Epigenetic therapeutics to overcome resistance against immune checkpoint inhibitors (ICI) in hepatocellular carcinoma (HCC): a proof-of-concept clinical trial by Stephen Chan, Alfred Cheng, Nick La Thangue, David Kerr

“…However, resistance to ICI is increasingly encountered in clinical practice in HCC patients. …”
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Digital Fire and Salvage Unit: A New Level of Training for Emercom Cadets by Igor A. Malyj, Vladislav V. Bulgakov, Irina Yu. Sharabanova

“…The practical training of cadets currently being implemented on the basis of the fire and rescue training unit has a time-limited training format, in the form of a day on duty in three days, which does not allow without the widespread use of digital technologies to increase the level of organization of the educational process and its effectiveness, for example, by ensuring constant access of trainees to educational materials.Materials and methods. …”
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Effects of wetting events on mass timber surface microbial communities and VOC emissions: implications for building operation and occupant well-being by Gwynne Á. Mhuireach, Susan Collins, Leslie Dietz, Patrick Finn Horve, Aurélie Laguerre, Dale Northcutt, Jason Stenson, Kevin Van Den Wymelenberg, Elliott Gall, Mark Fretz

“…IntroductionHumans have used wood as a construction material throughout history. Currently, mass timber products, such as cross-laminated timber (CLT), are becoming more popular as a structural material, since they are renewable and have a lower carbon footprint than concrete or steel. …”
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A Comparative Study of the Extraction Methods for the Simultaneous Detection of NPS Groups from Urine by M. Kuloglu Genc, S. Mercan, C. Bulut, Z. Turkmen

“…A total of 1,127 NPS have been reported worldwide as of 2022. The increasing chemical diversity and unprecedented substance numbers of NPS make this phenomenon even more difficult to detect, monitor and understand analytically. …”
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Nanostructured Strategies for Melanoma Treatment—Part I: Design and Optimization of Curcumin-Loaded Micelles for Enhanced Anticancer Activity by Valentina Paganini, Andrea Cesari, Silvia Tampucci, Patrizia Chetoni, Susi Burgalassi, Michele Lai, Giulia Sciandrone, Silvia Pizzimenti, Fabio Bellina, Daniela Monti

“…<b>Background/Objectives</b>: Melanoma is a pathology that affects a large part of the population, and the currently available therapies have many limitations, including the selective targeting of the site of action. …”
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Evaluation of the Antistaphylococcal Activity of the Pyrimidine Derivative by A. A. Tsibizova, A. L. Yasenyavskaya, I. N. Tyurenkov, A. A. Ozerov, O. A. Baskina, M. A. Samotrueva

“…The development of safe and effective drugs with antimicrobial activity is currently a priority task of modern pharmacology. The need to obtain new antimicrobial agents is associated with the presence of problems, the main of which is the development of polyresistance of the pathogenic pathogen to existing antibacterial drugs. …”
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Epidemiology of Disability of Adult Population in the Russian Federation by S. N. Puzin, M. A. Shurgaya, N. V. Dmitrieva, G. E. Pogosyan, I. V. Lyalina, A. M. Mammaraeva, T. A. Ivanova, L. S. Idrisova

“…Conclusions. Currently, the low level of rehabilitation and habilitation of persons with disabilities in the Russian Federation remains. …”
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An in-depth understanding of stakeholders’ experiences about their participation in the co-production of ‘Maze Out’: a serious game for the treatment of eating disorders by Maria Mercedes Guala, Aida Bikic, Kim Bul, David Clinton, Anette Søgaard Nielsen, Helene Nygaard Nielsen, Martina Scarpelli, Luciana Schneider, Regina Christiansen

“…Abstract Background Co-production is increasingly used in mental health research and clinical settings. …”
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Trade-Off Between Growth Regimes in <i>Chlorella vulgaris</i>: Impact on Carotenoid Production by Patrícia Acosta Caetano, Pricila Pinheiro Nass, Mariany Costa Deprá, Tatiele Casagrande do Nascimento, Eduardo Jacob-Lopes, Leila Queiroz Zepka

“…With the increasing awareness of socio-environmental issues, a global trend has emerged emphasizing the valorization of natural ingredients that promote health and well-being within sustainable production systems, such as microalgae-based carotenoids. …”
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Factors Related to Health Resilience in Students Affected by Disaster at Campus Graha Ananda Palu by Sadli Syam, Muhammad Sabri Syahrir, Muhammad Aji Satria, Iin Irawati

“…Follow stages disaster in Palu City, when these are the people affected disaster in Palu City now currently in phase recovery going to resilience, namely restore normal condition and strengthen Power stand public to disaster. …”
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Methods for the health technology assessment of complex interventions: a protocol for a scoping review by Tracy Merlin, Abdolvahab Baghbanian, Drew Carter, Shuhong Wang

“…Introduction In healthcare policy and economic literature, research on the health technology assessment (HTA) of complex interventions (CIs) is becoming increasingly important. In many developed countries, HTA guides decision-making to help achieve greater value for money when funding health care. …”
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Fuel cell technologies in the automotive sector: A focus on proton exchange membrane and Alkaline fuel cells by Vijay Bhooshan Kumar, Aakash Collin, M. Gopi Sankar, Kanakasabapathi Subramanian

