Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels. by Chunfang Gu, Miranda S C Wilson, Henning J Jessen, Adolfo Saiardi, Stephen B Shears

“…The HCT116 cell line, which has a pseudo-diploid karotype, is a popular model in the fields of cancer cell biology, intestinal immunity, and inflammation. In the current study, we describe two batches of diverged HCT116 cells, which we designate as HCT116NIH and HCT116UCL. …”
Get full text

Three-step fabrication of TiO2CdS spheres on SiO2 supports for enhanced hydrogen evolution performance by Zhengyou Li, Alexander V. Soldatov, Aslam Hossain

“…The overpotential exhibited a notable decrease from 793 mV to 264 mV at a current density of 10 mA/cm², demonstrating the improved electrocatalytic efficiency as CdS concentration increased. …”
Get full text

Transuterine relocation of pregnant uterine horn segment in an exploratory rat model with implications for tubal ectopic pregnancy by Cara Buskmiller, Christina Camilleri, Stephen Sammut

“…Abstract Ectopic pregnancy affects ~ 2% of pregnancies annually in the United States, with no current treatments allowing for the continuation of the pregnancy. …”
Get full text

Sensitivity Approach for Blood Glucose Impedance Data Using the Geselowitz Theorem by Bruna Gabriela Pedro, John Alexander Gomez Sanchez, Pedro Bertemes-Filho

“…The article presents a preclinical study focused on developing a non-invasive blood glucose monitoring device. Current glucose monitoring methods, such as capillary or venous tests, are inconvenient for frequent use, making continuous monitoring challenging. …”
Get full text

Insights and perspectives on PVDF/MgO NCs films: Structural and optical properties for optoelectronic device applications by Shivaraj Madivalappa, R.B. Basavaraj, P.B. Chethan, D.P. Aarti, P.K. Jisha

“…In the current investigation, pure polyvinylidene fluoride (PVDF) and PVDF-MgO nanocomposite (NC) thin films are fabricated via solvent casting method using PVDF as a polymer matrix with different proportions of magnesium oxide (MgO) (0.5–2 wt%). …”
Get full text

Is Brazil reaching malaria elimination? A time series analysis of malaria cases from 2011 to 2023. by Klauss Kleydmann Sabino Garcia, Seyi Soremekun, Amanda Amaral Abrahão, Paola Barbosa Marchesini, Chris Drakeley, Walter Massa Ramalho, André M Siqueira

“…Pf infections remain a persistent challenge to control in the country and may require novel measures for containment. Current government supporting actions towards combating illegal goldmining activities and protecting indigenous populations may help malaria control indicators for the following years.…”
Get full text

Shoulder complaints in wheelchair athletes: A systematic review. by Omar W Heyward, Riemer J K Vegter, Sonja de Groot, Lucas H V van der Woude

“…All articles in the English language that contained any type of shoulder complaint in relation with a wheelchair sports player, at any level of status (recreational to elite), of any sport, were included. …”
Get full text

Assessment of polyvinyl alcohol–stabilized compressed earth bricks on performance and durability of structures by Salman Farooq, Zia Ul Islam, Muhammad Saeed Khan, Muhammad Umair Umar, Abdullah Khan Jadoon

“…In a bid to overcome such hurdles, the current work discusses the prospect of using polyvinyl alcohol (PVA) as a stabilizing additive in a bid to lower environmental burden due to cement manufacture. …”
Get full text

Effect of Protein Concentration on the Corrosion Behavior of Magnesium Alloys by MA Yucong, WANG Pengjie, OUYANG Zhengzheng, Mohd TALHA, LIN Yuanhua

“…When magnesium alloy is used in the human physiological environment， it will be affected by protein.In this work， the corrosion mechanism of a magnesium alloy in phosphate-buffered saline (PBS) containing various concentrations of bovine serum albumin (BSA) (0，0.5， 1.0， 1.5， 2.0， 3.5 and 5.0 g/L) was systematically investigated.Surface characterisation was carried out by Fourier-transform infrared spectroscopy (FTIR)， scanning electron microscopy (SEM)，energy-dispersive spectroscopy (EDS) and contact-angle measurements，whereas electrochemical behaviour was evaluated through potentiodynamic polarisation， electrochemical impedance spectroscopy (EIS) and scanning electrochemical microscopy (SECM).Complementary immersion tests were performed to corroborate the electrochemical findings.To elucidate the time-dependent effect of protein concentration， the electrochemical response and corrosion products of specimens immersed for 1， 3 and 7 d in solutions containing 0， 2.0 and 5.0 g/L BSA were also examined.Results showed that the presence of BSA up to 2.0 g/L reduced the corrosion rate， and the minimum corrosion current density occurred at 2.0 g/L，whereas a higher concentration (5.0 g/L) of BSA significantly accelerated localized corrosion of magnesium alloy surface.In the later stages of immersion， the overall corrosion resistance of the alloy deteriorated.When the BSA concentration was kept below 2.0 g/L， protein molecules formed a monolayer via chemisorption on the alloy surface， leading to a continuous decrease in corrosion rate with increasing BSA concentration.During prolonged immersion， this non-dense adsorbed layer was penetrated by the corrosive medium and consequently lost its protective effect.At 5.0 g/L BSA， protein molecules chelated the metal ions released from the alloy， forming soluble complexes that accelerated corrosion.With further immersion， the continual deposition， detachment and chelation of high-concentration BSA further intensified the dissolution of the magnesium alloy.…”
Get full text

