Direct oral penicillin challenge in secondary care with low-risk patients: the SPACE mixed-methods study with cost-effectiveness analysis by Mamidipudi Thirumala Krishna, Yogini H Jani, Iestyn Williams, Ruben Mujica-Mota, Rebecca Bestwick, Michele Siciliano, Robert Michael West, Rashmeet Bhogal, Bee Yean Ng, Kornelija Kildonaviciute, Rachel Pollard, Nicola Jones, Louise Dunsmure, Mairead McErlean, Neil Powell, Chidanand C Hullur, Ariyur Balaji, Jonathan Sandoe, Amena Warner, Ron Daniels, Caroline Thomas, Siraj A Misbah, Louise Savic

“…Penicillin allergy labels lead to increased risk for serious hospital infections and longer hospital stay and are associated with higher estimated healthcare costs. …”
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Evaluating the impact, implementation experience and political economy of primary care networks in Kenya: protocol for a mixed methods study by Beatrice Amboko, Jacinta Nzinga, Benjamin Tsofa, Peter Mugo, Anita Musiega, Beryl Maritim, Ethan Wong, Caitlin Mazzilli, Wangari Ng’ang’a, Brittany Hagedorn, Gillian Turner, Anne Musuva, Felix Murira, Nirmala Ravishankar, Salim Hussein, Edwine Barasa

“…Abstract Background Primary care networks (PCNs) are increasingly being adopted in low- and middle-income countries (LMICs) to improve the delivery of primary health care (PHC). …”
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Assessing and Enhancing Nutrition and Physical Activity Environments in Early Childhood Education and Care Centers: Scoping Review of eHealth Tools by Joyce Hayek, Kelsi Dickson, Lynne M Z Lafave

“… BackgroundEarly childhood is a critical period for shaping lifelong health behaviors, making early childhood education and care (ECEC) environments ideal for implementing nutrition and physical activity interventions. eHealth tools are increasingly utilized in ECEC settings due to their accessibility, scalability, and cost-effectiveness, demonstrating promise in enhancing educators’ practices. …”
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Presentation of Financial Assets in the Monetary Statistics by V. N. Salin, O. Y. Sitnikova, L. Y. Arhangelskaya

“…The purpose of the study. Currently, the issues of determining, presenting and analyzing indicators of economic assets, in particular, financial ones, are relevant, since financial assets, along with nonfinancial ones, constitute the most important characteristic of national wealth as a level of development of the country and are the basis for constructing national accounts, indicators of monetary statistics and other sections of macroeconomic statistics. …”
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A comprehensive review of methodologies and application to use the real-world data and analytics platform TriNetX by Ralf J. Ludwig, Ralf J. Ludwig, Ralf J. Ludwig, Matthew Anson, Matthew Anson, Henner Zirpel, Diamant Thaci, Henning Olbrich, Katja Bieber, Khalaf Kridin, Khalaf Kridin, Khalaf Kridin, Astrid Dempfle, Philip Curman, Philip Curman, Philip Curman, Philip Curman, Sizheng S. Zhao, Uazman Alam, Uazman Alam, Uazman Alam

“…TriNetX’s federated network architecture allows real-time, privacy-compliant data access, significantly enhancing the ability to conduct retrospective studies and refine clinical trial designs. With access to currently over 150 million EHRs, TriNetX has proven particularly effective in filling gaps left by RCTs, especially in the context of rare diseases, rare endpoints, and diverse patient populations. …”
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Development and characterization of amaranth protein-based edible films incorporating Satureja khuzestanica essential oil by Elahe Khalili, Gholamreza Jahed Khaniki, Saeedeh Shojaee-Aliabadi, Nabi Shariatifar, Ramin Aslani, Leila Mirmoghtadaie

