Pharmacometric in silico studies used to facilitate a national dose standardisation process in neonatology – application to amikacin by Verena Gotta, Julia Anna Bielicki, Paolo Paioni, Chantal Csajka, Dominic Stefan Bräm, Christoph Berger, Elisabeth Giger, Michael Buettcher, Klara M. Posfay-Barbe, John van den Anker, Marc Pfister

“…We aimed to demonstrate how such pharmacometric modelling and simulation can provide a scientific rationale for optimising drug doses in the context of the Swiss national dose standardisation project in paediatrics using amikacin as a case study. …”
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Testosterone-induced erythrocytosis: addressing the challenge of metabolic syndrome and widely prescribed SGLT2-inhibitor drugs by Federica Tramontana, Azmi Mohammed, Yaasir H Mamoojee, Richard Quinton

“…Crucially, they also increase haematocrit by promoting haematopoiesis. This review focuses on the current best evidence for managing erythrocytosis, in the context of more prevalent obesity and prescriptions of testosterone and SGLT2i in this population. …”
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Mitochondrial Reactive Oxygen Species Dysregulation in Heart Failure with Preserved Ejection Fraction: A Fraction of the Whole by Caroline Silveira Martinez, Ancheng Zheng, Qingzhong Xiao

“…In this review, we will provide an overview and discussion of the recent findings on mtROS production, its threshold for imbalance, and the subsequent dysfunction that leads to related cardiac and systemic phenotypes in the context of HFpEF. We will also focus on newly discovered cellular and molecular mechanisms underlying ROS dysregulation, current therapeutic options, and future perspectives for treating HFpEF by targeting mtROS and the associated signal molecules.…”
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Objects of forensic documentary science by V. S. Sezonov

“…The scientific novelty lies in the establishment of promising areas for the development of an innovative methodology for conducting forensic document examination in the context of the use of special technical means and the methodology for the use of modern software products. …”
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Playing towards Motivation: Gamification and University Students in Physical Activity! by Victor Javier Sotos-Martinez, Salvador Baena-Morales, Manuel Sanchez-De Miguel, Alberto Ferriz-Valero

“…There is currently concern about the decrease in physical activity participation among university students. …”
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Economic benefits of rational perennial planting use under global climate change in Chuy by Belek uulu Esenbek, Rakhmatova Mavliuda, Ibraeva Nurila, Shakirova Klara, Chortonbaeva Asel, Ishekeev Nazarkul

“…The article examines the economic efficiency of using perennial plantings in the context of global climate change using the example of farms in the Chui region. …”
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Impact of financial stability and growth potential on the investment attractiveness of an organisation by O. E. Astafyeva, Yu. E. Khvostov

“…Receiving reliable and substantiated data on the financial stability of an organisation, a potential investor can draw conclusions and forecasts regarding the attractiveness of an investment object, and a potential investment object, in turn, gains the opportunity to take the necessary measures to increase its investment attractiveness. In the current economic realities, a characteristic feature of which is the complication of economic relations and resource maneuvering, it seems necessary to further study the relationship between the investment attractiveness and financial stability and study the influence of the latter on the growth potential in order to form a set of theoretical provisions and develop methods for increasing the economic stability of commercial enterprises, protecting their economic interests as well as for developing measures to enhance competitiveness and competitive advantages in the struggle for investments.…”
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The implications of and institutional barriers to compact land development for transportation: Evidence from Bejing by Pengjun Zhao

“…However, there are several institutional barriers related to the reintroduction of compact development in the current context of transition from a centrally planned system to a market system in China’s cities. …”
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TRENDS IN RURAL TOURISM DEVELOPMENT IN LVIV REGION BASED ON FORECASTING by Iryna DYDIV

“…Having built logarithmic, linear, exponential, power and polynomial trend models, the probable indicators for the specified period were forecasted. The current state and trends of rural tourism development during the COVID-19 pandemic and in the context of Russia's military aggression in Eastern Ukraine are considered. …”
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A Systematic Review of EEG Studies on the Neural Effects of Quran Listening by Hamid Majidi, Alireza Rajabi-Tavakkol

“…Despite promising findings, the current body of research is limited, particularly regarding nonlinear EEG dynamics and comprehensive study designs. …”
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Experiential Graphic Design: Informing, Inspiring, and Integrating People in Physical Spaces—A Review by Gorana Petković, Suzana Pasanec Preprotić, Anamarija Kozjan Cindrić

