The Functional Impact of VX-770 on the Cystic Fibrosis Transmembrane Conductance Regulator Is Enduring and Increases the Constitutive Activity of This Channel in Primary Airway Epi... by Heidi J. Nick, Sarah E. Christeson, Preston E. Bratcher

“…Acute VX-770 exposure resulted in an increase in CFTR-mediated currents in the absence of exogenous compounds that induce the phosphorylation/activation of CFTR, with acute exposure having the same effect as chronic exposure. …”
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Increasing day three parasitaemia is observed after treatment of patients with artemether-lumefantrine and single dose of primaquine for uncomplicated Plasmodium falciparum malaria... by Bontu Abate, Bokretsion Gidey Brhane, Tsegahun Manyazewal, Hussien Mohammed, Yonas Wuletaw, Moges Kassa, Mesay Hailu, Getachew Tollera, Geremew Tasew, Ashenafi Assefa, Eyasu Makonnen

“…These findings support the ongoing use of AL with a single dose of PQ as the primary treatment option for uncomplicated P. falciparum infections in the study area. In the context of the emergence and spread of partial artemisinin-based combination therapy(ACT) resistance in Africa, regular monitoring of the efficacy of current artemisinin-based combinations is recommended for the early detection of emerging drug resistance in the study setting and beyond.…”
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Survival Prediction of Esophageal Cancer Using 3D CT Imaging: A Context-Aware Approach With Non-Local Feature Aggregation and Graph-Based Spatial Interaction by Fuce Guo, Chen Huang, Shengmei Lin, Yongmei Dai, Qianshun Chen, Shu Zhang, Xunyu XU

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Estimating the Potential for Rooftop Generation of Solar Energy in an Urban Context Using High-Resolution Open Access Geospatial Data: A Case Study of the City of Tromsø, Norway by Gareth Rees, Liliia Hebryn-Baidy, Clara Good

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Development and external validation of a risk prediction score (DASHI) for cardiovascular events following acute respiratory infections: derivation and validation retrospective coh... by Joseph J. Lee, Constantinos Koshiaris, Cynthia Wright-Drakesmith, Jennifer A. Davidson, Charlotte Warren-Gash, F.D. Richard Hobbs, James P. Sheppard

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A multi-level implementation strategy to increase adoption of chiropractic care for low back pain in primary care clinics: a randomized stepped-wedge pilot study protocol by Eric J. Roseen, André Bussières, Rocky Reichman, Celia Bora, Jennifer Trieu, Kirsten Austad, Charles Williams, Ryan A. Fischer, Danielle Parrilla, Lance D. Laird, Michael LaValley, Roni L. Evans, Robert B. Saper, Natalia E. Morone

“…., manual therapy, exercise instruction, advice on self-care), implementation strategies to increase adoption of chiropractic care for LBP in primary care clinics are understudied, particularly in underserved communities. …”
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Competitive potential of ad ministrative-territorial units: assessment and development directions by Maxim B. Ivanov

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Trends in functional limitations among middle-aged and older adults in the Asia-Pacific: survey evidence from 778,507 observations across six countriesResearch in context by Marie Ishida, Sumit Kane, Teralynn Ludwick, Victoria Fan, Ajay Mahal

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Agent-Based Adaptive Dynamic Round Robin (AADRR) Scheduling Algorithm by Zafar Iqbal Khan, Muzafar Khan, Syed Nasir Mehmood Shah

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Assessing spirometry, exhaled nitric oxide, and asthma symptoms score as instruments for respiratory health evaluation among women in a low socioeconomic context: a cross-sectional... by Shamiso Muteti-Fana, Nkosana Jafta, Rajen N. Naidoo

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Use of integrated genomic surveillance by local public health authorities: Recommendations based on a mixed-methods study of current adoption, applications and success factors, Ger... by Simone Scheithauer

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Desigualdad urbana: la segregación residencial en contextos metropolitanos sin ordenación territorial integrada = Urban inequality: Residential segregation in metropolitan contexts... by José Manuel Gómez Giménez

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Global variation in antibiotic prescribing guidelines and the implications for decreasing AMR in the future by Emmama Jamil, Emmama Jamil, Zikria Saleem, Brian Godman, Brian Godman, Brian Godman, Matti Ullah, Afreenish Amir, Abdul Haseeb, Johanna C. Meyer, Johanna C. Meyer, Muhammad Usman Qamar, Safa S. Almarzoky Abuhussain