“…The automotive industry currently relies heavily on internal combustion engine (ICE) technology, which consumes large amounts of fossil fuels and significantly contributes to global environmental degradation and the ongoing energy crisis. …”
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Implementation of a community-based LC-UV drug checking service: promising preliminary findings on feasibility and validity by Nicolas Fabresse, Eurydice Papias, Alma Heckenroth, Victor Martin, Daniel Allemann, Perrine Roux

“…Abstract Background The increasing diversity of psychoactive substances on the unregulated drug market poses significant health, psychological, and social risks to people who use drugs (PWUD). …”
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“If that would have lessened my symptoms, that would have been great...”: a qualitative study about the acceptability of tecovirimat as treatment for mpox by Sara Paparini, Rosalie Hayes, Benjamin Weil, Will Nutland, Ismael Maatouk, Teodora Wi, Chloe M. Orkin, Rosamund Lewis

“…Conclusions This exploratory study suggest that offering tecovirimat (or comparable emergency-licensed treatments) to people with mpox is acceptable, although uptake will depend on knowledge of mpox treatment options, trust in medicine and medical professionals and provision of relevant information and choice. To increase acceptability of such treatments, clinicians should ensure patients are aware of mpox symptom management options, including pain relief; acknowledge and address patient concerns upfront and within the context of non-stigmatising care; and communicate offers in a consistent and supportive manner in line with locally approved eligibility criteria and protocols at the time.…”
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Molecular genetics is on the guard of the law by L. I. Kucherenko, I. V. Pavliuk, O. V. Khromylova

“…In the world, forensic DNA analysis is recognized as one of the most promising areas of development of forensic examinations, and its results are currently one of the most reliable pieces of evidence. …”
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Medical embryology and regenerative medicine: research and applications in clinical practice by Julia Soczyńska, Julia Soczyńska, Wiktor Gawełczyk, Wiktor Gawełczyk, Patrycja Obrycka, Patrycja Obrycka, Mateusz Żołyniak, Mateusz Żołyniak, Adrian Muzyka, Adrian Muzyka, Krzysztof Majcherczyk, Krzysztof Majcherczyk, Julia Papierkowska, Julia Papierkowska, Sławomir Woźniak

“…Taking this progress a step further, the ability to introduce stem cells into damaged tissues, thereby facilitating the formation of functional structures, has led to the growing interest in organoids -three-dimensional models that replicate key functions of real organs. Organoids are currently applied not only in drug screening but are also gaining increasing attention for their role in cancer therapy research. …”
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Advancing life cycle assessment of bioenergy crops with global land use models by Anders Arvesen, Florian Humpenöder, Tomás Navarrete Gutierrez, Thomas Gibon, Paul Baustert, Jan Philipp Dietrich, Konstantin Stadler, Cristina-Maria Iordan, Gunnar Luderer, Alexander Popp, Francesco Cherubini

“…We find that land use-related CO _2 emission for bioenergy range from 2 to 35 tonne TJ ^−1 , depending on bioenergy demand, policy context, year and accounting method. GHG emissions per unit of bioenergy do not increase with bioenergy demand in presence of an emission tax. …”
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The Symbiotic Bacterial Profile of Laboratory-Reared and Field-Caught <i>Aedes albopictus</i> Mosquitoes from Greece by Elias Asimakis, Ioannis Galiatsatos, Georgia Apostolopoulou, Eleni C. Savvidou, Georgios Balatsos, Vasileios Karras, Vasiliki Evangelou, Eva Dionyssopoulou, Antonios Augustinos, Nikos T. Papadopoulos, Antonios Michaelakis, Panagiota Stathopoulou, George Tsiamis

“…The use of symbiotic bacteria to improve the application of SIT or design combined SIT/incompatible insect technique (IIT) approaches is currently considered. In this context, exploring the microbiota of local mosquito populations is crucial for identifying interesting components. …”
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Epidemiological Situation on Cholera in the Russian Federation in 2023 and Forecast for 2024 by A. Yu. Popova, A. K. Noskov, E. B. Ezhlova, V. D. Kruglikov, E. V. Monakhova, O. S. Chemisova, A. A. Lopatin, S. M. Ivanova, O. A. Podoynitsyna, A. S. Vodop’yanov, D. A. Levchenko, I. V. Savina

“…It was established that the toxigenic strains isolated from patients belonged to the currently dominant in the world “post-Haitian” group, including in India and Bangladesh, with the genotype ctxB7 tcpACIRS rtxA4a VSP-IIΔ0495-0512. …”
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Toxicity of ivermectin to bed bugs (Cimex hemipterus) and risk factors associated with infestation in Kwale County, coastal Kenya by Tobias Odongo, Isaiah Omondi, Caroline Wanjiku, Miguel Okoko, Caroline Kiuru, Mercy Kariuki, Isaac Ringera, Bruno Otieno, Festus Mure, Joanna Furnival-Adams, Almudena Sanz Gutierrez, Rachel Otuko, Nelly Regina Rabinovich, Joseph Mwangangi, Carlos Chaccour, Marta Ferreira Maia

“…Ivermectin, an endectocide known to impact various neglected tropical diseases and hematophagous arthropods, is currently being assessed for malaria vector control. …”
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