Neutrophil-to-Lymphocyte ratio as surrogate for JAK2V617F suppression and event-free survival in polycythemia vera by Tiziano Barbui, Arianna Ghirardi, Victoria Empson, Francesca Fenili, Giuseppe Gaetano Loscocco, Annalisa Condorelli, Alessandra Iurlo, Daniele Cattaneo, Elena Rossi, Valerio De Stefano, Paola Guglielmelli, Christoph Klade, Heinz Gisslinger, Alessandro Rambaldi, Joseph M. Scandura, Alessandro Maria Vannucchi

“…Abstract Chronic systemic inflammation is a key driver of polycythemia vera (PV) progression, but the immunomodulatory effects of current treatments remain poorly defined. The neutrophil-to-lymphocyte ratio (NLR) is an accessible biomarker of systemic inflammation proven in other contexts, but its role in monitoring PV disease activity has not been established. …”
Get full text

Avoiding Error and Finding the Right Balance in European Health Technology Assessments: Insights Generated by the European Access Academy by Elaine Julian, Tom Belleman, Maria João Garcia, Maureen Rutten-van Mölken, Robin Doeswijk, Rosa Giuliani, Bernhard J. Wörmann, Daniel Widmer, Patrick Tilleul, Ruben Casado Arroyo, Valentina Strammiello, Kate Morgan, Marcus Guardian, Michael Ermisch, Renato Bernardini, Fabrizio Gianfrate, Stefano Capri, Carin A. Uyl-de Groot, Mira Pavlovic, Jörg Ruof

“…This research aims to explore how to address these challenges in a balanced manner and prioritise key actions for effective collaboration in the context of the EU HTA. Methods: The methodology included a pre-convention survey among relevant stakeholders as well as working groups and the plenary ranking of discussion outcomes at the European Access Academy (EAA) Spring Convention 2024. …”
Get full text

Ethical implications related to processing of personal data and artificial intelligence in humanitarian crises: a scoping review by Tino Kreutzer, James Orbinski, Lora Appel, Aijun An, Jerome Marston, Ella Boone, Patrick Vinck

“…Ethical risks, particularly from artificial intelligence (AI) data processing, are increasingly recognized yet inadequately addressed by current humanitarian data protection guidelines. …”
Get full text

A whole process resilience management practice in coastal engineering by Yingtao Zhou, Yingtao Zhou, Yingtao Zhou, Chenhui Jiang, Yuanshu Jiang, Yu Zhu, Yu Zhu, Yu Zhu, Yan Jin, Xian Wang, Xi Feng, Weibing Feng

“…Coastal zones are crucial for protecting land from marine disasters, but they are increasingly threatened by erosion caused by storms and rising sea levels. …”
Get full text

Artesunate-loaded Fe3O4 nanoparticles: A novel approach for combating 4T1 breast cancer cells in vitro and in vivo by Amirreza Safdarian, Massoumeh Ebtekar, zouhair Mohammad Hassan, Hossein Naderi Manesh, Hashemi Seyed Ali, Saeed Samaeinasab, Danial Habibi, Hossein Khorramdelazad

“…Results: The nanoparticle made in this article had good anticancer effects and caused apoptosis in cancer cells in breast cancer, and also strengthened the cellular immune system and further increased interferon gamma and increased the half-life of mice with cancer, while this nanoparticle It did not have the side effects of chemotherapy drugs.Conclusion: Artesunate-containing nanoparticles decreased 4T1 cell viability and increased apoptosis to a greater extent than nanoparticles without the drug. …”
Get full text

Clinical and cost-effectiveness of paramedics working in general practice: a mixed-methods realist evaluation by Matthew Booker, Sarah Voss, Nicky Harris, William Hollingworth, Nouf Jeynes, Hazel Taylor, Kirsty Garfield, Helen Baxter, Jonathan Benger, Andy Gibson, Trudy Goodenough, Justin Jagosh, Kim Kirby, Cathy Liddiard, Alyesha Proctor, Sarah Purdy, Behnaz Schofield, Hannah Stott, Grace Scrimgeour, Nicola Walsh