“…The current research aimed to investigate the physicochemical and antimicrobial characteristics of the edible film based on amaranth protein containing Satureja khuzestanica essential oil. …”
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BK channel activity in skin fibroblasts from patients with neurological disorder by Ria L. Dinsdale, Thomas R. Middendorf, Deborah Disilvestre, David Adams, William Gahl, Ellen F. Macnamara, Lynne Wolfe, Camilo Toro, Cynthia J. Tifft, Andrea L. Meredith

“…Fibroblasts from the individual harboring the E656A variant showed decreases in the number of BK channels detected and E656A-containing transcripts compared to controls. …”
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Valorising mango, cashew apple, and papaya by-products for sustainable small ruminant production in low-income food deficit countries—a review by Antoinette Simpah Anim-Jnr, Salma Binta Yusif Ishaq, Prince Sasu, Sadat Gyimah, Henry Michael Rivers Greathead, Christine Boesch, Faith Philemon Mabiki, Mohammad Naushad Emmambux

“…It emphasizes the need for further research to determine their nutritional value in local contexts, establish optimal inclusion levels, and devise strategies for prolonging shelf life. …”
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Anticipating how spatial fishing restrictions in EU waters perform to protect marine species, habitats, and dependent fisheries by François Bastardie, Amaia Astarloa, Logan Binch, Isabella Bitetto, Dimitrios Damalas, Jochen Depestele, Pierre-Yves Hernvann, Sigrid Lehuta, Jonas Letschert, Irida Maina, Stéphanie Mahévas, Georgia Papantoniou, Miriam Püts, Giovanni Romagnoni, Giovanni Romagnoni, Giovanni Romagnoni, Giovanni Romagnoni, Maria Teresa Spedicato, Klaas Sys, Irini Tsikopoulou, Gert Van Hoey, Walter Zupa, Anna Rindorf

“…As the proportion of closed regions increases, potential effects on marine ecosystems can even be damaging in the short term to some sensitive species (such as the endangered, threatened and protected species ETP) and vulnerable habitats (with currently high relative benthic status RBS). …”
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Long-term dynamics of forests with Pinus sibirica in the upper reaches of the River Kolva (Northern Pre-Urals, Russia) from 1938 to 2023 by Alexei A. Aleinikov, Vadim E. Aleksutin, Foma K. Vozmitel, Alexey N. Gunya

“…Due to the exceptionally slow regeneration following fires and logging activities, Pinus sibirica is absent in the forests formed over the studied period. The current federal legal restrictions prove ineffective as they target the preservation of forest stands containing over 30% of Pinus sibirica, while the majority of forests in the study area contain less proportion of this species. …”
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Interior Point Algorithm in Multi-objective Portfolio Optimization: GlueVaR Approach by Elaheh Gohania, Gholamreza Mansourfar, Fahimeh Biglari

“…Conclusion Based on the current findings, it is evident that the internal point algorithm is effective in resolving stock portfolio optimization issues. …”
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Manganese for Whom? A Review on Manganese Mining Permits towards the Existence of Springs’ Sacred Forest in Manggarai Flores by Bernadinus Steni, Hariadi Kartodihardjo, Soeryo Adiwibowo, Ruchyat Deni Djakapermana

“…Both the spatial analysis and qualitative data are then analyzed alongside the legal framework of land use and spring used to distill the institutional barriers leading to the issuance of permits in such contexts. The analysis then briefly traces the current political economy of mining’s permits underlying the institutional interactions to better understand why the institutions behave as they do. …”
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Genomic Insights into and Lytic Potential of Native Bacteriophages M8-2 and M8-3 Against Clinically Relevant Multidrug-Resistant <i>Pseudomonas aeruginosa</i> by Francisco Ricardo Rodríguez-Recio, Javier Alberto Garza-Cervantes, Francisco de Jesús Balderas-Cisneros, José Rubén Morones-Ramírez

