Coordinated regulation of timing and strength of synaptic outputs by adrenergic receptors through control of action potentials in Purkinje cells by Kei Furukawa, Kei Furukawa, Shin-ya Kawaguchi

“…We demonstrate that Purkinje cell axons exhibit negative control of action potentials in amplitude and conduction velocity by β-adrenergic receptors in a manner dependent on the axonal length through specific reduction of axonal Na+ currents. On the other hand, β-adrenergic receptors increased presynaptic release probability without changing the amount of readily releasable vesicles in axon terminals of Purkinje cells. …”
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Does the Experience of Being Phubbed by Friends Affect Psychological Well-Being? The Mediating Roles of Loneliness, Relationship Satisfaction, and Self-Esteem by Yeslam Al-Saggaf

“…Past research found that phubbing partners indirectly affected their well-being. The current study was aimed at investigating whether phubbing friends is also indirectly related to their well-being. …”
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The Association Between Traumatic Brain Injury and the Risk of Cognitive Decline: An Umbrella Systematic Review and Meta-Analysis by Ioannis Mavroudis, Dimitrios Kazis, Foivos Efstratios Petridis, Ioana-Miruna Balmus, Vasileios Papaliagkas, Alin Ciobica

“…Background: There is currently increasing interest in the implication of traumatic brain injury (TBI) as a potential risk factor for long-term neurodegenerative conditions, such as dementia and Alzheimer’s disease (AD). …”
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Reassessing immediate coal phase-out: Dual imperatives of capacity control and renewables expansion in China’s net-zero strategy by Jiaxing Wang, Xi Lu, Hao Wang, Yang Ou, Jianxiao Wang, Dan Tong, Yan Li, Ziwen Ruan, Zihua Yin, Wenlong Zhou, Benjamin McLellan, Emily Xing, Anna M. MacLennan, Jingli Fan, Xian Zhang, Michael B. McElroy, Kebin He

“…Broader context: Reducing CO2 emissions in power systems is crucial for China in achieving its net-zero emission target. …”
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Biological contingency and adaptation to celibacy among girls aged 35 and over in Yazd city by Ahmad Kalateh Sadati, Fatemeh Jafari Naeimi, Sara Sadeghieh, Zahra Sadeghian Moghadam

“…This phenomenon varies across different decades and contexts, influenced by social and cultural conditions, which can impart diverse meanings and biological patterns. …”
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Medical triage as an AI ethics benchmark by Nathalie Maria Kirch, Konstantin Hebenstreit, Matthias Samwald

“…Adversarial prompts significantly decreased accuracy. By demonstrating the influence of context and ethical framing on the performance of LLMs, we provide critical insights into the current capabilities and limitations of AI in high-stakes ethical decision making in medicine.…”
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La política de ordenación y desarrollo del País Vasco norte by Eguzki Urteaga

“…The current context is characterized at the same time by the exacerbation of the territorial tensions with the metropolization of regional capitals, the rise of the periurban phenomenum and the depopulation of rural areas where public services and employments are decreasing, and by the exhaustion of a model of development based on the clustering of productive activity, exploitation of natural resources and the growth of social inequalities. …”

ANALYSIS OF THE DYNAMICS AND TRENDS IN THE DEVELOPMENT OF MODERN INTERNATIONAL TOURIST MARKET by J. A. Pshenichnyh

“…Based on the statistical data of international organizations, the author studied indicators of international tourist flows, identified the main trends in the development of international tourism at the current stage, assessed the impact on the tourism sector of the COVID-19 pandemic and determined possibilities for its development in the context of the economic crisis, showed prospects for the development of the industry.…”
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Study on the Performance of Anti - Sulfur Tubing Materials 80S and 80S - 3Cr in H₂S/CO₂ Corrosion Environment by QI Jian-jing, HE Miao, YIN Zhi-fu, HUI Hao-yuan

“…Second, the potential (Ecorr) increases negatively with increasing sulfur-containing content, and the corrosion current density (Jcorr) decreases, and the Jcorr vaule of 80S-3Cr was smaller than the one of 80S under each corresponding testing condition. …”
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The relevance of creating a new combination drug for the treatment of cognitive disorders by L. I. Kucherenko, V. H. Slobodianyk

“…Conclusions. The review of current scientific literature devoted to the study of the causes of cognitive disorders reflects the current state of research in this area. …”
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OPTIMIZATION OF IMID-BASED THERAPIES by Murat Çınarsoy

“…In this case, it is clear that multiple myeloma treatment optimization cannot be achieved by considering multiple myeloma treatment only as applying the appropriate drug combination.In order to ensure the optimization of IMID-based therapies, it is necessary to take a broad perspective.This perspective should include the correct selection of the patient to be treated with IMID, the development and implementation of IMID forms that will increase patient compliance, the use of techniques to predict the development of resistance, side effect management during treatment, preventing the increase in disease burden with appropriate maneuvers by following the disease burden after treatment, and drug-free follow-up.It is recommended to avoid thalidomide in the presence of peripheral neuropathy, to prefer other agents instead of lenalidomide in the presence of renal function loss, and to avoid pomalidomide in patients with COPD.Nex-20, a once-monthly subcutaneous formulation of lenalidomide, is expected to be an important breakthrough in improving patient compliance.Prediction of which patients will develop resistance will be very useful in order to have the best treatment outcomes.Calculation of miRNA risk scores, measurement of lenalidomide metabolite levels in urine, measurement of cereblon levels in blood, or immunohistochemical detection of cereblon levels are some of the methods currently being tried to predict disease resistance.Patients who develop anemia should be treated with erythropoietin, skin reactions should be treated with steroids and antihistamines, diarrhea should be treated with loperamide and colestyramine, and in general, the drug should be discontinued and the same dose or a lower dose should be insisted upon.An important part of treatment is maintenance therapy with lenalidomide. …”
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Trends and Prospects in Educational Modernisation: A Hermeneutic Approach by A. F. Zakirova, Ye. N. Volodina

