Transcriptomic analysis on pancreatic adenocarcinoma patients uncovers KRAS-mediated PPAR pathway alteration by Giuseppe Defazio, Federico Scolari, Sara Fancelli, Simone Polvani, Daniele Lavacchi, Lucia Picariello, Alessandro Tubita, Michaela Luconi, Lorenzo Antonuzzo, Lorenzo Antonuzzo, Andrea Galli, Serena Pillozzi

“…The incidence and mortality of pancreatic adenocarcinoma (PC) are expected to increase in the coming years, with survival rates remaining poor due to limited treatment options. …”
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Tuberculosis mortality and drug resistance among patients under TB treatment before and during COVID-19 in Burundi: a case–control study by Arnaud Iradukunda, Fentabil Getnet, Emmanuel Nene Odjidja

“…Conclusion TB mortality increased during the COVID-19 pandemic, particularly among MDR-TB patients. …”
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Assessment of Reader Technologies for Over-the-Counter Diagnostic Testing by Mia Cirrincione, Maren Downing, Kevin Leite, Samuel Dolphin, Adam Samuta, Mack Schermer, Kimberly Noble, Brian Walsh

“…Reader technology type, which is predictive of core reader attributes, should be considered when selecting a reader technology for a specific LFA test within the context of regulatory guidance. As diagnostics increase in complexity, readers provide solutions to accessibility challenges, facilitate public health reporting, and ease the transition to multiplex testing, therefore increasing market availability.…”
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Defining, assessing, and implementing organizational health literacy: barriers, facilitators, and tools – a systematic review by Nicola Pelizzari, Loredana Covolo, Elisabetta Ceretti, Carlotta Fiammenghi, Umberto Gelatti

“…Abstract Background Organizational health literacy (OHL) is increasingly recognized as a fundamental aspect of high-quality healthcare delivery, focusing on organizations’ roles in enabling patients to access, understand, and use health information effectively. …”
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Co-benefits of resilience planning: a review of analysis tools and methods by Jennifer F. Helgeson, Azin Al Kajbaf, Juan F. Fung

“…Fung and Helgeson reviewed the literature on co-benefits with a specific focus on the definition of co-benefits, areas where co-benefits are used the most (considering the literature related to climate change), and co-benefit measurement and assessment methodologies in the context of resilience planning. The current study further explores these areas by focusing on the development of the literature on co-benefits published since 2017. …”
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CMIP6 multi-model ensemble projection of reference evapotranspiration using machine learning algorithms by Milad Nouri, Shadman Veysi

“…This highlights the critical necessity for adaptive strategies in agricultural water management to mitigate the adverse CC effects. In this context, the current findings can assist decision-makers in identifying hotspots and quantifying CC impacts, thereby enabling the design of crucial adaptations.…”
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Insurtech innovations and telematics as «drivers» of change in the insurance industry by A.Yu. Polchanov, K.O. Halatiuk

“…The purpose of the article is to analyze the impact of the introduction of innovative technologies (Insurtech) and telematics on the development of the insurance market in the context of increasing globalization trends. Results. …”
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Modelling the supply and need for health professionals for primary health care in Ghana: Implications for health professions education and employment planning. by James Avoka Asamani, Christmal Dela Christmals, Gerda Marie Reitsma

“…As Ghana's population increases and the disease burden doubles, it is imperative to estimate the potential supply and need for health professionals; and the level of investment in health professions education and employment that will be necessary to avert any mismatches.…”
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ANALYSIS OF THE PROFITABILITY - FINANCIAL POSITION CORRELATION by CĂRUNTU GENU ALEXANDRU

“…Economic-financial analysis plays an essential role in understanding the current context and in ensuring favorable results in the future. …”
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Topological transformation of microbial proteins into iron single-atom sites for selective hydrogen peroxide electrosynthesis by Xiaofeng Xiao, Zechao Zhuang, Shuhu Yin, Jiexin Zhu, Tao Gan, Ruohan Yu, Jinsong Wu, Xiaochun Tian, Yanxia Jiang, Dingsheng Wang, Feng Zhao

“…These moieties resemble the structural features of nonheme Fe-dependent enzymes while being effectively confined on a microbe-derived, electrically conductive carbon support, enabling high-current density electrolysis. A comparative analysis involving catalysts derived from eleven representative microbes reveals that the presence of 0.05 wt% Fe single-atom sites leads to a significant 26% increase in hydrogen peroxide selectivity. …”
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The new peas variety “Pamyati Popova” by F. A. Davletov, G. М. Nigmatullina, К. P. Gaynullina, А. V. Pleshkov, F. F. Safn

