Mitochondrial Reactive Oxygen Species Dysregulation in Heart Failure with Preserved Ejection Fraction: A Fraction of the Whole by Caroline Silveira Martinez, Ancheng Zheng, Qingzhong Xiao

“…In this review, we will provide an overview and discussion of the recent findings on mtROS production, its threshold for imbalance, and the subsequent dysfunction that leads to related cardiac and systemic phenotypes in the context of HFpEF. We will also focus on newly discovered cellular and molecular mechanisms underlying ROS dysregulation, current therapeutic options, and future perspectives for treating HFpEF by targeting mtROS and the associated signal molecules.…”
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Evidence of traditional Chinese medicine for treating type 2 diabetes mellitus: from molecular mechanisms to clinical efficacy by Yadong Ni, Xianglong Wu, Wenhui Yao, Yuna Zhang, Jie Chen, Xuansheng Ding

“…Context The global prevalence of type 2 diabetes mellitus (T2DM) has increased significantly in recent decades. …”
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Exploring the Acceptance and Opportunities of Using a Specific Generative AI Chatbot to Assist Parents in Managing Pediatric Rheumatological Chronic Health Conditions: Mixed Method... by Cheryl W Y Lau, Klaudia Kupiec, Polly Livermore

“…Understanding how we can support families better, without the need for increased personnel, will have implications for the health care systems. …”
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Good governance as the basis for the successful implementation of Ukraine’s state policy on European integration by O.V. Orel

“…To foster the development of Ukraine’s public administration in the context of European integration processes, this article substantiates and proposes the creation of a state policy document entitled «White Paper: Public Administration in Ukraine», structured as follows: Achievements (a brief overview of public administration reform outcomes in Ukraine); Benchmarks (description of good governance principles as key reform guidelines); Current State (description of the state of public administration in Ukraine at the time of research); Problems (overview of key issues, including an assessment of the compliance of public administration in Ukraine with good governance principles); Rationale for Reform (arguments in favour of further public administration reforms in Ukraine); Goals and Methodology (identification of the main purpose, goals, tasks, and applied research methods); Research Analysis (overview of the findings from major contemporary scientific and practical studies in the field of public administration in Ukraine and worldwide); Directions and Means of Reform Implementation (description of vectors for the future development of public administration in Ukraine and proposals for implementing core and alternative decisions); Results (description of intended outcomes, risks, and threats related to their achievement); Conclusions (logical summary of the material presented); Bibliography; Appendices. …”
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Unlocking the Shopper’s Mind: How Emerging Technologies Like Artificial Intelligence Is Shaping the Future of Retail by Florina-Gabriela MITU, Marius BOTA, Emil Emanuel SAVAN

“…While these approaches have been increasingly adopted by retailers, the current study investigates whether the drift toward digital platforms impacts the efficiency of neuromarketing strategies and how AI takes further priority in this direction (Goncalves et al., 2024). …”
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Measuring Sperm DNA Fragmentation and Clinical Outcomes of Medically Assisted Reproduction: A Systematic Review and Meta-Analysis. by Maartje Cissen, Madelon van Wely, Irma Scholten, Steven Mansell, Jan Peter de Bruin, Ben Willem Mol, Didi Braat, Sjoerd Repping, Geert Hamer

“…The present review suggests that current sperm DNA fragmentation tests have limited capacity to predict the chance of pregnancy in the context of MAR. …”
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Analysis of the distribution of digital tools in the activities of russian enterprises by Melnikov Alexander, Kalabina Elena

“…The information base was statistical data on the use of digital technologies by enterprises, as well as research on trends and management methods in the context of digital transformation. The result of the work was the formation of an assessment of the current state of the spread of digital technologies in the activities of enterprises in the Russian Federation. …”
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Anti-tumor efficacy and safety of AEV01 in preclinical glioblastoma and hepatocellular carcinoma models by Indrani Biswas, Senthilathiban Daisy Precilla, Aravinda Kumar, M. M. Sekhar, Renu Medasani, T. S. Anitha

“…AEV01, a specialized lipophilic extract derived from the roots of Picrorhiza kurroa, has shown promise as a potential anti-cancer agent. In this context, the current study aimed to evaluate the anti-tumor efficacy and safety profile of AEV01 both in vitro and in vivo in GB and HCC models. …”
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Crosstalk between ferroptosis and innate immune in diabetic kidney disease: mechanisms and therapeutic implications by Jinyang Wang, Haonan Shi, Ye Yang, Xueli Gong

“…This review presents an overview of ferroptosis within the context of DKD, beginning with its core mechanisms and delving into its potential roles in DKD progression. …”
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Protective graphene oxide layers for enhanced stability of copper cathodes in zinc-ion energy storage systems by Nikos Κavousanos, Ricardo Santamaría Ramirez, Athanasia Kostopoulou, Konstantinos Brintakis, Emmanuel Stratakis, Dimitra Vernardou

