Phenotypic and functional changes of NK cells in patients with myelodysplastic syndrome and acute myeloid leukemia treated with hypomethylating drugs by D. I. Zhigarev, M. V. Khoreva, L. V. Gankovskaya

“…Meanwhile, the origin of this change and its role are important in the context of the disease pathogenesis. Ultimately, a simple description of an increase or decrease in a single receptor expression is not illustrative, since it can lead to uncertain consequences. …”
Get full text

Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH). by Jessica Min-DeBartolo, Franklin Schlerman, Sandeep Akare, Ju Wang, James McMahon, Yutian Zhan, Jameel Syed, Wen He, Baohong Zhang, Robert V Martinez

“…Activation of PPARα pathway was supported by observed decrease in serum lipid levels. Our findings provide important insights into the role of TSP-1 in context of NAFLD/NASH and TSP-1 may be a target of interest to develop anti-fibrotic therapeutics for NAFLD/NASH.…”
Get full text

Teaching English Oral Expressionand Listening Comprehension at the Department ofLetters and English Language, University of Constantine 1: Past and Present Ups and Downs by Youcef BEGHOUL

“…It also suggests some solutions for a more practical teaching of these two crucial skills in a pedagogical context characterized by ever decreasing linguistic and cultural levels and more and more overcrowded classes.…”
Get full text

Investigating the Relationship between Types of Deprivation and Social Tolerance among Citizens of Tehran by Negar Firouzeh, Khadijeh Safiri

“…Specifically, as these forms of deprivation increased (excluding political deprivation), social tolerance tended to decrease. …”
Get full text

STATISTICAL ANALYSIS OF PRELIMINARY STUDIES FOR HEMP CONCRETE by Laurentiu ADAM, Dorina-Nicolina ISOPESCU, Loredana JUDELE, Roxana Dana BUCUR, Daniel LEPADATU

“…Waste is a major worldwide problem and its recycling has become mandatory in the current context of the decrease in natural resources. …”
Get full text

Virtual reality in the luxury fashion industry: a systematic literature review by Tong (Tripp) Liu, Caroline Swee Lin Tan, Carolina Quintero Rodriguez

“…By integrating current practice and existing research, this paper contributes to a better understanding of how and where VR is used in luxury fashion contexts.…”
Get full text

Wisdom of the Established Pattern by Joel Janhonen

“…According to their example, if someone is opposed to increasing as well as decreasing the average human intelligence, they need a good reason for why the current level is optimal. …”
Get full text

Effects of ibrutinib and venetoclax on the expression of immune checkpoint molecules in leukemic blasts of patients with acute lymphoblastic leukemia by Armin Dozandeh-Jouybari, Fatemeh Mousavi-Mirkalaei, Saeid Taghiloo, Hossein Karami, Mohammad Naderisorki, Ehsan Zaboli, Mohammad Eslami-Jouybari, Tohid Kazemi, Hossein Asgarian-Omran

“…Following treatment, the proliferation of leukemic cells was significantly decreased and the apoptosis rate was significantly increased, which was more remarkable for venetoclax. …”
Get full text

Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Results Our findings showed that CL-NPs loaded with anti-NOTCH1/-SF3B1 siRNAs-PTX significantly suppressed NOTCH1 and SF3B1 expression in PBMCs and BMMCs isolated from CLL cases in comparison with the untreated samples, leading to increased leukemic cell sensitivity to PTX and decreased the proliferative capacity of leukemic cells. …”
Get full text

Effect of Educational Intervention Guideline on Quality of Life among Women with Polycystic Ovary Syndrome by Aziza I. Mohamed, Shimaa A. Moustafa

“…Methods: The current study conducted at the outpatient gynecological clinic at Benha University Hospital. …”
Get full text

Identity and engagement in networked Open Educational Practice by Katerina Zourou

“…To unleash the potential of OER, current research lays emphasis on Open Educational Practice (OEP), as the (re-)use of open resources in learning and teaching contexts. …”
Get full text

Social and non-social risk-taking in adolescence by Weike Wang, Kylie Evans, Susanne Schweizer

