Kalirin, a Key Player in Synapse Formation, Is Implicated in Human Diseases by Prashant Mandela, Xin-Ming Ma

“…In cultured hippocampal/cortical neurons, overexpression of Kalirin-7 increases spine density and spine size whereas reduction of endogenous Kalirin-7 expression decreases synapse number, and spine density. In Kalirin-7 knockout mice, spine length, synapse number, and postsynaptic density (PSD) size are decreased in hippocampal CA1 pyramidal neurons; these morphological alterations are accompanied by a deficiency in long-term potentiation (LTP) and a decreased spontaneous excitatory postsynaptic current (sEPSC) frequency. …”
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Development and biomechanical evaluation of a 3D printed analogue of the human lumbar spine by Siril Teja Dukkipati, Mark Driscoll

“…Moreover, there are increasing ethical concerns with human dissection practices. …”
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Building a Robust Scenario Library for Safety Assurance of Automated Driving Systems: A Review by Antonio A. Bruto da Costa, Patrick Irvine, Tudor Dodoiu, Siddartha Khastgir, Paul Jennings

“…While every region has its specificities, certain contexts pose particular difficulties in scenario development. …”
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Recent research progress on metal ions and metal-based nanomaterials in tumor therapy by Yongcheng Xu, Aikebaier Reheman, Wenhua Feng, Wenhua Feng, Wenhua Feng

“…In addition, tumor recurrence and metastasis are also difficult problems faced in clinical treatment. In this context, the importance of metal-based nanomaterials in tumor therapy is increasingly highlighted. …”
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The Ecological Restoration Strategies in Terrestrial Ecosystems Were Reviewed: A New Trend Based on Soil Microbiomics by Yuanqi Zhao, Xiaojuan Yuan, Weiwei Ran, Zhibing Zhao, Di Su, Yuehua Song

“…This review aims to address the ecological crises currently experienced by diverse terrestrial ecosystems and to provide a comprehensive overview of the specific practices of soil microorganisms in the context of ecological restoration. …”
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WARFARIN AND ITS IMPORTANCE IN THE ERA OF NEW ORAL ANTICOAGULANTS. ISSUES OF MONITORING THE EFFECTIVENESS AND SAFETY OF TREATMENT by S. Yu. Martsevich, Y. V. Lukina

“…The use of OAC in AF has an extensive evidence base, which confirms a significant decrease in the number of strokes and total mortality in the context of anticoagulation therapy (ACT) in AF. …”
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Shifting of Distribution and Changing of Antibiotic Resistance in Gram-Positive Bacteria from Bile of Patients with Acute Cholangitis by Hao Y, Li L, Du W, Lu J

“…Yuqi Hao,1 Lianxin Li,2 Wenting Du,1 Jinshuai Lu1 1Department of General Internal Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China; 2Endoscopy Center, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of ChinaCorrespondence: Jinshuai Lu, Department of General Internal Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China, Email lujinshuai@xjrmyy.comBackground: Gram-negative bacteria are the predominant pathogens responsible for biliary infections; however, the prevalence of Gram-positive bacteria is currently increasing. Investigating the bacterial spectrum and evolving antibiotic resistance patterns of Gram-positive bacteria is crucial for optimizing the management of acute cholangitis, particularly in the context of the global rise in antibiotic resistance.Methods: This retrospective analysis focused on Gram-positive bacteria isolated from the bile of patients undergoing biliary drainage with acute cholangitis at our hospital from January 1, 2018, to March 31, 2024. …”
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Production of potassium hydroxide-activated biochar and its use as a filler in polylactic acid for food packaging by Serhat Balcı, Zeynep İrem Özyörü, Filiz Uğur Nigiz

“…Among various biopolymers, poly(lactide) (PLA) has found application in the food industry owing to its promising properties and is currently one of the most industrially produced bioplastics. …”
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Archéologie et nouvelles technologies appliquées à l’étude des dynamiques contemporaines de destruction du patrimoine culturel : le cas du pillage en Méso-Amérique by Aura Fossati

“…Archaeology is increasingly delving into the study of recent phenomena, seeking to understand current social practices to address contemporary societal challenges. …”
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A Study of Observed Climate Change Effects on Grapevine Suitability in Oltenia (Romania) by Mihaela Licurici, Alina Ștefania Vlăduț, Cristina Doina Burada

“…Viticulture represents an important agricultural sector in Oltenia, which is one of the Romanian regions most affected by temperature increases. The main purpose of the present study was to analyze the changes in climate suitability for grapevine and wine production against this climate context in the region. …”
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Paradigm shift: outcomes from a physician-scientist undergraduate pathway program by Alana C. Jones, Tyler R. McCaw, Randy L. Seay, Brian Sims, Robin G. Lorenz

“…Results Since its establishment in 2014, PARAdiGM is already increasing entry of URiM students into the physician-scientist pathway. …”
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SOME ASPECTS OF ADMINISTRATIVE-LEGAL REGULATION OF ACTIVITY OF EXECUTIVE POWER BODIES IN THE DIGITAL REALITY by B. Koybaev, Z. Zoloeva

“…As you know, the development of the information society is currently associated with the implementation of projects for the development of the digital economy. …”
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“It’s supposed to be real meat” – An analysis of media coverage of the first United States sales approval of cell-cultivated chicken by Alejandra Sofia Marquez, Ellen Messer, Suzannah Gerber, Sean B. Cash

“…The findings in this study can be utilized by industry stakeholders, policymakers, and academics to determine what information is currently being communicated to consumers through the media and how this information might be influencing consumers’ perceptions of cell-cultivated meat.…”
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SETup automotive: a Method for Systems Engineering Transformation in automotive industry by Iris Graessler, Benedikt Grewe

“…With this in mind, systems engineering (SE) is currently being introduced on a large scale into the automotive industry. …”
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Exploring the Role of EU Subsidies in Enhancing the Competitiveness of Slovak Farms by Ivana Kravčáková Vozárová, Rastislav Kotulič

“…The competitiveness of Slovak farms is currently strongly influenced not only by internal factors such as productivity, innovation, and management, but also by external factors, especially political and economic decisions at the EU level. …”
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Learner Engagement in Using Kahoot! within a University English Proficiency Course by Mohd Zulfadli Mat Husin, Ruhil Amal Azmuddin

“…Background/purpose – Game-based learning is becoming increasingly popular among educators in higher institutions. …”
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A Study on Macroeconomic Variables’ Effect on Unemployment across Europe by Flavius Ilie Radac, Vasile Paul Bresfelean, Cristina Roxana Tănăsescu

“…Due to the economic crisis of 2008, there was a significant increase in unemployment rates in several European countries, with notable impacts in some countries like Romania, Greece, Portugal, Spain, and Italy. …”
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Detecting and Responding to a Dengue Outbreak: Evaluation of Existing Strategies in Country Outbreak Response Planning by Julia Harrington, Axel Kroeger, Silvia Runge-Ranzinger, Tim O'Dempsey

“…Dengue outbreaks are occurring with increasing frequency and intensity. Evidence-based epidemic preparedness and effective response are now a matter of urgency. …”
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From Radicalism to Conformism: Post-Soviet Ideological Trajectory of Russian Communist Party in 1993–2022 by Georgy A. Mayorov

“…Currently, the Communist Party is going through a contradiction between radical rhetoric and conformist practice. …”
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Counterfactual choice and learning in a neural network centered on human lateral frontopolar cortex. by Erie D Boorman, Timothy E Behrens, Matthew F Rushworth

“…Although the neural system responsible for tracking the value of choices actually taken is increasingly well understood, whether a neural system tracks counterfactual information is currently unclear. …”
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