Design and Synthesis of Bis-Chalcones as Curcumin Simplified Analogs and Assessment of Their Antiproliferative Activities Against Human Lung Cancer Cells and <i>Trypanosoma cruzi</... by Gabriela Alves de Souza, Lorrane de Souza Chaves, Afonso Santine M. M. Velez, Jorge Lucas F. Lacerda, Paulo Pitasse-Santos, Jayane Clys Conceição dos Santos, Otávio Augusto Chaves, Carlos Serpa, Raphael do Carmo Valente, Leonardo Marques da Fonseca, Marcos André Rodrigues da Costa Santos, Jhenifer Santos dos Reis, Carlos Antônio do Nascimento Santos, Lucia Mendonça-Previato, Jose Osvaldo Previato, Celio Geraldo Freire-de-Lima, Debora Decoté-Ricardo, Leonardo Freire-de-Lima, Marco Edilson Freire de Lima

“…<b>Background: </b>Anticancer therapies represent the primary treatment option for a significant number of cancer patients globally; however, many of these treatments are associated with severe side effects as they target molecular structures present in both cancerous and healthy cells. In a similar context, the treatment of Chagas disease, a neglected tropical illness, is hindered by the high toxicity of the currently available drugs. …”
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Cranberry Leaves as Feed Additive in Poultry Nutrition: Effects on Performance and Oxidative Stability by Arabela Elena Untea, Iulia Varzaru, Mihaela Saracila, Petru Alexandru Vlaicu, Alexandra-Gabriela Oancea, Tatiana Dumitra Panaite

“…The leaves belonging to that species can be considered a cost-effective alternative in the context of reducing antibiotics strategy in animal nutrition. …”
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Adverse birth outcome research case definitions associated with maternal HIV and antiretroviral drug use in pregnancy: a scoping review by Kopano R. Dube, Shani T. de Beer, Kathleen M. Powis, Michael McCaul, Amy L. Slogrove

“…In conjunction with good reporting, variation in adverse birth outcome definitions can be decreased to facilitate comparability of studies as well as pooling of data for enhanced evidence synthesis.…”
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Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…Guiding Distributive Justice: Capability Theory Capability theory is an account of justice opportunity that places a fundamental moral significance on individuals' ability to reach proper functioning and well-being.[52] Whether or not an individual can make use of a particular set of resources and convert them into a state of functioning depends on personal, sociopolitical, and environmental conditions ("conversion factors").[53] In this sense, liberty is not the absence of restraint from others or institutions but the freedom achieved through capability-enhancing relationships.[54] Within the context of bioethics, capability theory shifts focus toward creating circumstances by which individuals can direct their lives as they choose.[55] Acting in accordance with the principle of beneficence, peer-support specialists could enhance the capability of patients to be self-determined and autonomous, which would promote patient well-being and empowerment.[56] Those living with SMI, such as schizophrenia and bipolar disorder, are among the most disadvantaged in society, experiencing social and economic hardship related to their illness.[57] These individuals are often feared and rejected by others, which increases depression, lowers self-esteem, and engenders feelings of social isolation.[58] Compounding their challenges, especially for those facing structural inequalities, is insufficient access to appropriate mental health services supporting recovery.[59] Capability theory provides a sound justification for the resource distribution necessary to create and sustain a thriving network of peer-support specialists, to which those with SMI currently do not have access. …”
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High prevalence of the hotspot complement factor I p.Ile357Met pathogenic variant in Tunisian atypical hemolytic uremic syndrome patients: report of three new cases and review of t... by Asma Tajouri, Asma Tajouri, Asma Tajouri, Imen Ayadi, Imen Ayadi, Rimeh BenBrahim, Rimeh BenBrahim, Ikram Mami, Abir Boussetta, Hend Jlajla, Hend Jlajla, Yousr Zerzeri, Haifa Arbi Sassi, Jamila Ben Sassi, Hela Sahli, Lilia Laadhar, Lilia Laadhar, Tahar Gargah, Mohamed Karim Zouaghi, Maryam Kallel Sellami, Maryam Kallel Sellami

“…The recurrence of this variant in the Tunisian cohort led us to suggest that it could be characteristic of the Tunisian population.MethodsIn this context, we conducted the current study which included 8 adults and three children with suspected aHUS and decreased factor I levels, as well as one relative. …”
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Comparison of the indirect immunofluorescence assay and a commercial ELISA to detect KSHV antibodies by Valentin Leducq, Léa Ben Said, Sophie Sayon, Vincent Calvez, Anne-Geneviève Marcelin, Aude Jary

“…The current gold-standard method, the indirect immunofluorescence assay (IFA), has a very good specificity of close to 100%, but a lower sensitivity of around 80–85%, which decreases to 64–67% in immunocompromised patients. …”
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Repetitive transcranial magnetic stimulation for the treatment of suicidality in opioid use disorder: a pilot feasibility randomized controlled trial by Victor M. Tang, Bernard Le Foll, Zafiris J. Daskalakis, An-Li Wang, Leslie Buckley, Daniel M. Blumberger, Daphne Voineskos

