The frequent variant A57F in the GNE gene in patients from Russia has Finno-Ugric Mari origin by Dmitrii Subbotin, Sofya Ionova, Andrey Marakhonov, Elena Saifullina, Artem Borovikov, Leila Akhmadeeva, Polina Chausova, Oksana Ryzhkova, Rena Zinchenko, Sergey Kutsev, Aysylu Murtazina

“…According to our study, the estimated age of the mutation’s spread is 160.46 years (95% CI: 45.55–244.14).DiscussionBy comparing the information gathered with historical data on migration patterns in the Middle Volga region and estimating the age of the variant’s dissemination, we propose hypotheses regarding its origin and the pathways through which it spread. In the current context of increased rate of interethnic marriages, investigating the spread of common pathogenic variants from historically isolated populations is important for molecular genetic diagnosis. …”
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Impact of demographic ageing on sustainability of public finance in Serbia by Zdravković Aleksandar, Domazet Ivana, Nikitović Vladimir

“…In this context, critical review of the current government approach to the pension growth dynamics was given from the perspective of medium-term sustainability of pension system, which resulted in appropriate recommendations. …”
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The Land Acquisition and Resettlement Frameworks for Irrigation Sector in the SADC Region: Strengths and Bottlenecks by devie Chilonga

“…This will still be a challenge with rapid population increases which are exerting pressure on land and the human rights watches actively operating in this sector, unless policies and legislation are responsive to current demands. …”
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Effects of ibrutinib and venetoclax on the expression of immune checkpoint molecules in leukemic blasts of patients with acute lymphoblastic leukemia by Armin Dozandeh-Jouybari, Fatemeh Mousavi-Mirkalaei, Saeid Taghiloo, Hossein Karami, Mohammad Naderisorki, Ehsan Zaboli, Mohammad Eslami-Jouybari, Tohid Kazemi, Hossein Asgarian-Omran

“…Following treatment, the proliferation of leukemic cells was significantly decreased and the apoptosis rate was significantly increased, which was more remarkable for venetoclax. …”
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Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Results Our findings showed that CL-NPs loaded with anti-NOTCH1/-SF3B1 siRNAs-PTX significantly suppressed NOTCH1 and SF3B1 expression in PBMCs and BMMCs isolated from CLL cases in comparison with the untreated samples, leading to increased leukemic cell sensitivity to PTX and decreased the proliferative capacity of leukemic cells. …”
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Japanese Model of Attracting Foreign Youth in the Higher Education System by S. V. Ryazantsev, T. K. Rostovskaya, N. S. Ryazantsev

“…National education and science systems are increasingly integrated into the international scientific and educational space in the context of increasing globalisation. …”
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Changing or validating physician opioid prescribing behaviors through audit and feedback and academic detailing interventions in primary care by Celia Laur, Natasha Kithulegoda, Nicola McCleary, Emily Nicholas Angl, Michael Strange, Barbara Sklar, Thivja Sribaskaran, Gail Dobell, Sharon Gushue, Jonathan M. C. Lam, Lindsay Bevan, Victoria Burton, Lena Salach, Justin Presseau, Laura Desveaux, Noah Ivers

“…Physicians mentioned that academic detailing validated current opioid practices or increased their belief about capabilities and their intentions , mediated by increased skills and the impact of environmental context and resources . …”
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Formation of the Soviet education system among the indigenous peoples of Southern Siberia in the 1920s by L. N. Aksenova, L. V. Sokolskaya, A. S. Valentonis, I. V. Shcherbinina

“…Today, the interest of researchers in regional history has increased all over the world; therefore, the current article will be useful to readers, as the analysis of new archival documents helps to fill the gaps in the scientific literature on the establishment of the Soviet school among the indigenous peoples of southern Siberia in the 1920s. …”
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Polymer carrier selection for creation of diosmin solid dispersion system by hot melt extrusion by A. A. Danilova, E. V. Vishnyakov, E. S. Surbeeva, K. A. Gusev, D. N. Maimistov, E. V. Flisyuk

“…Particular importance in the context of current approach is attached to the selection of an effective polymer matrix.Aim. …”
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Management system and optimal control for three-dimensional visualization and maintenance of thermal power plant by Zhiqiang Feng, Qiuxiang Liang, Mingyi Wei, Lei Li, Youzhu Bu, Yanqing Xin

“…After optimization by CNN technology, the response time of the system is increased by 5%. The calculation cost is reduced by 15%, and the data throughput is increased by 13%. …”
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From conflict to conservation: Understanding public attitudes of hunters and conservationists toward Carpathian lynx (Lynx lynx carpathicus) in Slovakia by Peter Smolko, Jakub Kubala, Peter Klinga, Tibor Lebocký, Rudolf Kropil, Ján Zbranek, Tomáš Iľko, Branislav Tám, Marek Svitok

