Comparison of the indirect immunofluorescence assay and a commercial ELISA to detect KSHV antibodies by Valentin Leducq, Léa Ben Said, Sophie Sayon, Vincent Calvez, Anne-Geneviève Marcelin, Aude Jary

“…The current gold-standard method, the indirect immunofluorescence assay (IFA), has a very good specificity of close to 100%, but a lower sensitivity of around 80–85%, which decreases to 64–67% in immunocompromised patients. …”
Get full text

Integrating Palliative Care and Heart Failure: the PalliatHeartSynthesis realist synthesis by Tracey McConnell, Carolyn Blair, Geoff Wong, Claire Duddy, Clare Howie, Loreena Hill, Joanne Reid

“…Our realist analysis developed and refined 6 overarching context–mechanism–outcome configurations and 30 sub context–mechanism–outcome configurations. …”
Get full text

Mesenchymal Stem Cell-Derived Microvesicles Support Ex Vivo Expansion of Cord Blood-Derived CD34+ Cells by Hui Xie, Li Sun, Liming Zhang, Teng Liu, Li Chen, Aiqi Zhao, Qian Lei, Fei Gao, Ping Zou, Qiubai Li, An-yuan Guo, Zhichao Chen, Hongxiang Wang

“…We speculate that MSC-MVs may recapitulate the hematopoiesis-supporting effects of their parent cells. In the current study, we found MSC-MVs containing microRNAs that are involved in the regulation of hematopoiesis. …”
Get full text

Incomplete epidemiological transition in Kazakhstan: changes in the structure of life expectancy and causes of death by А. Алдангаркызы, М. Денисенко

“… This article examines Kazakhstan's epidemiological transition, focusing on shifts in mortality patterns and life expectancy within the context of socioeconomic and demographic influences. …”
Get full text

Investigating the impact of armed conflict, cultural factors, and demographic characteristics on access to family planning services in Northwest Syria: a cross-sectional study by Okba Doghim, Abdulselam Daif, Abdulkarim Ekzayez, Kristen Meagher, Preeti Patel

“…Among them, 58% reported current contraceptive use. Analysis by age groups revealed that individuals aged 26–35 exhibited the highest proportion of contraceptive usage at 41.5%, while the under-18 age group showed the lowest at 7.7%. …”
Get full text

Challenges in modelling the impact of frost and heat stress on the yield of cool-season annual grain crops by Jonathan Richetti, Victor Oscar Sadras, Victor Oscar Sadras, Victor Oscar Sadras, Di He, Brenton Leske, Pengcheng Hu, Yacob Beletse, C. Mariano Cossani, C. Mariano Cossani, C. Mariano Cossani, Ha Nguyen, Bangyou Zheng, David Matthews Deery, M. Fernanda Dreccer, Jeremy Whish, Julianne Lilley

“…These developments are critical for improving crop yield predictions under extreme temperatures in the context of climate change.…”
Get full text

CanASM: a comprehensive database for genome-wide allele-specific DNA methylation identification and annotation in cancer by Jianmei Zhao, Zeyu Zhao, Hongfei Li, Haojie Yu, Hao Lin, Hanqi Chen, Xuecang Li, Di Liu, Yiming Wang, Guohua Wang

“…Despite the increasing recognition of ASM as a potential biomarker in tumorigenesis, systematic resources dedicated to identifying and annotating ASMs in cancer contexts remain limited. …”
Get full text

Assessment of the effect of the COVID-19 pandemic on levels of satisfaction in marital relationships during and post-lockdown by Rasha Aziz Attia Salama, Rabab Gad Abd El-Kader, Talaat Matter Tadross, Shaimaa Hashem Elsalous

“…The current study aimed to assess marital satisfaction during and post the lockdown of the COVID-19 pandemic and explore the factors influencing marital satisfaction among the public. …”
Get full text

Advances and prospect in natural beauty evaluation: insights for the World Heritage karst by Xi Zhao, Kangning Xiong, Meng Zhang

“…The combination of traditional and emerging technologies such as SD method, SBE method, AHP method, neuroscience, and UGC data has increased, breaking through time and space constraints and expanding data sources. (4) In future studies, the assessment of natural beauty should concentrate on aesthetic preferences across diverse cultural contexts, develop a concept of global localization, and enhance evaluators' aesthetic perception through multisensory integration. …”
Get full text

Exploring the feasibility of establishing a core set of sexual, reproductive, maternal, newborn, child and adolescent health indicators in humanitarian settings: a multimethods, mu... by Angel Foster, Allisyn C Moran, Loulou Hassan Kobeissi, Lale Say, Manizha Ashna, Kassandre Messier, Kathleen Louise Strong

“…With the collapse of health systems, reduced resources and increased vulnerabilities from displacement, there is a need to strengthen current practices and ensure the delivery of comprehensive sexual, reproductive, maternal, newborn, child and adolescent health (SRMNCAH) services. …”
Get full text

Global road extraction using a pseudo-label guided framework: from benchmark dataset to cross-region semi-supervised learning by Xiaoyan Lu, Yanfei Zhong, Zhuo Zheng, JunJue Wang, Dingyuan Chen, Yu Su

