Quinine Use and the Risk of Exacerbations of Chronic Obstructive Pulmonary Disease: A Nationwide Retrospective Registry Study by Vilstrup F, Sivapalan P, Eklöf J, Jordan A, Biering-Sørensen T, Sperling S, Jensen JUS

“…An unadjusted analysis on the unmatched population showed similar results (HR 1.475, 95% CI 1.39 to 1.56).Conclusion: In the current study, we found an association between the use of Quinine in patients with COPD and an increased risk of acute exacerbations and death. …”
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A Comparison of the 𝜶2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain by Sarah Nickolls, Hannah Mace, Rebecca Fish, Michelle Edye, Rachel Gurrell, Magnus Ivarsson, Tom Pitcher, Sachi Tanimoto-Mori, Denise Richardson, Catherine Sweatman, Janet Nicholson, Cameron Ward, John Jinks, Christine Bell, Kimberly Young, Huw Rees, Andrew Moss, Ross Kinloch, Gordon McMurray

“…GABAA receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result in analgesia. …”
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Emotional processing as mechanism of change in brief good psychiatric management for borderline personality disorder: results of a randomized controlled trial by Ueli Kramer, Loris Grandjean, José Blanco Machinea, Hélène Beuchat, Setareh Ranjbar, Yves de Roten, Jean-Nicolas Despland, Philippe Conus, Stéphane Kolly

“…The assessment of mechanisms of change contributes to focus the treatment on the essential ingredients of change. The current study aims to demonstrate the emotional processing as a mechanism of change, assessed in an ecologically valid experimental context, of brief GPM. …”
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Hydroxyapatite-filled osteoinductive and piezoelectric nanofibers for bone tissue engineering by Frederico Barbosa, Fábio F. F. Garrudo, Paola S. Alberte, Leonor Resina, Marta S. Carvalho, Akhil Jain, Ana C. Marques, Francesc Estrany, Frankie J. Rawson, Carlos Aléman, Frederico Castelo Ferreira, João C. Silva

“…The biological cues provided by the HAp nanoparticles enhanced the osteogenic differentiation of seeded human mesenchymal stem/stromal cells (MSCs) as observed by the increased ALP activity, cell-secreted calcium deposition and osteogenic gene expression levels observed for the HAp-containing fibers. …”
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Didgital-art цінних паперів by Oleh Kardash, Viktor Chelombitko

“…Scientific novelty. The current state of digital art is analyzed. Its branches have been studied and the connections with graphic design have been determined. …”
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Experimental study on tensile performance of horizontal joint bolted connections in fully assembled modular construction reinforced concrete by RAN Mingming, KOU Guangyun, XIONG Feng, ZHANG Dongdong, LI Wei

“…In Mode IV, when the load was increased to 134.2 kN, abrupt fracture failure of the concrete at the cross-section above the operating hand-hole of the specimen was observed, with limited cracking. …”
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Memory-Based Navigation in Elephants: Implications for Survival Strategies and Conservation by Margot Morel, Robert Guldemond, Melissa A. de la Garza, Jaco Bakker

“…This review synthesises current literature on elephant navigation and decision-making, exploring how their behavioural strategies contribute to resilience amid increasing anthropogenic pressures. …”
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Examining interprofessional collaboration in oncogenetic service delivery models for hereditary cancers: a scoping review protocol by Maude Laberge, Jason Robert Guertin, Hermann Nabi, Karine Bouchard, Michel Dorval, Maria Eugenia Espinoza Moya, Julie Lapointe

“…Introduction In a context of limited genetic specialists, collaborative models have been proposed to ensure timely access to high quality oncogenetic services for individuals with inherited cancer susceptibility. …”
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Relationship between TyG-related index and hearing loss in people over 45 s in China by Chao Wang, Mengdi Shi, Liangzhen Xie, Chenhao Jiang, Yunxin Li, Jingxiao Li, Shulin Li, Yan Li

“…It and its derivatives such as the TyG-BMI index are currently able to reflect the degree of insulin resistance and are closely related to a variety of metabolic diseases. …”
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Research hotspots and trends in the application of diffusion tensor imaging in ischemic stroke: a bibliometric analysis (2003–2024) by Xu Chen, Xu Chen, Meifang Liu, Xiaolin Yang, Mengqi Yue, Haocheng Yu, Haiqiang Wang, Zirong Wang, Jing Shi, Jing Shi, Yong Qiu

“…However, the current study still needs to strengthen cross-regional cooperation, and higher quality and broader research is still necessary to lay the foundation for reaching the consensus of various experts.…”
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Enhanced Broad-Spectrum Efficacy of an L2-Based mRNA Vaccine Targeting HPV Types 6, 11, 16, 18, with Cross-Protection Against Multiple Additional High-Risk Types by Kosuke Tsukamoto, Akio Yamashita, Masatoshi Maeki, Manabu Tokeshi, Hirotatsu Imai, Akira Fukao, Toshinobu Fujiwara, Koji Okudera, Nobuhisa Mizuki, Kenji Okuda, Masaru Shimada