Features of the bridge span performance when shifting the axis of the rail-sleeper grid by V. V. Korolev, A. A. Loktev, I. V. Shishkina, E. A. Gridasova

“…The joint work of the upper structure of the railway track and the supporting structures of the bridge crossing is an important condition for the normal operation of the railway section without various restrictions and additional work on the current maintenance and diagnostics of structural elements. …”
Get full text

Small Extracellular Vesicles with a High Sphingomyelin Content Isolated from Hypertensive Diabetic db/db Mice Inhibits Calcium Mobilization and Augments Amiloride-Sensitive Epithel... by Hunter Ramsay, Ling Yu, Faisal F. Alousi, Abdel A. Alli

“…Extracellular vesicles (EVs) contain bioactive lipids that play a key role in pathophysiology. …”
Get full text

Effects of rotational forces, and thermal diffusion on unsteady magnetohydrodynamic (MHD) flow of a viscoelastic fluid through porous media with isothermal inclined plates by Amjad Ali Pasha, Mohammed K. Al Mesfer, M.W Kareem, Raghunath Kodi, Mohd Danish, Shanawaz Patil, Ramachandra Reddy Vaddemani

“…The findings reveal that the fluid’s resultant velocity increases with higher Soret parameters across the fluid region, while the opposite trend is observed with an increase in both the aligned magnetic field and magnetic field intensity. …”
Get full text

Le réseau hydraulique à Pompéi (Italie) de l’époque des Samnites à Auguste (fin ive-fin ier s. av. J.-C.) by Federico Giletti

“…While the latter type appears equally in both private and public contexts, the burrow cistern by contrast differs in that it is excavated entirely into the lava stratum and has been demonstrated, as far as we currently know, only on the main outcrops of the lava plateau, such as on the rocky crest of the southern drop in height below insula 2 of Regio VIII.While the type of cistern with a burrow or bainhole seems to have been inspired by models already widespread in Punic-Carthaginian sites in Africa and on the islands and in the Magna-Greek area, cases of cisterns with a burrow collected to several arms primarily bear strong similarities to Etruscan-Latian examples, as does the technique of drainage tunnels entirely excavated in the geological bank and the custom of digging deep artesian wells. …”
Get full text

Patient partner engagement in the publication process: challenges and possible solutions by Krista E. Cooksey, Mark Neuman, Mara Bollini, Bethany Pennington, Hugo de O. Campos, Kathleen Oberst, Melissa Wurst, Mary C. Politi

“…When patients contribute to publications, they can bring unique perspectives that may enhance the impact, reach, and utility of the research in real-world contexts. Currently, there is limited systematic guidance to support patient partners as they navigate this complex publication process. …”
Get full text

Natural Alternatives in the Treatment of Colorectal Cancer: A Mechanisms Perspective by Karen Vanessa Fernandez-Muñoz, Cuauhtémoc Ángel Sánchez-Barrera, Marco Meraz-Ríos, Jose Luis Reyes, Eloy Andrés Pérez-Yépez, Maria Teresa Ortiz-Melo, Luis I. Terrazas, Monica Graciela Mendoza-Rodriguez

“…Curcumin, trimethylglycine, resveratrol, artemisinin, and some helminth-derived molecules, among others, are some natural compounds studied in the context of CRC. This review discusses the main benefits, mechanisms, advances, and dark side of conventional chemotherapeutics currently evaluated in CRC treatment. …”
Get full text

Dying of starvation if not from bombs: assessing measurement properties of the Food Insecurity Experiences Scale (FIES) in Gaza’s civilian population experiencing the world’s worst... by Feten Fekih-Romdhane, Kamel Jebreen, Tasnim Swaitti, Mohammed Jebreen, Eqbal Radwan, Wafa Kammoun-Rebai, Inad Nawajah, Omar Shamsti, Sahar Obeid, Souheil Hallit

“…To achieve this, field practitioners, researchers and decision-makers should be equipped with user-friendly and psychometrically sound measures tailored to real-life war situations and the Palestinian context. Therefore, the present study aimed to test the psychometric properties of the Food Insecurity Experiences Scale (FIES) in a sample of Arabic-speaking community adults currently living in the Gaza Strip during the war. …”
Get full text