“…To overcome this situation and to break this deadlock, a profound reconsideration of the values underlying mechanisms of reform is required, taking into account multifaceted personal, social, national and universal relations, as well as unity of content, forms and means of education.The aims of the research were identified as follows: to analyse the current trends of modernisation in comprehensive schools and higher educational establishments; to justify humanistic mechanisms for improving the modernisation in the context of language education, which performs personally developing and socialising functions under ideological pluralism and opposition of value systems.Methodology and research methods. …”
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Sala de aula invertida com Tecnologias Digitais e Ferramenta Metacognitiva para potencializar as aulas do Ensino Superior / Flipped classroom with digital technologies and metacogn... by Caroline Medeiros Martins de Almeida, Camila Maria Bandeira Scheunemann, Paulo Tadeu Campos Lopes

“…A utilização do material autossuficiente baseado nas tecnologias digitais auxiliou os alunos na apreensão dos conceitos de fibromialgia, pois oferecia o conteúdo de modo organizado, atendendo as necessidades dos estudantes. /// In the current digital context, students are increasingly involved by digital technologies in their daily lives, which drives their insertion in the educational field, at different levels of education, in order to make classes more attractive, interesting and dynamic. …”

Optimizing a Novel Smartphone App to Prevent Postpartum Depression Adapted From an Evidence-Based Cognitive Behavioral Therapy Program: Qualitative Study by Adam K Lewkowitz, Melissa Guillen, Katrina Ursino, Rackeem Baker, Liana Lum, Cynthia L Battle, Crystal Ware, Nina K Ayala, Melissa Clark, Megan L Ranney, Emily S Miller, Kate M Guthrie

“…Participants’ suggestions to improve MBapp were categorized within the FRAME as adaptations that improved either content or context to optimize reach, retention, engagement, and fit for end users. …”
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SOIL ORGANIC CARBON POTENTIAL OF BOZHURISHTE MUNICIPALITY: A CASE STUDY FROM WESTERN BULGARIA by Borislav GRIGOROV

“…The results of the study display several major zones of a large soil organic carbon pool, located to the northeast and the central parts of the municipality. The section, containing the largest soil organic carbon pool, may experience an increase of 376 400 tons/ha for 20 years in the medium scenario and 499 100 tons/ha in the high scenario. …”
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SOIL ORGANIC CARBON POTENTIAL OF BOZHURISHTE MUNICIPALITY: A CASE STUDY FROM WESTERN BULGARIA by Borislav GRIGOROV

“…The results of the study display several major zones of a large soil organic carbon pool, located to the northeast and the central parts of the municipality. The section, containing the largest soil organic carbon pool, may experience an increase of 376 400 tons/ha for 20 years in the medium scenario and 499 100 tons/ha in the high scenario. …”
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Evaluation of the applicability of the X-ray room technical passports in the medical facilities and approval of the X-ray department technical plans by the local radiological autho... by I. I. Berezin, S. S. Somov, К. V. Yakusheva

“…The purpose of this work was to assess the relevance and necessity of issuing a technical passport for the X-ray room and to coordinate the project of the X-ray room with the X-ray department in the light of the current sanitary legislation. Registration of a technical passport by organizations that have special permits for these types of work, and not only by the X-ray and radiological department, would increase the legal value of the technical passport. …”
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Effects of Mo Addition on Microstructure and Corrosion Resistance of Cr_25-xCo₂₅Ni₂₅Fe₂₅Mo_x High-Entropy Alloys via Directed E... by Han-Eol Kim, Jae-Hyun Kim, Ho-In Jeong, Young-Tae Cho, Osama Salem, Dong-Won Jung, Choon-Man Lee

“…The alloy containing 10% Mo had the highest corrosion potential and the lowest current density, indicating the slowest corrosion rate and the best initial corrosion resistance. …”
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Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT by Neil McHugh, Laura Bojke, Mel Brooke Turfrey, Rachel Charlton, Myka Ransom, Laura C Coates, Howard Collier, Claire Davies, Emma Dures, Philip Helliwell, Jana James, Anya Lissina, Vishnu B Madhok, Alison L Nightingale, Jonathan Packham, Catherine Smith, Eldon Spackman, Cerys Tassinari, William Tillett, Sarah T Brown

“…We had two main study aims: To understand experiences of diagnosis in the current healthcare context from the perspective of patients newly diagnosed with PsA. …”
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Enhancing digital literacy in primary education through augmented reality by Natalie Nevrelova, Lilla Korenova, Zsolt Lavicza, Nikola Bruzkova, Angelika Schmid

“…Currently, there is a need to develop digital competencies already because they are included in the new curriculum. …”
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