“…Background General practice services are under pressure due increased demand. Alongside substantial national recruitment challenges, there exists a shortage of general practitioners to meet current need. …”
Get full text

SHAZAM: Self-Supervised Change Monitoring for Hazard Detection and Mapping by Samuel Garske, Konrad Heidler, Bradley Evans, Kee Choon Wong, Xiao Xiang Zhu

“…The increasing frequency of hazardous events due to climate change underscores an urgent need for effective hazard monitoring systems. …”
Get full text

Graduate Student Literature Review: The DRB3 gene of the bovine major histocompatibility complex—Discovery, diversity, and distribution of alleles in commercial breeds of cattle an... by Thales Eduardo Galdino Andrade, Maurício Scavassini Peña, Jéssica Fiorotti, Renan de Souza Bin, Alexandre Rodrigues Caetano, Timothy Connelley, Isabel Kinney Ferreira de Miranda Santos

“…To catalog these alleles, 2 nomenclature methods were proposed, and the current use of both systems makes it difficult to list, comprehend and apply these data effectively. …”
Get full text

Neutron Spectrum Unfolding Method Based on Compressed Sensing Theory by WU Guanghao1, SHAO Gang2, SHI Guang3, LIU Bin4, 5, PAN Liangming4, 5, WANG Feng4, 5, ZHOU Xiaowei4, 5

“…Accurate information of neutron spectrum is very important for design and operation of nuclear facilities. The current unfolding methods commonly use the prior information as the initial values of the iteration process, which limits implementation of multiple prior information during the unfolding process and accuracies of the unfolding results are difficult to be enhanced. …”

Conjugate vaccines for enteric fever: proceedings of a meeting organized in New Delhi, India in 2009 by Audino Podda, Allan James Saul, Rashmi Arora, Zulfiqar Bhutta, Anju Sinha, Rajni Gaind, Tanu Singhal, Samir Saha, Abdullah Brooks, Laura B. Martin, Yeshwant Amdekar, Amar Jeet Chitkara, Mae Shieh, Ambujam Nair Kapur, Tulsi Das Chugh

“…To ensure good immunization coverage, the conjugate vaccine could be administered either to young infants, concomitantly with infant EPI vaccines, or to older infants, concomitantly with measles vaccine, currently given at 9 to 12 months. The need for new combination vaccines, containing both EPI and typhoid antigens, was discussed as a tool to increase coverage and reduce the number of injections and priority conflicts in a crowded infant vaccination schedule. …”
Get full text

Investigation of biomolecular dynamics by sensitivity-enhanced 1H–2H CPMAS NMR using matrix-free dynamic nuclear polarization by Thomas Biedenbänder, Aryana Rodgers, Mirjam Schröder, Liliya Vugmeyster, Björn Corzilius

“…Molecular dynamics of functional groups contain valuable information about structural properties and functional activities in biomolecules. …”
Get full text

Optical Identification of Plasmodium falciparum Malarial Byproduct for Parasite Density Estimation by Jerry Opoku-Ansah, Moses Jojo Eghan, Benjamin Anderson, Johnson Nyarko Boampong, Raymond Edziah, Peter Osei-Wusu Adueming, Charles Lloyd Yeboah Amuah

“…Empirical computation of ratio of the ODs for the blood absorption bands revealed reduction in the ODs with increasing PD. Multispectral images containing uninfected red blood cells (u-RBCs) and P. falciparum‐infected red blood cells (i-RBCs) on unstained blood smear slides exhibited spectrally determined decrease in both reflected and scattered pixel intensities and increase in transmitted pixel intensities with increasing PD. …”
Get full text

Fostering global primary care research: a capacity-building approach by Amanda Howe, Felicity Goodyear-Smith, Michael Kidd, Sherina Mohd Sidik, Chris van Weel, David Ponka, Megan Coffman, Krystle Elizabeth Fraser-Barclay, Richard D W Fortier, Robert P Lennon, Jeremiah K A Madaki, Bob Mash, Kristina Zawaly