“…Results: We identified that a construct containing E01 (a 5′-untranslated region) and SL2.7 (a poly(A) polymerase recruitment sequence) significantly increased protein expression. …”
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Improved lubricating and corrosion resistance of MAO coatings on ZK61 Mg alloy by co-doping with graphite and nano-zirconia by Chao Yang, Liyuan Sheng, Chaochao Zhao, Pinghu Chen, Wentai Ouyang, Daokui Xu, Yufeng Zheng, Paul K. Chu

“…Compared with doping with a single element, co-doping increases the content of ZrO2 and graphite in the MAO coating. …”
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Hybrid surface layers with antibacterial and anti-inflammatory activity for implants materials by Mariia A. Piatkova, Konstantine V. Nadaraia, Arina I. Ponomarenko, Igor V. Manzhulo, Mariia S. Gerasimenko, Arina I. Pleshkova, Evgeny A. Belov, Igor M. Imshinetskiy, Ksenia A. Fomenko, Ivan S. Osmushko, Aleksey G. Kozlov, Sergey V. Gnedenkov, Dmitry V. Mashtalyar

“…Currently, there is an essential need for bioresorbable bone implants with antibacterial, anti-inflammatory properties as well as osteoinductivity. …”
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Improving follow-up imaging practices for patients with community-acquired pneumonia by Meirian Evans, Aazaz Rehman, Joseph Marchant, Matthew Pavitt, Rachel Buxton-Thomas

“…Introduction: The incidence of lung cancer in patients presenting to hospital with community-acquired pneumonia (CAP) is variably reported as 1–9.2%.1–3 The radiographic features of pneumonia and lung cancer can be similar. Therefore, in the context of lower respiratory tract symptoms, a malignancy visible on a chest X-ray may be missed.The British Thoracic Society (BTS) guidelines for the management of CAP in adults (2009) recommend that high-risk patients (aged >50 and current or ex-smokers) with consolidation on a chest X-ray should be followed up with a repeat chest X-ray 6 weeks after their initial presentation to ensure resolution of changes and to exclude an underlying malignancy.3Initial audit data in our local respiratory department showed that 41% of patients were incorrectly not followed up with repeat imaging. …”
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Canine Distemper Virus in Mexico: A Risk Factor for Wildlife by Juan Macías-González, Rebeca Granado-Gil, Lizbeth Mendoza-González, Cesar Pedroza-Roldán, Rogelio Alonso-Morales, Mauricio Realpe-Quintero

“…Through an extensive review of recent scientific literature about CDV disease in wildlife that has been published in local and international databases, the findings were connected with the current needs of information from a local to global perspective, and conclusions were made to broaden the context of Mexican epidemiological scenarios as closely related to the neighboring regions.…”
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Leveraging Administrative Health Databases to Address Health Challenges in Farming Populations: Scoping Review and Bibliometric Analysis (1975-2024) by Pascal Petit, Nicolas Vuillerme

“…ObjectiveWe aimed to explore the reuse of AHDs in addressing health issues within farming populations by summarizing the current landscape of AHD-based research and identifying key areas of interest, research gaps, and unmet needs. …”
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Highly sensitive multiplex PCR for convenient quantification and differentiation of canine Oomycota pathogens: Pythium insidiosum, Lagenidium giganteum f. caninum, and Paralagenidi... by Asfiha Tarannum, Subarna Barua, Leonel Mendoza, Raquel Vilela, Priscilla Barger, Terri Hathcock, Amelia White, Kelly Chenoweth, Chengming Wang

“…Interestingly, the developed multiplex Oomycota PCR revealed that 45.5% (40/88) of serum samples positive for anti-Pythium antibody contained Pythium DNA. Additionally, among 24 suspected anti-Pythium antibody-positive samples, 54.2% (13/24) tested positive for Pythium DNA, while 8.3% (2/24) contained Lagenidium DNA. …”
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Mycochemistry, antioxidant, anticancer activity, and molecular docking of compounds of F12 of ethyl acetate extract of Astraeus asiaticus with BcL2 and Caspase 3 by Swapan Kumar Ghosh, Koushik Pandey, Madhuparna Ghosh, Pradip Kumar Sur

“…Abstract Globally the current research is going for cancer disease management by different strategies as frequency and severity of this disease are increasing day by day. …”
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Pedagogical Culture of Teachers at Technical Universities for Safe Educational Process During the War in Ukraine. by Natalia Tverdokhliebova, Nataliіa Yevtushenko

“… The entire education system is currently undergoing structural changes, which are reflected in the increased use of digital and distance learning technologies. …”
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Modeling consequences of spatial closures for offshore energy: Loss of fishing grounds and fishery‐independent data by M. Campbell, J. F. Samhouri, J. W. White

“…Abstract Many jurisdictions are currently pursuing renewable sources of energy from the ocean, including offshore wind farms (OWFs). …”
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