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Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage
Published 2025-05-01“…Several small-molecule inhibitors targeting ATM/Chk2 or ATR/Chk1 are currently being tested in preclinical and/or clinical settings, showing promise in cancer models and patients. …”
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564
Increasing efficiency and sustainability: A comparative analysis of concrete 3D printing and traditional methods based on case studies
Published 2025-01-01“…These are particularly important in the context of the current skilled labour shortage and emphasis on resource efficiency in construction. …”
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565
Does neoadjuvant chemotherapy increase the survival in patients with locally advanced gastric cancer patients? – A real-world evidence
Published 2020-01-01“…However, these findings were statistically not significant. The current study has contributed an important finding to the existing evidences of clinical practice in an Indian setting. …”
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566
Subunit-specific mechanisms of isoflurane-induced acute tonic inhibition in dentate gyrus granule neuron
Published 2024-10-01“…Furthermore, this study demonstrated that the increased tonic current in DGGCs was dependent on the δ subunit-containing GABAARs by using transgenic δ subunit knockout mice. …”
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567
UE Context Dissemination in Sparse LEO Constellations for 5G/6G Cellular IoT in Store and Forward Operation
Published 2025-01-01“…We present an enhanced architecture that contains the mechanisms for UE context dissemination and investigate key performance metrics, such as revisit times and end-to-end delays for data transmission. …”
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568
A Critical Analysis of Cooperative Caching in Ad Hoc Wireless Communication Technologies: Current Challenges and Future Directions
Published 2025-02-01“…In this paper, we discuss the problems and issues in the current wireless ad hoc paradigms as well as spotlight versatile cooperative caching as the potential solution to the increasing complications in ad hoc networks. …”
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569
Cost–consequence analysis of COPD treatment according to NICE and GOLD recommendations compared with current clinical practice in the UK
Published 2022-06-01“…Savings were achieved overall despite a small increase in the rate of exacerbations due to the redistribution of certain patients currently undergoing triple inhaled therapy to therapies not containing inhaled corticosteroids.Conclusion Redistribution of patients with COPD from current clinical practice to treatment according to published recommendations would provide substantial cost savings over the first year.…”
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570
A Bibliometric Analysis of Mountain Research Literature on Journal of Mountain Research and Development: Current Situation and Future Directions
Published 2023-12-01“…Academic studies on mountains have increased since the 1990s. The aim of this study is to examine the current situation and development of the international literature on mountainous areas. …”
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571
Citizens’ perspectives on sustainable mobility transitions in a semi-urban context: tensions between everyday practices and sustainability advancements
Published 2025-07-01“…As illuminated in the studied semi-urban context, many established everyday practices are car-dependent. …”
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Gathering insights of the global scenario of floating-bed agriculture through systematic literature review for its promotion in Indian context
Published 2024-12-01“…This literature review aims to comprehensively document the current global scenario of floating-bed agriculture to promote it in India. …”
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Approaches to clinical development of combination medicines in the Russian Federation and the Eurasian Economic Union in view of the requirements of the current legislation
Published 2019-03-01“…In recent years, there has been an increasing interest in the development of combination medicines (fixed drug combinations) containing two or more active ingredients in a single dosage form. …”
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Knowledge and Perception of Practicing Anesthetists on Current Techniques, Clinical Applications, and Limitations of Artificial Intelligence in Anesthesiology: An Indian Study
Published 2024-11-01“…Background: Artificial intelligence (AI) is increasingly gaining importance in modern medicine. Yet, there is a dearth of knowledge on what the anesthesiologists know and think about AI in context. …”
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Unraveling the Complexity of the Ne/Nc Ratio for Conservation of Large and Widespread Pelagic Fish Species: Current Status and Challenges
Published 2024-10-01“…Secondly, we outline current knowledge about the influence of life history traits on the Ne/Nc ratio in the light of examples drawn from large and abundant pelagic fish species. …”
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The effectiveness of home-based transcranial direct current stimulation on chronic pain: A systematic review and meta-analysis
Published 2024-11-01“…As pain is highly prevalent and imposes significant burdens, interest in its remote management is steadily increasing. Transcranial Direct Current Stimulation (tDCS) seems promising in this context. …”
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