A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer by Gary Middleton, Helen L. Robbins, Peter Fletcher, Joshua Savage, Manita Mehmi, Yvonne Summers, Alastair Greystoke, Nicola Steele, Sanjay Popat, Pooja Jain, James Spicer, Judith Cave, Paul Shaw, David Gilligan, Danielle Power, Dean Fennell, Maya Bajracharya, David J. McBride, Uma Maheswari, Alexander M. Frankell, Charles Swanton, Andrew D. Beggs, Lucinda Billingham

“…Abstract There are no current stratified medicine options for STK11-deficient NSCLC. …”
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Validation of the Mild Behavioral Impairment Scale (MBI-S) for brief self-assessment of Mild Behavioral Impairment in people without dementia by Paula Hinkl, Elmar Graessel, Nicolas Rohleder, Peter Landendoerfer, Thomas Kuehlein, Natascha Lauer, Anna Pendergrass

“…Abstract Background Mild Cognitive Impairment (MCI) and Mild Behavioral Impairment (MBI) are important constructs in the context of cognitive decline. MBI can be assessed with the Mild Behavioral Impairment Checklist (MBI-C). …”
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Intravesical instillation-based mTOR-STAT3 dual targeting for bladder cancer treatment by Dae Hoon Lee, Jung Ki Yoo, Ki Hwan Um, Wootae Ha, Soo Min Lee, Junseong Park, Min Jeong Kye, Jungyo Suh, Jin Woo Choi

“…Graphical Abstract The current investigation introduces an innovative conceptualization of bispecific short hairpin RNA (bs_shRNA) tailored for the equilibrated modulation of dual genes within a singular cellular context. …”
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Knowledge of Preconception Healthcare and Associated Factors: A Study among Mothers in Jinka Town, Southern Region, Ethiopia by Kassahun Fikadu Tesema, Tamirat Cheneka, Alemayehu Alemu, Mekonen Feyissa, Birhanu Birkaye, Hafiza Mohammed, Eleni Kidu, Getahun Wegaso, Biresaw Wasihun

“…Preconception healthcare is promising to improve the reproductive health status of women and couples if they receive care three months to two years before conception. In the current context of Ethiopia, however, preconception healthcare is overlooked in the continuum of care. …”
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Potential of the mortgage housing lending market by N. I. Parusimova, D. A. Dobrin

“…However, under conditions of increased uncertainty-driven by both external and internal factors, as well as technological and social changes – the Russian mortgage housing lending market is undergoing continuous transformation and facing new contemporary challenges. …”
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Holiday Weight Change in a US College Student Sample: A Prospective Observational Cohort Study by Hannah B. Yoo, Casen Bigham, Tanisha Basu, Sharmin Akter, Tiffany Tsai, Alexis Brown, Sara Kiros, Shruthi Durai, Claire Brown, Martin Binks

“…Weight gain occurred alongside increases in lean mass but not body fat. Results provide important context to previous findings observing weight gain in college students and adults over the holiday season. …”
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Cluster randomized trial of a team communication training implementation strategy for depression screening in a pediatric healthcare system: a study protocol by Nicole A. Stadnick, Gregory A. Aarons, Hannah N. Edwards, Amy W. Bryl, Cynthia L. Kuelbs, Jonathan L. Helm, Lauren Brookman-Frazee

“…First, the project will use mixed methods to refine the team training strategy to fit the organizational context and workflows. Next, a hybrid type 3 implementation-effectiveness pilot trial will assess the initial effectiveness of the team communication training (implementation strategy) paired with the current universal depression screening protocol (clinical intervention) on implementation outcomes (i.e., feasibility, acceptability, appropriateness, workflow efficiency) and clinical/services outcomes (increased frequency of needed screening and reduced time to service linkage). …”
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Young TPI: empowering animal-free science among the next- generation of scientists by Marta G. Valverde, Marta G. Valverde, Fatima Zohra Abarkan, Fatima Zohra Abarkan, Rebecca Van Eijden, Rebecca Van Eijden, Julia M. L. Menon, Julia M. L. Menon, Nikolas Gaio, Nikolas Gaio, Aarti Ramchandran, Aarti Ramchandran, Victoria C. De Leeuw, Victoria C. De Leeuw

“…In this context, Young TPI emerged as the-first-of-its-kind network comprising young professionals and students dedicated to revolutionizing scientific practices by catalyzing the shift towards animal-free research. …”
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Neurological disorders caused by recreational use of nitrous oxide—a retrospective study from a German metropolitan area and review of the literature by Asya Tshagharyan, Se-Jong You, Christian Grefkes, Elke Hattingen, Joachim P. Steinbach, Pia S. Zeiner, Marcel Hildner, Iris Divé

“…Abstract Background The recreational use of nitrous oxide (N2O) has seen a worldwide rise in the recent years, resulting in an increased incidence of neurological complications due to N2O-induced functional vitamin B12 deficiency. …”
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Improving mesophilic anaerobic digestion of compostable packaging through efficient and versatile thermo-alkaline pre-treatment by Gaël Huet, Julie Lamarque, Florian Monlau, Valentin Puchelle, Cecilia Sambusiti, Juliana Catalina Suarez Murcia, Sandra Domenek, Florian Pion, Emmanuelle Gastaldi

