Pharmacometric in silico studies used to facilitate a national dose standardisation process in neonatology – application to amikacin by Verena Gotta, Julia Anna Bielicki, Paolo Paioni, Chantal Csajka, Dominic Stefan Bräm, Christoph Berger, Elisabeth Giger, Michael Buettcher, Klara M. Posfay-Barbe, John van den Anker, Marc Pfister

“…Simulations showed that extending the dosing interval to ≥36 h in the subpopulation of clinical concern increased the frequency of a desirable Ctrough below 5 mg/l to >80%. …”
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Testosterone-induced erythrocytosis: addressing the challenge of metabolic syndrome and widely prescribed SGLT2-inhibitor drugs by Federica Tramontana, Azmi Mohammed, Yaasir H Mamoojee, Richard Quinton

“…Crucially, they also increase haematocrit by promoting haematopoiesis. This review focuses on the current best evidence for managing erythrocytosis, in the context of more prevalent obesity and prescriptions of testosterone and SGLT2i in this population. …”
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Mitochondrial Reactive Oxygen Species Dysregulation in Heart Failure with Preserved Ejection Fraction: A Fraction of the Whole by Caroline Silveira Martinez, Ancheng Zheng, Qingzhong Xiao

“…In this review, we will provide an overview and discussion of the recent findings on mtROS production, its threshold for imbalance, and the subsequent dysfunction that leads to related cardiac and systemic phenotypes in the context of HFpEF. We will also focus on newly discovered cellular and molecular mechanisms underlying ROS dysregulation, current therapeutic options, and future perspectives for treating HFpEF by targeting mtROS and the associated signal molecules.…”
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Objects of forensic documentary science by V. S. Sezonov

“…The increase in the number of offences requiring the examination of electronic data storage devices poses new challenges for forensic experts, requiring modern means of recording and comparing them with standards. …”
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Psychiatry and Sports Medicine by Roeh A, Hasan A

“…We discuss the findings in the context of their implementation in current treatment guidelines: The guidelines only provide general advice and no concrete statements regarding type, duration and intensity of exercise therapies, as the existing studies varied in their methodology. …”
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Digital-Inclusive Transformation and Teacher Preparedness for Foreign Language Education – A Bilateral German-Norwegian Perspective by Solveig Chilla, Gerard Doetjes, Karin Vogt, Lina Abed Ibrahim, Dina Tsagari

“…Researchers in the field state a pressing need to increase digital-inclusive transformation uptake in foreign language teacher education programmes to develop a transformation ‘mindset’ in (educational) stakeholders and (future) teachers. …”
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Modern ideas about the role of the galaninergic system in the pathogenesis of heart failure and myocardial remodeling by A. A. Yafarova, A. R. Kiselev, A. F. Sheptulina, O. M. Drapkina

“…In this regard, the search for new molecules for therapeutic action aimed at preventing myocardial remodeling is of undoubted interest. In this context, the galaninergic system seems to be a promising target. …”
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Development and evaluation of superhydrophobic carbon nanotube coatings onmaraging steel: Corrosion protection, and anti-fouling characteristics by F.abdel Mouez, H. Halfa, Ahmed Yahia, H.M. Hussien, Mohab Gaber, Heba H. Ali

“…Atomic force microscopy indicated a substantial increase in surface roughness, contributing to the superhydrophobic behavior. …”
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Evaluation of Urban Composite Carbon Sink Value: A Case Study of Shenyang by Tiemao SHI, Di WANG, Yu TANG, Peiying LI

“…The proportion of carbon sink value contributed by vegetation and soil decreased from 43.61% and 46.15% in 2003 to 34.70% and 36.62% respectively, whereas the proportion contributed by buildings increased from 10.24% to 28.70%.ConclusionThe important contribution of urban space to carbon sinks in terrestrial ecosystems should not be ignored. …”
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A Sociological Study of Monetary Attitudes among Citizens of Tehran by Nahid Abdoli, Asadollah Babaiefard

“…IntroductionAs the physical form of money increasingly gives way to digital representations in electronic societies, its role continues to transform. …”
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STUDENT ATTITUDES TOWARD THE USE OF CHATBOTS IN CUSTOMER SERVICE by Iwona Lupa-Wójcik