“…Their safety profile, high target specificity, and robust lytic activity underscore the feasibility of incorporating phage-based strategies into current antimicrobial protocols. This study contributes to the broader goal of developing sustainable and effective phage therapies for diverse clinical and environmental contexts.…”
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Mapping the Dream: Designing Optimal E-Bike Routes in Valparaíso, Chile, Using a Multicriteria Analysis and an Experimental Study by Vicente Aprigliano, Catalina Toro, Gonzalo Rojas, Iván Bastías, Marcus Cardoso, Tálita Santos, Marcelino Aurélio Vieira da Silva, Emilio Bustos, Ualison Rébula de Oliveira, Sebastian Seriani

“…These findings challenge the current regulatory limit of 250 W for non-motorized vehicles in Chile, highlighting the potential benefits of increasing their power limits to enhance sustainable mobility in the hilly urban contexts of this country. …”
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Medical embryology and regenerative medicine: research and applications in clinical practice by Julia Soczyńska, Julia Soczyńska, Wiktor Gawełczyk, Wiktor Gawełczyk, Patrycja Obrycka, Patrycja Obrycka, Mateusz Żołyniak, Mateusz Żołyniak, Adrian Muzyka, Adrian Muzyka, Krzysztof Majcherczyk, Krzysztof Majcherczyk, Julia Papierkowska, Julia Papierkowska, Sławomir Woźniak

“…Taking this progress a step further, the ability to introduce stem cells into damaged tissues, thereby facilitating the formation of functional structures, has led to the growing interest in organoids -three-dimensional models that replicate key functions of real organs. Organoids are currently applied not only in drug screening but are also gaining increasing attention for their role in cancer therapy research. …”
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Clinical and cost-effectiveness of first contact physiotherapy for musculoskeletal disorders in primary care: the FRONTIER, mixed method realist evaluation by Nicola E Walsh, Alice Berry, Serena Halls, Rachel Thomas, Hannah Stott, Cathy Liddiard, Zoe Anchors, Fiona Cramp, Margaret E Cupples, Peter Williams, Heather Gage, Dan Jackson, Paula Kersten, Dave Foster, Justin Jagosh

“…Year on year, there continue to be unprecedented numbers of consultations in primary care; between 20% and 30% are related to MSKDs. Given the increasing demand for general practitioner (GP) services and current difficulties surrounding GP recruitment and retention, alternative implementable and affordable models of care are essential. …”
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Interference in melanoma CD248 function reduces vascular mimicry and metastasis by Cheng-Hsiang Kuo, Ya-Fang Wu, Bi-Ing Chang, Chao-Kai Hsu, Chao-Han Lai, Hua-Lin Wu

“…Abstract Background Tumor vascular mimicry is an emerging issue that affects patient survival while having no treatment at the current moment. Despite several factors implicated in vascular mimicry, little is known about stromal factors that modulate tumor microenvironment and shape malignant transformation. …”
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3D-printed resin for permanent/definitive restorations: meta-analysis for bond strength by Minjoo Ki, Marc Hayashi, Mijoo Kim

“…This meta-analysis aimed to synthesize the current knowledge on the adhesion of 3D-printed restorations to resin cements and identify areas for future research. …”
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Emotional literacy programme in special schools for children with a learning disability in England: the ZF-SEND feasibility RCT by Biza Stenfert Kroese, Gemma Unwin, Richard Hastings, Andrew Jahoda, Rachel McNamara, David Gillespie, Jeremy Segrott, Kate Ingarfield, Myrsini Gianatsi, Elizabeth Randell, Zoe Mather, Barbara Barrett, Poushali Ganguli, John Rose, Mariam Sahle, Emily Warren, Nathan Da Cruz

“…Future work On the basis of the current findings, an application for a full trial will be prepared and submitted with a number of amendments. …”
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Evaluation of urban energy transition and identification of barrier factors under the “dual carbon” goals: an empirical study of the Yangtze River economic belt by Haoran Yan, Jingke Gao, Shixiang Li, Jun Bai, Ziyuan Liu, Chen Mai

“…The results show: (1) The overall level of urban energy transition increased by 35.86%, with persistent inter-city disparities, though their intensity has been alleviated. …”
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