Hypertonic Activity of Injection Solutions Can Cause Post-injection Complications (Review) by A. L. Urakov, N. A. Urakova, Z. V. Shubina, L. V. Lovtsova, A. V. Samorodov, K. G. Gurevich, A. P. Stolyarenko, V. I. Korunas, D. O. Lipatov, D. D. Muminov

“…Therefore, currently injectable solutions considered to be of high quality may not have isotonic activity and high postinjection safety.Text. …”
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Gut opportunistic pathogens contribute to high-altitude pulmonary edema by elevating lysophosphatidylcholines and inducing inflammation by Xianduo Sun, Gaosheng Hu, Yuting Li, Wenjing Li, Yong Wang, Hui Yan, Guoqing Long, Long Zhao, Anhua Wang, Jingming Jia

“…We performed a fecal microbiome analysis and found a significant decrease in intestinal Klebsiella and Escherichia-Shigella, along with a notable increase in intestinal Bifidobacterium and Lactobacillus, as volunteers recovered from acute mountain sickness (AMS). …”
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Repetitive transcranial magnetic stimulation use in neuropathic pain with comorbid depression: a review of efficient treatment protocols’ parameters by D. S. Astafyeva, Ya. V. Vlasov, A. I. Strelnik, O. V. Chigareva, E. A. Markina, T. I. Shishkovskaya, D. A. Smirnova, A. Ya. Gayduk

“…Across the data analysis we evaluated such rTMS parameters as the type of a coil, type of stimulation area, locus of gained evoked motor potential, amplitude of stimulation, duration of session, frequency/number of sessions per day/month, tie duration between sessions, number and frequency of trains, amount and frequency of pulses containing and efficacy of treatment. Those studies that performed repetitive transcranial magnetic stimulation using the figure‑of‑8 coil over the M1 brain area, for 10 or more daily sessions with duration from 7 up to 40 minutes, of 10–20 Hz frequency, intensity 80–90 % of resting motor threshold and total pulses number over 1500 per session demonstrated the greater efficacy in pain level decrease and depression scores reduction among neuropathic pain patients with comorbid depression. …”
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Preliminary results on novel adjuvant combinations suggest enhanced immunogenicity of whole inactivated pandemic influenza vaccines by Allegra Peletta, Aurélie Marmy, Samo Guzelj, Alcidia Ramos Barros, Žiga Jakopin, Gerrit Borchard

“…Adjuvanted influenza vaccines can increase immune responses, thereby achieving better protection and cross-reactivity to help contain the spread of the disease. …”
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Biooxidation of Arsenopyrite by <i>Acidithiobacillus ferriphilus</i> QBS 3 Exhibits Arsenic Resistance Under Extremely Acidic Bioleaching Conditions by Run Liu, Siyu Liu, Xiaoxuan Bai, Shiping Liu, Yuandong Liu

“…As described in this paper, through arsenic acclimation, the maximum arsenic tolerance concentration of <i>Acidithiobacillus ferriphilus</i> QBS 3 isolated from arsenic-containing acid mine drainage was increased to 80 mM As(Ⅲ) and 100 mM As(V). …”
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Development of an Effective Single-Dose PCV2/CSFV Bivalent Subunit Vaccine Against Classical Swine Fever Virus and Porcine Circovirus Type 2 by Yu-Chieh Chen, Wen-Bin Chung, Hso-Chi Chaung, Yen-Li Huang, Chi-Chih Chen, Guan-Ming Ke

“…Therefore, swine operations in CSF-endemic regions are encouraged to immunize piglets with both PCV2 and CSFV vaccinations. Currently, there is no commercially available bivalent vaccine for PCV2/CSFV. …”
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Multiscale feature tuned trans-DeepLabV3+ based semantic segmentation of aerial images using improved red piranha optimization algorithm by P. Anilkumar, K. Lokesh, A. Naveen Kumar, D. John Pradeep, Y. V. Pavan Kumar, Rammohan Mallipeddi