“…Recent advancements in satellite remote sensing technology and computer vision have enabled rapid extraction of road networks from massive, Very High-Resolution (VHR) satellite imagery. However, current road extraction methods face the following limitations: 1) Insufficient availability of accurate and diverse training datasets for global-scale road extraction; 2) Costly and time-consuming manual labeling of millions of road samples; and 3) Limited generalization ability of deep learning models across diverse global contexts, resulting in better performance for regions well-represented in the training dataset, but worse performance when faced with domain gaps. …”
Get full text

Apolipoprotein L1 (APOL1): Consideration of Molecular Evolution, Interaction with APOL3, and Impact of Splice Isoforms Advances Understanding of Cellular and Molecular Mechanisms o... by Razi Khalaila, Karl Skorecki

“…In the absence of a consistent mechanistic explanation for differential kidney injury, we propose pursuing three interrelated avenues of investigation informed by prior epidemiological and mechanistic evidence linking them to APOL1’s cytotoxicity: (1) Molecular evolution of APOL1 haplotypes in human populations, (2) APOL1 splicing and consequent splice isoforms, (3) Interaction of APOL1 with other APOL gene family members, prioritizing APOL3. In the current study, we use reanalysis of population genetics datasets to resolve the haplotype contexts of all protein-altering APOL1 variants, uncovering previously unrecognized variant–haplotype couplings. …”
Get full text

Improving follow-up imaging practices for patients with community-acquired pneumonia by Meirian Evans, Aazaz Rehman, Joseph Marchant, Matthew Pavitt, Rachel Buxton-Thomas

“…Introduction: The incidence of lung cancer in patients presenting to hospital with community-acquired pneumonia (CAP) is variably reported as 1–9.2%.1–3 The radiographic features of pneumonia and lung cancer can be similar. Therefore, in the context of lower respiratory tract symptoms, a malignancy visible on a chest X-ray may be missed.The British Thoracic Society (BTS) guidelines for the management of CAP in adults (2009) recommend that high-risk patients (aged >50 and current or ex-smokers) with consolidation on a chest X-ray should be followed up with a repeat chest X-ray 6 weeks after their initial presentation to ensure resolution of changes and to exclude an underlying malignancy.3Initial audit data in our local respiratory department showed that 41% of patients were incorrectly not followed up with repeat imaging. …”
Get full text

Canine Distemper Virus in Mexico: A Risk Factor for Wildlife by Juan Macías-González, Rebeca Granado-Gil, Lizbeth Mendoza-González, Cesar Pedroza-Roldán, Rogelio Alonso-Morales, Mauricio Realpe-Quintero

“…Through an extensive review of recent scientific literature about CDV disease in wildlife that has been published in local and international databases, the findings were connected with the current needs of information from a local to global perspective, and conclusions were made to broaden the context of Mexican epidemiological scenarios as closely related to the neighboring regions.…”
Get full text

Leveraging Administrative Health Databases to Address Health Challenges in Farming Populations: Scoping Review and Bibliometric Analysis (1975-2024) by Pascal Petit, Nicolas Vuillerme

“…ObjectiveWe aimed to explore the reuse of AHDs in addressing health issues within farming populations by summarizing the current landscape of AHD-based research and identifying key areas of interest, research gaps, and unmet needs. …”
Get full text

Novel approach to enhancing brain DHA uptake: the role of nannochloropsis microalgae extract by Kunpeng Ma, Shuhui Xie, Shuhui Xie, Ying Zhang, Haixiang Liu, Wei Yu, Peihua Chen, Peihua Chen

“…Despite its significance, the bioavailability of DHA from current supplements is suboptimal due to the limited absorption capacity of the adult brain. …”
Get full text

SOCIAL CONSTRUCTION OF TUBERCULOSIS by Andrei DOBRE

“…Despite the medical knowledge about the disease, analizing it from a sociological and anthropological point of view could generate a better understating of the disease, it’s social factors and the complexity of the context. Being the leading cause of death among the socio-professionally active population, with approximately 2 million deaths annually, prior to the establishment of certain control and surveillance measures, it is necessary to we understand the social factors and the costs of the disease, elements that increase the risk of infection / death, and what are the needs and services to be addressed. …”
Get full text

Teaching communication skills to OTL-HNS residents: multisource feedback and simulated scenarios by Pier-Luc Beaudoin, Mathilde Labbé, Amanda Fanous, Meredith Young, Jamie Rappaport, Yoon Soo Park, John Manoukian, Lily H. P. Nguyen

“…Abstract Background Effective communication has been linked to a reduction in adverse events and improved patient compliance. Currently in Otolaryngology – Head and Neck Surgery (OTL-HNS) residency programs, there is limited explicit teaching of communication skills. …”
Get full text

Expanding a primary care nurse practitioner fellowship to support rural and underserved pediatric patients in the US by Aaron Carpenter, Catherine Haut, Sarah Wawrzynski, Stacey Bachman, Lisa Kelly

“… Context: A significant shortage of primary care and mental healthcare providers currently exists in the US and is predicted to worsen, emphasizing the imperative for mental health training and collaboration within primary care settings, especially in rural and underserved areas. …”
Get full text

Epidemiology of Horsepox. The New Aspects by L. F. Stovba, A. A. Petrov, S. A. Melnikov, O. V. Chukhralia, N. K. Cherniкova, S. V. Borisevich

“…Although horsepox is currently considered extinct, its pathogen may persist in unknown reservoirs. …”
Get full text