High prevalence of the hotspot complement factor I p.Ile357Met pathogenic variant in Tunisian atypical hemolytic uremic syndrome patients: report of three new cases and review of t... by Asma Tajouri, Asma Tajouri, Asma Tajouri, Imen Ayadi, Imen Ayadi, Rimeh BenBrahim, Rimeh BenBrahim, Ikram Mami, Abir Boussetta, Hend Jlajla, Hend Jlajla, Yousr Zerzeri, Haifa Arbi Sassi, Jamila Ben Sassi, Hela Sahli, Lilia Laadhar, Lilia Laadhar, Tahar Gargah, Mohamed Karim Zouaghi, Maryam Kallel Sellami, Maryam Kallel Sellami

“…The recurrence of this variant in the Tunisian cohort led us to suggest that it could be characteristic of the Tunisian population.MethodsIn this context, we conducted the current study which included 8 adults and three children with suspected aHUS and decreased factor I levels, as well as one relative. …”
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Refining the link between obesity and heart failure: insights from GLP-1 receptor agonist trials and studies adopting direct adiposity measures by Nicola Riccardo Pugliese, Francesco Paneni, Domenico Tricò, Alessandra Violet Bacca, Nicolò De Biase, Hermann Dalpiaz, Alessandro Mengozzi, Agostino Virdis, Lorenzo Ghiadoni, Stefano Taddei, Reinhold Kreutz, Konstantinos Tsioufis, Stefano Masi

“…While overweight/obesity increases the risk of developing HF, its impact on patient outcomes remains complex. …”
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Improvement of oilseed Brassica crops by Trichoderma use: Gene transfer and direct interaction by Tamara Sánchez-Gómez, Jorge Martín-García, Óscar Santamaría, Jorge Poveda

“…Global agriculture must urgently adopt a new approach to ensure adequate food production for the increasing population in the current context of adverse conditions, while prioritizing environmental sustainability. …”
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Development of a Self‐Deploying Extra‐Aortic Compression Device for Medium‐Term Hemodynamic Stabilization: A Feasibility Study by Adrienne Ji, James Davies, Phuoc Thien Phan, Chi Cong Nguyen, Bibhu Sharma, Kefan Zhu, Emanuele Nicotra, Jingjing Wan, Hoang‐Phuong Phan, Christopher Hayward, Nigel H. Lovell, Thanh Nho Do

“…Current mechanical assistive devices, such as intra‐aortic balloon pumps (IABP) and extracorporeal membrane oxygenation (ECMO), offer temporary stabilization but are limited to short‐term use due to risks associated with prolonged blood contact. …”
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Comparison of the indirect immunofluorescence assay and a commercial ELISA to detect KSHV antibodies by Valentin Leducq, Léa Ben Said, Sophie Sayon, Vincent Calvez, Anne-Geneviève Marcelin, Aude Jary

“…The current gold-standard method, the indirect immunofluorescence assay (IFA), has a very good specificity of close to 100%, but a lower sensitivity of around 80–85%, which decreases to 64–67% in immunocompromised patients. …”
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Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review. by John Danesh, Stephen Kaptoge, Andrea G Mann, Nadeem Sarwar, Angela Wood, Sara B Angleman, Frances Wensley, Julian P T Higgins, Lucy Lennon, Gudny Eiriksdottir, Ann Rumley, Peter H Whincup, Gordon D O Lowe, Vilmundur Gudnason

“…An updated systematic review of electronic databases and other sources identified 15 relevant previous population-based prospective studies of IL-6 and clinical coronary outcomes (i.e., MI or coronary death). Including the two current studies, the 17 available prospective studies gave a combined odds ratio of 1.61 (95% CI 1.42-1.83) per 2 SD increase in baseline IL-6 (corresponding to an odds ratio of 3.34 [95% CI 2.45-4.56] per 2 SD increase in usual [long-term average] IL-6 levels).…”
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Challenges in modelling the impact of frost and heat stress on the yield of cool-season annual grain crops by Jonathan Richetti, Victor Oscar Sadras, Victor Oscar Sadras, Victor Oscar Sadras, Di He, Brenton Leske, Pengcheng Hu, Yacob Beletse, C. Mariano Cossani, C. Mariano Cossani, C. Mariano Cossani, Ha Nguyen, Bangyou Zheng, David Matthews Deery, M. Fernanda Dreccer, Jeremy Whish, Julianne Lilley

“…These temperature extremes are increasing in frequency and intensity due to climate change in many parts of the broadacre cropping regions globally, presenting challenges to food production. …”
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Experimental study on tensile performance of horizontal joint bolted connections in fully assembled modular construction reinforced concrete by RAN Mingming, KOU Guangyun, XIONG Feng, ZHANG Dongdong, LI Wei

“…In Mode IV, when the load was increased to 134.2 kN, abrupt fracture failure of the concrete at the cross-section above the operating hand-hole of the specimen was observed, with limited cracking. …”
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Matching action to need: an analysis of Global Burden of Disease 2017 and population health data to focus adolescent health policy and actions in Myanmar by Karly I. Cini, Phone Myint Win, Zay Yar Swe, Kyu Kyu Than, Thin Mar Win, Ye Win Aung, Aye Aye Myint, Nisaa R. Wulan, Lia J. Burns, Elissa C. Kennedy, Kate L. Francis, Sanda, Su Mon Myat, Sithu Swe, Aung Ko Ko, Yadanar, Margaret Hellard, Chad L. Hughes, George C. Patton, Ali H. Mokdad, Peter S. Azzopardi