“…Nonetheless, supervised learning necessitates a substantial quantity of images with pixel-level labeling. Currently, available techniques, which are mostly Deep Semantic Segmentation Networks (DSSN), might not be appropriate for application domains with a dearth of labels containing targeted masks of outputs. …”
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Anticipating how spatial fishing restrictions in EU waters perform to protect marine species, habitats, and dependent fisheries by François Bastardie, Amaia Astarloa, Logan Binch, Isabella Bitetto, Dimitrios Damalas, Jochen Depestele, Pierre-Yves Hernvann, Sigrid Lehuta, Jonas Letschert, Irida Maina, Stéphanie Mahévas, Georgia Papantoniou, Miriam Püts, Giovanni Romagnoni, Giovanni Romagnoni, Giovanni Romagnoni, Giovanni Romagnoni, Maria Teresa Spedicato, Klaas Sys, Irini Tsikopoulou, Gert Van Hoey, Walter Zupa, Anna Rindorf

“…The research addresses the effectiveness of prohibiting certain fishing practices in the context of the EU Common Fisheries Policy (CFP). We investigate spatial- and effort-based fisheries management strategies based on spatial ecosystem modelling, which provides insights into species interactions and distribution shifts, and bioeconomic fisheries models which incorporate finely defined fishing fleets and economic dynamics. …”
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Improving outcomes for people with autism spectrum disorders by reducing mental health problems: the IAMHealth research programme including one RCT by Emily Simonoff, Gillian Baird, Bryony Beresford, Tony Charman, Martin Knapp, Andrew Pickles, Carol Povey, Tom Purser, Paramala Santosh, Vicky Slonims, Stephen Scott

“…Autism is common, occurring in ~1–1.5% of the population, lifelong and hugely expensive. Currently, there are very limited treatments for its core symptoms. …”
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Electrodeposited p‐Cu2O Films – Role of Redox‐Active Compounds Under Photoelectrochemical Operation Revisited by Michael Neumann‐Spallart, Dharini Bhagat, Šárka Paušová, Josef Krýsa, Indrajit Mukhopadhyay

“…Under electrical bias, cathodic and photocathodic currents passed and increased dramatically when reducible redox compounds were added. …”
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Development of a vaccine adjuvant based on squalene and study of its adjuvant properties by E. A. Volosnikova, D. N. Shcherbakov, V. V. Ermolaev, N. V. Volkova, O. N. Kaplina, M. B. Borgoyakova, E. D. Danilenko

“…The use of modern subunit vaccines involves adjuvant introduction into their composition. Currently, the search for new and improvement of existing adjuvant systems is actively underway. …”
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COVID-19 outbreak in Mauritania: epidemiology and health system response by Mohamed Lemine Cheikh Brahim Ahmed, Sidi Zehaf, Mohamed Mahmoud El Alem, Ahmed Elbara, Mohamed Mahmoud Ely Mahmoud, Mohamed Val Mohamed Abdellahi, Jorg Heukelbach

“…During the first wave, there were 38 ICU beds nationwide, but the ICU’s capacity increased in short time. Conclusions: Mauritania has passed through the first pandemic wave with relatively low case fatality rates, currently being at the end of the second wave. …”
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Stochastic simulation modeling of the economics of providing additional living space for housed dairy cows by Jake S. Thompson, Chris D. Hudson, Jon N. Huxley, Jasmeet Kaler, Martin J. Green

“…When building a new shed with a high living space versus control at a 4.00% interest rate, a median net return on infrastructure investment of +£23.00 per cow per year was identified (range –£25.91 to +£64.16 for 10th to 90th percentile). Since decreased living space is likely to lead to poorer welfare, it can be considered a negative production externality associated with current production systems, the cost of which should also be accounted for when analyzing the economics of housing. …”
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L-Sort: On-Chip Spike Sorting With Efficient Median-of-Median Detection and Localization-Based Clustering by Yuntao Han, Yihan Pan, Xiongfei Jiang, Cristian Sestito, Shady Agwa, Themis Prodromakis, Shiwei Wang