“…Experiential graphic design (XGD) has increased in importance over the past decade, with technological advances and a focus on user engagement. …”
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‘Nous fêterons’ or ‘On va fêter’? by Valerie Hekkel, Friederike Schulz, Marta Lupica Spagnolo

“…These findings highlight the potential and limitations of current LLMs in capturing age-specific variation while encouraging further integration of sociolinguistic methods into LLM research. …”
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Breast asymmetry: literature review and a new proposal for clinical classification by Gladstone Eustáquio de Lima Faria, Dov Charles Goldenberg, Ricardo Frota Boggio

“…These available classifications date from the 60s and 70s and need to be updated to the current clinical context. A more simplified and reproducible classification was proposed after a comprehensive literature review, considering the most frequent asymmetries in aesthetic plastic surgery offices, with their respective treatment guides. …”
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NON-CONVENTIONAL AGRICULTURAL LAND USE: A WAY TO ACCELERATE ECOLOGIZATION AND CAPITALIZATION by Anton TRETIAK, Valentina TRETIAK, Tatyana PRIADKA, Valeriy LYASHYNSKYY, Nataliia TRETIAK

“…Which made it possible to divide the regions into six groups and show that with an increase in the area of agricultural land in the regions, the intensity of its use also increases, this contributes to degradation processes and, in general, less efficient use of land. …”
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The effect of population size on urban heat island and NO2 air pollution: Review and meta-analysis by Yufei Wei, Rémi Lemoy, Geoffrey Caruso

“…After pooling data we estimate that each 10-fold increase in population, increases the temperature gap between the city and countryside by almost 2 °C or a 40 % increase when cities get very large. …”
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A comparative analysis of the development modes of the IoT for telecom operators by Kaikai LIU, Xun ZHANG

“…In recent years,the development of IoT is in full swing.It is of great significance for the current transformation and development of domestic telecom operators.In this context,the business model is very important for operators to achieve “overtaking” in the IoT industry.Based on the analysis of the operation status of the IoT of operators,the development strategies of the IoT industry at home and abroad were compared,and three different development strategies was summarized.Telecom operators had advantages in customers,channels and other aspects,but limited by many factors.It was suggested that in constructing the development model,they should follow the principle of gradual progress,fully according to their own enterprise positioning,combined with national policies,pay attention to their own positioning in the industry chain of the IoT,pay attention to risks,and ultimately realize it.Better development model improve the current situation of increasing revenue in the telecommunications industry.…”
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Clinical characteristics and risk factors of premature rupture of membranes infection in pregnant and lying-in women by Shufang Xiao, Meimei Lin

“…Premature rupture of membranes is one of the more common symptoms of pregnant women before labor, which can lead to an increased rate of preterm birth and a higher mortality rate of the fetus born from it. …”
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Trade and economic cooperation between Kazakhstan and Russia: features and development priorities by A. M. Myrzakhmetova, D. U. Alshimbayeva, K. A. Turkeeva, A. T. Yerimpasheva

“…The main approach is to expand regional trade through the mechanism of participation in the Eurasian Union, the intensifi of corporate ties through the creation of joint ventures, based on the use of advanced scientifi technologies to increase the production of competitive products. The presented article reveals the current state of trade, economic and investment cooperation between Kazakhstan and Russia in the context of the growing processes of globalization and regionalization. …”
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LEGITIMACY DEFICIT AND INSTITUTIONAL FAILURE OF THE GOVERNMENT OF UKRAINE: CHALLENGES AND WAYS TO OVERCOME by Nataliia Kononenko, Oleh Kononenko

“…The article analyzes the institutional capacity and legitimacy of governmental structures in Ukraine, particularly in the context of the current war. The main problem that undermines the effectiveness of the government is the regulatory and legal traps that arise from unreformed mechanisms of relations between the branches of government. …”
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Role of self-regulation in controlling cyber loafing and smartphone addiction: Reducing health risk at the university level by Aisha Bibi, Asia Mushtaq, Wajeeha Aurangzeb, Sadaf Z. Ahmed, Mushtaq Ahmad

“…Additional factors such as students’ disengagement from tasks, lack of context familiarities, and the boring nature of the task or teaching method may increase the mobile addiction. …”
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