“…However, this enhancement led in a slight initial drop in capacitance, attributed to the increased resistance of Zn+2 interactions with the cathode.…”
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Blood-based biomarkers in mild behavioral impairment: an updated overview by Efthalia Angelopoulou, Xenia Androni, Chiara Villa, Alexandros Hatzimanolis, Nikolaos Scarmeas, Sokratis Papageorgiou

“…A growing number of studies have recently begun to explore the relationship between MBI and several blood-based biomarkers associated with Alzheimer’s disease (AD) pathology, neurodegeneration, as well as systemic metabolic and inflammatory dysregulation. In this context, MBI has been associated with lower plasma Aβ42/Αβ40 ratio, higher plasma phosphorylated tau at threonine 181 (p-tau181), increased neurofilament light chain (NfL) levels, as well as disturbances in metabolic markers, including homocysteine, insulin and ferritin, suggesting a multifaceted neurobiological basis for this syndrome. …”
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The Role of Extracellular Vesicles in Aging and Age-Related Disorders by Bharathi Hassan Ganesh, Himabindu Padinjarathil, Ramya Lakshmi Rajendran, Prasanna Ramani, Prakash Gangadaran, Byeong-Cheol Ahn

“…Mitochondrial malfunction and increased oxidative stress are major contributors for the aging process. …”
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Assessment of Health-Oriented Layout and Perceived Density in High-Density Public Residential Areas: A Case Study of Shenzhen by Guangxun Cui, Menghan Wang, Yue Fan, Fei Xue, Huanhui Chen

“…The authors attempt to go beyond current regulations to propose tailored solutions for Shenzhen’s high-density context, improving spatial efficiency and residential comfort in future public housing designs. …”
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Objects of forensic documentary science by V. S. Sezonov

“…The scientific novelty lies in the establishment of promising areas for the development of an innovative methodology for conducting forensic document examination in the context of the use of special technical means and the methodology for the use of modern software products. …”
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Crop simulation models as decision tools to enhance agricultural system productivity and sustainability – a critical review by Koushik Banerjee, Suman Dutta, Sumanta Das, Rahul Sadhukhan

“…Feeding the growing global population necessitates increased agricultural production, yet agriculture remains a vulnerable sector facing significant challenges from limited land resources, environment, and climatic constraints. …”
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The frequent variant A57F in the GNE gene in patients from Russia has Finno-Ugric Mari origin by Dmitrii Subbotin, Sofya Ionova, Andrey Marakhonov, Elena Saifullina, Artem Borovikov, Leila Akhmadeeva, Polina Chausova, Oksana Ryzhkova, Rena Zinchenko, Sergey Kutsev, Aysylu Murtazina

“…According to our study, the estimated age of the mutation’s spread is 160.46 years (95% CI: 45.55–244.14).DiscussionBy comparing the information gathered with historical data on migration patterns in the Middle Volga region and estimating the age of the variant’s dissemination, we propose hypotheses regarding its origin and the pathways through which it spread. In the current context of increased rate of interethnic marriages, investigating the spread of common pathogenic variants from historically isolated populations is important for molecular genetic diagnosis. …”
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Impact of demographic ageing on sustainability of public finance in Serbia by Zdravković Aleksandar, Domazet Ivana, Nikitović Vladimir

“…In this context, critical review of the current government approach to the pension growth dynamics was given from the perspective of medium-term sustainability of pension system, which resulted in appropriate recommendations. …”
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The Land Acquisition and Resettlement Frameworks for Irrigation Sector in the SADC Region: Strengths and Bottlenecks by devie Chilonga

“…This will still be a challenge with rapid population increases which are exerting pressure on land and the human rights watches actively operating in this sector, unless policies and legislation are responsive to current demands. …”
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Changing or validating physician opioid prescribing behaviors through audit and feedback and academic detailing interventions in primary care by Celia Laur, Natasha Kithulegoda, Nicola McCleary, Emily Nicholas Angl, Michael Strange, Barbara Sklar, Thivja Sribaskaran, Gail Dobell, Sharon Gushue, Jonathan M. C. Lam, Lindsay Bevan, Victoria Burton, Lena Salach, Justin Presseau, Laura Desveaux, Noah Ivers

“…Physicians mentioned that academic detailing validated current opioid practices or increased their belief about capabilities and their intentions , mediated by increased skills and the impact of environmental context and resources . …”
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Formation of the Soviet education system among the indigenous peoples of Southern Siberia in the 1920s by L. N. Aksenova, L. V. Sokolskaya, A. S. Valentonis, I. V. Shcherbinina

“…Today, the interest of researchers in regional history has increased all over the world; therefore, the current article will be useful to readers, as the analysis of new archival documents helps to fill the gaps in the scientific literature on the establishment of the Soviet school among the indigenous peoples of southern Siberia in the 1920s. …”
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