Contribution of the TRPM4 Channel to Osteogenic Differentiation of Human Aortic Valve Interstitial Cells by Margaux Aize, Arthur Boilève, Benoit D. Roussel, Laura Brard, Harlyne Mpweme Bangando, Corentin Kerevel, Alexandre Lebrun, Hind Messaoudi, Vladimir Saplacan, Alain Manrique, Romain Guinamard, Christophe Simard

“…Results Western blot on VICs revealed TRPM4 protein expression and channel functionality was confirmed by patch‐clamp recordings exhibiting a cationic current sensitive to voltage and internal Ca2+. VICs maintained in pro‐calcifying media exhibited a higher mineralization than in standard media, with an increase in osteogenic markers. …”
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Effects of pharmacological and non-pharmacological interventions for the management of sleep problems in people with fibromyalgia: a multi-methods evidence synthesis by Mari Imamura, Clare Robertson, Jemma Hudson, Daniel Whibley, Lorna Aucott, Katie Gillies, Marcus Beasley, Martin J Stevens, Paul Manson, Debra Dulake, Abhishek Abhishek, Nicole KY Tang, Gary J Macfarlane, Miriam Brazzelli

“…However, heterogeneity, imprecision and low quality of the current evidence base preclude any firm conclusions. …”
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Automated Mapping of the Freshwater Ecosystem Functional Groups of the International Union for Conservation of Nature Global Ecosystem Typology in a Large Region of Arid Australia by Roxane J. Francis, Hedley S. Grantham, David A. Keith, Jose R. Ferrer-Paris, Richard T. Kingsford

“…The classification of freshwater ecosystems is essential for effective biodiversity conservation and ecosystem management, particularly with increasing threats. We developed an automated approach to mapping and classifying freshwater ecosystem functional groups based on the IUCN Global Ecosystem Typology (GET), offering a scalable, dynamic and efficient alternative to current manual methods. …”
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Cooperative control method for multi-agent ground fracturing truck group based on offline reinforcement learning by RuYi Wang, HuiShen Jiao, YingCheng Tian, Yi Zhao, SiQi Wang, Ke Zhang, Bo Huang, QinRui Sun, DanDan Zhu

“…Abstract The increasing scale of unconventional oil and gas resource development has driven the demand for complex fracturing technologies. …”
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A review on the synergism between corrosion and fatigue of magnesium alloys: Mechanisms and processes on the micro-scale by Mara Cristina Lopes de Oliveira, Rejane Maria Pereira da Silva, Ricardo M. Souto, Renato Altobelli Antunes

“…Understanding the interaction between cyclic stresses and corrosion of magnesium (Mg) and its alloys is increasingly in demand due to the continuous expansion of structural applications of these materials. …”
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Ozonolytic synthesis of 2-hydroxybenzyl alcohol for the production of gastrodin by A. H. Halstian, A. S. Hasanova, H. V. Tarasenko

“…Continuous monitoring of the current concentration of ozone, with the recording of the analysis results in the form of a kinetic curve, was carried out when ozone-containing gas passed through the curette at a certain wavelength of a monochromatic light source. …”
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Tracking development assistance for health from China, 2007–2017 by Angela E Micah, Catherine S Chen, Abigail Chapin, Joseph L Dieleman, Paul H Lee, Michael R Phillips, Kun Tang, Shenglan Tang, Jost Jonas, Shiwei Liu, Yingxi Zhao, Bianca S. Zlavog, Golsum Tsakalos, Stephen Gloyd, Man Tat Alexander Ng, Enrico Rubagotti, Mustafa Younis, Yunquan Zhang

“…However, relative to population size and government spending, China’s contributions are modest.Conclusion In the current context of plateauing in the growth rate of DAH contributions, China has the potential to contribute to future global health financing, especially financing for health system strengthening.…”
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Differences between the European and Eurasian Good Pharmacovigilance Practices by A. V. Matveev, A. E. Krasheninnikov, E. A. Matveeva, B. K. Romanov

“…However, the number of differences between the documents increases, as changes are made to the EU GVP. A more comprehensive harmonisation of the EAEU GVP with the current version of the EU GVP will make it possible to develop and use uniform pharmacovigilance documents in the EU and EAEU, and will facilitate the introduction of EAEU medicines into the global pharmaceutical market.…”
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Surface modification of aluminum on a silicon chip by citric acid treatment by Moataz Mekawy, Kazuya Iida, Akitsu Shigetou, Jin Kawakita

“…However, the inevitable formation of an oxide layer on its surface during atmospheric heat treatment accompanying the fabrication process increases surface resistivity. This necessitates a surface treatment to mitigate the negative effects of the oxide layer. …”
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Microbiological examination of aerosols and sprays by O. V. Gunar, N. G. Sakhno

“…Medicinal products formulated as aerosols and sprays are increasingly used in clinical practice, which makes the control of their quality, including microbiological testing, a highly topical issue. …”
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Insect farming: A bioeconomy-based opportunity to revalorize plastic wastes by Juan C. Sanchez-Hernandez, Mallavarapu Megharaj

