrueva, A. L. Yasenyavskaya, E. N. Chernysheva, S. V. Glukhovskaya, I. A. Levina, E. A. Shirshova, E. B. Dorzhieva, E. Z. Urbanova, N. Yu. Borovkova, V. K. Kurashin, A. S. Tokareva, Yu. I. Ragino, G. I. Simonova, A. D. Khudyakova, V. N. Nikulin, O. R. Aslyamov, G. V. Khokhlova, A. V. Solovyova, A. A. Rodionov, A. V. Kryachkova, Yu. Yu. Shamurova, I. V. Tantsyreva, I. N. Baryshikova, M. G. Ataev, M. O. Radzhabov, M. M. Isakhanova, M. A. Umetov, L. V. Elgarova, I. A. Khakuasheva, E. I. Yamashkina, M. V. Esina, T. A. Kunyaeva, A. M. Nikitina, N. V. Savvina, Yu. E. Spiridonova, E. A. Naumova, B. M. Nazarov, A. A. Keskinov, V. S. Yudin, S. M. Yudin, A. V. Kontsevaya

“…The results obtained characterize the current situation and time trends of the last decade and contain important information on smoking epidemiology in Russia.…”
Get full text

An overview of drug‐induced sodium channel blockade and changes in cardiac conduction: Implications for drug safety by Khuram W. Chaudhary, Colleen E. Clancy, Pei‐Chi Yang, Jennifer B. Pierson, Alan L. Goldin, John E. Koerner, Todd A. Wisialowski, Jean‐Pierre Valentin, John P. Imredy, Armando Lagrutta, Simon Authier, Robert Kleiman, Philip T. Sager, Peter Hoffmann, Michael K. Pugsley

“…Drug‐dependent block of Nav1.5 current (INa) can lead to significant alterations in cardiac electrophysiology, potentially resulting in conduction slowing and an increased risk of proarrhythmic events. …”
Get full text

METHODOLOGY FOR EVALUATING THE EFFECTIVENESS OF ANTI-CORRUPTION ACTIVITIES IN THE MILITARY SECTOR UNDER CONDITIONS OF ENSURING FINANCIAL SECURITY by Myroslav Kryshtanovych, Oleksandr Nazarenko, Serhii Bazyka, Oleksii Vasyliev, Anna Munko, Yaroslav Panas

“…The volumes of financial provision for military affairs have increased dramatically, and thus, the temptation for corrupt actions has risen. …”
Get full text

Vaccination against SARS-COV‑2 in oncology by A. A. Polyakov, V. V. Lunin, F. M. Abbaysbeyli, O. L. Timofeeva, V. B. Larionova, P. A. Zeynalova, A. A. Fedenko

“…This paper reflects considerations and recommendations for the vaccination of cancer patients by Russian and foreign specialists in the context of COVID‑19 pandemic. The review presents current recommendations for vaccination against SARS-COV‑2 in patients with solid tumors, hematological malignancies, recipients of hematopoietic stem cells and cell therapy.Conclusion. …”
Get full text

Climate change adaptation: policy, practice and adaptation gaps in the agriculture sector in Bangladesh, India and Nepal by Shobha Shrestha, Prem Sagar Chapagain, Yili Zhang, Linshan Liu, Jianzhong Yan, Suresh Chand Rai, Md. Nurul Islam, Basanta Paudel

“…Reactive adaptation, such as increased use of chemical fertilizers and changing crop varieties without proper understanding, is a common adaptive action (inclining toward maladaptation) among farmers. …”
Get full text