“…Our data suggest that increasing public awareness of lynx, implementing adaptive science‐based management, and involving hunters in citizen science and management decisions might be the most effective way to develop policies balancing conservation goals with the socio‐cultural context of human‐large carnivore coexistence.…”
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Stakeholder perspectives on scaling up potassium-enriched salt to reduce cardiovascular disease in Australia: a qualitative study by Juliette Crowther, Annet C. Hoek, Kathy Trieu, Inez Denham, Irene Deltetto, Alain Balaguer-Mercado, James D. Bullen, Katrina Kissock, Dori Patay, Emalie Rosewarne, Simone Pettigrew, Bruce Neal, Jacqui Webster

“…Interviewees identified increased awareness, support for industry research and development, and leveraging current policies and initiatives (such as the Australian Health Star Rating system) as potential enablers. …”
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Burden of Diabetes Mellitus in Nepal: An Analysis of Global Burden of Disease Study 2019 by Achyut Raj Pandey, Krishna Kumar Aryal, Niraj Shrestha, Dikshya Sharma, Jasmine Maskey, Meghnath Dhimal

“…Globally, the number of people living with diabetes mellitus (DM) increased by 62% between 1990 and 2019, affecting 463 million people in 2019, and is projected to increase further by 51% by 2045. …”
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Pharmacokinetics of levosimendan in critically Ill children on extracorporeal membrane oxygenation: a prospective observational study by Stéphane Bertin, David Haefliger, Maria-Helena Perez, Monia Guidi, Monia Guidi, Laurent A. Decosterd, Vivianne Chanez, Ermindo R. Di Paolo, Thierry Buclin, Françoise Livio

“…This suggests that dosage should be increased in this context, to achieve optimal exposure of levosimendan and its active metabolite.…”
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Assessment of the state of crops in the territory of the Chelyabinsk Research Institute of Agricultural Sciences based on remote sensing data by Gusev A.S., Inysheva V.A., Lopukhov P.M., Anisimov Yu.B., Bronitskaya S.A.

“…In the context of climate change and increasing food demand, it is important to optimize agricultural production processes. …”
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THE LABOR MARKET IN ROMANIA AND ITS INFLUENCING FACTORS by Marius Dan Benta, Claudiu-Liviu Manea, Costin Daniel Avram, Daniel Toba

“…The objectives of this research of the labor market are: the analysis of the current situation generated by the current context of the labor market in Romania, the highlighting of gaps in the labor force deficit, the effects generated by the labor force deficit, but also the outline of strategies aimed at reducing the deficit, the outline of strategies that highlight a series of actions to recover and balance the workforce deficit. …”
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Unitization Based Memory Enhancement in Younger and Older Adults by Joshua Kah Meng Khoo, Roni Tibon

“…Memory for episodic associations declines with ageing due to decreased recollection abilities. Unitization—the encoding of multiple items as one integrated entity—has been shown to support familiarity-based retrieval that is independent of recollection and is relatively preserved in healthy ageing. …”
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PM2.5 prediction and its influencing factors in the Beijing-Tianjin-Hebei urban agglomeration using spatial temporal graph convolutional networks by Yawen Zhao

“…In the context of rapid urbanization, PM _2.5 pollution poses a significant threat to public health and environmental quality. …”
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Outcomes following single level posterior lumbar fusion in patients with systemic and discoid lupus: A retrospective national database study by Meera M. Dhodapkar, MD, MHS, Scott J. Halperin, MD, MHS, Wesley Day, BA, Comron Saifi, MD, Daniel R. Rubio, MD, Fotios Koumpouras, MD, Jonathan N. Grauer, MD, Arya Varthi, MD

“…On multivariable analysis of the matched populations, patients with SLE were at most increased odds of 90-day (in decreasing ORs): pneumonia (OR 4.45), urinary tract infection (OR 4.24), minor adverse events (OR 3.17), all adverse events (OR 2.78), deep vein thrombosis (OR 2.71), acute kidney injury (OR 2.62), transfusion (OR 2.08), pulmonary embolism (OR 1.98), sepsis (OR 1.66), surgical site infection (OR 1.29) (p<.0033 for all). …”
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Multi-Scale Contextual Coding for Human-Machine Vision of Volumetric Medical Images by Jietao Chen, Weijie Chen, Qianjian Xing, Feng Yu

“…Different from the existing 3D convolutional compression algorithms oriented only for human vision, this paper proposes a Multi-scale Contextual Autoencoder (MCAE) architecture that recurrently incorporates anatomical inter-slice context to optimize the compression of the current slice for both human and machine vision. …”
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