“…Conclusions: These results highlight the need to focus current efforts on addressing disease and mortality experienced by adolescents in Myanmar, with a specific focus on injury, mental health and non-communicable disease.…”
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Apple phenotyping using deep learning and 3D depth analysis: An experimental study on fruitlet sizing during early development by Giorgio Checola, Damiano Moser, Paolo Sonego, Cristian Iob, Franco Micheli, Pietro Franceschi

“…Current research in apple-growing focuses on collecting extensive biometric data to better understand physiological processes, improve orchard productivity and predict yields. …”
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Repetitive transcranial magnetic stimulation for the treatment of suicidality in opioid use disorder: a pilot feasibility randomized controlled trial by Victor M. Tang, Bernard Le Foll, Zafiris J. Daskalakis, An-Li Wang, Leslie Buckley, Daniel M. Blumberger, Daphne Voineskos

“…Conclusion We present the first data piloting a structural neuroimaging-guided, multi-session rTMS treatment course in outpatients with suicidality and OUD in the current North American context. Recruitment and retention were the main challenges given the highly unstable medical and psychosocial context of this patient population. …”
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Kyrgyz SSR During the Great Patriotic War: Demographic Processes and Challenges by Shaiyrkul Batyrbaeva, Anara Karyeva

“…By 1943, natural growth became negative, which was accompanied by an increase in migration losses caused by the return of evacuees and a general increase in mortality. …”
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EDUCATIONAL AUTONOMY AS AN IMPORTANT PREREQUISITE FOR THE FORMATION OF FUTURE PHDS’ RESEARCH COMPETENCE IN THE CONDITIONS OF POSTGRADUATE STUDIES by Oliinyk Iryna

“…The purpose of this research is to examine the concept of “learning autonomy” as an effective method of increasing the awareness of future PhD candidates in the process of developing research competence in terms of postgraduate studies. …”
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New radar altimetry datasets of Greenland and Antarctic surface elevation, 1991–2012 by M. R. Suryawanshi, M. R. Suryawanshi, M. McMillan, J. Maddalena, F. Piras, J. Aublanc, J.-A. Daguzé, C. Grau, Q. Huang

“…To reliably constrain multi-decadal trends in ice sheet imbalance, and to place current observations within a longer-term context, requires continued efforts to optimise the processing of data acquired by the older historical missions and to evaluate the accuracy of these measurements. …”
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Access to veterinary care in Canada: a cross-sectional survey of animal healthcare organizations and interventions by Quinn Rausch, Maryam Alhamdan, Shane Bateman, Michelle Evason, Valli Fraser-Celin, Courtney Graham, Jamie Saad, Michelle Tuma, Karen Ward, Lauren Van Patter

“…IntroductionMany Canadians struggle to access healthcare for their animals, but little data is available from the Canadian context on how barriers to care are being addressed, and with what effects.MethodsThe aim of this research was to characterize service providing organizations, barrier mitigation tools, community partnerships, and evaluation metrics used by organizations attempting to increase access to animal healthcare in Canada. …”
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Study on the Corrosion Resistance and Application of Nano-Y₂O₃/Al₂O₃-Modified Anchor Rod Coatings Based on Electrodeposition Method by Xiujuan Feng, Falong Qiu

“…The hardness of the coating increased from 98.7 Hv to 347.9 Hv, and the hardness and wear resistance of the coating were improved. …”
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The substance use profiles of adults who sought mental health and addiction services through a centralized intake process in Nova Scotia (2020–2021) by Matiwos Soboka, Philip G. Tibbo, Sherry H. Stewart, Sherry H. Stewart, Sherry H. Stewart, Patryk Simon, JianLi Wang, JianLi Wang

“…BackgroundDespite the increasing substance use in Canada, our understanding of how substance use varies based on the intersections of gender, ethnicity/race, and income sources among preclinical populations remains limited. …”
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Towards a sustainable rare disease and orphan drug ecosystem in Saudi Arabia: policy insights from a multi-stakeholder workshop by Ghada Mohammed Abozaid, Ghada Mohammed Abozaid, Hussain Abdulrahman Al-Omar, Abdulaziz Alrabiah, Asma AlMuaither, Amy Jayne McKnight

“…Through a series of presentations, educational sessions, and plenary discussions, participants examined the current landscape of RDs in SA, identified barriers to accessing ODs, and recommended strategies and initiatives to improve the accessibility, innovation, and sustainability of ODs.ResultsThe workshop highlighted key challenges recognized by a diverse group of 59 participants, including the absence of a national strategy, absent of local RDs and ODs definitions in the Saudi context, limited awareness and understanding of RDs among healthcare professionals, delayed diagnoses, scarcity of treatment and diagnosis centers for RDs, insufficient screening and prevention programs, regulatory hurdles in approving and importing ODs, and financial constraints. …”
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‘Communities are attempting to tackle the crisis’: a scoping review on community plans to prevent and reduce opioid-related harms by Carol Strike, Michael Parkinson, Nimitha Paul, Sue Keller-Olaman, Susan Massarella, Jayne Caldwell, Greg Penney, Rita Henderson

“…Stakeholders identified three key implications to our findings: addressing equity and stigma-related barriers towards people with lived experience of substance use; improving data collection to facilitate evaluation; and enhancing community partnerships by involving people with lived experience of substance use.Conclusion Current understanding of the implementation and context of community opioid-related plans demonstrates a need for evaluation to advance the evidence base. …”
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Trends in Research on Hypertrophic Cardiomyopathy and Mitochondria From 2003 to 2023: A Bibliometric Analysis by Lulu Yang, Heng Zhang, Zhiyang Zhu, Jianming Wang, Xiaojuan Liu, Lijie Lu, Jinliang Huang, Miaoran Wang, Zhengchuan Zhu

“…The investigation of mitochondria, particularly in the context of cardiovascular medicine and HCM, demonstrates an unstoppable momentum. …”
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