NECROSIS AS A COMPLICATION OF LOCAL ANESTHESIA IN DENTISTRY by V.V. Lepsky, C. V. Osik

“…However, as a rule, most of the groups of painkillers contain vasoconstrictors of the cartridge, such as adrenaline hydrochloride, noradrenaline, although the last one is currently banned for use because of the complications that it can cause. …”
Get full text

Warming Yang,Promoting Blood Circulation and Inducing Diuresis in the treatment of diabetic nephropathy:a meta-analysis by WANG Lan, WANG Xiao-qin

“…Objective To evaluate the efficacy and safety of ’Warming Yang,Promoting Blood Circulation and Inducing Diuresis’ in the treatment of diabetic nephropathy(DN).Methods The used electronic databases contained foreign databases such as PubMed,EMBASE,Cochrane Library,and Chinese databases such as CNKI,SinoMed,Wanfang Data,CQVIP.The clinical data of "Warming Yang,Promoting Blood Circulation and Inducing Diuresis" in treatment of DN were collected comprehensively.The literature retrieval ended on April 1,2016,and the meta analysis of appropriate literature was processed by RevMan 5.3 software.Results The cases of randomized controlled trials totaled16 and the cases of DN patients totaled 1 107.The results of Meta analysis showed that compared to western medicine control group,the experimental group of integrated traditional Chinese medicine and western medicine,based on "Warming Yang and Benefiting Qi,Promoting Blood Circulation and Inducing Diuresis",perfonned better in the significant efficiency and total efficiency of the treatment of DN(RR=1.97,95%CI 1.50~2.59,Z = 4.86,P<0.01;RR=1.48,95%CI 1.35~1.62,Z=8.58,P<0.01),in the decrease of the serum creatinine(MD=-32.33,95%CI-58.20~-6.47,Z =2.45,P= 0.01),in the increase of high density lipoprotein(MD= 0.16,95%CI 0.09~0.23,Z =4.33,P<0.01),in the decrease of cholesterol,triglyceride,low density lipoprotein(MD=-0.82,95%CI 1.28~-0.36,Z = 3.49,P = 0.0005;MD=-0.40,95%CI-0.53~-0.26,Z=5.95,P<0.01;MD=-0.49,95%CI-0.76~-0.21,Z=3.46,P = 0.000 5),in the decrease of urinary protein(MD=-0.46,95%I-0.61~-0.31,Z=6.01,P<0.01),in the control of fasting blood glucose(MD=-0.34,95%CI-0.57~-0.12,Z = 3.00,P = 0.003),and performed the same in the decrease of the levels of tumor necrosis factor alpha(P= 0.33).Conclusions The current limited evidence suggests that the efficacy and safety of integrated traditional Chinese medicine and western medicine in the treatment of DN is better than the traditional protocols alone.…”
Get full text

Immuno‐Nanocomplexes Target Heterogenous Network of Inflammation and Immunity in Myocardial Infarction by Fan Su, Weifan Ye, Yi Shen, Yujie Xie, Chong Zhang, Qianyun Zhang, Zhengqi Tang, Meihua Yu, Yu Chen, Bin He

“…Abstract Despite the proceeds in the management of acute myocardial infarction (AMI), the current therapeutic landscape still suffers from limited success in the clinic. …”
Get full text

GBD: incidence rates and prevalence of anxiety disorders, depression and schizophrenia in countries with different SDI levels, 1990–2021 by Jueqi Wang, Xue Guan, Ning Tao

“…Data were categorized into 5-year age groups and 95% uncertainty intervals (UI) were calculated to account for data variability.ResultsIn countries with different SDI levels, the age-standardized average annual percentage change (AAPC) in the incidence of anxiety were all shown to be increasing, and there were large gender differences between the different SDI levels, with a maximum of 0.97 (0.76–1.18) for females in countries with a high SDI level, Age-standardized more rates per 100,000 people in high SDI countries, from 658.87 in 1990 to 841.56 in 2021, and the largest gender differences in countries with a low to moderate SDI level, with AAPCs for males and females of 0.04 (0.04–0.05), 0.86 (0.63–1.09); for depression, only the countries with medium-high SDI levels were statistically significant compared to the countries with medium-low SDI levels, with AAPCs of 0.05 (0.04–0.07), 0.04 (0.04–0.05); for schizophrenia in addition to the AAPCs of the countries with medium-high SDI levels showed an increase of 0.16 (0.13–0.18); the rest decreased.ConclusionThis study highlights the current status of global incidence and prevalence of mental disorders and examines the complex interactions between the period of onset and cohort of onset of mental disorders using APC modeling, with differences in gender differences in mental disorders in countries with different SDIs, and significant differences in countries with low to medium SDI levels, requiring further exploration of the mechanisms by which socio-economic development influences gender-specific mental health. …”
Get full text