A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer by Gary Middleton, Helen L. Robbins, Peter Fletcher, Joshua Savage, Manita Mehmi, Yvonne Summers, Alastair Greystoke, Nicola Steele, Sanjay Popat, Pooja Jain, James Spicer, Judith Cave, Paul Shaw, David Gilligan, Danielle Power, Dean Fennell, Maya Bajracharya, David J. McBride, Uma Maheswari, Alexander M. Frankell, Charles Swanton, Andrew D. Beggs, Lucinda Billingham

“…Abstract There are no current stratified medicine options for STK11-deficient NSCLC. …”
Get full text

Innovating through tradition: kava-talanoa as a culturally aligned medico-behavioral therapeutic approach to amelioration of PTSD symptoms by S. Apo Aporosa, Dennis Itoga, Julia Ioane, Jan Prosser, Sione Vaka, Emily Grout, Martin J. Atkins, Mitchell A. Head, Jonathan D. Baker, Tanecia Blue, David H. Sanday, Mahonri W. Owen, Chris Murray, Karthik Sivanathan, Tua’ipulotu W. Cuthers, Anau Mesui-Henry, Mary-Jane McCarthy, James Bunn, Ifereimi Waqainabete, Helen Turner, Helen Turner, Helen Turner

“…Our core hypothesis is that, combined, kava-talanoa will outperform current standards of care in PTSD symptom management as a culturally augmented cognitive-behavioral group therapy intervention. …”
Get full text

The role of assessment of quality of life and health with the index of vital activity in patients with arterial hypertension combined with gout in the family doctor practice. by O. M. Lazarenko, A. P. Kuzmina

“…The number of studies that assess the quality of life of patients with various comorbid diseases is increasing annually. Arterial hypertension and gout is no exception. …”
Get full text

Young TPI: empowering animal-free science among the next- generation of scientists by Marta G. Valverde, Marta G. Valverde, Fatima Zohra Abarkan, Fatima Zohra Abarkan, Rebecca Van Eijden, Rebecca Van Eijden, Julia M. L. Menon, Julia M. L. Menon, Nikolas Gaio, Nikolas Gaio, Aarti Ramchandran, Aarti Ramchandran, Victoria C. De Leeuw, Victoria C. De Leeuw

“…The Dutch government has promoted initiatives such as Transitie Proefdiervrije Innovatie (TPI) to make the public aware of the current situation. However, the transition towards animal-free innovations will span over more than two generations. …”
Get full text

Analysis of clinical and epidemiological interactions of phenol and phthalate levels in blood and urine with anamnestic and biochemical health measures during the formation of mult... by I. Yu. Torshin, O. A. Gromova, T. E. Bogacheva, A. N. Gromov

“…Higher urine levels of phenol were associated with increased levels of bone and cartilage destruction markers, hematopoiesis disorders (decreased hemoglobin and mean corpuscular volume), liver and kidney dysfunction (increased creatinine and albumin levels), decreased systolic blood pressure (hypotension) in the setting of lower intake of fiber, vitamins E, A, C, B2, B6, folates, and magnesium. …”
Get full text

Bio-capped synthesis of TiO2 nanoparticle using Murraya koenigii leaf extract via ultrasonication assisted sol-gel method and its advanced DSSC performance by Yoganand Singh, Himanshu Patel, Ananya Rai, Sakshi Singh, Nikhil Srivastav, Pankaj Srivastava

“…In this eco-friendly approach, the MK extract that contained diverse phytochemicals such as flavonoids, carbohydrates, quinones, and alkaloids was utilized as both a reducing and stabilizing agent during nanoparticle formation. …”
Get full text

Diagnostic value of inflammatory biomarkers of ESR and CRP in differentiating severe and moderate cases of COVID-19 patients hospitalized in Shahid Beheshti Hospital in Kashan, Ira... by Reza Razaghi, Mansooreh Momen_Heravi, Reihaneh Faghihi, Hamidreza Nahri, Mohammdhasan Fallahzadeh, Mohammad Javad Azadchehr, Mohammad Javad Razaghi

“…Background and Aim: The levels of inflammatory biomarkers ESR and CRP are significantly increased in the early stages of the COVID-19 and their levels are related to the severity of the disease. …”
Get full text

RETRACTED: Tax procedural proof: problems of theory and practice by I. V. Glazunova, D. S. Sheptunov

“…RETRACTED ARTICLEThe subject of this study is the legal norms contained in legislation, other legal acts, as well as materials of law enforcement practice that determine the specifics of tax procedural evidence. …”
Get full text

Biomass and Yield in Solanum lycopersicum Expressing a Synthetic Photorespiration Pathway by Laura Dougherty, Bret Cooper, James Bunce, Bryan Vinyard, John Stommel

“…The current study investigated whether a novel synthetic photorespiratory pathway demonstrated to reduce photorespiratory metabolic energy demands and increase plant vegetative biomass in model species could boost tomato crop yield, notably yield of marketable fruit. …”
Get full text

Manganese Intoxication Induced by Total Parenteral Nutrition in the Intensive Care Unit: A Case Report by Victoria Seijas-Martínez-Echevarría, Rita Martínez-Manzanal, Ester Mena-Pérez, Pilar Nuñez-Valentín, Guadalupe Ruiz-Martin