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Explainable deep learning algorithm for identifying cerebral venous sinus thrombosis-related hemorrhage (CVST-ICH) from spontaneous intracerebral hemorrhage using computed tomograp... by Kai-Cheng Yang, Yunzhi Xu, Qing Lin, Li-Li Tang, Jia-wei Zhong, Hong-Na An, Yan-Qin Zeng, Ke Jia, Yujia Jin, Guoshen Yu, Feng Gao, Li Zhao, Lu-Sha Tong

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Deep learning-based body composition analysis from whole-body magnetic resonance imaging to predict all-cause mortality in a large western populationResearch in context by Matthias Jung, Vineet K. Raghu, Marco Reisert, Hanna Rieder, Susanne Rospleszcz, Tobias Pischon, Thoralf Niendorf, Hans-Ulrich Kauczor, Henry Völzke, Robin Bülow, Maximilian F. Russe, Christopher L. Schlett, Michael T. Lu, Fabian Bamberg, Jakob Weiss

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Realist evaluation of Autism ServiCe Delivery (RE-ASCeD): which diagnostic pathways work best, for whom and in what context? Findings from a rapid realist review by Patricia M Wilson, Venkat Reddy, Ian Male, William Farr, Jeremy Parr, Vanessa Abrahamson, Wenjing Zhang, Anna Peckham

“…Objectives Waiting times in the UK for an autism diagnostic assessment have increased rapidly in the last 5 years. This review explored research (including ‘grey’ literature) to uncover the current evidence base about autism diagnostic pathways and what works best, for whom and in what circumstances, to deliver high quality and timely diagnosis.Design We performed a Rapid Realist Review consistent with recognised standards for realist syntheses. …”
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Pre-Separation Mother–Child Relationship and Adjustment Behaviors of Young Children Left Behind in Rural China: Pathways Through Distant Mothering and Current Mother–Child Relation... by Ruwen Liang, Karla Van Leeuwen

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Changing age profile and incidence of injecting drug use initiation among people in Australia who inject drugs: evidence from two national repeated cross-sectional studiesResearch... by Olivia Price, Lisa Maher, Amy Peacock, Farzaneh Zolala, Louisa Degenhardt, Paul Dietze, Sarah Larney, Seraina Agramunt, Samantha Colledge-Frisby, Bradley Mathers, Dan Lewer, Rachel Sutherland

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Risk and impact of stroke across 38 countries and territories of the Americas from 1990 to 2021: a population-based trends analysis from the Global Burden of Disease Study 2021Rese... by Ramón Martinez, Paula Muñoz-Venturelli, Pedro Ordunez, Felipe Fregni, Carlos Abanto, Matias Alet, Tony Fabián Alvarez, Pablo Amaya, Sebastian Ameriso, Antonio Arauz, Miguel A. Barboza, Hernán Bayona, Antonio Bernabé-Ortiz, Juan Calleja, Vanessa Cano-Nigenda, Leonardo Augusto Carbonera, Rodrigo M. Carrillo-Larco, Angel Corredor, Ana Cláudia de Souza, Claudio Jimenez, Fernando Lanas, Sheila Martins, Victor Navia, Nelson Novarro-Escudero, Verónica Olavarría, Bruce Ovbiagele, Kevin Pacheco-Barrios, Octavio Pontes-Neto, Virginia Pujol, Alejandro Rabinstein, Julieta Rosales, Andrés Rosende, Gisele Sampaio Silva, Gustavo Saposnik, Souvik Sen, Fernando D. Testai, Victor Urrutia, Craig S. Anderson, Pablo M. Lavados

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De la stabilité des sites ornés de rivière en contexte tropical lors d’événements pluviométriques majeurs : Le cas de la tempête Fiona en Guadeloupe by Julien Monney, Johan Berthet, Pascal Mora

“…This article addresses the impact of extreme weather events on rock art sites located along rivers in humid tropical contexts. Drawing on archaeological and hydrogeomorphological observations made in Guadeloupe following the passage of Tropical Storm Fiona in September 2022, we provide an analysis of the modifications caused by the floods and discuss the implications for the current spatial distribution of engraved rocks in the landscape, as well as their vulnerability/stability in the face of the recurrence of such climatic hazards.The results reveal highly variable consequences depending on the sites, with their nature and extent depending on the location of the rock art sites in relation to precipitation distribution, their position within the hydrographic network (terraces, active bed, transit zone, flood zone), and the maturity of the latter. …”
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