“…This is in contrast with adolescent-typical behaviour, which is characterised by heightened risk-taking in social contexts. The current study aimed to investigate how low self-perceived social value influences risk-taking in social compared to non-social contexts during adolescence. 114 adolescents (aged 12–23 years) completed the Balloon Analogue Risk Task (BART) in individual and social contexts. …”
Get full text

Assessment of Sexual Functions among Infertile Women by Azza A. Mohamed, Aziza A. Attia, Hanan A. Mahjoub

“… Context: Sexual function plays a vital role in the quality of life and is determined by both biological and psychosocial factors. …”
Get full text

Advancing Energy Transition: A Circular Economy Framework for Co-Optimizing Energy, Water, and Emissions in Low-Carbon Systems by Mohamed Elsir, Ameena Saad Al-Sumaiti, Mohamed Shawky El Moursi

“…Current models fail to address the dynamic interplay between RES, CC, and desalination, especially given the complexities of temperature-sensitive desalination processes and operational uncertainties. …”
Get full text

ISSUES AND TRENDS OF PROGRESS TOWARDS SUSTAINABLE DEVELOPMENT GOALS IN ROMANIA by Dumitru Florin FRONE, Simona FRONE

“…Monitoring SDG 12 in an EU context focuses on progress made in decoupling environmental impacts from economic growth, in decreasing energy consumption and in tackling waste generation and management. …”
Get full text

A Comparative Approach of Cultural Intelligence Profile of Management and Non-Management Romanian Students by Laura BRANCU, Valentin MUNTEANU, Ionut GOLET

“…Cultural intelligence (CQ) is defined as the as individuals’ ability to act efficiently in different cultural contexts. Due to a significant growth of Internet-based communication, enabling virtual work teams, geographically and culturally dispersed (Stanko & Gibson , 2009), and to increased globalization over the past 20 years, the number of people who currently get in touch with other cultures has grown significantly (Eisenberg et al., 2013). …”
Get full text

Optimising Connectivity and Energy: The Future of LoRaWAN Routing Protocols for Mobile IoT Applications by Izzah N. Buang, K. Zen, Syahrul N. Junaini

“…The proliferation of Internet of Things (IoT) applications has significantly increased the demand for communication protocols that are both resilient and energy-efficient. …”
Get full text

Practitioners’ Needs for Addressing the Challenges of Sea‐Level Rise—A Qualitative Assessment by D. Hirschfeld, K. M. Archie, E. Mateo, J. C. Arnott, J. A. Vano

“…Abstract Practitioners at the local and regional scale are under increased pressure to reduce risks to people and property posed by the threats of sea‐level rise (SLR) and associated impacts. …”
Get full text

The Immune Environment in Colorectal Adenoma: A Systematic Review by Ugne Silinskaite, Jurate Valciukiene, Matas Jakubauskas, Tomas Poskus

“…<b>Methods:</b> In this systematic review, we aim to provide a thorough analysis of the current research examining the immune infiltration patterns in sporadic colorectal adenoma tissues in the context of immune cell-based, cytokine-based, and other immunological factor-related changes along the conventional adenoma–carcinoma sequence. …”
Get full text

Neutrophil-to-Lymphocyte ratio as surrogate for JAK2V617F suppression and event-free survival in polycythemia vera by Tiziano Barbui, Arianna Ghirardi, Victoria Empson, Francesca Fenili, Giuseppe Gaetano Loscocco, Annalisa Condorelli, Alessandra Iurlo, Daniele Cattaneo, Elena Rossi, Valerio De Stefano, Paola Guglielmelli, Christoph Klade, Heinz Gisslinger, Alessandro Rambaldi, Joseph M. Scandura, Alessandro Maria Vannucchi

“…Abstract Chronic systemic inflammation is a key driver of polycythemia vera (PV) progression, but the immunomodulatory effects of current treatments remain poorly defined. The neutrophil-to-lymphocyte ratio (NLR) is an accessible biomarker of systemic inflammation proven in other contexts, but its role in monitoring PV disease activity has not been established. …”
Get full text