Anti-tumor activity of a novel compound-CDF is mediated by regulating miR-21, miR-200, and PTEN in pancreatic cancer. by Bin Bao, Shadan Ali, Dejuan Kong, Sanila H Sarkar, Zhiwei Wang, Sanjeev Banerjee, Amro Aboukameel, Subhash Padhye, Philip A Philip, Fazlul H Sarkar

“…<h4>Methodology/principal findings</h4>In the current study we showed, for the first time, that CDF could significantly inhibit the sphere-forming ability (pancreatospheres) of PC cells consistent with increased disintegration of pancreatospheres, which was associated with attenuation of CSC markers (CD44 and EpCAM), especially in gemcitabine-resistant (MIAPaCa-2) PC cells containing high proportion of CSCs consistent with increased miR-21 and decreased miR-200. …”
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Effects of sudden commencement on the ionosphere: PFISR observations and global MHD simulation by Shasha Zou, Dogacan Ozturk, Roger Varney, Ashton Reimer

“…The simulation provides a global context for linking localized PFISR observations to large‐scale dynamic processes in the MI system.…”
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FINANCIAL SUPPORT FOR FORMATION OF INTELLECTUAL CAPITAL OF ENTERPRISES by V. G. Semenova

“…The formation and active use of intellectual capital of the enterprise becomes a guarantee of increasing its competitiveness and efficiency of activities both in the context of solving current problems and in the strategic perspective. …”
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The Role of Different Planting Types in Mitigating Urban Heat Island Effects: A Case Study of Gaziantep, Turkey by Ahmet Salih Günaydın, Murat Yücekaya

“…In this context, different planting options with only leafy, only coniferous, leafy and coniferous at half at 4 m, 6 m, and 8 m intervals along with the current planting state of the study area in Gaziantep, Turkey were prepared. …”
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The effectiveness of the cardiac resynchronization in a patient with ischemic cardiomyopathy by Diana R. Tudorașcu, Constantin Bătăiosu, Alina Paraschiv, Elena-Anca Târtea, Ionuț Donoiu, Cristina Florescu

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A protective lipidomic biosignature associated with a balanced omega-6/omega-3 ratio in fat-1 transgenic mice. by Giuseppe Astarita, Jennifer H McKenzie, Bin Wang, Katrin Strassburg, Angela Doneanu, Jay Johnson, Andrew Baker, Thomas Hankemeier, James Murphy, Rob J Vreeken, James Langridge, Jing X Kang

“…In fat-1 mice, an unbiased profiling showed a significant increase in the levels of unesterified eicosapentaenoic acid (EPA), EPA-containing cholesteryl ester, and omega-3 lysophosphospholipids. …”
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Evaluation of the applicability of the X-ray room technical passports in the medical facilities and approval of the X-ray department technical plans by the local radiological autho... by I. I. Berezin, S. S. Somov, К. V. Yakusheva

“…The purpose of this work was to assess the relevance and necessity of issuing a technical passport for the X-ray room and to coordinate the project of the X-ray room with the X-ray department in the light of the current sanitary legislation. Registration of a technical passport by organizations that have special permits for these types of work, and not only by the X-ray and radiological department, would increase the legal value of the technical passport. …”
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Giant pandas hold great potential umbrella effectiveness for golden snub‐nosed monkeys under climate change by Jia‐Wen Liu, Yang Yu, Rui‐Feng Wu, Wen‐Bo Li, Cyril C. Grueter, Xue‐Lin Jin, Yang Teng, Ying Shen, Ming Li

“…However, empirical data on their potential effectiveness, particularly in the context of climate change, is limited and inconclusive. …”
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Optimization of The Budget of The Industrial Complex Transformation Strategy Based on Neural Network Modeling by A. G. Boev, A. G. Puzakov, Yu. P. Anisimov

“…Currently, Russian industry is developing mainly along an extensive path that does not provide a deep innovative transformation of business and the necessary increase in labor productivity.Materials and methods. …”
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Systemic hormonal contraception and risk of venous thromboembolism by Oskari Heikinheimo, Elena Toffol, Timo Partonen, Anna But, Antti Latvala, Jari Haukka