“…Recently, increasing attention has focused on the potential of certain insect larvae species to chew, consume, and partially biodegrade synthetic polymers such as polystyrene and polyethylene, offering novel biotechnological opportunities for plastic waste management. …”
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Mesenchymal stem cell- derived exosomes as cell-free therapeutics for sensorineural hearing loss by Maria Perde-Schrepler, Ioana Brie, Alma Maniu

“…Stem cell therapies, particularly those involving mesenchymal stem cells (MSCs), are being increasingly explored in regenerative medicine. MSCs are multipotent cells capable of differentiating into mesodermal lineage cells and possess immunomodulatory and regenerative properties, making them potential candidates for SNHL treatment. …”
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The Circular Kitchen by Bas Jansen

“…While start-ups favor radical innovation, established manufacturers, like the CIK’s producer, opt for incremental improvements (outside of a research context). This suggests that when aiming for large-scale implementation that can only be reached with large-scale production, the feasibility of the design should be prioritized, while still improving environmental performance compared to current, non-circular kitchens. …”
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The Effect of Monetary Rewards on the Performance of Employees in an Organisation: A Case Study of Kabale District Local Government. by Nayebare, Gaston

“…Though, some of the major goals of training employees contain, increase in production, lesser labor turnover rate, higher confidence and better management and training facilitates to decrease cost as it enhances productivity, and promotes objective congruency. …”
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Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…Guiding Distributive Justice: Capability Theory Capability theory is an account of justice opportunity that places a fundamental moral significance on individuals' ability to reach proper functioning and well-being.[52] Whether or not an individual can make use of a particular set of resources and convert them into a state of functioning depends on personal, sociopolitical, and environmental conditions ("conversion factors").[53] In this sense, liberty is not the absence of restraint from others or institutions but the freedom achieved through capability-enhancing relationships.[54] Within the context of bioethics, capability theory shifts focus toward creating circumstances by which individuals can direct their lives as they choose.[55] Acting in accordance with the principle of beneficence, peer-support specialists could enhance the capability of patients to be self-determined and autonomous, which would promote patient well-being and empowerment.[56] Those living with SMI, such as schizophrenia and bipolar disorder, are among the most disadvantaged in society, experiencing social and economic hardship related to their illness.[57] These individuals are often feared and rejected by others, which increases depression, lowers self-esteem, and engenders feelings of social isolation.[58] Compounding their challenges, especially for those facing structural inequalities, is insufficient access to appropriate mental health services supporting recovery.[59] Capability theory provides a sound justification for the resource distribution necessary to create and sustain a thriving network of peer-support specialists, to which those with SMI currently do not have access. …”
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SISTEMAS FISIOGRÁFICOS DEL ÁREA NATURAL PROTEGIDA “VALLE CRETÁCICO”, PROVINCIA DE RÍO NEGRO by Romina Solorza, Marcos D. Mare

“…The physiographic systems study shows that there is a marked susceptibility to the erosion processes increase, especially gully erosion. The natural vegetation, as a consequence of its physiognomic characteristics adapted to semiarid and mesothermal climate and of the historical social land use overloading , currently presents a low coverage, associated with low levels of soil aggregation. …”
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The human long noncoding RNAs CoroMarker, MALAT1, CDR1as, and LINC00460 in whole blood of individuals after controlled short-term exposure with ultrafine metal fume particles at wo... by Theresa Scheurer, Jan Steffens, Agnieszka Markert, Miriam Du Marchie Sarvaas, Christoph Roderburg, Lothar Rink, Frank Tacke, Tom Luedde, Thomas Kraus, Ralf Baumann

“…Results In THP-1 macrophages, we observed a 2.3-fold increase of CDR1as at 1 h (Wilcoxon p = 0.03), a non-significant increase of CoroMarker at 1 h, and an increase of LINC00460 at 2 h (p = 0.03) and at 4 h (p = 0.06). …”
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Potential therapeutic effects of IL28RA inhibition on acute myocardial infarction through phosphorylated JAK1/STAT1 signaling pathways by Ge Gong, Xiangxuan Chen, Xinghu Zhang, Jian Yin, Wenhui Wan

“…Abstract While current coronary intervention therapies and surgical bypass procedures are widely utilized, the treatment of acute myocardial infarction (AMI) in the elderly continues to pose significant challenges. …”
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Characteristics, outcomes, and maternity care experiences of women with children’s social care involvement who subsequently died: national cohort study and confidential enquiry by Marian Knight, Abigail Easter, Jane Sandall, Elsa Montgomery, Nicola Vousden, Emma Rose, Claire Mason, Kirsty Kitchen, Kaat De Backer, Allison Marjorie Felker, Caroline Bull, Oluwaseun Labisi

“…Multiple individual and systemic barriers hindered access and engagement with healthcare.Conclusions Women with CSC involvement who died during or in the year after pregnancy encountered multiple inequalities and were at an increased risk of maternal mortality from psychiatric causes and homicide. …”
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The Problem of Ensuring Maritime Security in the Asian Region by V. N. Koval, S. V. Ochkurenko, S. A. Vasiliev

“…As a territorial scope, interstate relations of Asian countries, including Russia, were considered as the most promising and interesting region from a scientific point of view, including in the context of increased measures of negative economic pressure on Russia from a number of states in North America and Europe. …”
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