“…According to the Competitive Variety Testing, the average yield increase of the variety “Pamyati Popova” was on 3.9 hwt/ha in 2016–2019. …”
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Effect of Tin Oxide/Black Paint Coating on Absorber Plate Temperature for Improved Solar Still Production: A Controlled Indoor and Outdoor Investigation by Sayfar Rasachak, Rana Sami Ullah Khan, Laveet Kumar, Taiba Zahid, Usman Ghafoor, Jeyraj Selvaraj, Rehena Nasrin, Muhammad Shakeel Ahmad

“…The ever-increasing water stress and availability of fresh drinking water are becoming a major challenge in rural and urban communities. …”
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N-Acetyl-cysteine and Mechanisms Involved in Resolution of Chronic Wound Biofilm by Xin Li, Jane Kim, Jiabin Wu, Alaa’ I Ahamed, Yinsheng Wang, Manuela Martins-Green

“…Mechanistically, we show that NAC can penetrate the bacterial membrane, increase oxidative stress, and halt protein synthesis. …”
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Non-linear oral bioavailability and clinical pharmacokinetics of high-dose Andrographis paniculata ethanolic extract: relevant dosage implications for COVID-19 treatment by Phanit Songvut, Jaratluck Akanimanee, Tawit Suriyo, Nanthanit Pholphana, Nuchanart Rangkadilok, Duangchit Panomvana, Porranee Puranajoti, Jutamaad Satayavivad

“…The maximum plasma concentration (Cmax) of andrographolide did not exhibit a dose-proportional increase, reaching 6.44 and 11.62 µg/L for single and repeated doses of 60 mg/day, respectively. …”
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Stability and change in latent movement behaviour profiles during adolescence and links with future depressive symptoms by Christopher Knowles, Gavin Breslin, Angela Carlin, Kyle Paradis, Stephen Shannon

“…During adolescence, daily movement diminishes while depressive symptoms increase. The principle of time displacement dictates that when awake, altering time spent in one movement state (i.e., Sedentary, Light Physical Activity or Moderate-to-Vigorous Physical Activity) necessarily alters time spent in others, yet few studies examine daily movement behaviour using composite behavioural profiles. …”
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TIM-3 teams up with PD-1 in cancer immunotherapy: mechanisms and perspectives by Zhuohong Yan, Chunmao Wang, Jinghong Wu, Jinghui Wang, Teng Ma

“…Among these candidates, T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is considered a promising target. …”
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Descriptive, analytical and molecular epidemiology of pancreatic cancer by O. V. Shangina, D. M. Maximovich, D. G. Zaridze

“…The purpose of the study was to present current data on the role of lifestyle and heredity factors in the etiology of pancreatic cancer (PC). …”
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An integrated knowledge mobilization approach to substance use health by Sheena Taha, Shea Wood, Chandni Sondagar, Eftyhia Helis, Doris Payer, Miguel Hernandez-Basurto

“…Through an iterative process of generating and mobilizing knowledge (for example, supporting the scale and spread of innovations, developing new tools and generating or tailoring evidence for a specific audience/context/substance/setting, among others), outputs such as increased awareness, knowledge, use of information and strengthened capacity occur. …”
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A second horizon scan of biogeography: Golden Ages, Midas touches, and the Red Queen by Michael N Dawson, Jan C. Axmacher, Carl Beierkuhnlein, Jessica L. Blois, Bethany A. Bradley, Anna F. Cord, Jürgen Dengler, Kate S. He, Lawrence R. Heaney, Roland Jansson, Miguel D. Mahecha, Corinne Myers, David Nogués-Bravo, Anna Papadopoulou, Björn Reu, Francisco Rodríguez-Sánchez, Manuel J. Steinbauer, Alycia Stigall, Mao-Ning Tuanmu, Daniel G. Gavin

“…., advances in genetics, remote sensing, modeling) that promote studies with increasing detail and at increasing scales; disciplinary breadth is being diversified (e.g., by developments in paleobiogeography and microbiology) and integrated through the transfer of approaches and sharing of theory (e.g., spatial modeling and phylogenetics in evolutionary–ecological contexts). …”
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Evolution of standardization of therapeutic and diagnostic allergens produced in Russia by S. S. Masalskiy, E. I. Sakanyan, M. A. Yasnaya

“…A method of competitive enzyme-linked immunosorbent assay using specific sera containing specific IgE antibodies is used for this purpose.In addition, the specific activity of allergen preparations is certified through three additional characteristics: total protein content (using the Bradford method), protein profile (through electrophoresis in a polyacrylamide gel with sodium dodecyl sulfate under reducing conditions), and authenticity through the presence of major specific components, which is determined by the Western blot method using sera containing IgE antibodies specific for the corresponding allergen.Currently, in the Russian Federation, the standardization of therapeutic and diagnostic allergens is conducted simultaneously according to two indicators: protein nitrogen content, expressed in Protein Nitrogen Units (PNU), and allergenic (specific) activity expressed in units of allergenic activity per milliliter (EAA/ml). …”
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