“…The article addresses an important and current problem related to the use of chatbots in customer service, according to students. …”
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Effects of ultrasonic vibration on residual stress distribution and local mechanical properties of AA6061/Ti6Al4V dissimilar joints by resistance spot welding by Mohan He, Qian Wang, Yingjun He, Jinxiang Wang, Ninshu Ma, Yuanxun Wang

“…The maximum load of welding nugget region increased from 19.6 N to 22.3 N, and the elongation obtained 10% increase. …”
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Assessing climate change impacts on Pacific salmon and trout using bioenergetics and spatiotemporal explicit river temperature predictions under varying riparian conditions. by Andrew R Spanjer, Andrew S Gendaszek, Elyse J Wulfkuhle, Robert W Black, Kristin L Jaeger

“…Under the current thermal regime, bioenergetics modeling predicts juvenile fish lose weight in the lower river; this loss of potential growth worsens by an average of 20-83% in the lower river by 2080, increasing with the loss of riparian shading. …”
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Evaluation of Asthma Course in Patients Hospitalized in Pediatric Intensive Care Unit Due to Severe Asthma Exacerbation by Ahmet Selmanoglu, Hatice Irmak Celik, Cankat Genis, Esra Kockuzu, Zeynep Sengul Emeksiz, Emine Dibek Misirlioglu

“…Post-discharge, 72.3% of patients continued follow-up at pediatric allergy clinics. Of the 60 patients contacted, 67.5% were on current asthma treatment and 48.2% had experienced an exacerbation in the past year. …”
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THE SOURCES OF COMPETITIVE ADVANTAGES OF ELECTRIC SCOOTER SHARING SERVICES by S. V. Ilkevich

“…In the past few years, there has been a sharp increase in the need for both conceptualizations and applied research on the current radical reformatting of urban mobility. …”
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Climate change reduces warming potential of nitrous oxide by an enhanced Brewer‐Dobson circulation by Daniela Kracher, Christian H. Reick, Elisa Manzini, Martin G. Schultz, Olaf Stein

“…N2O is a potent greenhouse gas and the most relevant currently emitted ozone‐depleting substance. Here we examine the implications of a reduced N2O lifetime in the context of climate change. …”
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ISSUES AND TRENDS OF PROGRESS TOWARDS SUSTAINABLE DEVELOPMENT GOALS IN ROMANIA by Dumitru Florin FRONE, Simona FRONE

“…Monitoring SDG 12 in an EU context focuses on progress made in decoupling environmental impacts from economic growth, in decreasing energy consumption and in tackling waste generation and management. …”
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Impact of demographic ageing on sustainability of public finance in Serbia by Zdravković Aleksandar, Domazet Ivana, Nikitović Vladimir

“…In this context, critical review of the current government approach to the pension growth dynamics was given from the perspective of medium-term sustainability of pension system, which resulted in appropriate recommendations. …”
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Unveiling biomarkers via plasma metabolome profiling for diabetic macrovascular and microvascular complications by Zhixi Li, Yuhan Ren, Feng Jiang, Kai Zhang, Xuan Meng, Yingfeng Zheng, Mingguang He

“…As for reverse MR, DN was relevant to decreased level of serum ratio of docosahexaenoic acid to total fatty acids (OR = 0.97, 95% CI 0.95–0.99, P = 0.019), increased level of the ratio of triglycerides to total lipids in very large VLDL (OR = 1.03, 95% CI 1.01–1.05, P = 0.019), and pyruvate (OR = 1.03, 95% CI 1.01–1.05, P = 0.046). …”
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What ‘unexplored’ means: mapping regions with digitized natural history records to look for ‘biodiversity blindspots’ by Laymon Ball, Sheila Rodríguez-Machado, Diego Paredes-Burneo, Samantha Rutledge, David A. Boyd, David Vander Pluym, Spenser Babb-Biernacki, Austin S. Chipps, Rafet Ç. Öztürk, Yahya Terzi, Prosanta Chakrabarty

“…We also argue for increased scientific infrastructure so that more reference collections with vouchers can be kept in the countries of origin (particularly those countries lacking such infrastructure currently).…”
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