“…Abstract Introduction The increased risk of venous thromboembolism associated with the use of hormonal contraception is well recognized, but evidence regarding hormonal contraception containing natural estradiol is limited. …”
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Promising opportunities to improve polio vaccines by E. E. Evreinova, L. M. Khantimirova, V. A. Shevtsov, V. A. Merkulov, V. P. Bondarev

“…In order to meet the needs of global health, it is planned to increase the use of traditional and optimised inactivated polio vaccines and introduce new types of vaccines that are being developed based on the current understanding of RNA-containing viruses. …”
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MicroRNA as a Potential Biomarker for Amyotrophic Lateral Sclerosis (ALS) by José Augusto Nogueira-Machado, Amanda Tábita da Silva Albanaz, Fabiana Rocha-Silva

“…<b>Aim</b>: This review analyzes dysregulated microRNA signaling pathways and their interactions with metabolic pathways in the context of ALS progression. <b>Significance:</b> Despite this, biomarkers remain unreliable, and the current medications prolong life without providing a cure. …”
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The Relationship between the Tenure of an Audit Firm Partner and Audit Quality: Examining the Moderating Role of Audit Firm Change by MohammadReza Haghdadi, Mansour Garkaz, Alireza Moetoofi

“…The research aims to explore this relationship while examining the moderating role of switching audit firms.MethodsThe current research was conducted within the unique context of Iran, focusing on evaluating the turnover of audit firm partners. …”
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TIM-3 expression on monocyte-derived dendritic cells by T. V. Tyrinova, O. Yu. Leplina, E. R. Chernykh

“…Further studies of the regulation of TIM-3 expression by monocyte-derived dendritic cells will expand the understanding of the biological significance of inhibitory receptors on DCs from the point of view of the immune response, as well as, in the future, increase the effectiveness of current approaches in cancer immunotherapy using IFN-DCs and inhibitors of checkpoint molecules.…”
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Prophylactic Treatment of Probiotic and Metformin Mitigates Ethanol-Induced Intestinal Barrier Injury: In Vitro, In Vivo, and In Silico Approaches by Farhin Patel, Kirti Parwani, Priyashi Rao, Dhara Patel, Rakesh Rawal, Palash Mandal

“…Rats fed with ethanol-containing Lieber-DeCarli liquid diet showed decreased expression of TJ proteins, and increased intestinal barrier injury resulting in pro-inflammatory response and oxidative stress in the colon. …”
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Impact of imported COVID-19 cases on South Korea’s response: variant transitions and regional patterns (2020–2023) by Haram Seo, Minchan Choi, Gerardo Chowell, Hyosun Lee, Byul Nim Kim, Sunmi Lee

“…Results The findings reveal a significant increase in imported cases during the transition from the Delta to Omicron variants, highlighting the increased transmissibility of Omicron and its impact on imported case numbers. …”
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Microstructure and Properties of Ion Permeated W - Ni - Al Alloy on Tungsten Surface for Power Switch by SUN Xi-bao, ZHAI Wen-sheng

“…Meantime, the coating contained WNi2Al3&#x00A0;and NiW2. When the surface was covered by the W-Ni-Al coating, the hardness increased significantly. …”
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HUMAN RESOURCES OF HEALTHCARE IN UKRAINE DURING THE COVID-19 PANDEMIC AND WAR by Oleksandr P. Volosovets, Dmytro D. Diachuk, Igor A. Lurin, Oleksandr M. Naumenko, Valentin D. Pariy, Anton O. Volosovets

“…To analyze the human resources for health in Ukraine in the context of the ongoing war and pandemic, and to identify the regions of the country and specialties of physicians and residents most affected by the current challenges. …”
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Cost-effective screening strategy to prevent venous thromboembolism in combined oral contraceptive users by Jonathan Douxfils, Jonathan Douxfils, Jonathan Douxfils

“…Combined oral contraceptives (COCs) increase VTE risk by 2- to 6-fold, resulting in approximately 22,925 cases annually in the European Economic Area (EEA). …”
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Effect of ammonium/phosphate molar ratio on struvite production via electrolysis using a sacrificial magnesium anode by Aditya Kurnia Aji Pangestu, Arseto Yekti Bagastyo, Ervin Nurhayati, Jr-Lin Lin, Fahrudin Sidik

“…Increasing the ammonium molarity in the test solution to 10:1 increased the phosphate reduction ratio to 96.38% while decreasing the ammonium reduction ratio to 26.28%. …”
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