“…Conclusion We present the first data piloting a structural neuroimaging-guided, multi-session rTMS treatment course in outpatients with suicidality and OUD in the current North American context. Recruitment and retention were the main challenges given the highly unstable medical and psychosocial context of this patient population. …”
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“Locality – Adaptation” Research of Hydropower Resettlement Communities in the Jinsha River Basin: A Case Study of Ludila Hydropower Station by Fang WANG, Zhuoqi LI, Haoyi XU, Jiaqi YAN

“…ObjectiveWithin human – environment systems, river basins constitute the earliest geographical units of human activity and currently represent the most critical zones of strained human – environment interactions. …”
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On the added value of sequential deep learning for the upscaling of evapotranspiration by B. Kraft, B. Kraft, B. Kraft, J. A. Nelson, S. Walther, F. Gans, U. Weber, G. Duveiller, M. Reichstein, W. Zhang, M. Rußwurm, D. Tuia, M. Körner, Z. Hamdi, M. Jung

“…However, together with the non-temporal FCN model, they exhibited a larger ensemble spread than XGBoost, and they yielded lower global ET estimates than what is currently understood. XGBoost showed a smaller ensemble spread compared to neural networks, in particular when conditions were poorly represented in the training data, but it was more sensitive to the covariate setup. …”
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Regulatory culture and architectural project by Mario Losasso

“…They are attentive to a quality that does not depend on construction solutions or on techno-typological, morphological or physical-chemical characteristics, but which is linked to a system of needs to be satisfied, the outcome of the interaction between construction and cultural, socio-economic and environmental context. Today’s regulatory landscape has expanded, increasing sensitivities to environmental challenges, health and the qualities of living space. …”
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Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the IL‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants... by J. C. vanMaanen, F. C. Bach, J. W. Snuggs, K. Ito, M. H. M. Wauben, C. L. Le Maitre, M. A. Tryfonidou

“…Secretion of IL‐6 and C‐X‐C motif chemokine ligand 1 was significantly decreased in NC‐EV + IL‐1β vs. control+IL‐1β but not compared to EV‐depleted human explant controls. …”
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Residents’ Perceptions of Impending Forced Relocation in Urban China by Xin Li

“…On the other hand, many homeowners and older people are unwilling to move, since their current neighbourhood makes them feel rooted and enables them to develop living strategies to relieve their deprived socio-economic situation. …”
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Helminth Coinfections Modulate Disease Dynamics and Vaccination Success in the Era of Emerging Infectious Diseases by Brice Armel Nembot Fogang, Linda Batsa Debrah, Michael Owusu, George Agyei, Julia Meyer, Jonathan Mawutor Gmanyami, Manuel Ritter, Kathrin Arndts, Derrick Adu Mensah, Tomabu Adjobimey, Achim Hörauf, Alexander Yaw Debrah

“…Helminth infection can also negatively impact vaccine efficacy by suppressing B cell activity, reducing antibody levels, and decreasing vaccine effectiveness against infectious diseases. …”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…This paper describes the current transplant system’s use of subjective evaluation criteria, particularly psychosocial support and compliance. …”
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Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection by Carrie L. Butler, Nicole M. Valenzuela, Kimberly A. Thomas, Elaine F. Reed

“…This review highlights what is currently known about the clinical context of pre and posttransplant antibodies, antibody characteristics that influence AMR, and the paths after donor specific antibody production (no rejection, subclinical rejection, and clinical dysfunction with AMR).…”
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Does Beta Explain Global Equity Market Volatility – Some Empirical Evidence by Radosław Kurach

“…In the subsidiary outcomes of our verification procedure, we argue that country betas are time-varying and that currently, global factors are the dominant source of equity market volatility. …”
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Incomplete epidemiological transition in Kazakhstan: changes in the structure of life expectancy and causes of death by А. Алдангаркызы, М. Денисенко

“… This article examines Kazakhstan's epidemiological transition, focusing on shifts in mortality patterns and life expectancy within the context of socioeconomic and demographic influences. …”
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Progress of arylacetamide deacetylase research in metabolic diseases by Liu Yang, Zhe-Zhen Liao, Li Ran, Xin-Hua Xiao

“…It plays a significant role in drug metabolism, lipid metabolism, and the pathogenesis of various diseases. In the context of drug metabolism, AADAC is vital for ensuring the safety of ester-based drugs. …”
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A novel RNN architecture to improve the precision of ship trajectory predictions by Martha Dais Ferreira, Jessica N. A. Campbell

“…Currently, the Ornstein-Uhlenbeck (OU) model is considered the state-of-the-art for STP. …”
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Life expectancy by religious affiliation in Finland 1972–2020 by Julia Klein, Jan Saarela, Martin Kolk

“…Non-affiliated persons have about one-year shorter life expectancy than Evangelical Lutherans, but the difference has decreased over time, and they currently are at a similar level. …”
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