“…In the current European regulatory context, which requires its Member States to collect biowaste separately with a view to its organic recovery, the co-processing of compostable food packaging with biowaste by mesophilic anaerobic digestion (AD) offers the dual opportunity of promoting its conversion into biogas while reducing plastic contamination of the environment. …”
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A Novel CTC-Binding Probe: Enzymatic vs. Shear Stress-Based Detachment Approaches by Sophia Krakowski, Sara Campos, Henri Wolff, Gabi Bondzio, Felix Hehnen, Michael Lommel, Ulrich Kertzscher, Paul Friedrich Geus

“…<b>Background/Objectives</b>: Liquid biopsy is a minimally invasive alternative to tissue biopsy and is used to obtain information about a disease from a blood sample or other body fluids. In the context of cancer, circulating tumor cells (CTC) can be used as biomarkers to determine the nature of the tumor, its stage of progression, and the efficiency of the administered therapy through monitoring. …”
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Prediction of potential habitat of Verbena officinalis in China under climate change based on optimized MaxEnt model by Shimao Chen, Zixuan Jiang, Jia Song, Tao Xie, Yu Xue, Qingshan Yang, Qingshan Yang, Qingshan Yang

“…Under future climate change scenarios (SSP1-2.6 and SSP5-8.5), the total suitable habitat area shows an overall increasing trend, reaching a maximum in the 2070s under the high-emission scenario (an increase of 3.6 × 105 km2 compared to the current distribution). …”
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Digital kiosks and inclusivity: a novel perspective on mobility hubs by Lluis Martinez, Kelt Garritsen, Jelten Baguet, Anna Grigolon, Karla Münzel, Imre Keserü, Karst Geurs

“…Abstract Mobility hubs facilitate multimodal transport and have the potential to improve the accessibility and usability of new mobility services. However, in the context of increasing digitalisation, using mobility hubs requires digital literacy or even owning a smartphone. …”
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The Effect of Information Quality of the Instagram Account @bemhimaperpusinfo on the Fulfillment of Information Needs of its Followers by Alvin Tessar Permata, Kuntum Khaira Ummatin, Gema Rullyana, Fikri Dwi Oktaviani

“…Background: Recent studies on social media use in academic settings underline its increasing importance in fulfilling students' information needs.  …”
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Droughts of the early 19th century (1790–1830) in the northeastern Iberian Peninsula: integration of historical and instrumental data for high-resolution reconstructions of extre... by J. Barriendos, M. Hernández, S. Gil-Guirado, J. Olcina Cantos, M. Barriendos

“…<p>Drought represents a prevalent climate risk in the Mediterranean region. In the context of climate change, an increase in both frequency and intensity is anticipated over the next century. …”
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Predictors for psychosocial consequences of screening for liver diseases: A data-driven approach. by Urs Alexander Fichtner, Andy Maun, Erik Farin-Glattacker

“…Inconsistent findings from studies, mainly originally from cancer research, are not easily transferable to the context of liver screening. This study aimed to identify predictors of psychosocial consequences in asymptomatic adults screened for early-stage liver cirrhosis, thereby contributing to the current knowledge on screening impact.…”
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Promotive, preventive, and treatment interventions for adolescent mental health in sub-Saharan Africa: A protocol for two scoping reviews including systematic analyses of intervent... by James Steel, Fantacy Twagira, Maaike L Seekles, Angela I Obasi

“…It is important that interventions to address this are rooted in an understanding of the unique local context and culture. Yet, the current use, development, and effectiveness of adolescent mental health interventions in sub-Saharan Africa is unclear. …”
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Social Media Addiction and Social Skills: Implications for Societal Learning Systems, Technology, Social Economy, and Societal Challenges by Semra Tetik, Catalin Popescu, Bülent Akkaya

“…The impact of social media use on societal challenges and individual development can be more effectively understood through the utilization of a systems thinking approach. The current study offers significant implications for the manner in which social media addiction and social skills are shaped in the context of social learning systems, technology and the social economy and explores the social effects of social media addiction and suggests effective interventions in the fields of education, policy and social work. …”
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Foreign Policy Image of the Eurasian Economic Union in the Mass Media of the United Kingdom by Olga Yu. Vikhrova, Iaroslava S. Gorlova

“…Due to the aggravation of the political crisis in 2022, the EAEU returned to the agenda of the British media, but mainly in the context of Russia’s foreign policy. This leads to the assumption that in the period from 2014 to 2022 the EAEU did not take any actions that would contribute to the formation of its foreign policy image, which underlines the necessity of such a study in the current circumstances.…”
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Natural science education in the university core curriculum by D. N. Kyrov, N. V. Nesterova, O. A. Prituzhalova, L. D. Cheremnykh

“…Introduction. One of the current issues in the theory and methodology of higher education is the development of its content that responds to societal challenges. …”
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