“…The advancement of neural probes facilitates the recording of a high number of neurons with an increase in channel counts, arising a higher data volume and challenging the current on-chip spike sorters. …”
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Application of Jane Jacobs’ Theory in the Analysis of the Borders of Territory Monitoring in Urban Spaces from Citizens’ Points of View in Bandar Abbas by Amirhamzeh Shahbazi, Esmaeil zakerimnabi, Alireza Shahbazi

“…The inclination to monitor such spaces decreased after age 40, reaching zero among those over 70. …”
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New insights on physicochemical features and toxicological outcome provided from incineration of nanocomposites by Claire Longuet, Carine Chivas-Joly, Nora Lambeng, Valérie Forest, Lara Leclerc, Gwendoline Sarry, Jérémie Pourchez, José-Marie Lopez-Cuesta

“…A specific management of nanocomposites end-of-life should be implemented as recommended by the Organization for Economic Co-operation and Development (OECD) in order to limit nanoparticles dissemination by landfilling and particularly in incineration facilities where their presence is significantly increasing. The aim of our study was to expand the current knowledge of the partition of nanowaste, mainly in case of nanocomposites mixture, and the potential synergetic or antagonistic impact of potential hazardous nanowastes on the toxicological profile. …”
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The prevalence of obesity and overweight among Iranian population: an umbrella systematic review and meta-analysis by Azadeh Dehghani, Roghayeh Molani-Gol, Maryam Mohammadi-Narab, Abdolreza Norouzy, Mohammad Hassan Abolhassani, Seyed Mohammad Tabatabaee Jabali, Abdolreza Pazouki, Fahimeh Soheilipour, Fatemeh Mohammadi-Nasrabadi

“…The meta-analyses included in this study examined the prevalence of obesity and overweight in Iran. The current umbrella meta-analysis finally contained 24 meta-analyses. …”
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Monitoring Welfare of Individual Broiler Chickens Using Ultra-Wideband and Inertial Measurement Unit Wearables by Imad Khan, Daniel Peralta, Jaron Fontaine, Patricia Soster de Carvalho, Ana Martos Martinez-Caja, Gunther Antonissen, Frank Tuyttens, Eli De Poorter

“…To conclude the paper, we identify current challenges and future research lines in the field.…”
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Neutrophil-to-Lymphocyte ratio as surrogate for JAK2V617F suppression and event-free survival in polycythemia vera by Tiziano Barbui, Arianna Ghirardi, Victoria Empson, Francesca Fenili, Giuseppe Gaetano Loscocco, Annalisa Condorelli, Alessandra Iurlo, Daniele Cattaneo, Elena Rossi, Valerio De Stefano, Paola Guglielmelli, Christoph Klade, Heinz Gisslinger, Alessandro Rambaldi, Joseph M. Scandura, Alessandro Maria Vannucchi

“…Abstract Chronic systemic inflammation is a key driver of polycythemia vera (PV) progression, but the immunomodulatory effects of current treatments remain poorly defined. The neutrophil-to-lymphocyte ratio (NLR) is an accessible biomarker of systemic inflammation proven in other contexts, but its role in monitoring PV disease activity has not been established. …”
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The clinically applied PARP inhibitor talazoparib ameliorates imiquimod-induced psoriasis in mice without reducing skin inflammation by Petra Molnár, Máté Ágoston Demény, Beáta Várkonyi, Beáta Várkonyi, Zsuzsanna Polgár, Ágnes Pór, Ilona Kovács, Andrea Szegedi, Andrea Szegedi, Attila Gábor Szöllősi, Attila Gábor Szöllősi, Magdolna Szántó

“…BackgroundConsidering the role PARPs play in inflammation, we assessed the effect of PARP inhibition in an inflammatory skin condition, psoriasis, to explore novel avenues for the potential repurposing of PARP inhibitors that are currently used in tumour therapy.MethodsThe imiquimod (IMQ)-induced model of psoriasis was applied in BALB/c mice. …”
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