“…<b>Case Presentation:</b> A 73-year-old man was logged for 210 days in the intensive care unit (ICU), receiving parenteral nutrition (PN) for a month, and was then transferred, first, to the internal medicine ward and, then, to the rehabilitation hospital, and 223 days after discharge from the ICU, he had current disease, chorea-type movements in the head and neck, and left hemibody. …”
Get full text

Spatial transcriptomic characteristics of gastric cancer in young and the expression and role of TMEM176B in gastric cancer cells by Zhenhua Jiang, Yongfeng Wang, Chi Zhang, Shuangyin Han

“…Abstract Background Gastric cancer in young (GCY) is increasing in incidence with poor prognosis. Current screening and molecular methods are inadequate, necessitating new approaches to explore its pathogenesis. …”
Get full text

Pediatric Brain Tumor Risk Associated with Head Computed Tomography: Systematic Literature Review by Dilara R. Kuznetsova, Diana A. Gabdullina, Alina F. Makhmudova, Elena V. Bochkina, Elizaveta O. Platonova, Bogdan O. Zhirnov, Elnara E. Akhmetgareeva, Liliya S. Atangulova, Ruslan S. Shein, Kristina I. Rakhimova, Vlastilin V. Pakalnis, Elza R. Ganieva

“…Cumulative effect in such cases may increase the minimal risk of carcinogenesis. Larger and advanced epidemiological studies are required to better understand these risks.…”
Get full text

Silenced SOX2‐OT alleviates ventricular arrhythmia associated with heart failure by inhibiting NLRP3 expression via regulating miR‐2355‐3p by Yuming Liang, Boqun Wang, Huijuan Huang, Maoyun Wang, Qianwen Wu, Yaxin Zhao, Yan He

“…Abstract Background Nucleotide‐binding oligomerization domain‐like receptor family pyrin domain containing 3 (NLRP3) inflammasomes are the most important factors in ventricular arrhythmia associated with heart failure (VA‐HF). …”
Get full text

Modeling pathogen-driven neonatal late-onset sepsis: a modification to the murine cecal slurry by Camryn Sellers-Porter, Shiloh R. Lueschow-Guijosa, Jessica M. Santana, Anjali J. Cera, Geoanna M. Bautista, Michele Persiani, Misty Good, Steven J. McElroy

“…NEC’teria exposure significantly increased serum inflammatory cytokines, resulted in intestinal injury, altered the microbiome composition, and induced significant changes in local and systemic immune cell expression. …”
Get full text

Prevalence, Molecular Characterization, and Immune Status Response of Hepatitis B Virus Among Healthcare Workers in Yaoundé General Hospital, Cameroon, During May to June 2024: A H... by Marie Atsama‐Amougou, Fredy Brice Nemg Simo, Cedric Fossi Tchinda, Marie Moukam, Marcel Tongo‐Passo, Paul Moundipa‐Fewou

“…However, healthcare workers (HCWs) are at increased risk of HBV transmission due to occupational exposure. …”
Get full text

Evaluating Policy Shifts on Perceived Greenspace Quality: Applying Regression Discontinuity During the COVID-19 Reopening Period by Chensong Lin, Chenjie Jia, Baisen Wang, Shuhao Kang, Hongyu Chen, Di Li, Longfeng Wu

“…However, the impact of changing containment policies on residents’ perceived greenspace quality remains insufficiently explored. …”
Get full text

Construction of medical scientific data repositories in China: analysis of survey and recommendations by Jia Song, Jia Song, Chunqiu Li, Wirapong Chansanam

“…BackgroundIn the context of global open science trends, medical open-access repositories (OARs) promote transparency in research and facilitate the sharing of scientific data. …”
Get full text

Soundscape research in wind farms: A state-of-art review by Xinyan Xu, Huan Tong, Jian Kang

“…By reviewing these articles, this review found that current research related to the soundscape study of wind farms is still lacking, with more researchers focussing on wind power noise and its effects on the physical and psychological health of residents rather than on the influence of the integrated acoustic environment and context of wind farms on residents' perception. …”
Get full text

Pregnancy-related acute kidney injury leads to hypertension, reduced kidney function and cognitive impairment in postpartum rats by Ashley Griffin, Jamie Szczepanski, Shauna-Kay Spencer, Shauna-Kay Spencer, Lucia Solis, Teylor Bowles, Reanna Robinson, Jan M. Williams, Patrick B. Kyle, Kedra Wallace, Kedra Wallace

“…Both hypertensive disorders of pregnancy and Acute Kidney Injury (AKI) outside the context of pregnancy have been associated with an increased risk of developing Chronic Kidney Disease (CKD) and cognitive impairment. …”
Get full text

Genome-Wide DNA Methylation Analysis during Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Yangyang Cao, Haoqing Yang, Luyuan Jin, Juan Du, Zhipeng Fan

“…We found that the majority of cytosines in a CpG context were methylated in induced BMSCs. Our results also revealed that, along with the induced osteogenic differentiation in BMSCs, the average genomic methylation levels and CpG methylation in transcriptional factor regions (TFs) were increased, the CpG methylation level of various genomic elements was mainly in the medium-high methylation section, and CpG methylation levels in the repeat element had highly methylated levels. …”
Get full text