“…Our aim is to explore the current risks or barriers to primary care research capacity building, identify the ongoing tensions that need to be resolved and offer some solutions, focusing on emerging contexts. …”
Get full text

Research Progress on Catalytic Conversion of Lignin to Chemicals by Xuezhi ZENG, Wenyu WANG, Minxian HUO, Yi QI, Xueqing QIU, Xuliang LIN, Yanlin QIN

“…Currently, lignin is primarily used for combustion to generate process heat. …”
Get full text

Ferroptosis Among the Antiproliferative Pathways Activated by a Lipophilic Ruthenium(III) Complex as a Candidate Drug for Triple-Negative Breast Cancer by Maria Grazia Ferraro, Federica Iazzetti, Marco Bocchetti, Claudia Riccardi, Daniela Montesarchio, Rita Santamaria, Gabriella Misso, Marialuisa Piccolo, Carlo Irace

“…<b>Background/Objectives</b>: In the context of preclinical studies, we have hitherto showcased that a low-molecular-weight ruthenium(III) complex we named AziRu holds significant potential for further developments as an anticancer candidate drug. …”
Get full text

CONFRONTATION AND MUTUAL REFLECTION OF TWO WORLDS IN “THE GRASS DANCER” BY SUSAN POWER by Oksana G. Shostak

“…We have a desire to separate the indigenous tradition from the broad American, in particular, Anglo-American and recognize Indian writing as a component of the multicultural paradigm. Currently, there is a noticeable confrontation between two camps of literary critics: one of them is oriented to European literary theories and believes that they should form the basis of literary interpretations of indigenous writers’ works; another wing is determined by the need to clarify the peculiarities of the literary paradigm of “Indian realism” in the context of a globalized society taking into account new literary models of the perception of ethnic minorities. …”
Get full text

Stylistic Techniques in Russian and Chinese Medical and Cosmetic Youth Advertising Texts by Liliya R. Sakaeva, Dawulan Maierhali, Yakhin M. Ajdarovich, Muryasov Rahim Zakievich, Bazarova Liliya Vyazirovna, Ivanova Tatiana Konstantinovna, Konovalova Zhanna Georgievna, Shkilev Roman Evgenevich, Kenzhetayeva Gulzira Kabayevna

“… Background: An endless stream of messages aimed at disseminating information about the sale of certain products attracts the attention of philologists who study the features of media works and the language of advertising, distinguished by various linguistic units, techniques, methods, tactics, etc. Currently, there are dozens of different aspects of mass media research communications. …”
Get full text

Validity and reliability study of the Turkish version of the autism spectrum knowledge scale by Ayten Doğan Keskin, Nuray Öztürk, Nazan Kaytez, Neriman Aral, Fatma Elibol

“…Purpose: The prevalence rates of Autism Spectrum Disorder are witnessing a steady increase worldwide, and the numbers for Türkiye are remarkably high. …”
Get full text

Viroscope™: a universal solution for plant virus and viroid diagnostics using HTS and cloud-based analysis by Verónica Morgante, Juan Cristóbal Jiménez, Claudio Ponce, Cristóbal Urrutia, Fernanda Vera, Camila Farías, Rocío Camps de la Maza, Valentina Caro, Marco Muñoz, Bernardo Pollak

“…Border biosecurity and food supply face significant global challenges due to the increasing threat of plant viruses, exacerbated by international plant trade. …”
Get full text

AliC and AliD of nonencapsulated Streptococcus pneumoniae enhance virulence in a Galleria mellonella model of infection by contributing to reactive oxygen species resistance by Courtney D. Thompson, Md Fahim Khan, Lucas R. G. Crosby, Shelby G. Holcomb, Ana G. Jop Vidal, Jorge E. Vidal, Jorge E. Vidal, Larry S. McDaniel, Larry S. McDaniel, Lance E. Keller, Lance E. Keller

“…Due to the lack of capsule in NESp strains the current vaccines, that target the pneumococcal capsule are ineffective. …”
Get full text